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Aliases for ZNF492 Gene

Aliases for ZNF492 Gene

  • Zinc Finger Protein 492 2 3 5
  • Zinc Finger Protein 115 (Y20) 2 3
  • ZNF115 3 4
  • Zinc Finger Protein 115 4
  • KIAA1473 4

External Ids for ZNF492 Gene

Previous HGNC Symbols for ZNF492 Gene

  • ZNF115

Previous GeneCards Identifiers for ZNF492 Gene

  • GC19P022627
  • GC19P022609
  • GC19P022608
  • GC19P022817

Summaries for ZNF492 Gene

GeneCards Summary for ZNF492 Gene

ZNF492 (Zinc Finger Protein 492) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF98.

UniProtKB/Swiss-Prot for ZNF492 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF492 Gene

Genomics for ZNF492 Gene

Regulatory Elements for ZNF492 Gene

Enhancers for ZNF492 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G022633 0.6 ENCODE 33.4 -0.1 -76 1.1 PKNOX1 POLR2A SIN3A SP2 ZBTB40 GABPA ZNF492 LINC01859 LINC01785
GH19G022783 0.4 ENCODE 25 +149.9 149857 1.2 MAFK ZNF492 BNIP3P34 ZNF99 GC19P022800
GH19G023116 0.7 ENCODE 7.3 +482.9 482902 1.7 GTF2F1 MXI1 PKNOX1 CHD1 SIN3A E2F4 REST EP300 SP1 E2F1 LINC01859 ZNF492 IPO5P1 BNIP3P37 GC19P023114
GH19G023074 0.7 ENCODE 6.9 +441.3 441324 2.1 GTF2F1 MXI1 ESRRA ZNF133 SIN3A CHD1 REST E2F1 TFDP1 POLR2A ZNF730 ZNF492 ZNF728 ENSG00000267924 GC19P023094
GH19G023123 0.3 FANTOM5 6.9 +489.4 489448 0.4 ZNF492 BNIP3P37 GC19P023114
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF492 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF492 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108365 77 1599 PKNOX1 SIN3A SP2 ZBTB40 GABPA

Genomic Location for ZNF492 Gene

22,634,324 bp from pter
22,667,670 bp from pter
33,347 bases
Plus strand

Genomic View for ZNF492 Gene

Genes around ZNF492 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF492 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF492 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF492 Gene

Proteins for ZNF492 Gene

  • Protein details for ZNF492 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 492
    Protein Accession:
    Secondary Accessions:
    • Q08EI7
    • Q08EI8

    Protein attributes for ZNF492 Gene

    531 amino acids
    Molecular mass:
    61158 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA95997.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF492 Gene

Post-translational modifications for ZNF492 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF492 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF492 Gene

Domains & Families for ZNF492 Gene

Gene Families for ZNF492 Gene

Protein Domains for ZNF492 Gene

Suggested Antigen Peptide Sequences for ZNF492 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF492: view

Function for ZNF492 Gene

Molecular function for ZNF492 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF492: view

Phenotypes for ZNF492 Gene

GenomeRNAi human phenotypes for ZNF492:
genes like me logo Genes that share phenotypes with ZNF492: view

Animal Model Products

CRISPR Products

miRNA for ZNF492 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF492 Gene

Localization for ZNF492 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF492 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF492 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF492: view

Pathways & Interactions for ZNF492 Gene

SuperPathways for ZNF492 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF492: view

Pathways by source for ZNF492 Gene

2 Reactome pathways for ZNF492 Gene

Interacting Proteins for ZNF492 Gene

Gene Ontology (GO) - Biological Process for ZNF492 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF492: view

No data available for SIGNOR curated interactions for ZNF492 Gene

Drugs & Compounds for ZNF492 Gene

No Compound Related Data Available

Transcripts for ZNF492 Gene

mRNA/cDNA for ZNF492 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF492 Gene

Zinc finger protein 492:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF492 Gene

No ASD Table

Relevant External Links for ZNF492 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF492 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF492 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF492 Gene

This gene is overexpressed in Testis (x8.5).

