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Aliases for ZNF490 Gene

Aliases for ZNF490 Gene

  • Zinc Finger Protein 490 2 3 5
  • KIAA1198 4

External Ids for ZNF490 Gene

Previous GeneCards Identifiers for ZNF490 Gene

  • GC19M012547
  • GC19M012687
  • GC19M012259

Summaries for ZNF490 Gene

GeneCards Summary for ZNF490 Gene

ZNF490 (Zinc Finger Protein 490) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF490 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF490 Gene

Genomics for ZNF490 Gene

Regulatory Elements for ZNF490 Gene

Enhancers for ZNF490 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF490 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF490 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF490 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF490 Gene

Chromosome:
19
Start:
12,576,106 bp from pter
End:
12,640,098 bp from pter
Size:
63,993 bases
Orientation:
Minus strand

Genomic View for ZNF490 Gene

Genes around ZNF490 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF490 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF490 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF490 Gene

Proteins for ZNF490 Gene

  • Protein details for ZNF490 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULM2-ZN490_HUMAN
    Recommended name:
    Zinc finger protein 490
    Protein Accession:
    Q9ULM2

    Protein attributes for ZNF490 Gene

    Size:
    529 amino acids
    Molecular mass:
    61340 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86512.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF490 Gene

Proteomics data for ZNF490 Gene at MOPED

Post-translational modifications for ZNF490 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF490 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF490 Gene

Domains & Families for ZNF490 Gene

Gene Families for ZNF490 Gene

Protein Domains for ZNF490 Gene

Suggested Antigen Peptide Sequences for ZNF490 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULM2

UniProtKB/Swiss-Prot:

ZN490_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF490: view

Function for ZNF490 Gene

Molecular function for ZNF490 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF490 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with ZNF490: view
genes like me logo Genes that share phenotypes with ZNF490: view

Animal Model Products

CRISPR Products

miRNA for ZNF490 Gene

miRTarBase miRNAs that target ZNF490

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF490 Gene

Localization for ZNF490 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF490 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF490 Gene COMPARTMENTS Subcellular localization image for ZNF490 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF490 Gene

Pathways & Interactions for ZNF490 Gene

SuperPathways for ZNF490 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF490: view

Pathways by source for ZNF490 Gene

2 Reactome pathways for ZNF490 Gene

Gene Ontology (GO) - Biological Process for ZNF490 Gene

None

No data available for SIGNOR curated interactions for ZNF490 Gene

Drugs & Compounds for ZNF490 Gene

No Compound Related Data Available

Transcripts for ZNF490 Gene

mRNA/cDNA for ZNF490 Gene

Unigene Clusters for ZNF490 Gene

Zinc finger protein 490:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF490 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3:

Relevant External Links for ZNF490 Gene

GeneLoc Exon Structure for
ZNF490
ECgene alternative splicing isoforms for
ZNF490

Expression for ZNF490 Gene

mRNA expression in normal human tissues for ZNF490 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF490 Gene



SOURCE GeneReport for Unigene cluster for ZNF490 Gene Hs.655860

genes like me logo Genes that share expression patterns with ZNF490: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF490 Gene

Orthologs for ZNF490 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF490 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF490 35
  • 99.81 (n)
  • 100 (a)
ZNF490 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
ManyToMany
Species with no ortholog for ZNF490:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF490 Gene

ENSEMBL:
Gene Tree for ZNF490 (if available)
TreeFam:
Gene Tree for ZNF490 (if available)

Paralogs for ZNF490 Gene

(449) SIMAP similar genes for ZNF490 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF490 Gene

genes like me logo Genes that share paralogs with ZNF490: view

Variants for ZNF490 Gene

Sequence variations from dbSNP and Humsavar for ZNF490 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12975874 -- 12,583,756(+) ATTGC(G/T)CTCTC intron-variant
rs12976653 -- 12,584,071(+) tccca(A/G)agtgc intron-variant
rs12976659 -- 12,584,079(+) tgctg(A/G)gatta intron-variant
rs12976867 -- 12,584,087(+) ttaca(A/G)gcgtg intron-variant
rs12977946 -- 12,583,791(+) tctct(A/C)tATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF490 Gene

Variant ID Type Subtype PubMed ID
nsv510755 CNV Loss 20534489
nsv2419 CNV Loss 18451855
esv997496 CNV Deletion 20482838
dgv54n16 CNV Deletion 17901297
nsv512563 CNV Loss 21212237
nsv821459 CNV Deletion 20802225
nsv828441 CNV Loss 20364138
esv2657078 CNV Deletion 23128226
nsv498893 CNV Loss 21111241
nsv820210 CNV Gain 19587683
esv23136 CNV Gain+Loss 19812545
esv996849 CNV Gain 20482838
nsv828443 CNV Loss 20364138
nsv514889 CNV Loss 21397061

Variation tolerance for ZNF490 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF490 Gene

Human Gene Mutation Database (HGMD)
ZNF490

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF490 Gene

Disorders for ZNF490 Gene

Relevant External Links for ZNF490

Genetic Association Database (GAD)
ZNF490
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF490

No disorders were found for ZNF490 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF490 Gene

Publications for ZNF490 Gene

  1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y. … Zhang H. (Genet. Epidemiol. 2011) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3

Products for ZNF490 Gene

Sources for ZNF490 Gene

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