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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF490 Gene

protein-coding   GIFtS: 51
GCID: GC19M012687

Zinc Finger Protein 490

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 4901 2
KIAA11983

External Ids:    HGNC: 237051   Entrez Gene: 574742   Ensembl: ENSG000001880337   UniProtKB: Q9ULM23   

Export aliases for ZNF490 gene to outside databases

Previous GC identifers: GC19M012547 GC19M012259


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF490 Gene: 
ZNF490 (zinc finger protein 490) is a protein-coding gene. Diseases associated with ZNF490 include bipolar disorder, and schizophrenia, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN490_HUMAN, Q9ULM2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF490
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF490 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF490

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF490


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF490 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF490 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012687:  view genomic region     (about GC identifiers)

Start:
12,686,920 bp from pter      End:
12,750,912 bp from pter
Size:
63,993 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN490_HUMAN, Q9ULM2 (See protein sequence)
Recommended Name: Zinc finger protein 490  
Size: 529 amino acids; 61340 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA86512.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for ZNF490: NX_Q9ULM2

Explore proteomics data for ZNF490 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULM2

  • ZNF490 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF490 Protein Expression
    REFSEQ proteins: NP_065765.1  
    ENSEMBL proteins: 
     ENSP00000311521   ENSP00000402719   ENSP00000404112  
    Reactome Protein details: Q9ULM2
    Human Recombinant Protein Products for ZNF490: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF490 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF490 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ZNF490


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9ULM2

    ProtoNet protein and cluster: Q9ULM2

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN490_HUMAN, Q9ULM2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF490 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN490_HUMAN, Q9ULM2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF490 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF490:
     Increased gamma-H2AX phosphory  Small cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF490 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF490 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF490
        Generic Transcription Pathway
    Gene Expression



    ZNF490 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF490

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for ZNF490 (Q9ULM23 ENSP000003115214) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTNBP1Q96EV83, ENSP000003416804I2D: score=2 STRING: ENSP00000341680
    HOXB13Q928263, ENSP000002902954I2D: score=1 STRING: ENSP00000290295
    RBMXP381593, ENSP000003596454I2D: score=1 STRING: ENSP00000359645
    LZTR1Q8N6533, ENSP000002157394I2D: score=1 STRING: ENSP00000215739
    RNPS1Q152873, ENSP000003158594I2D: score=1 STRING: ENSP00000315859
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF490 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF490 (ZN490)

    Search CenterWatch for drugs/clinical trials and news about ZNF490 / ZN490

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF490 gene: 
    NM_020714.2  

    Unigene Cluster for ZNF490:

    Zinc finger protein 490
    Hs.655860  [show with all ESTs]
    Unigene Representative Sequence: BC038586
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311437(uc002mtz.2) ENST00000414906 ENST00000440366 ENST00000465656

    miRNA
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    hsa-miR-199a-5p hsa-miR-199b-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    Sirion Biotech Customized lentivirus for stable overexpression of ZNF490 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF490 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF490
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF490

    Additional mRNA sequence: 

    AB033024.1 BC038586.1 

    3 DOTS entries:

    DT.95154945  DT.100751846  DT.101975455 

    24/31 AceView cDNA sequences (see all 31):

    BE047776 AI752918 BM469171 BE745585 NM_020714 BC038586 BX095189 AA349989 
    AW504245 AI302688 AI934409 BQ063669 CF135974 AB033024 BE741811 BM457368 
    AI709138 AA890473 BF805242 W90539 BF894392 W90578 CD706518 T86410 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF490    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -           -                           
    SP2:                          -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for ZNF490

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF490 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACTACCTT
    ZNF490 Expression
    About this image


    See ZNF490 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF490

    SOURCE GeneReport for Unigene cluster: Hs.655860
        SABiosciences Custom PCR Arrays for ZNF490
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF490

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF490 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp9615 zinc finger protein 961   --   8 (34.63 cM) 71951038 


    ENSEMBL Gene Tree for ZNF490 (if available)
    TreeFam Gene Tree for ZNF490 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF490 gene
    ZNF6692  ZNF5642  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  ENSG000002697552  
    ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF442  ZNF4392  ZNF8232  
    ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  ZNF202  
    ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF5632  ZNF6272  
    ENSG000002573552  ZNF1362  ZNF5562  ZNF6702  ZNF7632  ZNF1242  ENSG000002687442  ZNF6992  
    ZNF8442  ZNF772  
    18/445 SIMAP similar genes for ZNF490 using alignment to 3 protein entries:     ZN490_HUMAN (see all proteins) (see all similar genes):
    ZNF625    ZNF124    ZNF627    ZNF669    MGC12518    ZNF788
    ZNF833P    ZNF443    ZNF791    DKFZp666M039    ZNF14    ZNF44
    ZNF709    ZNF844    ZNF146    ZNF556    DKFZp666C237    ZNF564

    ZNF490 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF490
    PGOHUM00000257126


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/679 SNPs in ZNF490 are shown (see all 679)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504036071,2
    --12686585(+) CGTGAC/GAGCAA 1 -- ds50010--------
    rs1823336791,2
    --12686742(+) TGGAAA/GTTGAT 1 -- ds50010--------
    rs1381793271,2
    C--12686743(+) GGAAAC/TTGATC 1 -- ds50010--------
    rs81057581,2
    C,H--12686978(+) caccaG/Actcca 1 -- ut316Minor allele frequency- A:0.00NS EA NA 422
    rs1495603861,2
    C--12687015(+) GGAAAG/TCAGGC 1 -- ut310--------
    rs81068111,2
    C,F--12687043(+) CCagcC/Ggggcc 1 -- ut310--------
    rs1461636651,2
    --12687125(+) GACCAG/TCCTGG 1 -- ut310--------
    rs1902084201,2
    --12687264(+) GCAGTA/GAGCCG 1 -- ut310--------
    rs1401710281,2
    --12687298(+) TTGGTA/GACAGA 1 -- ut310--------
    rs81019871,2
    C,F,A--12687356(+) aggcaG/Cagtgg 1 -- ut316Minor allele frequency- C:0.50NA WA CSA 12

    HapMap Linkage Disequilibrium report for ZNF490 (12686920 - 12750912 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for ZNF490 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv997496CNV Deletion20482838
    esv2657078CNV Deletion23128226
    dgv54n16CNV Deletion17901297
    nsv821459CNV Deletion20802225
    nsv828443CNV Loss20364138
    nsv2419CNV Loss18451855
    nsv498893CNV Loss21111241
    nsv512563CNV Loss21212237
    nsv514889CNV Loss21397061
    nsv510755CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF490:    About MalaCards
    bipolar disorder    schizophrenia


    ZNF490 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF490

    Export disorders for ZNF490 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF490 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF490)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Propensity score-based nonparametric test revealing ge netic variants underlying bipolar disorder. (PubMed id 21254220)1, 4 Jiang Y. and Zhang H. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    6. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57474 HGNC: 23705 AceView: ZNF490 Ensembl:ENSG00000188033 euGenes: HUgn57474
    ECgene: ZNF490 H-InvDB: ZNF490

    (According to HUGE)
    About This Section
    HUGE: KIAA1198

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF490 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF490 gene:
    Search GeneIP for patents involving ZNF490

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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