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Aliases for ZNF480 Gene

Aliases for ZNF480 Gene

  • Zinc Finger Protein 480 2 3 5

External Ids for ZNF480 Gene

Previous GeneCards Identifiers for ZNF480 Gene

  • GC19P057493
  • GC19P057494
  • GC19P052800
  • GC19P049130

Summaries for ZNF480 Gene

GeneCards Summary for ZNF480 Gene

ZNF480 (Zinc Finger Protein 480) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF480 Gene

  • Involved in transcriptional regulation as an activator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF480 Gene

Genomics for ZNF480 Gene

Regulatory Elements for ZNF480 Gene

Promoters for ZNF480 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF480 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF480 Gene

Chromosome:
19
Start:
52,297,169 bp from pter
End:
52,325,927 bp from pter
Size:
28,759 bases
Orientation:
Plus strand

Genomic View for ZNF480 Gene

Genes around ZNF480 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF480 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF480 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF480 Gene

Proteins for ZNF480 Gene

  • Protein details for ZNF480 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV37-ZN480_HUMAN
    Recommended name:
    Zinc finger protein 480
    Protein Accession:
    Q8WV37
    Secondary Accessions:
    • Q5JPG9
    • Q6P0Q4
    • Q8N1M5

    Protein attributes for ZNF480 Gene

    Size:
    535 amino acids
    Molecular mass:
    61708 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF480 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF480 Gene

Proteomics data for ZNF480 Gene at MOPED

Post-translational modifications for ZNF480 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF480 Gene

No data available for DME Specific Peptides for ZNF480 Gene

Domains & Families for ZNF480 Gene

Gene Families for ZNF480 Gene

Protein Domains for ZNF480 Gene

Suggested Antigen Peptide Sequences for ZNF480 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV37

UniProtKB/Swiss-Prot:

ZN480_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF480: view

Function for ZNF480 Gene

Molecular function for ZNF480 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation as an activator.

Gene Ontology (GO) - Molecular Function for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF480: view
genes like me logo Genes that share phenotypes with ZNF480: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF480 Gene

Localization for ZNF480 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF480 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF480 Gene COMPARTMENTS Subcellular localization image for ZNF480 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF480 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF480: view

Pathways & Interactions for ZNF480 Gene

SuperPathways for ZNF480 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF480: view

Pathways by source for ZNF480 Gene

2 Reactome pathways for ZNF480 Gene

Interacting Proteins for ZNF480 Gene

Gene Ontology (GO) - Biological Process for ZNF480 Gene

None

No data available for SIGNOR curated interactions for ZNF480 Gene

Drugs & Compounds for ZNF480 Gene

No Compound Related Data Available

Transcripts for ZNF480 Gene

Unigene Clusters for ZNF480 Gene

Zinc finger protein 480:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF480 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - -
SP3: -

Relevant External Links for ZNF480 Gene

GeneLoc Exon Structure for
ZNF480
ECgene alternative splicing isoforms for
ZNF480

Expression for ZNF480 Gene

mRNA expression in normal human tissues for ZNF480 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF480 Gene



SOURCE GeneReport for Unigene cluster for ZNF480 Gene Hs.729317

mRNA Expression by UniProt/SwissProt for ZNF480 Gene

Q8WV37-ZN480_HUMAN
Tissue specificity: Expressed in fetal heart, heart, skeletal muscle, pancreas and placenta.
genes like me logo Genes that share expression patterns with ZNF480: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF480 Gene

Orthologs for ZNF480 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF480 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF480 35
  • 98.88 (n)
  • 98.5 (a)
-- 36
  • 91 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
ManyToMany
ZNF415 35
  • 64.04 (n)
  • 51.87 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 45 (a)
ManyToMany
Species with no ortholog for ZNF480:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF480 Gene

ENSEMBL:
Gene Tree for ZNF480 (if available)
TreeFam:
Gene Tree for ZNF480 (if available)

Paralogs for ZNF480 Gene

(568) SIMAP similar genes for ZNF480 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF480: view

Variants for ZNF480 Gene

Sequence variations from dbSNP and Humsavar for ZNF480 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs13343641 - 52,321,779(+) AAACC(C/T)CCATT reference, missense
VAR_035584 A colorectal cancer sample
rs321904 -- 52,317,233(-) caaga(C/T)gagcc intron-variant
rs321911 -- 52,308,367(-) ATTGC(A/G)CTACT intron-variant
rs167706 -- 52,315,828(-) CTGTT(G/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF480 Gene

Variant ID Type Subtype PubMed ID
nsv833873 CNV Gain 17160897
nsv912299 CNV Loss 21882294
esv27010 CNV Loss 19812545
nsv458742 CNV Loss 19166990

Variation tolerance for ZNF480 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF480 Gene

HapMap Linkage Disequilibrium report
ZNF480

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF480 Gene

Disorders for ZNF480 Gene

Relevant External Links for ZNF480

Genetic Association Database (GAD)
ZNF480
Human Genome Epidemiology (HuGE) Navigator
ZNF480
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF480

No disorders were found for ZNF480 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF480 Gene

Publications for ZNF480 Gene

  1. A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE. (PMID: 15219843) Yi Z. … Wu X. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  3. Investigation of rare variants in LRP1, KPNA1, ALS2CL and ZNF480 genes in schizophrenia patients reflects genetic heterogeneity of the disease. (PMID: 23425335) Jouan L. … Rouleau G.A. (Behav Brain Funct 2013) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ZNF480 Gene

Sources for ZNF480 Gene

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