Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF480 Gene

Aliases for ZNF480 Gene

  • Zinc Finger Protein 480 2 3 5

External Ids for ZNF480 Gene

Previous GeneCards Identifiers for ZNF480 Gene

  • GC19P057493
  • GC19P057494
  • GC19P052800
  • GC19P049130

Summaries for ZNF480 Gene

GeneCards Summary for ZNF480 Gene

ZNF480 (Zinc Finger Protein 480) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF880.

UniProtKB/Swiss-Prot for ZNF480 Gene

  • Involved in transcriptional regulation as an activator.

Additional gene information for ZNF480 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF480 Gene

Genomics for ZNF480 Gene

Regulatory Elements for ZNF480 Gene

Enhancers for ZNF480 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H051687 1.8 FANTOM5 ENCODE dbSUPER 35.2 -606.7 -606679 6 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF207 ZNF143 SP3 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ZNF175 ENSG00000269825 ZNF836 ENSG00000268970
GH19H051338 1.1 ENCODE 20.8 -957.4 -957384 2 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF416 ZNF143 DEK ZNF841 ZNF616 ZNF577 ZNF766 ZNF350 ZNF836 POLD1 ZNF175 ZNF613 ZNF480
GH19H051784 1.5 Ensembl ENCODE dbSUPER 12.4 -511.2 -511182 3 PKNOX1 ATF1 TCF12 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 JUNB FPR3 ZNF577 ZNF175 ZNF841 ZNF137P ZNF616 ZNF432 ZNF649 ZNF578 ZNF766
GH19H051393 1.5 FANTOM5 ENCODE 10.1 -902.1 -902122 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 ZNF143 FOS SP3 ZNF577 ZNF766 ZNF841 ZNF616 ZNF175 ZNF432 ZNF836 ZNF613 ZNF614 SPACA6P-AS
GH19H052335 0.8 ENCODE 11.1 +39.4 39370 1 ARID4B SIN3A ELK1 RUNX3 CREM THAP11 SP3 ZNF362 CBFB ELF1 ZNF480 ZNF528 ZNF610 ENSG00000269535
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF480 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF480 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111292 31 1601 HDAC1 ELF3 ARID4B SIN3A DMAP1 ZBTB40 ETS1 EGR1 ZNF207 ETV6

Genomic Location for ZNF480 Gene

Chromosome:
19
Start:
52,297,169 bp from pter
End:
52,325,927 bp from pter
Size:
28,759 bases
Orientation:
Plus strand

Genomic View for ZNF480 Gene

Genes around ZNF480 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF480 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF480 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF480 Gene

Proteins for ZNF480 Gene

  • Protein details for ZNF480 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV37-ZN480_HUMAN
    Recommended name:
    Zinc finger protein 480
    Protein Accession:
    Q8WV37
    Secondary Accessions:
    • Q5JPG9
    • Q6P0Q4
    • Q8N1M5

    Protein attributes for ZNF480 Gene

    Size:
    535 amino acids
    Molecular mass:
    61708 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF480 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF480 Gene

Post-translational modifications for ZNF480 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF480 Gene

Domains & Families for ZNF480 Gene

Gene Families for ZNF480 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF480 Gene

Suggested Antigen Peptide Sequences for ZNF480 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV37

UniProtKB/Swiss-Prot:

ZN480_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF480: view

Function for ZNF480 Gene

Molecular function for ZNF480 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation as an activator.

Gene Ontology (GO) - Molecular Function for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF480: view
genes like me logo Genes that share phenotypes with ZNF480: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF480
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF480 Gene

Localization for ZNF480 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF480 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF480 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF480: view

Pathways & Interactions for ZNF480 Gene

SuperPathways for ZNF480 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF480: view

Pathways by source for ZNF480 Gene

2 Reactome pathways for ZNF480 Gene

Interacting Proteins for ZNF480 Gene

Gene Ontology (GO) - Biological Process for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF480: view

No data available for SIGNOR curated interactions for ZNF480 Gene

Drugs & Compounds for ZNF480 Gene

No Compound Related Data Available

Transcripts for ZNF480 Gene

Unigene Clusters for ZNF480 Gene

Zinc finger protein 480:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF480
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF480 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - -
SP3: -

Relevant External Links for ZNF480 Gene

GeneLoc Exon Structure for
ZNF480
ECgene alternative splicing isoforms for
ZNF480

Expression for ZNF480 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF480 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF480 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF480 Gene:

ZNF480

SOURCE GeneReport for Unigene cluster for ZNF480 Gene:

Hs.729317

mRNA Expression by UniProt/SwissProt for ZNF480 Gene:

Q8WV37-ZN480_HUMAN
Tissue specificity: Expressed in fetal heart, heart, skeletal muscle, pancreas and placenta.

Evidence on tissue expression from TISSUES for ZNF480 Gene

  • Nervous system(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZNF480: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF480 Gene

Orthologs for ZNF480 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF480 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF480 33
  • 98.88 (n)
-- 34
  • 91 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia ZNF415 33
  • 64.04 (n)
-- 34
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 45 (a)
ManyToMany
Species where no ortholog for ZNF480 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF480 Gene

ENSEMBL:
Gene Tree for ZNF480 (if available)
TreeFam:
Gene Tree for ZNF480 (if available)

Paralogs for ZNF480 Gene

(568) SIMAP similar genes for ZNF480 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF480: view

Variants for ZNF480 Gene

Sequence variations from dbSNP and Humsavar for ZNF480 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035584 A colorectal cancer sample
rs1000004859 -- 52,313,983(+) CAAAA(A/C)AAAGA intron-variant
rs1000078366 -- 52,312,479(+) TGAAG(G/T)TCCAT intron-variant
rs1000101457 -- 52,320,071(+) TTGGC(C/G)TCCCA intron-variant
rs1000219687 -- 52,309,354(+) TGCTG(A/G)GGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF480 Gene

Variant ID Type Subtype PubMed ID
esv27010 CNV loss 19812545
esv3644688 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv458742 CNV loss 19166990
nsv475700 CNV novel sequence insertion 20440878
nsv580008 CNV loss 21841781
nsv833873 CNV gain 17160897

Variation tolerance for ZNF480 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF480 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF480

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF480 Gene

Disorders for ZNF480 Gene

Relevant External Links for ZNF480

Genetic Association Database (GAD)
ZNF480
Human Genome Epidemiology (HuGE) Navigator
ZNF480
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF480

No disorders were found for ZNF480 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF480 Gene

Publications for ZNF480 Gene

  1. A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE. (PMID: 15219843) Yi Z … Wu X (Biochemical and biophysical research communications 2004) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for ZNF480 Gene

Sources for ZNF480 Gene

Content
Loading form....