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ZNF485 Gene

protein-coding   GIFtS: 51
GCID: GC10P044101

Zinc Finger Protein 485

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4851 2
Zinc Finger Protein 93 (Zinc Finger Protein HTF34)2

External Ids:    HGNC: 234401   Entrez Gene: 2209922   Ensembl: ENSG000001982987   UniProtKB: Q8NCK33   

Export aliases for ZNF485 gene to outside databases

Previous GC identifers: GC10P043256 GC10P043421 GC10P040628


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF485 Gene:
ZNF485 (zinc finger protein 485) is a protein-coding gene. An important paralog of this gene is ZNF275.

UniProtKB/Swiss-Prot: ZN485_HUMAN, Q8NCK3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF485 gene promoter:
         GATA-3   Nkx2-2   p300   POU3F2   LCR-F1   YY1   GATA-1   GATA-2   Ik-2   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF485 promoter sequence
   Search Chromatin IP Primers for ZNF485

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF485


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

ZNF485 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF485 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P044101:  view genomic region     (about GC identifiers)

Start:
44,101,855 bp from pter      End:
44,113,352 bp from pter
Size:
11,498 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN485_HUMAN, Q8NCK3 (See protein sequence)
Recommended Name: Zinc finger protein 485  
Size: 441 amino acids; 50280 Da
Sequence caution: Sequence=AAH14161.1; Type=Frameshift; Positions=3; Sequence=CAH73487.1; Type=Erroneous gene
model prediction;
Secondary accessions: Q96CL0

Explore the universe of human proteins at neXtProt for ZNF485: NX_Q8NCK3

Explore proteomics data for ZNF485 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys411
  • Modification sites at PhosphoSitePlus

  • See ZNF485 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660355.2  
    ENSEMBL proteins: 
     ENSP00000354694   ENSP00000393570   ENSP00000363558   ENSP00000363560  
    Reactome Protein details: Q8NCK3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8NCK3

    ProtoNet protein and cluster: Q8NCK3

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN485_HUMAN, Q8NCK3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF485           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN485_HUMAN, Q8NCK3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF485           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF485:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF485

    miRNA
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    miRTarBase miRNAs that target ZNF485:
    hsa-mir-378a-5p (MIRT043989)

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    hsa-miR-3671 hsa-miR-513b
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN485_HUMAN, Q8NCK3: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF485           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF485 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF485           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF485
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF485
    Interactions:

        Search GeneGlobe Interaction Network for ZNF485

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF485           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF485 (ZN485)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF485 gene: 
    NM_145312.3  

    Unigene Cluster for ZNF485:

    Zinc finger protein 485
    Hs.147440  [show with all ESTs]
    Unigene Representative Sequence: NM_145312
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361807(uc010qfc.2 uc010qfd.2) ENST00000480678 ENST00000430885
    ENST00000374435 ENST00000374437
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZNF485:
    hsa-miR-3671 hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidZNF485 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF485
      QuantiFast Probe-based Assays in human, mouse, rat ZNF485

    Additional mRNA sequence: 

    AK074679.1 AK299707.1 AK313328.1 BC014161.2 BX648149.1 

    3 DOTS entries:

    DT.91736246  DT.40227248  DT.121216000 

    22 AceView cDNA sequences:

    BP345695 BP346384 AK074679 AI214727 NM_145312 CA841103 BP354989 BF575645 
    BX476601 BM263252 BX648149 BU784649 BC014161 BP375841 CA394799 BG280960 
    BI004159 BE541840 CA841366 CD695698 AW404591 AA903551 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF485    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                    -           -                           
    SP2:                                -                           
    SP3:                    -                                       


    ECgene alternative splicing isoforms for ZNF485

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF485 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAATATACC
    ZNF485 Expression
    About this image

    ZNF485 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF485 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.147440
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF485

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF485 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF4851 zinc finger protein 485 88.31(n)
    85.42(a)
      100687256  XM_005637501.1  XP_005637558.1 


    ENSEMBL Gene Tree for ZNF485 (if available)
    TreeFam Gene Tree for ZNF485 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF485 gene
    ZNF2752  
    Selected SIMAP similar genes for ZNF485 using alignment to 3 protein entries:     ZN485_HUMAN (see all proteins) (see all similar genes):
    ZFS-5    ZNF78L1    ZNF345    ZNF56    ZNF818P    DKFZp686B16128
    ZNF287    ZNF418    ZNF502    ZSCAN23    HZF41    ZFS-1
    ZNF323    ZNF676    ZNF826P    ZNF883    ZNF664    ZNF677

    Find genes that share paralogs with ZNF485           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF485
    PGOHUM00000259558


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF485 (see all 300)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842456941,2
    --44099881(+) GTTTGG/TTTAGA 1 -- us2k10--------
    rs1160344541,2
    C,F--44099940(+) CAGAAA/GAAGAT 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1890541901,2
    --44100015(+) TTGGTA/GGAATA 1 -- us2k10--------
    rs1397542001,2
    C--44100028(+) CCCCAA/CAGCTC 1 -- us2k10--------
    rs1818428901,2
    --44100076(+) AGCTGA/CTTTGG 1 -- us2k10--------
    rs96637701,2
    C,A--44100274(+) AAAGAA/CCCCAG 1 -- us2k1 tfbs30--------
    rs1864379771,2
    --44100429(+) GCACTA/GGCTAT 1 -- us2k10--------
    rs1474570651,2
    --44100488(+) TTTGTG/TGATGG 1 -- us2k10--------
    rs1142732471,2
    C,F--44100492(+) TTGATG/AGAAAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs668675771,2
    C,F--44100524(+) CTGAAC/GTTTGA 1 -- us2k14Minor allele frequency- G:0.33NA WA 242

    HapMap Linkage Disequilibrium report for ZNF485 (44101855 - 44113352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF485:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522992CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF485
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF485

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF485           About GenesLikeMe

    Genetic Association Database (GAD): ZNF485
    Human Genome Epidemiology (HuGE) Navigator: ZNF485 (1 document)

    Export disorders for ZNF485 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF485 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF485)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 220992 HGNC: 23440 AceView: ZNF485 Ensembl:ENSG00000198298 euGenes: HUgn220992
    ECgene: ZNF485 H-InvDB: ZNF485

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF485 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF485 gene:
    Search GeneIP for patents involving ZNF485

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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