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Aliases for ZNF473 Gene

Aliases for ZNF473 Gene

  • Zinc Finger Protein 473 2 3 5
  • Zinc Finger Protein 100 Homolog 3 4
  • ZFP100 3 4
  • KIAA1141 4
  • Zfp-100 4
  • ZN473 3

External Ids for ZNF473 Gene

Previous GeneCards Identifiers for ZNF473 Gene

  • GC19P055221
  • GC19P050529
  • GC19P046905

Summaries for ZNF473 Gene

Entrez Gene Summary for ZNF473 Gene

  • This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZNF473 Gene

ZNF473 (Zinc Finger Protein 473) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Termination and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF473 Gene

  • Involved in histone 3-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.

Gene Wiki entry for ZNF473 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF473 Gene

Genomics for ZNF473 Gene

Regulatory Elements for ZNF473 Gene

Enhancers for ZNF473 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF473 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF473 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF473 Gene

Chromosome:
19
Start:
50,025,383 bp from pter
End:
50,053,414 bp from pter
Size:
28,032 bases
Orientation:
Plus strand

Genomic View for ZNF473 Gene

Genes around ZNF473 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF473 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF473 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF473 Gene

Proteins for ZNF473 Gene

  • Protein details for ZNF473 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTR7-ZN473_HUMAN
    Recommended name:
    Zinc finger protein 473
    Protein Accession:
    Q8WTR7
    Secondary Accessions:
    • A8K8T7
    • Q9ULS9
    • Q9Y4Q7

    Protein attributes for ZNF473 Gene

    Size:
    871 amino acids
    Molecular mass:
    100182 Da
    Quaternary structure:
    • Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner.
    SequenceCaution:
    • Sequence=BAA86455.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF473 Gene

neXtProt entry for ZNF473 Gene

Post-translational modifications for ZNF473 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF473 Gene

Domains & Families for ZNF473 Gene

Gene Families for ZNF473 Gene

Protein Domains for ZNF473 Gene

Suggested Antigen Peptide Sequences for ZNF473 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WTR7

UniProtKB/Swiss-Prot:

ZN473_HUMAN :
  • The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 20 C2H2-type zinc fingers.
Domain:
  • The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 20 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF473: view

Function for ZNF473 Gene

Molecular function for ZNF473 Gene

UniProtKB/Swiss-Prot Function:
Involved in histone 3-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.

Gene Ontology (GO) - Molecular Function for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16714279
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF473: view
genes like me logo Genes that share phenotypes with ZNF473: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF473 Gene

Localization for ZNF473 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF473 Gene

Nucleus. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF473 Gene COMPARTMENTS Subcellular localization image for ZNF473 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0015030 Cajal body IDA 16714279
genes like me logo Genes that share ontologies with ZNF473: view

Pathways & Interactions for ZNF473 Gene

genes like me logo Genes that share pathways with ZNF473: view

Gene Ontology (GO) - Biological Process for ZNF473 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006398 mRNA 3-end processing by stem-loop binding and cleavage IDA 16714279
GO:0008334 histone mRNA metabolic process TAS --
genes like me logo Genes that share ontologies with ZNF473: view

No data available for SIGNOR curated interactions for ZNF473 Gene

Drugs & Compounds for ZNF473 Gene

No Compound Related Data Available

Transcripts for ZNF473 Gene

Unigene Clusters for ZNF473 Gene

Zinc finger protein 473:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF473 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: -

Relevant External Links for ZNF473 Gene

GeneLoc Exon Structure for
ZNF473
ECgene alternative splicing isoforms for
ZNF473

Expression for ZNF473 Gene

mRNA expression in normal human tissues for ZNF473 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF473 Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for ZNF473 Gene

This gene is overexpressed in Monocytes (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF473 Gene



Protein tissue co-expression partners for ZNF473 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF473 Gene:

ZNF473

SOURCE GeneReport for Unigene cluster for ZNF473 Gene:

Hs.440553
genes like me logo Genes that share expression patterns with ZNF473: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF473 Gene

Orthologs for ZNF473 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF473 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF473 34
  • 76.98 (n)
  • 66.74 (a)
ZNF473 35
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp473 34
  • 70.03 (n)
  • 55.91 (a)
Zfp473 16
Zfp473 35
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF473 34
  • 99.12 (n)
  • 98.39 (a)
ZNF473 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp473 34
  • 71.13 (n)
  • 57.62 (a)
cow
(Bos Taurus)
Mammalia ZNF473 35
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF473 35
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
CSA.1668 35
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF473 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF473 Gene

ENSEMBL:
Gene Tree for ZNF473 (if available)
TreeFam:
Gene Tree for ZNF473 (if available)

Paralogs for ZNF473 Gene

(514) SIMAP similar genes for ZNF473 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF473: view

No data available for Paralogs for ZNF473 Gene

Variants for ZNF473 Gene

Sequence variations from dbSNP and Humsavar for ZNF473 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10419876 - 50,041,768(+) ATGGC(A/G)GTGAA reference, missense
rs10419911 - 50,041,813(+) CAACA(A/G)GCCCT reference, missense
rs16981705 - 50,044,934(+) TTCCA(C/T)GGGAG reference, missense
rs16981706 - 50,045,369(+) TGGTG(A/G)GCATC reference, missense
rs10424809 - 50,046,404(+) AAAGA(C/T)CTTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF473 Gene

Variant ID Type Subtype PubMed ID
dgv3622n100 CNV gain 25217958
esv2751796 CNV gain 17911159
esv2758766 CNV loss 17122850
esv3644630 CNV gain 21293372
esv3644635 CNV gain 21293372
nsv1062974 CNV gain 25217958
nsv1065753 CNV gain 25217958
nsv1067191 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv428369 CNV loss 18775914
nsv458722 CNV gain 19166990
nsv458723 CNV loss 19166990
nsv469748 CNV gain+loss 16826518
nsv579912 CNV gain 21841781
nsv579913 CNV gain 21841781
nsv579914 CNV loss 21841781
nsv9739 CNV gain+loss 18304495

Variation tolerance for ZNF473 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF473 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF473

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF473 Gene

Disorders for ZNF473 Gene

Relevant External Links for ZNF473

Genetic Association Database (GAD)
ZNF473
Human Genome Epidemiology (HuGE) Navigator
ZNF473
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF473

No disorders were found for ZNF473 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF473 Gene

Publications for ZNF473 Gene

  1. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. (PMID: 16714279) Wagner E.J. … Marzluff W.F. (RNA 2006) 3 4 22 65
  2. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. (PMID: 11782445) Dominski Z. … Marzluff W.F. (Genes Dev. 2002) 2 3 4 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. ZFP100, a component of the active U7 snRNP limiting for histone pre- mRNA processing, is required for entry into S phase. (PMID: 16914750) Wagner E.J. … Marzluff W.F. (Mol. Cell. Biol. 2006) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for ZNF473 Gene

Sources for ZNF473 Gene

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