ZNF473 Gene
protein-coding GIFtS: 55
GCID: GC19P050529
|
|
zinc finger protein 473
| |
Aliases
for ZNF473 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4731 2 | | ZN4732 | | HZFP1001 2 | | Zfp-1003 | | KIAA11411 3 | | Zinc Finger Protein ZFP1002 | | Zinc Finger Protein 100 Homolog2 3 | | ZFP1003 | | DKFZP434N0431 | | Zfp-1003 |
Export aliases for ZNF473 gene to outside databasesPrevious GC identifers: GC19P055221 GC19P046905 |
Summaries
for ZNF473 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN473_HUMAN, Q8WTR7Function: Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting withSLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, whenoverexpressed. Required for cell cycle progression from G1 to S phases
Gene Wiki entry for ZNF473
|
Genomic Views
for ZNF473 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF473 gene promoter:
Bach2 SREBP-1c SREBP-1b E2F-1 E2F SREBP-1a Zic1 IRF-7A ZIC2/Zic2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF473
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF473 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33ZNF473 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P050529: view genomic region
(about GC identifiers)
Start:
|
50,529,212 bp from pter |
End:
|
50,552,033 bp from pter |
Size:
|
22,822 bases |
Orientation:
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plus strand |
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Proteins
for ZNF473 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN473_HUMAN, Q8WTR7 (See
protein sequence)Recommended Name: Zinc finger protein 473 Size: 871 amino acids; 100182 Da
Subunit: Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependentmanner
Subcellular location: Nucleus. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA
Sequence caution: Sequence=BAA86455.1; Type=Erroneous initiation;
6/14 PDB 3D structures from  and Proteopedia  for ZNF473 (see all 14):2EMB (3D)
2EMC (3D)
2EME (3D)
2EOU (3D)
2EOX (3D)
2EOY (3D)
Secondary accessions: A8K8T7 Q9ULS9 Q9Y4Q7Explore the universe of human proteins at neXtProt for ZNF473: NX_Q8WTR7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WTR7
ZNF473 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006657.1 NP_056243.1
ENSEMBL proteins: ENSP00000270617 ENSP00000375697 ENSP00000388961 Reactome Protein details: Q8WTR7
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF473 for ontologies About GeneDecksing
ZNF473 Antibody Products:
Assay Products for ZNF473: |
Protein
Domains /
Families
for ZNF473 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF473 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WTR7ProtoNet protein and cluster: Q8WTR7 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN473_HUMAN, Q8WTR7Domain: The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. TheC2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10confer activity in histone pre-mRNA processingSimilarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 20 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF473 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN473_HUMAN, Q8WTR7Function: Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting withSLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, whenoverexpressed. Required for cell cycle progression from G1 to S phases
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF473 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF473 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF473 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF473 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF473 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF473 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF473:
|
Pathways & Interactions
for ZNF473 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase II Transcription Termination | | | 2 | Transcription | | | 3 | Post-Elongation Processing of Intronless pre-mRNA | | | 4 | Generic Transcription Pathway | | | 5 | SLBP independent Processing of Histone Pre-mRNAs | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/12 
Reactome Pathways for ZNF473 (see all 12)
ZNF473 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF473
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/18 Interacting proteins for ZNF473 (Q8WTR72, 3 ENSP000002706174) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006369 | termination of RNA polymerase II transcription |
TAS | -- | | GO:0006397 | mRNA processing |
TAS | -- | | GO:0006398 | histone mRNA 3'-end processing |
IDA | 16714279 |
ZNF473 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF473 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF473
Search CenterWatch for drugs/clinical trials and news about ZNF473 / ZN473
|
Transcripts
for ZNF473 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF473 gene (2 alternative transcripts): NM_001006656.1 NM_015428.1 Unigene Cluster for ZNF473: Zinc finger protein 473 Hs.440553 [show with all ESTs]Unigene Representative Sequence: NM_0154283 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000270617(uc002prm.3) ENST00000391821(uc002prn.3 uc010ybo.2)
ENST00000445728
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF473 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF473 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF473 (NM_015428) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF473 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF473 |
Additional cDNA sequence: AB032967.1 AF454744.1 AK054671.1 AK292452.1 AK302293.1 AL080143.1 BC018612.1 BX648093.1 9 DOTS entries: DT.311795 DT.100813005 DT.121502541 DT.101979050 DT.121502533 DT.91684586 DT.97791785 DT.121502605 DT.75139644 24/120 AceView cDNA sequences (see all 120): BE466917 AL561429 AA609459 AI244004 BU839090 CR596386 BG395689 AI651002 AF454744 AK054671 BM463581 AL525742 CB134076 AI823634 AI824864 AI633357 BQ676229 AI288584 AI167257 AI857641 BQ682551 BX492803 BC018612 BI060357
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF473 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF473
|
Expression
for ZNF473 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF473 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF473 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF473
SOURCE GeneReport for Unigene cluster: Hs.440553
SABiosciences Custom PCR Arrays for ZNF473
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF473
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF473 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF473 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF473 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF473 |
Orthologs
for ZNF473 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF473 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZNF473 (if available)
TreeFam Gene Tree for ZNF473 (if available) |
Paralogs
for ZNF473 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNF473 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF473 (50529212 - 50552033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF473
4 CNVs: 2247 8874 4084 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF473 |
|
Disorders
/ Diseases
for ZNF473 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF473 for disorders About GeneDecksing
1  disease for ZNF473: About MalaCardsretinoblastoma
Human Genome Epidemiology (HuGE) Navigator: ZNF473 (1 document)
Export disorders for ZNF473 gene to outside databases
|
Publications
for ZNF473 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF473 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZNF473) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. (PubMed id 11782445)1, 2, 3 Dominski Z.... Marzluff W.F. (2002)
- Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. (PubMed id 16714279)1, 2, 9 Wagner E.J.... Marzluff W.F. (2006)
- ZFP100, a component of the active U7 snRNP limiting for histone pre- mRNA processing, is required for entry into S phase. (PubMed id 16914750)1, 2 Wagner E.J. and Marzluff W.F. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. (PubMed id 12975319)1, 2 Pillai R.S.... Schuemperli D. (2003)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for ZNF473 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF473 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF473 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF473 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF473 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF473 gene:
Search GeneIP for patents involving ZNF473
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF473 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF473 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF473 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF473 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF473 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF473 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF473 |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF473 |
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