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Aliases for ZNF474 Gene

Aliases for ZNF474 Gene

  • Zinc Finger Protein 474 2 3 5
  • Testis-Specific Zinc Finger Protein 3 4
  • TSZFP 3 4
  • 4933409D10Rik 3

External Ids for ZNF474 Gene

Previous GeneCards Identifiers for ZNF474 Gene

  • GC05P121494
  • GC05P116656
  • GC05P121465

Summaries for ZNF474 Gene

GeneCards Summary for ZNF474 Gene

ZNF474 (Zinc Finger Protein 474) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF474 Gene

Genomics for ZNF474 Gene

Regulatory Elements for ZNF474 Gene

Genomic Location for ZNF474 Gene

Chromosome:
5
Start:
122,129,513 bp from pter
End:
122,179,617 bp from pter
Size:
50,105 bases
Orientation:
Plus strand

Genomic View for ZNF474 Gene

Genes around ZNF474 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF474 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF474 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF474 Gene

Proteins for ZNF474 Gene

  • Protein details for ZNF474 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6S9Z5-ZN474_HUMAN
    Recommended name:
    Zinc finger protein 474
    Protein Accession:
    Q6S9Z5
    Secondary Accessions:
    • A8K4M0
    • Q96M07

    Protein attributes for ZNF474 Gene

    Size:
    364 amino acids
    Molecular mass:
    40315 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71507.1; Type=Frameshift; Positions=318; Evidence={ECO:0000305};

neXtProt entry for ZNF474 Gene

Proteomics data for ZNF474 Gene at MOPED

Post-translational modifications for ZNF474 Gene

  • Ubiquitination at Lys 327
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF474 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF474 Gene

Domains & Families for ZNF474 Gene

Gene Families for ZNF474 Gene

Protein Domains for ZNF474 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF474 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6S9Z5

UniProtKB/Swiss-Prot:

ZN474_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF474: view

Function for ZNF474 Gene

Phenotypes for ZNF474 Gene

genes like me logo Genes that share phenotypes with ZNF474: view

Animal Model Products

CRISPR Products

miRNA for ZNF474 Gene

miRTarBase miRNAs that target ZNF474

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF474 Gene

Localization for ZNF474 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF474 Gene COMPARTMENTS Subcellular localization image for ZNF474 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF474 Gene

Pathways & Interactions for ZNF474 Gene

SuperPathways for ZNF474 Gene

No Data Available

Interacting Proteins for ZNF474 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296600%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000324897%0d%0a9606.ENSP00000257430%0d%0a
Selected Interacting proteins: ENSP00000296600 for ZNF474 Gene via STRING

Gene Ontology (GO) - Biological Process for ZNF474 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF474 Gene

Drugs & Compounds for ZNF474 Gene

No Compound Related Data Available

Transcripts for ZNF474 Gene

Unigene Clusters for ZNF474 Gene

Zinc finger protein 474:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF474 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3: -

Relevant External Links for ZNF474 Gene

GeneLoc Exon Structure for
ZNF474
ECgene alternative splicing isoforms for
ZNF474

Expression for ZNF474 Gene

mRNA expression in normal human tissues for ZNF474 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF474 Gene

This gene is overexpressed in Testis (x23.6).

SOURCE GeneReport for Unigene cluster for ZNF474 Gene Hs.729673

genes like me logo Genes that share expression patterns with ZNF474: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF474 Gene

Orthologs for ZNF474 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF474 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF474 35
  • 97.53 (n)
  • 95.33 (a)
ZNF474 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF474 36
  • 46 (a)
OneToOne
LOC781423 35
  • 82.85 (n)
  • 74.71 (a)
dog
(Canis familiaris)
Mammalia LOC474655 35
  • 84.25 (n)
  • 76.52 (a)
ZNF474 36
  • 47 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp474 16
Zfp474 36
  • 70 (a)
OneToOne
Zfp474 35
  • 77.07 (n)
  • 70.55 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF474 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF474 36
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp474 35
  • 76.41 (n)
  • 67.25 (a)
lizard
(Anolis carolinensis)
Reptilia ZNF474 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494841 35
  • 55.56 (n)
  • 54.3 (a)
worm
(Caenorhabditis elegans)
Secernentea M153.4 36
  • 31 (a)
OneToOne
M153.4 35
  • 56.16 (n)
  • 56.52 (a)
Species with no ortholog for ZNF474:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF474 Gene

ENSEMBL:
Gene Tree for ZNF474 (if available)
TreeFam:
Gene Tree for ZNF474 (if available)

Paralogs for ZNF474 Gene

Pseudogenes.org Pseudogenes for ZNF474 Gene

genes like me logo Genes that share paralogs with ZNF474: view

No data available for Paralogs for ZNF474 Gene

Variants for ZNF474 Gene

Sequence variations from dbSNP and Humsavar for ZNF474 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_031146 -
rs754594117 -- 122,127,528(+) ATTTA(C/T)TCACT upstream-variant-2KB
rs775286131 -- 122,127,533(+) CTCAC(G/T)GATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF474 Gene

Variant ID Type Subtype PubMed ID
esv272075 CNV Insertion 20981092

Variation tolerance for ZNF474 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.53; 88.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF474 Gene

HapMap Linkage Disequilibrium report
ZNF474

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF474 Gene

Disorders for ZNF474 Gene

Relevant External Links for ZNF474

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF474

No disorders were found for ZNF474 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF474 Gene

Publications for ZNF474 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF474 Gene

Sources for ZNF474 Gene

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