NURSA nuclear receptor signaling pathways regulating expression of ZNF492 Gene:


SOURCE GeneReport for Unigene cluster for ZNF492 Gene:


Evidence on tissue expression from TISSUES for ZNF492 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF492: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF492 Gene

Orthologs for ZNF492 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF492 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100611724 34
  • 95.61 (n)
-- 35
  • 90 (a)
(Mus musculus)
Mammalia Zfp493 35
  • 56 (a)
(Bos Taurus)
Mammalia -- 35
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
-- 35
  • 40 (a)
(Canis familiaris)
Mammalia -- 35
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 54 (a)
-- 35
  • 40 (a)
-- 35
  • 38 (a)
-- 35
  • 33 (a)
-- 35
  • 31 (a)
-- 35
  • 31 (a)
-- 35
  • 30 (a)
-- 35
  • 28 (a)
Species where no ortholog for ZNF492 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF492 Gene

Gene Tree for ZNF492 (if available)
Gene Tree for ZNF492 (if available)

Paralogs for ZNF492 Gene

(509) SIMAP similar genes for ZNF492 Gene using alignment to 1 proteins: Pseudogenes for ZNF492 Gene

genes like me logo Genes that share paralogs with ZNF492: view

Variants for ZNF492 Gene

Sequence variations from dbSNP and Humsavar for ZNF492 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000079659 -- 22,651,573(+) GTCTT(C/G)TCTAC intron-variant
rs1000233324 -- 22,663,618(+) CTTAC(-/TTTAA)TTTTT intron-variant
rs1000661517 -- 22,667,502(+) TCCAT(C/T)ACCTT utr-variant-3-prime
rs1000796770 -- 22,667,621(+) CAAGT(A/G)TAAAA utr-variant-3-prime
rs1000915325 -- 22,634,776(+) ACGGG(A/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF492 Gene

Variant ID Type Subtype PubMed ID
dgv140n111 CNV duplication 26073780
dgv3n43 CNV gain 19587683
dgv511e201 CNV deletion 23290073
dgv512e201 CNV deletion 23290073
dgv633e199 CNV deletion 23128226
esv2236506 CNV deletion 18987734
esv2657662 CNV deletion 23128226
esv2674355 CNV deletion 23128226
esv2718358 CNV deletion 23290073
esv2751784 CNV gain 17911159
esv2758750 CNV gain+loss 17122850
esv34340 CNV loss 17911159
esv3556193 CNV deletion 23714750
esv3643959 CNV loss 21293372
esv3643960 CNV gain 21293372
esv3643962 CNV loss 21293372
esv3643963 CNV loss 21293372
esv3643964 CNV loss 21293372
esv3893182 CNV gain 25118596
esv4924 OTHER complex 18987735
nsv1062447 CNV loss 25217958
nsv1078307 OTHER inversion 25765185
nsv1120056 OTHER inversion 24896259
nsv436853 CNV insertion 17901297
nsv525240 CNV gain 19592680
nsv9683 CNV loss 18304495
nsv9684 CNV loss 18304495
nsv978794 CNV duplication 23825009

Variation tolerance for ZNF492 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF492 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF492 Gene

Disorders for ZNF492 Gene

Relevant External Links for ZNF492

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF492 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF492 Gene

Publications for ZNF492 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter. (PMID: 16714237) Lu Z. … Redmond T.M. (Curr. Eye Res. 2006) 3 22 64
  3. Genome-wide diet-gene interaction analyses for risk of colorectal cancer. (PMID: 24743840) Figueiredo J.C. … . (PLoS Genet. 2014) 3 64
  4. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. (PMID: 21979947) Li X. … Rabinowitz Y.S. (Hum. Mol. Genet. 2012) 46 64
  5. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PMID: 22331829) Chasman D.I. … Ridker P.M. (Circ Cardiovasc Genet 2012) 46 64

Products for ZNF492 Gene

Sources for ZNF492 Gene

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