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Aliases for ZNF485 Gene

Aliases for ZNF485 Gene

  • Zinc Finger Protein 485 2 3

External Ids for ZNF485 Gene

Previous GeneCards Identifiers for ZNF485 Gene

  • GC10P043256
  • GC10P043421
  • GC10P044101
  • GC10P040628

Summaries for ZNF485 Gene

GeneCards Summary for ZNF485 Gene

ZNF485 (Zinc Finger Protein 485) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF275.

UniProtKB/Swiss-Prot for ZNF485 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF485 Gene

Genomics for ZNF485 Gene

Regulatory Elements for ZNF485 Gene

Genomic Location for ZNF485 Gene

Start:
43,606,407 bp from pter
End:
43,617,904 bp from pter
Size:
11,498 bases
Orientation:
Plus strand

Genomic View for ZNF485 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF485 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF485 Gene

Proteins for ZNF485 Gene

  • Protein details for ZNF485 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCK3-ZN485_HUMAN
    Recommended name:
    Zinc finger protein 485
    Protein Accession:
    Q8NCK3
    Secondary Accessions:
    • B4DSE6
    • Q96CL0

    Protein attributes for ZNF485 Gene

    Size:
    441 amino acids
    Molecular mass:
    50280 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14161.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305}; Sequence=CAH73487.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF485 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF485 Gene

Proteomics data for ZNF485 Gene at MOPED

Post-translational modifications for ZNF485 Gene

  • Ubiquitination at Lys411
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF485 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF485 Gene

Domains for ZNF485 Gene

Gene Families for ZNF485 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF485 Gene

Suggested Antigen Peptide Sequences for ZNF485 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCK3

UniProtKB/Swiss-Prot:

ZN485_HUMAN :
  • Q8NCK3
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF485: view

Function for ZNF485 Gene

Molecular function for ZNF485 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF485: view

Phenotypes for ZNF485 Gene

GenomeRNAi human phenotypes for ZNF485:
genes like me logo Genes that share phenotypes with ZNF485: view

miRNA for ZNF485 Gene

miRTarBase miRNAs that target ZNF485

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF485 Gene

Localization for ZNF485 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF485 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF485 Gene COMPARTMENTS Subcellular localization image for ZNF485 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF485: view

Pathways for ZNF485 Gene

SuperPathways for ZNF485 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF485: view

Pathways by source for ZNF485 Gene

2 Reactome pathways for ZNF485 Gene

Interacting Proteins for ZNF485 Gene

Gene Ontology (GO) - Biological Process for ZNF485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF485: view

Transcripts for ZNF485 Gene

Unigene Clusters for ZNF485 Gene

Zinc finger protein 485:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF485 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for ZNF485 Gene

GeneLoc Exon Structure for
ZNF485
ECgene alternative splicing isoforms for
ZNF485

Expression for ZNF485 Gene

mRNA expression in normal human tissues for ZNF485 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF485 Gene

SOURCE GeneReport for Unigene cluster for ZNF485 Gene Hs.147440

genes like me logo Genes that share expressions with ZNF485: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF485 Gene

Orthologs for ZNF485 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF485 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF485 35
  • 99.7 (n)
  • 99.09 (a)
ZNF485 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF485 35
  • 88.31 (n)
  • 85.42 (a)
ZNF485 36
  • 84 (a)
OneToOne
Species with no ortholog for ZNF485:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF485 Gene

ENSEMBL:
Gene Tree for ZNF485 (if available)
TreeFam:
Gene Tree for ZNF485 (if available)

Paralogs for ZNF485 Gene

Paralogs for ZNF485 Gene

Selected SIMAP similar genes for ZNF485 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF485 Gene

genes like me logo Genes that share paralogs with ZNF485: view

Variants for ZNF485 Gene

Sequence variations from dbSNP and Humsavar for ZNF485 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2039723 -- 43,613,576(-) ACACA(A/G)TGAGT intron-variant
rs3123679 -- 43,614,696(-) TGTTA(A/G)TAAAT intron-variant
rs3123680 -- 43,612,681(-) GATGT(A/G)GAGAA intron-variant
rs3123681 -- 43,612,314(-) AAAAC(A/G)TAAAT intron-variant
rs3123682 -- 43,611,835(-) AATCT(A/C)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF485 Gene

Variant ID Type Subtype PubMed ID
nsv522992 CNV Loss 19592680

Relevant External Links for ZNF485 Gene

HapMap Linkage Disequilibrium report
ZNF485

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF485 Gene

Disorders for ZNF485 Gene

Relevant External Links for ZNF485

Genetic Association Database (GAD)
ZNF485
Human Genome Epidemiology (HuGE) Navigator
ZNF485
genes like me logo Genes that share disorders with ZNF485: view

No data available for UniProtKB/Swiss-Prot for ZNF485 Gene

Publications for ZNF485 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF485 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF485
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF485
  • Block miRNA regulation of ZNF485 using miScript Target Protectors

Sources for ZNF485 Gene

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