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Aliases for ZNF488 Gene

Aliases for ZNF488 Gene

  • Zinc Finger Protein 488 2 3 5

External Ids for ZNF488 Gene

Previous GeneCards Identifiers for ZNF488 Gene

  • GC10P047749
  • GC10P047975
  • GC10P048355
  • GC10P043107

Summaries for ZNF488 Gene

GeneCards Summary for ZNF488 Gene

ZNF488 (Zinc Finger Protein 488) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is PRDM8.

UniProtKB/Swiss-Prot for ZNF488 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF488 Gene

Genomics for ZNF488 Gene

Regulatory Elements for ZNF488 Gene

Enhancers for ZNF488 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF488 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF488 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF488 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF488 Gene

Chromosome:
10
Start:
47,365,496 bp from pter
End:
47,384,333 bp from pter
Size:
18,838 bases
Orientation:
Minus strand

Genomic View for ZNF488 Gene

Genes around ZNF488 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF488 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF488 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF488 Gene

Proteins for ZNF488 Gene

  • Protein details for ZNF488 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MN9-ZN488_HUMAN
    Recommended name:
    Zinc finger protein 488
    Protein Accession:
    Q96MN9
    Secondary Accessions:
    • Q05CE0

    Protein attributes for ZNF488 Gene

    Size:
    340 amino acids
    Molecular mass:
    36962 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF488 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF488 Gene

Proteomics data for ZNF488 Gene at MOPED

Post-translational modifications for ZNF488 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF488 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF488 Gene

Domains & Families for ZNF488 Gene

Gene Families for ZNF488 Gene

Protein Domains for ZNF488 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96MN9

UniProtKB/Swiss-Prot:

ZN488_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 2 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF488: view

Function for ZNF488 Gene

Molecular function for ZNF488 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF488 Gene

genes like me logo Genes that share phenotypes with ZNF488: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF488 Gene

Localization for ZNF488 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF488 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF488 Gene COMPARTMENTS Subcellular localization image for ZNF488 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF488 Gene

Pathways & Interactions for ZNF488 Gene

SuperPathways for ZNF488 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF488 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0014003 oligodendrocyte development IBA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF488: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF488 Gene

Drugs & Compounds for ZNF488 Gene

No Compound Related Data Available

Transcripts for ZNF488 Gene

Unigene Clusters for ZNF488 Gene

Zinc finger protein 488:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF488 Gene

No ASD Table

Relevant External Links for ZNF488 Gene

GeneLoc Exon Structure for
ZNF488
ECgene alternative splicing isoforms for
ZNF488

Expression for ZNF488 Gene

mRNA expression in normal human tissues for ZNF488 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF488 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x14.9), Brain - Substantia nigra (x7.4), and Brain - Hippocampus (x5.0).

SOURCE GeneReport for Unigene cluster for ZNF488 Gene Hs.27788

genes like me logo Genes that share expression patterns with ZNF488: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF488 Gene

Orthologs for ZNF488 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF488 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF488 35
  • 77.3 (n)
  • 68.73 (a)
dog
(Canis familiaris)
Mammalia ZNF488 35
  • 74.97 (n)
  • 65.11 (a)
mouse
(Mus musculus)
Mammalia Zfp488 35
  • 69.28 (n)
  • 57.37 (a)
Zfp488 16
chimpanzee
(Pan troglodytes)
Mammalia ZNF488 35
  • 95.49 (n)
  • 94.44 (a)
rat
(Rattus norvegicus)
Mammalia Zfp488 35
  • 69.38 (n)
  • 57.37 (a)
Species with no ortholog for ZNF488:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF488 Gene

ENSEMBL:
Gene Tree for ZNF488 (if available)
TreeFam:
Gene Tree for ZNF488 (if available)

Paralogs for ZNF488 Gene

Paralogs for ZNF488 Gene

genes like me logo Genes that share paralogs with ZNF488: view

Variants for ZNF488 Gene

Sequence variations from dbSNP and Humsavar for ZNF488 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs35618062 - 47,368,615(+) CAGTG(C/T)GGAGC reference, missense
rs12251609 - 47,368,513(+) GCTGC(A/C/T)GAGGA reference, missense
rs3814160 - 47,368,085(-) AGGTG(C/T)CCCCA reference, missense
rs1870180 -- 47,380,523(+) CCCCT(A/G)TTGCC intron-variant, upstream-variant-2KB
rs1902717 -- 47,379,915(+) GCTAC(C/G)TGGCT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF488 Gene

Variant ID Type Subtype PubMed ID
dgv252e1 CNV Complex 17122850
nsv510991 OTHER Complex 20534489
nsv8636 CNV Gain+Loss 18304495
nsv436102 CNV Deletion 17901297
nsv7203 OTHER Inversion 18451855
esv2736163 CNV Deletion 23290073
nsv467059 CNV Gain 19166990
esv21870 CNV Gain+Loss 19812545
nsv831860 CNV Gain 17160897
dgv696n71 CNV Gain 21882294
nsv895342 CNV Loss 21882294
nsv895343 CNV Gain 21882294
nsv895344 CNV Loss 21882294
nsv831861 CNV Loss 17160897
essv16333 CNV CNV 17122850

Variation tolerance for ZNF488 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF488 Gene

HapMap Linkage Disequilibrium report
ZNF488

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF488 Gene

Disorders for ZNF488 Gene

Relevant External Links for ZNF488

Genetic Association Database (GAD)
ZNF488
Human Genome Epidemiology (HuGE) Navigator
ZNF488
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF488

No disorders were found for ZNF488 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF488 Gene

Publications for ZNF488 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF488 Gene

Sources for ZNF488 Gene

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