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ZNF492 Gene

protein-coding   GIFtS: 48
GCID: GC19P022817

Zinc Finger Protein 492

(Previous name: zinc finger protein 115 (Y20))
(Previous symbol: ZNF115)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4921 2
ZNF1151 2 3
Zinc Finger Protein 115 (Y20)1 2
KIAA14733
Zinc Finger Protein 1153

External Ids:    HGNC: 237071   Entrez Gene: 576152   Ensembl: ENSG000002296767   UniProtKB: Q9P2553   

Export aliases for ZNF492 gene to outside databases

Previous GC identifers: GC19P022627 GC19P022609 GC19P022608


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF492 Gene:
ZNF492 (zinc finger protein 492) is a protein-coding gene. Diseases associated with ZNF492 include keratoconus, and endotheliitis. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN492_HUMAN, Q9P255
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF492 gene promoter:
         RFX1   IRF-1   NF-AT   NF-AT4   NF-AT2   E2F   E2F-1   deltaCREB   NF-AT3   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF492

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF492


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p13.11

ZNF492 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF492 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P022817:  view genomic region     (about GC identifiers)

Start:
22,817,126 bp from pter      End:
22,850,472 bp from pter
Size:
33,347 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN492_HUMAN, Q9P255 (See protein sequence)
Recommended Name: Zinc finger protein 492  
Size: 531 amino acids; 61158 Da
Sequence caution: Sequence=BAA95997.1; Type=Erroneous initiation;
Secondary accessions: Q08EI7 Q08EI8

Explore the universe of human proteins at neXtProt for ZNF492: NX_Q9P255

Explore proteomics data for ZNF492 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys204, Lys422
  • Modification sites at PhosphoSitePlus

  • See ZNF492 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065906.1  
    ENSEMBL proteins: 
     ENSP00000413660  
    Reactome Protein details: Q9P255

    ZNF492 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9P255

    ProtoNet protein and cluster: Q9P255

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN492_HUMAN, Q9P255
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF492 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN492_HUMAN, Q9P255
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF492 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN492_HUMAN, Q9P255: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF492 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF492 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF492
        Generic Transcription Pathway



    ZNF492 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF492
    Interactions:

        Search GeneGlobe Interaction Network for ZNF492

    1 Interacting protein for ZNF492 (Q9P2553) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAG2Q9UGJ03I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF492 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF492 (ZN492)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF492 gene: 
    NM_020855.2  

    Unigene Cluster for ZNF492:

    Zinc finger protein 492
    Hs.232108  [show with all ESTs]
    Unigene Representative Sequence: NM_020855
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000456783(uc002nqw.3)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: ZNF492 (NM_020855)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF492
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF492
      QuantiFast Probe-based Assays in human, mouse, rat ZNF492

    Additional mRNA sequence: 

    AB040906.1 BC110575.1 

    2 DOTS entries:

    DT.91930341  DT.75112103 

    8 AceView cDNA sequences:

    BX117088 AA807424 AW024096 AB040906 BP871882 AL705393 AA947978 AI085619 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF492 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACTCCGTC
    ZNF492 Expression
    About this image

    ZNF492 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF492 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.232108
        Custom PCR Arrays for ZNF492
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF492

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF492 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    54(a)
    40(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)
            Species with no ortholog for ZNF492

    ENSEMBL Gene Tree for ZNF492 (if available)
    TreeFam Gene Tree for ZNF492 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF492 gene
    ZNF981 2  ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  
    ZNF1382  ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  
    ZNF2532  ZNF932  ZNF6822  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2542  ZNF7372  ZNF724P2  ZNF7162  ZNF7142  ZNF4292  ZNF5192  
    ZNF4302  ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF492 using alignment to 1 protein entry:     ZN492_HUMAN(see all similar genes):
    ZNF98    MGC12518    ZNF738    ZNF506    ZNF273    ZNF737
    DKFZp762K012    ZNF254    ZNF430    ZNF100    ZNF730    ZNF78L1
    DKFZp686M04222    ZFS-6    ZNF724P    ZNF818P    smap-7    ZNF626

    ZNF492 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF492
    PGOHUM00000234575


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF492 (see all 968)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129743971,2
    C,F,A--22815267(+) CCTCCG/ACCTCC 1 -- us2k13Minor allele frequency- A:0.50NA 6
    rs350854631,2
    C,F--22815391(+) GTTAGG/CCAGGA 1 -- us2k13Minor allele frequency- C:0.33NA 6
    rs1415423011,2
    C--22815425(+) GATCCA/GCCTGC 1 -- us2k10--------
    rs126096751,2
    C,F,H--22815472(+) GCACCG/ATGCCC 1 -- us2k19Minor allele frequency- A:0.12NA WA EA 370
    rs1444370271,2
    --22815525(+) TTTAGC/TCCCAA 1 -- us2k10--------
    rs169995211,2
    C,F,H--22815530(+) CCCCAA/GTTCGG 1 -- us2k120Minor allele frequency- G:0.14NA NS EA WA 2156
    rs1485982051,2
    --22815666(+) TATATA/GTACAA 1 -- us2k10--------
    rs1905391871,2
    --22815727(+) CAATAA/GTTTGG 1 -- us2k10--------
    rs739270411,2
    C,F--22815761(+) GACTTA/GGCGGC 1 -- us2k12Minor allele frequency- G:0.34WA 120
    rs1827245281,2
    --22815811(+) GTCACC/TTAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF492 (22817126 - 22850472 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF492 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718358CNV Deletion23290073
    dgv552e201CNV Deletion23290073
    esv2236506CNV Deletion18987734
    esv2657662CNV Deletion23128226
    esv2674355CNV Deletion23128226
    dgv553e201CNV Deletion23290073
    dgv633e199CNV Deletion23128226
    nsv436853CNV Insertion17901297
    esv34340CNV Loss17911159
    nsv9683CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF492
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF492

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF492:    About MalaCards
    keratoconus    endotheliitis


    ZNF492 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF492

    Export disorders for ZNF492 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF492 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF492)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter. (PubMed id 16714237)1, 9 Lu Z....Redmond T.M. (Curr. Eye Res. 2006)
    3. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. (PubMed id 21979947)4 Li X....Rabinowitz Y.S. (Hum. Mol. Genet. 2012)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PubMed id 22331829)4 Chasman D.I....Ridker P.M. (Circ Cardiovasc Genet 2012)
    6. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. (PubMed id 20421499)4 Levy D....Aviv A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    9. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57615 HGNC: 23707 AceView: ZNF492 Ensembl:ENSG00000229676 euGenes: HUgn57615
    ECgene: ZNF492 H-InvDB: ZNF492

    (According to HUGE)
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    HUGE: KIAA1473

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF492 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF492 gene:
    Search GeneIP for patents involving ZNF492

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