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Aliases for ZNF492 Gene

Aliases for ZNF492 Gene

  • Zinc Finger Protein 492 2 3
  • Zinc Finger Protein 115 (Y20) 2 3
  • ZNF115 3 4
  • Zinc Finger Protein 115 4
  • KIAA1473 4

External Ids for ZNF492 Gene

Previous Symbols for ZNF492 Gene

  • ZNF115

Summaries for ZNF492 Gene

GeneCards Summary for ZNF492 Gene

ZNF492 (Zinc Finger Protein 492) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF492 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF492 Gene

Genomics for ZNF492 Gene

Genomic Location for ZNF492 Gene

Start:
22,634,324 bp from pter
End:
22,667,670 bp from pter
Size:
33,347 bases
Orientation:
Plus strand

Genomic View for ZNF492 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF492 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF492 Gene

Regulatory Elements for ZNF492 Gene

Proteins for ZNF492 Gene

  • Protein details for ZNF492 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P255-ZN492_HUMAN
    Recommended name:
    Zinc finger protein 492
    Protein Accession:
    Q9P255
    Secondary Accessions:
    • Q08EI7
    • Q08EI8

    Protein attributes for ZNF492 Gene

    Size:
    531 amino acids
    Molecular mass:
    61158 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA95997.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF492 Gene

Proteomics data for ZNF492 Gene at MOPED

Post-translational modifications for ZNF492 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys204 and Lys422

Other Protein References for ZNF492 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF492 Gene

Domains for ZNF492 Gene

Gene Families for ZNF492 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF492 Gene

Suggested Antigen Peptide Sequences for ZNF492 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P255

UniProtKB/Swiss-Prot:

ZN492_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q9P255
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9P255
Similarity:
  • Contains 13 C2H2-type zinc fingers.:
    • Q9P255
genes like me logo Genes that share domains with ZNF492: view

Function for ZNF492 Gene

Molecular function for ZNF492 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF492: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF492 Gene

Localization for ZNF492 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF492 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF492 Gene COMPARTMENTS Subcellular localization image for ZNF492 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF492: view

Pathways for ZNF492 Gene

SuperPathways for ZNF492 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF492: view

Pathways by source for ZNF492 Gene

2 Reactome pathways for ZNF492 Gene

Gene Ontology (GO) - Biological Process for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF492: view

Transcripts for ZNF492 Gene

mRNA/cDNA for ZNF492 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF492 Gene

Zinc finger protein 492:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF492 Gene

No ASD Table

Relevant External Links for ZNF492 Gene

GeneLoc Exon Structure for
ZNF492
ECgene alternative splicing isoforms for
ZNF492

Expression for ZNF492 Gene

mRNA expression in normal human tissues for ZNF492 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF492 Gene

This gene is overexpressed in Testis (8.5).

SOURCE GeneReport for Unigene cluster for ZNF492 Gene Hs.232108

genes like me logo Genes that share expressions with ZNF492: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF492 Gene

Orthologs for ZNF492 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF492 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 90 (a)
OneToMany
LOC100611724 35
  • 95.61 (n)
  • 91.6 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 56 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for ZNF492:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF492 Gene

ENSEMBL:
Gene Tree for ZNF492 (if available)
TreeFam:
Gene Tree for ZNF492 (if available)

Paralogs for ZNF492 Gene

Selected SIMAP similar genes for ZNF492 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF492 Gene

genes like me logo Genes that share paralogs with ZNF492: view

Variants for ZNF492 Gene

Sequence variations from dbSNP and Humsavar for ZNF492 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs601404 -- 22,652,721(+) actac(A/G)ggctc intron-variant
rs629800 -- 22,654,871(-) gtaat(C/T)ctagc intron-variant
rs684399 -- 22,664,087(+) AGAAA(C/T)CTTTC missense, reference
rs1125907 -- 22,635,906(-) acaaa(A/C)ctgca intron-variant
rs1230334 -- 22,659,312(+) tctat(C/G)aagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF492 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
dgv552e201 CNV Deletion 23290073
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
esv34340 CNV Loss 17911159
dgv553e201 CNV Deletion 23290073
dgv633e199 CNV Deletion 23128226
nsv436853 CNV Insertion 17901297
nsv525240 CNV Gain 19592680
dgv3813n71 CNV Gain 21882294
dgv3814n71 CNV Gain 21882294
dgv3n43 CNV Gain 19587683
esv2751784 CNV Gain 17911159
esv2657662 CNV Deletion 23128226
nsv911451 CNV Gain 21882294
nsv9683 CNV Loss 18304495
esv2236506 CNV Deletion 18987734
esv2718358 CNV Deletion 23290073
esv2674355 CNV Deletion 23128226
nsv9684 CNV Loss 18304495

Relevant External Links for ZNF492 Gene

HapMap Linkage Disequilibrium report
ZNF492

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF492 Gene

Disorders for ZNF492 Gene

Relevant External Links for ZNF492

Genetic Association Database (GAD)
ZNF492
genes like me logo Genes that share disorders with ZNF492: view

No data available for UniProtKB/Swiss-Prot for ZNF492 Gene

Publications for ZNF492 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter. (PMID: 16714237) Lu Z. … Redmond T.M. (Curr. Eye Res. 2006) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PMID: 17567985) Tsuritani K. … Suzuki Y. (Genome Res. 2007) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF492 Gene

Sources for ZNF492 Gene

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