ZNF483 Gene
protein-coding GIFtS : 49
GCID: GC09 P114287
zinc finger protein 483
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Aliasesfor ZNF483 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger Protein 483 1 2 ZKSCAN161 2 3 ZSCAN481 2 KIAA19621 3 Zinc Finger Protein With KRAB And SCAN Domains 162 3 Zinc Finger Protein HIT-102
Export aliases for ZNF483 gene to outside databases Previous GC identifers: GC09P109667 GC09P111366 GC09P113327 GC09P083886
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Summariesfor ZNF483 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZN483_HUMAN, Q8TF39 Function : May be involved in transcriptional regulation
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Genomic Viewsfor ZNF483 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF483 gene promoter: E2F-3a STAT1 Brachyury Nkx2-2 E2F-2 NF-E2 NF-E2 p45 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF483 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF483
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q32 ZNF483 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P114287: view genomic region
(about GC identifiers )
Start:
114,287,439 bp from pter
End:
114,340,124 bp from pter
Size:
52,686 bases
Orientation:
plus strand
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Proteinsfor ZNF483 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZN483_HUMAN, Q8TF39 (See
protein sequence )Recommended Name: Zinc finger protein 483 Size : 744 amino acids; 85098 Da
Subcellular location : Nucleus (Probable)
Sequence caution : Sequence=BAB85548.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ZNF483 :2CTU (3D)
 
Secondary accessions : Q5VZN2 Q8NAE1Alternative splicing : 2 isoforms : Q8TF39-1 Q8TF39-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF483: NX_Q8TF39 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TF39 ZNF483 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001007170.1 NP_597721.2 ENSEMBL proteins: ENSP00000350871 ENSP00000363494 ENSP00000311679 ENSP00000438048 Reactome Protein details: Q8TF39 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
ZNF483 for ontologies About GeneDecksing ZNF483 Antibody Products: Assay Products for ZNF483:
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Protein
Domains / Familiesfor ZNF483 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF483 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q8TF39 ProtoNet protein and cluster: Q8TF39
2 Blocks protein families : IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN UniProtKB/Swiss-Prot: ZN483_HUMAN, Q8TF39 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity : Contains 11 C2H2-type zinc fingersSimilarity : Contains 1 KRAB domainSimilarity : Contains 1 SCAN box domain
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Functionfor ZNF483 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ZN483_HUMAN, Q8TF39 Function : May be involved in transcriptional regulation
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF483 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF483 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ZNF483 (NM_133464 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF483 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF483
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF483
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
-- -- GO:0003677 DNA binding
IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0008270 zinc ion binding
IEA --
ZNF483 for ontologies About GeneDecksing
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Pathways & Interactionsfor ZNF483 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Generic Transcription Pathway
Pathway sources See GeneCards unified pathways Show all pathways 2
Reactome Pathways for ZNF483
ZNF483 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF483 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)4 Interacting proteins for ZNF483 (Q8TF39 3 ENSP00000311679 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0016032 viral reproduction
IEA --
ZNF483 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZNF483 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ZNF483 Search CenterWatch for drugs/clinical trials and news about ZNF483 / ZN483
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Transcriptsfor ZNF483 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZNF483 gene (2 alternative transcripts): NM_001007169.2 NM_133464.2 Unigene Cluster for ZNF483:
Zinc finger protein 483 Hs.660784 [show with all ESTs ] Unigene Representative Sequence: NM_133464 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000358151 (uc004bfg.2 ) ENST00000374374 (uc010mud.1 ) ENST00000309235 (uc004bff.2 )ENST00000355824 (uc011lwq.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF483 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF483 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ZNF483 (NM_133464 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF483 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF483
Additional cDNA sequence: AB075842.1 AK092811.1 AK291267.1 BC020893.1 BC065738.1 BC136695.1 BC136696.1 BC152427.1 BC152433.1
4 DOTS entries : DT.100057 DT.40210437
DT.100678417 DT.95353760 24/25 AceView cDNA sequences (see all 25 ):
AA102760 AB075842 AW005032 BX092394 BX955571 AK092811 AI371029 BG542255 BE464721 BM462877 CA941876 BC020893 AX747743 BC065738 AI342906 CA941875 AA992194 AI376204 CD654420 AA102759 AW901813 AI217187 AA993648 AF026101 GeneLoc Exon Structure
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Expression for ZNF483 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZNF483 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAGTGTGATG
About this image ZNF483 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Matrigel embedded cells (Derivation of cardio... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ZNF483 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF483 SOURCE GeneReport for Unigene cluster: Hs.660784 SABiosciences Custom PCR Arrays for ZNF483 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF483Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ZNF483 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF483 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF483 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF483
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Orthologsfor ZNF483 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ZNF483 gene from 1/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for ZNF483 (if available)TreeFam Gene Tree for ZNF483 (if available)
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Paralogsfor ZNF483 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ZNF483 gene ZNF274 2 ZSCAN18 2 ZNF215 2 ZSCAN1 2 18/451 SIMAP similar genes for ZNF483 using alignment to 4 protein entries: ZN483_HUMAN (see all proteins )
(see all similar genes ):ZNF396 ZNF75CP HZF36 ZNF383 ZIK1 ZKSCAN2 ZNF146 ZNF485 ZNF501 DKFZp434G1930 DKFZp762K012 HZF30 ZNF ZSCAN23 DKFZp666M039 ZNF323 ZNF506 ZNF829
ZNF483 for paralogs About GeneDecksing
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Genomic Variantsfor ZNF483 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZNF483 (114287439 - 114340124 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for ZNF483 1 CNV : 62942 1 Indel : 43137
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF483
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Disorders
/ Diseasesfor ZNF483 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section ZNF483 for disorders About MalaCards
ZNF483 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: ZNF483 (2 documents) Export disorders for ZNF483 gene to outside databases
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Publicationsfor ZNF483 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZNF483 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with ZNF483) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319) 1 , 2 Nagase T.... Ohara O. (2001) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462) 1 Elks C.E....Murray A. (2010) A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791) 1 Gorbea C.... Rechsteiner M. (2010) Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864) 1 Nozawa R.S....Obuse C. (2010) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004)
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External Searches for ZNF483 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF483 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF483 gene
(According to HUGE )
About This Section
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Specialized Databases showing ZNF483 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZNF483 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZNF483 gene: Search GeneIP for patents involving ZNF483 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF483 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZNF483 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZNF483 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF483 OriGene Protein Over-expression Lysate for ZNF483 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZNF483 OriGene 3'-UTR Clone for ZNF483 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF483 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF483 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ZNF483 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZNF483 OriGene Custom Protein Services for ZNF483 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF483 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF483 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF483 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZNF483 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF483 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF483
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ZNF483 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF483
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF483
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