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Aliases for ZNF486 Gene

Aliases for ZNF486 Gene

  • Zinc Finger Protein 486 2 3 5
  • KRAB Domain Only Protein 2 3 4
  • KRAB Domain Only 2 2 3
  • KRBO2 3 4
  • KRAB Box Only Protein 2 3

External Ids for ZNF486 Gene

Previous HGNC Symbols for ZNF486 Gene

  • KRBO2

Previous GeneCards Identifiers for ZNF486 Gene

  • GC19P020139
  • GC19P019976
  • GC19P020278

Summaries for ZNF486 Gene

GeneCards Summary for ZNF486 Gene

ZNF486 (Zinc Finger Protein 486) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF90.

UniProtKB/Swiss-Prot for ZNF486 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF486 Gene

Genomics for ZNF486 Gene

Regulatory Elements for ZNF486 Gene

Enhancers for ZNF486 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F021019 1.3 Ensembl ENCODE 13.2 +855.1 855063 4.6 ATF1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 FOS KLF13 SP3 ZNF714 ZNF90 BNIP3P26 RPL7AP10 ZNF66 ZNF431 LOC641367 ZNF486 BNIP3P16 VN1R82P
GH19F020226 0.3 FANTOM5 8.2 +59.7 59717 0.2 ZNF486 ZNF90 ZNF93 ZNF682 ENSG00000280079 LOC105372310
GH19F020166 0.8 ENCODE 0.8 +0.1 72 2.1 SOX13 CTCF PKNOX1 SAP130 SIN3A CEBPG RAD21 POLR2A NFYB FOS BNIP3P15 ZNF486 BNIP3P16
GH19F020152 0.4 ENCODE 0.4 -14.4 -14448 0.2 POLR2A BNIP3P15 PIR40095 ZNF486
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF486 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF486 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000344968 387 1600 CTCF PKNOX1 SAP130 SIN3A CEBPG RAD21 POLR2A NFYB FOS SP3

Genomic Location for ZNF486 Gene

Chromosome:
19
Start:
20,167,214 bp from pter
End:
20,200,490 bp from pter
Size:
33,277 bases
Orientation:
Plus strand

Genomic View for ZNF486 Gene

Genes around ZNF486 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF486 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF486 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF486 Gene

Proteins for ZNF486 Gene

  • Protein details for ZNF486 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H40-ZN486_HUMAN
    Recommended name:
    Zinc finger protein 486
    Protein Accession:
    Q96H40
    Secondary Accessions:
    • Q0VG00

    Protein attributes for ZNF486 Gene

    Size:
    463 amino acids
    Molecular mass:
    53631 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08936.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH08936.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ZNF486 Gene

Post-translational modifications for ZNF486 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF486 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF486 Gene

Domains & Families for ZNF486 Gene

Gene Families for ZNF486 Gene

Protein Domains for ZNF486 Gene

Suggested Antigen Peptide Sequences for ZNF486 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96H40

UniProtKB/Swiss-Prot:

ZN486_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF486: view

Function for ZNF486 Gene

Molecular function for ZNF486 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF486 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF486: view

Phenotypes for ZNF486 Gene

genes like me logo Genes that share phenotypes with ZNF486: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF486 Gene

Localization for ZNF486 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF486 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF486 gene
Compartment Confidence
extracellular 5
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF486 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ZNF486: view

Pathways & Interactions for ZNF486 Gene

SuperPathways for ZNF486 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF486: view

Pathways by source for ZNF486 Gene

2 Reactome pathways for ZNF486 Gene

Interacting Proteins for ZNF486 Gene

Gene Ontology (GO) - Biological Process for ZNF486 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF486: view

No data available for SIGNOR curated interactions for ZNF486 Gene

Transcripts for ZNF486 Gene

mRNA/cDNA for ZNF486 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF486 Gene

Zinc finger protein 486:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF486 Gene

No ASD Table

Relevant External Links for ZNF486 Gene

GeneLoc Exon Structure for
ZNF486
ECgene alternative splicing isoforms for
ZNF486

Expression for ZNF486 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF486 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF486 Gene

This gene is overexpressed in Thyroid (x8.4).

NURSA nuclear receptor signaling pathways regulating expression of ZNF486 Gene:

ZNF486

SOURCE GeneReport for Unigene cluster for ZNF486 Gene:

Hs.590991
genes like me logo Genes that share expression patterns with ZNF486: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF486 Gene

Orthologs for ZNF486 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF486 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF728 34
  • 99.14 (n)
ZNF486 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 31 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp386 35
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
Species where no ortholog for ZNF486 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF486 Gene

ENSEMBL:
Gene Tree for ZNF486 (if available)
TreeFam:
Gene Tree for ZNF486 (if available)

Paralogs for ZNF486 Gene

(509) SIMAP similar genes for ZNF486 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF486: view

Variants for ZNF486 Gene

Sequence variations from dbSNP and Humsavar for ZNF486 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401241 -- 20,187,446(+) ATGGG(C/T)ACAAt intron-variant
rs10402731 -- 20,188,161(+) ATAGG(A/C)AGAAC intron-variant
rs10406552 -- 20,200,706(+) GTTCC(C/T)ATAGG intron-variant, downstream-variant-500B
rs10407956 -- 20,179,520(+) TGTTA(A/G)AGCAG intron-variant
rs10408074 -- 20,171,143(+) ctaca(A/G)atatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF486 Gene

Variant ID Type Subtype PubMed ID
nsv963020 CNV duplication 23825009
nsv817820 CNV gain 17921354
nsv578807 CNV loss 21841781
nsv578806 CNV loss 21841781
nsv578805 CNV gain 21841781
nsv578804 CNV gain 21841781
nsv520325 CNV gain 19592680
nsv519535 CNV gain 19592680
nsv1131412 CNV deletion 24896259
nsv1061915 CNV loss 25217958
nsv1061846 CNV loss 25217958
nsv1059188 CNV loss 25217958
esv3643876 CNV loss 21293372
esv3643875 CNV loss 21293372
esv3643874 CNV loss 21293372
esv3583276 CNV loss 25503493
esv3574330 CNV gain 25503493
esv34357 CNV gain 17911159
esv2758748 CNV gain 17122850
esv2718305 CNV deletion 23290073
esv2718296 CNV deletion 23290073
esv2663395 CNV deletion 23128226
dgv630e199 CNV deletion 23128226
dgv6303n54 CNV loss 21841781
dgv509e201 CNV deletion 23290073
dgv3459n100 CNV loss 25217958
dgv3458n100 CNV loss 25217958
dgv3457n100 CNV gain 25217958
dgv3456n100 CNV gain 25217958

Variation tolerance for ZNF486 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF486 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF486

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF486 Gene

Disorders for ZNF486 Gene

Relevant External Links for ZNF486

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF486

No disorders were found for ZNF486 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF486 Gene

Publications for ZNF486 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3 64
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF486 Gene

Sources for ZNF486 Gene

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