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ZNF487 Gene

protein-coding   GIFtS: 22
GCID: GC10P043933

Zinc Finger Protein 487

(Previous names: KRAB domain only 1, zinc finger protein 487, pseudogene)
(Previous symbols: KRBO1, ZNF487P)
  Search for ZNF487
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4871 2
KRBO11 2 3
ZNF487P1 2 3
KRAB Domain Only 11
Zinc Finger Protein 487, Pseudogene1
KRAB Domain Only Protein 13

External Ids:    HGNC: 234881   Entrez Gene: 6428192   Ensembl: ENSG000002436607   UniProtKB: B1APH43   

Export aliases for ZNF487 gene to outside databases

Previous GC identifer: GC10P043252


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF487 Gene:
ZNF487 (zinc finger protein 487) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN487_HUMAN, B1APH4
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF487 gene promoter:
         STAT5B   STAT4   ATF-2   STAT6   FOXO3   STAT5A   FOXO3b   RORalpha1   STAT3   FOXO3a   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF487


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

ZNF487 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF487 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P043933:  view genomic region     (about GC identifiers)

Start:
43,932,282 bp from pter      End:
43,991,517 bp from pter
Size:
59,236 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN487_HUMAN, B1APH4 (See protein sequence)
Recommended Name: Putative zinc finger protein 487  
Size: 448 amino acids; 51624 Da
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=CAI15018.3; Type=Erroneous gene model prediction; Sequence=CAO03512.1; Type=Erroneous
gene model prediction;
Secondary accessions: B1APH5

Explore the universe of human proteins at neXtProt for ZNF487: NX_B1APH4

Explore proteomics data for ZNF487 at MOPED


See ZNF487 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000314093   ENSP00000395343   ENSP00000392335   ENSP00000395135   ENSP00000388421  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry B1APH4

ProtoNet protein and cluster: B1APH4

UniProtKB/Swiss-Prot: ZN487_HUMAN, B1APH4
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 3 C2H2-type zinc fingers
Similarity: Contains 2 KRAB domains


Find genes that share domains with ZNF487           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN487_HUMAN, B1APH4
Function: May be involved in transcriptional regulation (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF487           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN487_HUMAN, B1APH4: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

Find genes that share ontologies with ZNF487           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF487
Interactions:

    Search GeneGlobe Interaction Network for ZNF487

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with ZNF487           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZNF487 (ZN487)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000315429 ENST00000456416 ENST00000437590(uc010qfb.1) ENST00000490208
ENST00000451167 ENST00000596267 ENST00000431662
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

ZNF487 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF487 Protein Expression
    Custom PCR Arrays for ZNF487
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF487 gene from Selected species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
16(a)
many ↔ many
4(305112-345062)


ENSEMBL Gene Tree for ZNF487 (if available)
TreeFam Gene Tree for ZNF487 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF487 gene
ZNF1752  ZNF6742  ZNF5102  ZIM32  ZNF6142  ZNF1572  ZNF262  ZNF6132  
ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  ENSG000002365752  
ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  RBAK-RBAKDN2  
Selected SIMAP similar genes for ZNF487 using alignment to 4 protein entries:     ZN487_HUMAN (see all proteins) (see all similar genes):
ZNF81    ZNF624    ZNF776    ZNF420    ZNF510    ZNF718
ZNF669    ZNF177    ZNF28    ZNF561    POM121C    ZNF250
ZNF300P1    ZNF506    ZNF569    ZNF823    MGC12518    ZNF273

Find genes that share paralogs with ZNF487           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF487 (see all 891)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs45845281,2
C,F--43930578(+) tccttT/Ccctca 1 -- us2k19Minor allele frequency- C:0.42NA WA CSA EA 369
rs752435431,2
C,F--43930579(+) CCTTCC/TCTCAG 1 -- us2k13Minor allele frequency- T:0.15WA 122
rs44349501,2
C,F,H--43930603(+) tcgtcT/Agatat 1 -- us2k15Minor allele frequency- A:0.01NS EA NA 390
rs1896226561,2
--43930751(+) GATCTC/TGGCTC 1 -- us2k10--------
rs1411121451,2
--43930802(+) CTCAGA/CCTCCC 1 -- us2k10--------
rs618590021,2
C,F--43931002(+) TTAATA/GATGCT 1 -- us2k110Minor allele frequency- G:0.38NA WA CSA EA 371
rs24924061,2
C,F--43931322(-) caggcC/Gcccgc 1 -- us2k17Minor allele frequency- G:0.27NA WA CSA 15
rs1808736601,2
--43931357(+) AGGCAA/GGACAA 1 -- us2k10--------
rs1131695041,2
C,F--43931404(+) GAGATG/CGCGCC 1 -- us2k11Minor allele frequency- C:0.50WA 2
rs108998021,2
C,A--43931587(+) AGCCTC/GAGGTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ZNF487 (43932282 - 43991517 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ZNF487: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing ZNF487
DNA2.0 Custom Variant and Variant Library Synthesis for ZNF487

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for ZNF487 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF487)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 642819 HGNC: 23488 Ensembl:ENSG00000243660 euGenes: HUgn642819 ECgene: ZNF487
H-InvDB: ZNF487

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF487 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF487 gene:
Search GeneIP for patents involving ZNF487

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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