ZNF491 Gene
protein-coding GIFtS: 36
GCID: GC19P011908
|
|
zinc finger protein 491
| |
Aliases
for ZNF491 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4911 2 | | FLJ347911 |
Export aliases for ZNF491 gene to outside databasesPrevious GC identifers: GC19P011771 GC19P011772 GC19P011773 GC19P011484 |
Summaries
for ZNF491 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN491_HUMAN, Q8N8L2Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF491 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF491
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF491
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF491 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2ZNF491 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P011908: view genomic region
(about GC identifiers)
Start:
|
11,908,482 bp from pter |
End:
|
11,920,437 bp from pter |
Size:
|
11,956 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF491 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN491_HUMAN, Q8N8L2 (See
protein sequence)Recommended Name: Zinc finger protein 491 Size: 437 amino acids; 50950 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAC03809.1; Type=Erroneous termination; Positions=408; Note=Translated as Glu;
Secondary accessions: Q3MJ35 Q8NAT8Explore the universe of human proteins at neXtProt for ZNF491: NX_Q8N8L2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N8L2
ZNF491 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689569.2
ENSEMBL proteins: ENSP00000313443 ENSP00000392176
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF491 for ontologies About GeneDecksing
ZNF491 Antibody Products:
Assay Products for ZNF491: |
Protein
Domains /
Families
for ZNF491 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF491 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N8L2ProtoNet protein and cluster: Q8N8L2 UniProtKB/Swiss-Prot: ZN491_HUMAN, Q8N8L2Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 13 C2H2-type zinc fingers |
Function
for ZNF491 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN491_HUMAN, Q8N8L2Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF491
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF491 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF491 (NM_152356) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF491 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF491 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF491 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF491 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF491 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF491
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF491 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF491 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF491
Search CenterWatch for drugs/clinical trials and news about ZNF491 / ZN491
|
Transcripts
for ZNF491 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF491 gene: NM_152356.3 Unigene Cluster for ZNF491: Zinc finger protein 491 Hs.631634 [show with all ESTs]Unigene Representative Sequence: NM_1523564 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479762 ENST00000323169(uc002mso.1) ENST00000450087 ENST00000492230
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF491
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF491 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF491 (NM_152356) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF491 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF491 |
Additional cDNA sequence: AK092110.1 AK297479.1 BC101590.1 BC101592.1 5 DOTS entries: DT.40276119 DT.121462744 DT.97799308 DT.121463022 DT.99930057 15 AceView cDNA sequences: AK096593 NM_152356 BM682810 BX115473 BM719488 AA083811 AI609055 AK092110 BV192879 AI356181 AI885488 AX747359 AA083980 AI828514 BQ185979
GeneLoc Exon Structure
|
Expression
for ZNF491 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF491 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF491 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF491
SOURCE GeneReport for Unigene cluster: Hs.631634
SABiosciences Custom PCR Arrays for ZNF491
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF491
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF491 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF491 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF491 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF491 |
Orthologs
for ZNF491 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF491 (if available)
TreeFam Gene Tree for ZNF491 (if available) |
Paralogs
for ZNF491 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF491 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ZNF142 ENSG000001968262
- ZNF7002 ZNF692 ZNF4402 ZNF4432 ZNF442 ZNF4392 ZNF8232 ENSG000001884742
- ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912 ZNF4422
- ZNF4332 ZNF572 ZNF5632 ZNF6272 ENSG000002573552 ZNF1362 ZNF5562 ZNF6702
- ZNF7632 ZNF1242 ZNF6992 ZNF8442 ZNF772
18/473 SIMAP similar genes for ZNF491 using alignment to 2 protein entries: ZN491_HUMAN (see all proteins)
(see all similar genes):ZNF844 DKFZp666C237 HZF36 ZNF439 ZNF20 ZNF55
ZNF627 ZSCAN23 ZNF700 ZNF14 ZNF433 ZNF664
ZNF763 DKFZp686H10254 ZNF391 ZNF436 ZNF558 ZNF662
ZNF491 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF491
PGOHUM00000250595
|
Genomic Variants
for ZNF491 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF491 (11908482 - 11920437 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF491: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF491 |
|
Disorders
/ Diseases
for ZNF491 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF491 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF491 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF491) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)
|
External Searches for ZNF491 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF491 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF491 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF491 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF491 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF491 gene:
Search GeneIP for patents involving ZNF491
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF491 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF491 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF491 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF491 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF491 | | OriGene 3'-UTR Clone for ZNF491 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF491 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF491 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF491 | | OriGene Custom Protein Services for ZNF491 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF491 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF491 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF491 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF491 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF491 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF491 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF491 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF491 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF491 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF491 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF491 |
|
|
|
|
