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Aliases for ZNF491 Gene

Aliases for ZNF491 Gene

  • Zinc Finger Protein 491 2 3

External Ids for ZNF491 Gene

Previous GeneCards Identifiers for ZNF491 Gene

  • GC19P011771
  • GC19P011772
  • GC19P011908
  • GC19P011484

Summaries for ZNF491 Gene

GeneCards Summary for ZNF491 Gene

ZNF491 (Zinc Finger Protein 491) is a Protein Coding gene. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF491 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF491 Gene

Genomics for ZNF491 Gene

Genomic Location for ZNF491 Gene

11,797,667 bp from pter
11,809,622 bp from pter
11,956 bases
Plus strand

Genomic View for ZNF491 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF491 Gene

No data available for Regulatory Elements for ZNF491 Gene

Proteins for ZNF491 Gene

  • Protein details for ZNF491 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 491
    Protein Accession:
    Secondary Accessions:
    • Q3MJ35
    • Q8NAT8

    Protein attributes for ZNF491 Gene

    437 amino acids
    Molecular mass:
    50950 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03809.1; Type=Erroneous termination; Positions=408; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for ZNF491 Gene

Proteomics data for ZNF491 Gene at MOPED

Post-translational modifications for ZNF491 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF491 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF491 Gene

Domains for ZNF491 Gene

Gene Families for ZNF491 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF491 Gene

Suggested Antigen Peptide Sequences for ZNF491 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8N8L2
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF491: view

Function for ZNF491 Gene

Molecular function for ZNF491 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF491 Gene

Localization for ZNF491 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF491 Gene

Subcellular locations from

Jensen Localization Image for ZNF491 Gene COMPARTMENTS Subcellular localization image for ZNF491 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF491: view

Pathways for ZNF491 Gene

SuperPathways for ZNF491 Gene

No Data Available

Interacting Proteins for ZNF491 Gene

Gene Ontology (GO) - Biological Process for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Pathways by source for ZNF491 Gene

Transcripts for ZNF491 Gene

mRNA/cDNA for ZNF491 Gene

(15) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF491 Gene

Zinc finger protein 491:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF491 Gene

No ASD Table

Relevant External Links for ZNF491 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF491 Gene

mRNA expression in normal human tissues for ZNF491 Gene

SOURCE GeneReport for Unigene cluster for ZNF491 Gene Hs.631634

genes like me logo Genes that share expressions with ZNF491: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF491 Gene

Orthologs for ZNF491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF491 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF491 35
  • 98.09 (n)
  • 95.42 (a)
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
Species with no ortholog for ZNF491:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF491 Gene

Gene Tree for ZNF491 (if available)
Gene Tree for ZNF491 (if available)

Paralogs for ZNF491 Gene

Selected SIMAP similar genes for ZNF491 Gene using alignment to 2 proteins: Pseudogenes for ZNF491 Gene

genes like me logo Genes that share paralogs with ZNF491: view

Variants for ZNF491 Gene

Sequence variations from dbSNP and Humsavar for ZNF491 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs184056 -- 11,799,463(+) ttaat(C/T)agAGT intron-variant
rs286215 -- 11,804,071(-) cacgc(A/G)ccacc intron-variant, upstream-variant-2KB
rs286227 -- 11,796,867(-) cttct(C/T)atcag upstream-variant-2KB
rs286228 -- 11,796,906(+) gtaaa(C/T)gtctg upstream-variant-2KB
rs286229 -- 11,796,977(+) gatga(C/T)atatc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF491 Gene

Variant ID Type Subtype PubMed ID
nsv525966 CNV Gain 19592680
nsv911068 CNV Gain 21882294

Relevant External Links for ZNF491 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF491 Gene

Disorders for ZNF491 Gene

No disorders were found for ZNF491 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF491 Gene

Publications for ZNF491 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3

Products for ZNF491 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF491
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF491
    • Block miRNA regulation of ZNF491 using miScript Target Protectors

    Sources for ZNF491 Gene

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