ZNF485 Gene
protein-coding GIFtS: 47
GCID: GC10P044101
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|
zinc finger protein 485
| |
Aliases
for ZNF485 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4851 2 | | Zinc Finger Protein 93 (Zinc Finger Protein HTF34)2 |
Export aliases for ZNF485 gene to outside databasesPrevious GC identifers: GC10P043256 GC10P043421 GC10P040628 |
Summaries
for ZNF485 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN485_HUMAN, Q8NCK3Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF485 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_033985.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF485 gene promoter:
GATA-3 Nkx2-2 p300 POU3F2 LCR-F1 YY1 GATA-1 GATA-2 Ik-2 Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF485
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF485 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.21 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.21ZNF485 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P044101: view genomic region
(about GC identifiers)
Start:
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44,101,855 bp from pter |
End:
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44,113,352 bp from pter |
Size:
|
11,498 bases |
Orientation:
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plus strand |
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Proteins
for ZNF485 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN485_HUMAN, Q8NCK3 (See
protein sequence)Recommended Name: Zinc finger protein 485 Size: 441 amino acids; 50280 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH14161.1; Type=Frameshift; Positions=3; Sequence=CAH73487.1; Type=Erroneous gene modelprediction;
Secondary accessions: Q96CL0Explore the universe of human proteins at neXtProt for ZNF485: NX_Q8NCK3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCK3
ZNF485 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660355.2
ENSEMBL proteins: ENSP00000354694 ENSP00000393570 ENSP00000363558 ENSP00000363560 Reactome Protein details: Q8NCK3
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF485 for ontologies About GeneDecksing
ZNF485 Antibody Products:
Assay Products for ZNF485: |
Protein
Domains /
Families
for ZNF485 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF485 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NCK3ProtoNet protein and cluster: Q8NCK3 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN485_HUMAN, Q8NCK3Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF485 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN485_HUMAN, Q8NCK3Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF485 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF485 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF485 (NM_145312) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF485 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF485 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF485 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF485 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF485:
|
Pathways & Interactions
for ZNF485 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF485
ZNF485 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF485
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF485 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF485 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF485
Search CenterWatch for drugs/clinical trials and news about ZNF485 / ZN485
|
Transcripts
for ZNF485 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF485 gene: NM_145312.3 Unigene Cluster for ZNF485: Zinc finger protein 485 Hs.147440 [show with all ESTs]Unigene Representative Sequence: NM_1453125 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361807(uc010qfc.2 uc010qfd.2) ENST00000430885 ENST00000480678
ENST00000374435 ENST00000374437
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF485 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF485 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF485 (NM_145312) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF485 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF485 |
Additional cDNA sequence: AK074679.1 AK299707.1 AK313328.1 BC014161.2 BX648149.1 3 DOTS entries: DT.91736246 DT.40227248 DT.121216000 22 AceView cDNA sequences: BP345695 AK074679 BP346384 BM263252 NM_145312 BX648149 CA394799 BP354989 BX476601 BP375841 BF575645 BU784649 AI214727 BC014161 CA841103 BE541840 BG280960 BI004159 AA903551 CD695698 AW404591 CA841366
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF485 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
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| SP1: | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF485
|
Expression
for ZNF485 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF485 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAATATACC
About this image
See ZNF485 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF485
SOURCE GeneReport for Unigene cluster: Hs.147440
SABiosciences Custom PCR Arrays for ZNF485
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF485
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF485 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF485 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF485 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF485 |
Orthologs
for ZNF485 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF485 (if available)
TreeFam Gene Tree for ZNF485 (if available) |
Paralogs
for ZNF485 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF485 gene
- ZNF4542
18/544 SIMAP similar genes for ZNF485 using alignment to 3 protein entries: ZN485_HUMAN (see all proteins)
(see all similar genes):ZFS-5 ZNF78L1 ZNF345 ZNF56 ZNF818P DKFZp686B16128
ZNF287 ZNF418 ZNF502 ZSCAN23 HZF41 ZFS-1
ZNF43 ZNF676 ZNF826P ZNF845 ZNF883 ZSCAN31
ZNF485 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF485
PGOHUM00000259558
|
Genomic Variants
for ZNF485 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF485 (44101855 - 44113352 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF485: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF485 |
|
Disorders
/ Diseases
for ZNF485 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF485 for disorders About GeneDecksing
1  disease for ZNF485: About MalaCardsalzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: ZNF485 (1 document)
Export disorders for ZNF485 gene to outside databases
|
Publications
for ZNF485 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF485 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF485) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF485 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF485 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF485 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF485 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF485 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF485 gene:
Search GeneIP for patents involving ZNF485
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF485 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF485 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF485 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF485 | | | OriGene Protein Over-expression Lysate for ZNF485 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF485 | | OriGene 3'-UTR Clone for ZNF485 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF485 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF485 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF485 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF485 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF485 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF485 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF485 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF485 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF485 |
| |  |  |  |  | | | | |
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 | | | ZNF485 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF485 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF485 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF485 |
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