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Aliases for ZNF490 Gene

Aliases for ZNF490 Gene

  • Zinc Finger Protein 490 2 3
  • KIAA1198 4

External Ids for ZNF490 Gene

Previous GeneCards Identifiers for ZNF490 Gene

  • GC19M012547
  • GC19M012687
  • GC19M012259

Summaries for ZNF490 Gene

GeneCards Summary for ZNF490 Gene

ZNF490 (Zinc Finger Protein 490) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF490 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF490 Gene

Genomics for ZNF490 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF490 Gene

Start:
12,576,106 bp from pter
End:
12,640,098 bp from pter
Size:
63,993 bases
Orientation:
Minus strand

Genomic View for ZNF490 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF490 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF490 Gene

No data available for Regulatory Elements for ZNF490 Gene

Proteins for ZNF490 Gene

  • Protein details for ZNF490 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULM2-ZN490_HUMAN
    Recommended name:
    Zinc finger protein 490
    Protein Accession:
    Q9ULM2
    Secondary Accessions:

    Protein attributes for ZNF490 Gene

    Size:
    529 amino acids
    Molecular mass:
    61340 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86512.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF490 Gene

Proteomics data for ZNF490 Gene at MOPED

Post-translational modifications for ZNF490 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF490 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF490 Gene

Domains for ZNF490 Gene

Gene Families for ZNF490 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF490 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULM2

UniProtKB/Swiss-Prot:

ZN490_HUMAN :
  • Q9ULM2
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF490: view

Function for ZNF490 Gene

Molecular function for ZNF490 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF490: view

Phenotypes for ZNF490 Gene

GenomeRNAi human phenotypes for ZNF490:
genes like me logo Genes that share phenotypes with ZNF490: view

Animal Model Products

CRISPR Products

miRNA for ZNF490 Gene

miRTarBase miRNAs that target ZNF490

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF490

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF490 Gene

Localization for ZNF490 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF490 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF490 Gene COMPARTMENTS Subcellular localization image for ZNF490 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF490: view

Pathways for ZNF490 Gene

SuperPathways for ZNF490 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF490: view

Pathways by source for ZNF490 Gene

2 Reactome pathways for ZNF490 Gene

Gene Ontology (GO) - Biological Process for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF490: view

Transcripts for ZNF490 Gene

mRNA/cDNA for ZNF490 Gene

Unigene Clusters for ZNF490 Gene

Zinc finger protein 490:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF490

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF490 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3:

Relevant External Links for ZNF490 Gene

GeneLoc Exon Structure for
ZNF490
ECgene alternative splicing isoforms for
ZNF490

Expression for ZNF490 Gene

mRNA expression in normal human tissues for ZNF490 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF490 Gene

SOURCE GeneReport for Unigene cluster for ZNF490 Gene Hs.655860

genes like me logo Genes that share expressions with ZNF490: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF490 Gene

Orthologs for ZNF490 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF490 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF490 35
  • 99.81 (n)
  • 100 (a)
ZNF490 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp961 16
Species with no ortholog for ZNF490:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF490 Gene

ENSEMBL:
Gene Tree for ZNF490 (if available)
TreeFam:
Gene Tree for ZNF490 (if available)

Paralogs for ZNF490 Gene

Selected SIMAP similar genes for ZNF490 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF490 Gene

genes like me logo Genes that share paralogs with ZNF490: view

Variants for ZNF490 Gene

Sequence variations from dbSNP and Humsavar for ZNF490 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1864081 -- 12,597,164(-) GCCTC(C/T)GTAAG intron-variant
rs1864082 -- 12,597,090(-) CGGCT(A/G)TGGGA intron-variant
rs1864083 -- 12,596,488(-) TGCTC(A/G)TGCTA intron-variant
rs1975038 -- 12,608,493(-) actct(A/G)tctca intron-variant
rs2042946 -- 12,594,540(-) ccata(C/T)ggcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF490 Gene

Variant ID Type Subtype PubMed ID
nsv510755 CNV Loss 20534489
nsv2419 CNV Loss 18451855
esv997496 CNV Deletion 20482838
dgv54n16 CNV Deletion 17901297
nsv512563 CNV Loss 21212237
nsv821459 CNV Deletion 20802225
nsv828441 CNV Loss 20364138
esv2657078 CNV Deletion 23128226
nsv498893 CNV Loss 21111241
nsv820210 CNV Gain 19587683
esv23136 CNV Gain+Loss 19812545
esv996849 CNV Gain 20482838
nsv828443 CNV Loss 20364138
nsv514889 CNV Loss 21397061

Relevant External Links for ZNF490 Gene

HapMap Linkage Disequilibrium report
ZNF490
Human Gene Mutation Database (HGMD)
ZNF490

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF490 Gene

Disorders for ZNF490 Gene

Relevant External Links for ZNF490

Genetic Association Database (GAD)
ZNF490
genes like me logo Genes that share disorders with ZNF490: view

No data available for UniProtKB/Swiss-Prot for ZNF490 Gene

Publications for ZNF490 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y. … Zhang H. (Genet. Epidemiol. 2011) 3 48
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF490 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF490
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF490
  • Block miRNA regulation of ZNF490 using miScript Target Protectors

Sources for ZNF490 Gene

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