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Aliases for ZNF491 Gene

Aliases for ZNF491 Gene

  • Zinc Finger Protein 491 2 3 5

External Ids for ZNF491 Gene

Previous GeneCards Identifiers for ZNF491 Gene

  • GC19P011771
  • GC19P011772
  • GC19P011908
  • GC19P011484

Summaries for ZNF491 Gene

GeneCards Summary for ZNF491 Gene

ZNF491 (Zinc Finger Protein 491) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF491 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF491 Gene

Genomics for ZNF491 Gene

Regulatory Elements for ZNF491 Gene

Enhancers for ZNF491 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF491 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF491 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF491 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF491 Gene

11,797,667 bp from pter
11,809,622 bp from pter
11,956 bases
Plus strand

Genomic View for ZNF491 Gene

Genes around ZNF491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF491 Gene

Proteins for ZNF491 Gene

  • Protein details for ZNF491 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 491
    Protein Accession:
    Secondary Accessions:
    • Q3MJ35
    • Q8NAT8

    Protein attributes for ZNF491 Gene

    437 amino acids
    Molecular mass:
    50950 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03809.1; Type=Erroneous termination; Positions=408; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for ZNF491 Gene

Proteomics data for ZNF491 Gene at MOPED

Post-translational modifications for ZNF491 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF491 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF491

No data available for DME Specific Peptides for ZNF491 Gene

Domains & Families for ZNF491 Gene

Gene Families for ZNF491 Gene

Protein Domains for ZNF491 Gene

Suggested Antigen Peptide Sequences for ZNF491 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF491: view

Function for ZNF491 Gene

Molecular function for ZNF491 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF491 Gene

GenomeRNAi human phenotypes for ZNF491:
genes like me logo Genes that share phenotypes with ZNF491: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF491 Gene

Localization for ZNF491 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF491 Gene

Subcellular locations from

Jensen Localization Image for ZNF491 Gene COMPARTMENTS Subcellular localization image for ZNF491 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF491 Gene

Pathways & Interactions for ZNF491 Gene

SuperPathways for ZNF491 Gene

No Data Available

Interacting Proteins for ZNF491 Gene

Gene Ontology (GO) - Biological Process for ZNF491 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF491: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF491 Gene

Drugs & Compounds for ZNF491 Gene

No Compound Related Data Available

Transcripts for ZNF491 Gene

mRNA/cDNA for ZNF491 Gene

Unigene Clusters for ZNF491 Gene

Zinc finger protein 491:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF491 Gene

No ASD Table

Relevant External Links for ZNF491 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF491 Gene

mRNA expression in normal human tissues for ZNF491 Gene

SOURCE GeneReport for Unigene cluster for ZNF491 Gene Hs.631634

genes like me logo Genes that share expression patterns with ZNF491: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF491 Gene

Orthologs for ZNF491 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF491 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF491 35
  • 98.09 (n)
  • 95.42 (a)
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
Species with no ortholog for ZNF491:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF491 Gene

Gene Tree for ZNF491 (if available)
Gene Tree for ZNF491 (if available)

Paralogs for ZNF491 Gene

(471) SIMAP similar genes for ZNF491 Gene using alignment to 2 proteins: Pseudogenes for ZNF491 Gene

genes like me logo Genes that share paralogs with ZNF491: view

Variants for ZNF491 Gene

Sequence variations from dbSNP and Humsavar for ZNF491 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7260645 -- 11,800,812(+) gagcc(C/T)aggag intron-variant
rs12977564 -- 11,809,400(+) CCCTC(A/G)TTTTT reference, missense
rs8103944 -- 11,803,280(+) acctg(C/G)ccata intron-variant, upstream-variant-2KB
rs13346799 -- 11,809,818(+) ATCAC(A/C)CAGGC downstream-variant-500B
rs17001666 -- 11,807,939(+) AGAAG(C/G)AACAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF491 Gene

Variant ID Type Subtype PubMed ID
nsv525966 CNV Gain 19592680
nsv911068 CNV Gain 21882294

Variation tolerance for ZNF491 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF491 Gene

Disorders for ZNF491 Gene

Relevant External Links for ZNF491

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF491 Gene

Publications for ZNF491 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3

Products for ZNF491 Gene

Sources for ZNF491 Gene