ZNF486 Gene
protein-coding GIFtS: 40
GCID: GC19P020278
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zinc finger protein 486(Previous name: KRAB domain only 2 )
(Previous symbol: KRBO2)
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Aliases
for ZNF486 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4861 2 | | KRBO21 2 3 | | KRAB Domain Only 21 2 | | KRAB Domain Only Protein 22 3 | | MGC23961 | | KRAB Box Only Protein 22 |
Export aliases for ZNF486 gene to outside databasesPrevious GC identifers: GC19P020139 GC19P019976 |
Summaries
for ZNF486 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN486_HUMAN, Q96H40Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF486 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF486 gene promoter:
Meis-1a NF-Y Evi-1 Meis-1b Meis-1 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF486
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF486 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p13.11ZNF486 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P020278: view genomic region
(about GC identifiers)
Start:
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20,278,083 bp from pter |
End:
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20,308,984 bp from pter |
Size:
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30,902 bases |
Orientation:
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plus strand |
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Proteins
for ZNF486 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN486_HUMAN, Q96H40 (See
protein sequence)Recommended Name: Zinc finger protein 486 Size: 463 amino acids; 53631 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH08936.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH08936.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q0VG00Explore the universe of human proteins at neXtProt for ZNF486: NX_Q96H40
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96H40
ZNF486 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_443084.2
ENSEMBL proteins: ENSP00000335042 Reactome Protein details: Q96H40
Human Recombinant Protein Products for ZNF486:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF486 for ontologies About GeneDecksing
ZNF486 Antibody Products:
Assay Products for ZNF486: |
Protein
Domains /
Families
for ZNF486 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF486 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96H40ProtoNet protein and cluster: Q96H40 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN486_HUMAN, Q96H40Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF486 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN486_HUMAN, Q96H40Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF486 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF486
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF486
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF486 (NM_052852) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF486 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF486 |
|
Pathways & Interactions
for ZNF486 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF486
ZNF486 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF486
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF486 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF486 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF486
Search CenterWatch for drugs/clinical trials and news about ZNF486 / ZN486
|
Transcripts
for ZNF486 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF486 gene: NM_052852.3 Unigene Cluster for ZNF486: Zinc finger protein 486 Hs.590991 [show with all ESTs]Unigene Representative Sequence: NM_0528521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000335117(uc002nou.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF486
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF486
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF486 (NM_052852) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF486 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF486 |
Additional cDNA sequence: AB209550.1 BC008936.2 BC027608.1 BC117268.1 9 DOTS entries: DT.91890654 DT.75154095 DT.121492567 DT.121492927 DT.97858455 DT.75129029 DT.70105097 DT.95312637 DT.97828802 18 AceView cDNA sequences: BC027608 BC008936 CD635312 BM904772 BX474263 CD635314 CD635313 CD635315 AW247184 AW248211 CB409263 CB988873 BG149811 BE177799 CB988883 CB409262 BG150073 CD635311
GeneLoc Exon Structure
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Expression
for ZNF486 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF486 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTGCAGGC
About this image
Genevestigator expression for ZNF486
SOURCE GeneReport for Unigene cluster: Hs.590991
SABiosciences Custom PCR Arrays for ZNF486
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF486
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF486 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF486 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF486 |
Orthologs
for ZNF486 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF486 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for ZNF486 (if available)
TreeFam Gene Tree for ZNF486 (if available) |
Paralogs
for ZNF486 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF486 gene
- ZNF852 ZNF4932 ZNF1002 ZNF922 ZNF7322 ZNF1382 ZNF6752 ZNF5062
- ZNF2732 ZNF66P2 ZNF6952 ZNF6262 ZNF6802 ZNF2532 ZNF4792 ZNF932
- ZNF4922 ZNF6822 ZNF6762 ZNF1412 ZNF6812 ZNF6792 ZNF2572 ZNF2542
- ZNF7372 ZNF724P2 ZNF982 ZNF849P2 ZNF7162 ZNF7142 ZNF4292 ZNF4302
- ZNF7302 ZNF6782 ZNF1172 ZNF7082 ZNF1072 ZNF4312 ZNF902
18/494 SIMAP similar genes for ZNF486 using alignment to 3 protein entries: ZN486_HUMAN (see all proteins)
(see all similar genes):ZFS-4 MGC12518 ZNF66 ZNF506 ZNF818P kr-znf3
ZNF273 ZNF737 ZNF78L1 ZNF93 ZNF726 ZNF85
DKFZp762K012 ZNF66P ZNF232 DKFZp686M04222 ZFS-6 ZNF253
ZNF486 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF486 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF486 (20278083 - 20308984 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF486
4 CNVs: 9789 3182 8865 4069 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZNF486 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF486 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF486 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF486) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF486 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF486 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF486 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF486 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF486 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF486 gene:
Search GeneIP for patents involving ZNF486
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF486 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF486 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF486 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF486 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF486 | | OriGene 3'-UTR Clone for ZNF486 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF486 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF486 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF486 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF486 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF486 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF486 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF486 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF486 |
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 | | | ZNF486 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF486 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF486 |
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