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Aliases for ZNF473 Gene

Aliases for ZNF473 Gene

  • Zinc Finger Protein 473 2 3
  • Zinc Finger Protein 100 Homolog 3 4
  • Zfp-100 3 4
  • Zinc Finger Protein ZFP100 3
  • KIAA1141 4
  • HZFP100 3
  • ZFP100 4
  • ZN473 3

External Ids for ZNF473 Gene

Summaries for ZNF473 Gene

GeneCards Summary for ZNF473 Gene

ZNF473 (Zinc Finger Protein 473) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF473 Gene

  • Involved in histone 3-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.

Gene Wiki entry for ZNF473 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF473 Gene

Genomics for ZNF473 Gene

Genomic Location for ZNF473 Gene

Start:
50,025,714 bp from pter
End:
50,053,414 bp from pter
Size:
27,701 bases
Orientation:
Plus strand

Genomic View for ZNF473 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF473 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF473 Gene

Regulatory Elements for ZNF473 Gene

Proteins for ZNF473 Gene

  • Protein details for ZNF473 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTR7-ZN473_HUMAN
    Recommended name:
    Zinc finger protein 473
    Protein Accession:
    Q8WTR7
    Secondary Accessions:
    • A8K8T7
    • Q9ULS9
    • Q9Y4Q7

    Protein attributes for ZNF473 Gene

    Size:
    871 amino acids
    Molecular mass:
    100182 Da
    Quaternary structure:
    • Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner.
    SequenceCaution:
    • Sequence=BAA86455.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF473 Gene

neXtProt entry for ZNF473 Gene

Proteomics data for ZNF473 Gene at MOPED

Post-translational modifications for ZNF473 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF473 Gene

No data available for DME Specific Peptides for ZNF473 Gene

Domains for ZNF473 Gene

Gene Families for ZNF473 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF473 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WTR7

UniProtKB/Swiss-Prot:

ZN473_HUMAN
Domain:
  • The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing:
    • Q8WTR7
  • Contains 1 KRAB domain.:
    • Q8WTR7
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8WTR7
Similarity:
  • Contains 20 C2H2-type zinc fingers.:
    • Q8WTR7
genes like me logo Genes that share domains with ZNF473: view

Function for ZNF473 Gene

Molecular function for ZNF473 Gene

UniProtKB/Swiss-Prot Function: Involved in histone 3-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.

Gene Ontology (GO) - Molecular Function for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16714279
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF473: view

Phenotypes for ZNF473 Gene

genes like me logo Genes that share phenotypes with ZNF473: view

miRNA for ZNF473 Gene

miRTarBase miRNAs that target ZNF473

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF473 Gene

Localization for ZNF473 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF473 Gene

Nucleus. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF473 Gene COMPARTMENTS Subcellular localization image for ZNF473 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm TAS --
GO:0015030 Cajal body IDA 16714279
genes like me logo Genes that share ontologies with ZNF473: view

Pathways for ZNF473 Gene

genes like me logo Genes that share pathways with ZNF473: view

Gene Ontology (GO) - Biological Process for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006398 histone mRNA 3-end processing IDA 16714279
GO:0008334 histone mRNA metabolic process TAS --
genes like me logo Genes that share ontologies with ZNF473: view

Transcripts for ZNF473 Gene

Unigene Clusters for ZNF473 Gene

Zinc finger protein 473:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF473 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: -

Relevant External Links for ZNF473 Gene

GeneLoc Exon Structure for
ZNF473
ECgene alternative splicing isoforms for
ZNF473

Expression for ZNF473 Gene

mRNA expression in normal human tissues for ZNF473 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF473 Gene

This gene is overexpressed in Testis (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF473 Gene

SOURCE GeneReport for Unigene cluster for ZNF473 Gene Hs.440553

genes like me logo Genes that share expressions with ZNF473: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF473 Gene

Orthologs for ZNF473 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF473 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF473 35
  • 99.12 (n)
  • 98.39 (a)
ZNF473 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF473 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF473 35
  • 76.98 (n)
  • 66.74 (a)
ZNF473 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp473 35
  • 70.03 (n)
  • 55.91 (a)
Zfp473 16
Zfp473 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF473 36
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp473 35
  • 71.13 (n)
  • 57.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
CSA.1668 36
  • 29 (a)
ManyToMany
Species with no ortholog for ZNF473:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF473 Gene

ENSEMBL:
Gene Tree for ZNF473 (if available)
TreeFam:
Gene Tree for ZNF473 (if available)

Paralogs for ZNF473 Gene

Selected SIMAP similar genes for ZNF473 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF473: view

Variants for ZNF473 Gene

Sequence variations from dbSNP and Humsavar for ZNF473 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15189 -- 50,048,660(-) CAATG(A/G)CTGCC utr-variant-3-prime
rs157548 -- 50,036,980(+) tttct(A/G)taagt intron-variant
rs157549 -- 50,036,814(+) cagga(C/G/T)gaccc intron-variant
rs157550 -- 50,036,114(+) accac(A/G)cccag intron-variant
rs245112 -- 50,036,389(+) gctca(A/C)tgcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF473 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
esv2751796 CNV Gain 17911159
nsv458722 CNV Gain 19166990
nsv469748 CNV Complex 16826518
dgv1108e1 CNV Complex 17122850
nsv428369 CNV Loss 18775914
nsv458723 CNV Loss 19166990

Relevant External Links for ZNF473 Gene

HapMap Linkage Disequilibrium report
ZNF473

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF473 Gene

Disorders for ZNF473 Gene

Relevant External Links for ZNF473

Genetic Association Database (GAD)
ZNF473
Human Genome Epidemiology (HuGE) Navigator
ZNF473
genes like me logo Genes that share disorders with ZNF473: view

No data available for UniProtKB/Swiss-Prot for ZNF473 Gene

Publications for ZNF473 Gene

  1. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. (PMID: 16714279) Wagner E.J. … Marzluff W.F. (RNA 2006) 3 4 23
  2. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. (PMID: 11782445) Dominski Z. … Marzluff W.F. (Genes Dev. 2002) 2 3 4
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  4. Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. (PMID: 12975319) Pillai R.S. … Schuemperli D. (Genes Dev. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ZNF473 Gene

Sources for ZNF473 Gene

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