ZNF480 Gene
protein-coding GIFtS: 48
GCID: GC19P052800
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zinc finger protein 480
| |
Aliases for ZNF480 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4801 2 | | MGC321041 |
Export aliases for ZNF480 gene to outside databasesPrevious GC identifers: GC19P057493 GC19P057494 GC19P049130 |
Summaries for ZNF480 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZN480_HUMAN, Q8WV37Function: Involved in transcriptional regulation as an activator
|
Genomic Views for ZNF480 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF480 gene promoter: STAT1 AP-1 ATF-2 STAT1beta STAT1alpha AREB6 Chx10 c-Jun ATF6 Ik-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF480
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF480 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41ZNF480 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P052800: view genomic region
(about GC identifiers)
Start:
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52,800,426 bp from pter |
End:
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52,829,175 bp from pter |
Size:
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28,750 bases |
Orientation:
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plus strand |
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Proteins for ZNF480 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN480_HUMAN, Q8WV37 (See
protein sequence)Recommended Name: Zinc finger protein 480 Size: 535 amino acids; 61708 Da
Subcellular location: Nucleus
Developmental stage: Expressed in heart as early as the 24th week of gestation
Caution: It is uncertain whether Met-1 or Met-20 is the initiator. A 'GT' insertion (rs59214675) allows to extend thesequence in the N-terminus. The majority of mRNAs do not have this insertion and the corresponding protein sequencesstart at Met-20
Secondary accessions: Q5JPG9 Q6P0Q4 Q8N1M5Alternative splicing: 3 isoforms: Q8WV37-1 Q8WV37-2 Q8WV37-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF480: NX_Q8WV37
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WV37 ZNF480 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_653285.2 ENSEMBL proteins: ENSP00000417424 ENSP00000418618 ENSP00000335670 ENSP00000334164 Reactome Protein details: Q8WV37 Human Recombinant Protein Products for ZNF480:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ZNF480 for ontologies About GeneDecksing
ZNF480 Antibody Products: Assay Products for ZNF480: |
Protein
Domains / Families for ZNF480 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF480 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WV37ProtoNet protein and cluster: Q8WV37 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN480_HUMAN, Q8WV37Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function for ZNF480 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: ZN480_HUMAN, Q8WV37Function: Involved in transcriptional regulation as an activator Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF480 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF480 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF480 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF480 (NM_144684) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF480 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF480  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF480 |
|
Pathways & Interactions for ZNF480 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Reactome Pathways for ZNF480
ZNF480 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF480
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF480 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF480 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF480 Search CenterWatch for drugs/clinical trials and news about ZNF480 / ZN480 
|
Transcripts for ZNF480 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF480 gene: NM_144684.2 Unigene Cluster for ZNF480: Zinc finger protein 480 Hs.729317 [show with all ESTs]Unigene Representative Sequence: NM_1446844 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000468240 ENST00000490272 ENST00000335090(uc010ydl.2 uc002pyv.3 uc010ydm.2 uc010epn.3) ENST00000334564
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF480 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF480 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF480 (NM_144684) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF480 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF480  |
Additional cDNA sequence: AK096442.1 AK096559.1 AK303271.1 AL832560.1 AY512662.1 BC007056.1 BC018783.1 BC054018.1 BC065503.1 7 DOTS entries: DT.97764651 DT.86854601 DT.121450810 DT.101960728 DT.121450826 DT.95091397 DT.95362104 24/128 AceView cDNA sequences (see all 128): AA886255 CD358945 BU626851 AA494119 AK096559 BQ228515 AU131744 AA747809 AK091395 CB240928 AK024074 AK096442 BX113744 BQ447637 AK024268 AI221353 AA810260 BQ430456 AL832560 AU143777 BQ673970 BG403621 BU948769 AW511127 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF480 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZNF480
|
Expression for ZNF480 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF480 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAAAAAAGCA
 About this image See ZNF480 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF480
SOURCE GeneReport for Unigene cluster: Hs.729317
UniProtKB/Swiss-Prot: ZN480_HUMAN, Q8WV37Tissue specificity: Expressed in fetal heart, heart, skeletal muscle, pancreas and placenta SABiosciences Custom PCR Arrays for ZNF480
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF480 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF480 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF480 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF480 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF480 |
Orthologs for ZNF480 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF480 (if available) TreeFam Gene Tree for ZNF480 (if available)  |
Paralogs for ZNF480 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF480 gene
- ZNF5342 ZNF321P2 ZNF4682 ZNF5782 ZNF8802 ZNF7662 ZNF3202 ZNF5252
- ZNF8602 ZNF4152 ZNF6002 ZNF282 ZNF5282 ZNF6112 ZNF6772 ZNF832
- ZNF8162 ZNF6102 ZNF7012 ZNF7652 ZNF8132
18/545 SIMAP similar genes for ZNF480 using alignment to 6 protein entries: ZN480_HUMAN (see all proteins)
(see all similar genes):ZNF528 ZNF78L1 kr-znf3 ZNF880 ZFS-6 ZNF146 ZNF232 ZNF534 DKFZp666C237 DKFZp686H10254 DKFZp686M04222 DKFZp762K012 HZF30 HZF36 ZNF56 ZSCAN21 ZNF519 ZNF283
ZNF480 for paralogs About GeneDecksing
|
Genomic Variants for ZNF480 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 19 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF480 (52800426 - 52829175 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ZNF480 1 Indel: 73411 Human Gene Mutation Database (HGMD): ZNF480
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF480 |
|
Disorders
/ Diseases for ZNF480 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF480 for disorders About MalaCards
ZNF480 for disorders About GeneDecksing
OMIM gene information: 613910
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: ZNF480 (1 document) Export disorders for ZNF480 gene to outside databases
|
Publications for ZNF480 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF480 gene integrated from 9 sources: (articles sorted by number of sources associating them with ZNF480) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE. (PubMed id 15219843)1, 2, 3 Yi Z.... Wu X. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF480 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF480 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF480 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF480 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF480 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF480 gene: Search GeneIP for patents involving ZNF480
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF480 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF480 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF480 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF480 | | OriGene Protein Over-expression Lysate for ZNF480 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ZNF480 | | OriGene 3'-UTR Clone for ZNF480 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF480 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF480 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | Search Tocris compounds for ZNF480 |
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 | | ZNF480 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF480 |
|  |  |  |  | | | Search ThermoFisher Antibodies for ZNF480 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF480 |
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