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Aliases for ZNF491 Gene

Aliases for ZNF491 Gene

  • Zinc Finger Protein 491 2 3 5

External Ids for ZNF491 Gene

Previous GeneCards Identifiers for ZNF491 Gene

  • GC19P011771
  • GC19P011772
  • GC19P011908
  • GC19P011484

Summaries for ZNF491 Gene

GeneCards Summary for ZNF491 Gene

ZNF491 (Zinc Finger Protein 491) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF700.

UniProtKB/Swiss-Prot for ZNF491 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF491 Gene

Genomics for ZNF491 Gene

Regulatory Elements for ZNF491 Gene

Enhancers for ZNF491 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F011531 1.5 FANTOM5 Ensembl ENCODE 46.1 -265.2 -265229 1.6 PKNOX1 ATF1 ZFP64 ZNF493 FOS ZNF202 ZNF263 REST ZNF518A ZNF623 ZNF627 ZNF136 ZNF844 ZNF442 ZNF625 ZNF44 ZNF799 ZNF441 ZNF491 ZNF700
GH19F011317 1.4 Ensembl ENCODE 46.1 -476.0 -475985 9.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ZNF627 ZNF136 ZNF844 ZNF625 ENSG00000267174 ZNF44 ZNF441 ZNF491 ZNF700 ZNF763
GH19F011420 1.3 Ensembl ENCODE 46.1 -375.8 -375824 3.1 ATF1 PKNOX1 ZNF493 ZFP64 SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 ZNF627 ZNF136 ZNF442 ZNF844 ZNF625 ZNF44 ZNF799 ZNF763 ZNF441 ZNF491
GH19F012781 1.7 FANTOM5 ENCODE 35.2 +991.6 991631 16.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF136 CCDC130 ZNF564 ZNF442 ZNF844 ZNF44 WDR83OS ZNF799 TRMT1 ZNF625
GH19F012034 1 ENCODE 22.9 +237.9 237859 2.1 PKNOX1 ZNF493 ARID4B ZNF48 ZNF2 YY1 GLIS2 SP3 NFYC REST LOC101928464 ZNF491 ZNF788 ZNF441 ZNF439 ZNF709 ZNF625 RNA5SP464 ZNF763 ZNF44
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF491 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF491 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000140645 1233 1401 TBP PKNOX1 ARID4B SIN3A ZNF48 ZSCAN9 RAD21 RFX5 GLIS2 THAP11

Genomic Location for ZNF491 Gene

Chromosome:
19
Start:
11,797,667 bp from pter
End:
11,809,622 bp from pter
Size:
11,956 bases
Orientation:
Plus strand

Genomic View for ZNF491 Gene

Genes around ZNF491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF491 Gene

Proteins for ZNF491 Gene

  • Protein details for ZNF491 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8L2-ZN491_HUMAN
    Recommended name:
    Zinc finger protein 491
    Protein Accession:
    Q8N8L2
    Secondary Accessions:
    • Q3MJ35
    • Q8NAT8

    Protein attributes for ZNF491 Gene

    Size:
    437 amino acids
    Molecular mass:
    50950 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03809.1; Type=Erroneous termination; Positions=408; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for ZNF491 Gene

Post-translational modifications for ZNF491 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF491 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF491 Gene

Domains & Families for ZNF491 Gene

Gene Families for ZNF491 Gene

Protein Domains for ZNF491 Gene

Suggested Antigen Peptide Sequences for ZNF491 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8L2

UniProtKB/Swiss-Prot:

ZN491_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF491: view

Function for ZNF491 Gene

Molecular function for ZNF491 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF491: view

Phenotypes for ZNF491 Gene

GenomeRNAi human phenotypes for ZNF491:
genes like me logo Genes that share phenotypes with ZNF491: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF491 Gene

Localization for ZNF491 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF491 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF491 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF491: view

Pathways & Interactions for ZNF491 Gene

SuperPathways for ZNF491 Gene

No Data Available

Interacting Proteins for ZNF491 Gene

Gene Ontology (GO) - Biological Process for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF491 Gene

Transcripts for ZNF491 Gene

mRNA/cDNA for ZNF491 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF491 Gene

Zinc finger protein 491:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF491 Gene

No ASD Table

Relevant External Links for ZNF491 Gene

GeneLoc Exon Structure for
ZNF491
ECgene alternative splicing isoforms for
ZNF491

Expression for ZNF491 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF491 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF491 Gene:

ZNF491

SOURCE GeneReport for Unigene cluster for ZNF491 Gene:

Hs.631634
genes like me logo Genes that share expression patterns with ZNF491: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF491 Gene

Orthologs for ZNF491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF491 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF491 34
  • 98.09 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 41 (a)
ManyToMany
Species where no ortholog for ZNF491 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF491 Gene

ENSEMBL:
Gene Tree for ZNF491 (if available)
TreeFam:
Gene Tree for ZNF491 (if available)

Paralogs for ZNF491 Gene

(471) SIMAP similar genes for ZNF491 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF491 Gene

genes like me logo Genes that share paralogs with ZNF491: view

Variants for ZNF491 Gene

Sequence variations from dbSNP and Humsavar for ZNF491 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10417354 -- 11,804,036(+) cgtct(C/T)tacta intron-variant
rs111570520 -- 11,806,360(+) GTTTT(A/G/T)TGGGA reference, missense
rs111647427 -- 11,797,322(+) CTACA(A/G)GTTCA upstream-variant-2KB
rs111847177 -- 11,799,448(+) GTGAG(A/G)CACAA intron-variant
rs112159359 -- 11,806,404(+) ATGAA(C/T)GAACT reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for ZNF491 Gene

Variant ID Type Subtype PubMed ID
nsv960790 CNV duplication 23825009
nsv525966 CNV gain 19592680
esv3643677 CNV gain 21293372
dgv3428n100 CNV gain 25217958

Variation tolerance for ZNF491 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF491 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF491

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF491 Gene

Disorders for ZNF491 Gene

Relevant External Links for ZNF491

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF491

No disorders were found for ZNF491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF491 Gene

Publications for ZNF491 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3 64

Products for ZNF491 Gene

Sources for ZNF491 Gene

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