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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF471 Gene

protein-coding GIFtS: 48
GCID: GC19P057019

zinc finger protein 471

Search for ZNF471
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 471¹ ²
Z1971¹ ²
KIAA1396¹ ³
ERP1² ³
EZFIT-Related Protein 1² ³

External Ids:	HGNC: 23226¹	Entrez Gene: 57573²	Ensembl: ENSG00000196263⁷	UniProtKB: Q9BX82³

Export aliases for ZNF471 gene to outside databases

Previous GC identifers: GC19P061711 GC19P061610 GC19P053329

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN471_HUMAN, Q9BX82

Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF471

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF471 gene promoter:
PPAR-gamma1 GCNF-1 GCNF PPAR-gamma2 GCNF-2 POU3F2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF471 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF471

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF471

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

ZNF471 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF471 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P057019: view genomic region (about GC identifiers)

Start:	57,019,212 bp from pter	End:	57,041,590 bp from pter
Size:	22,379 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN471_HUMAN, Q9BX82 (See protein sequence)

Recommended Name: Zinc finger protein 471

Size: 626 amino acids; 73009 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=AAC32422.1; Type=Erroneous gene model prediction;

Secondary accessions: O75260 Q08AD6 Q08AD7 Q8N3V1 Q9P2F1

Explore the universe of human proteins at neXtProt for ZNF471: NX_Q9BX82

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BX82

ZNF471 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065864.2

ENSEMBL proteins:

ENSP00000309161 ENSP00000466224 ENSP00000467570

Reactome Protein details: Q9BX82
Human Recombinant Protein Products for ZNF471:

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	Uscn Proteins for ZNF471

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--

ZNF471 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF471 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9BX82

ProtoNet protein and cluster: Q9BX82

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN471_HUMAN, Q9BX82

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 15 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN471_HUMAN, Q9BX82

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF471 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ZNF471:

Decreased viability

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF471

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF471

	Generic Transcription Pathway
	Gene Expression

ZNF471 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF471

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

4 Interacting proteins for ZNF471 (Q9BX82³ ENSP00000309161⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CARD14	Q9BXL6³	I2D: score=1
COPS7B	Q9H9Q2³	I2D: score=1
EPS8	Q12929³	I2D: score=1
PTEN	ENSP00000361021⁴	STRING: ENSP00000361021

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF471 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF471
Search CenterWatch for drugs/clinical trials and news about ZNF471 / ZN471

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF471 gene:

NM_020813.2

Unigene Cluster for ZNF471:

Zinc finger protein 471

Hs.710590 [show with all ESTs]

Unigene Representative Sequence: AB037817

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000308031(uc002qnh.3) ENST00000591537 ENST00000593197 ENST00000591759

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Additional cDNA sequence:

AB037817.1 AF352026.1 AK291416.1 AK293908.1 AL831845.1 BC016830.1 BC028227.1 BC125221.1

BC125222.1

5 DOTS entries:

DT.408949 DT.445176 DT.100018114 DT.102820965 DT.40313309

24/41 AceView cDNA sequences (see all 41):

AF352026 BM991696 AI985270 BC028227 BX646388 BP872291 AA428231 AA628406

AA460308 AA461597 AL042522 BM697680 AA908195 AA634443 BI915634 AL831845

NM_020813 AW090770 CD357395 AI375847 BV169417 BU568418 BC016830 BU852740

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF471 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGTTCACA

About this image

ZNF471 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF471 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF471

SOURCE GeneReport for Unigene cluster: Hs.710590

SABiosciences Custom PCR Arrays for ZNF471

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF471 (if available)
TreeFam Gene Tree for ZNF471 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF471 gene

ZNF570² ZNF287² ZNF181² ZFP28² ZNF7² ZNF250² ZNF879² ZNF302²

ZNF354C² ZNF74² ZNF583² ZFP90² ZNF189² ZNF354A² ZNF354B² ZNF135²

ZNF568² ZNF34² ZNF527² ZNF8² ZNF569² ZNF470²

18/454 SIMAP similar genes for ZNF471 using alignment to 3 protein entries: ZN471_HUMAN (see all proteins) (see all similar genes):

ZNF738 ZNF75A ZNF721 ZNF583 ZNF790 ZNF232

ZNF527 ZNF283 ZFP90 ZNF81 ZNF707 HZF36

MGC12518 ZNF519 ZNF573 ZNF813 ZNF124 ZNF720

ZNF471 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73934941^1,2	C	--	57017405(+)	`TTTAGC/GGATGT`	1	--	us2k¹		2		WA	120
rs114866029^1,2		--	57017424(+)	`TTTCCA/GTACTG`	1	--	us2k¹		1		WA	118
rs147268847^1,2		--	57017427(+)	`CCATAA/CTGTAA`	1	--	us2k¹		0	--	--	--	--
rs113110849^1,2		--	57017429(+)	`ATACTG/TTAAAT`	1	--	us2k¹		1		CSA	2
rs142998393^1,2	C	--	57017457(+)	`TTTCAA/GTCTAC`	1	--	us2k¹		0	--	--	--	--
rs147468655^1,2		--	57017646(+)	`GAAAGA/GCAGTA`	1	--	us2k¹		0	--	--	--	--
rs11671219^1,2	C,H	--	57017657(+)	`tttcaA/Gccaca`	1	--	us2k¹		0	--	--	--	--
rs188199849^1,2		--	57017725(+)	`GGGGGG/TAGTGG`	1	--	us2k¹		0	--	--	--	--
rs142222546^1,2		--	57017735(+)	`GTGGCC/TAGTTG`	1	--	us2k¹		0	--	--	--	--
rs193264783^1,2		--	57017749(+)	`GAGGAA/GCCAGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF471 (57019212 - 57041590 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF471: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF471 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with ZNF471)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57573	HGNC: 23226	AceView: ZNF471	Ensembl:ENSG00000196263	euGenes: HUgn57573
ECgene: ZNF471	H-InvDB: ZNF471

(According to HUGE)
About This Section

HUGE: KIAA1396

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF471	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF471 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF471 gene:
Search GeneIP for patents involving ZNF471

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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ZNF471 Gene

zinc finger protein 471

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ZNF471 Gene

zinc finger protein 471

Aliasesfor ZNF471 gene

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Protein Domains /Familiesfor ZNF471 gene

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for ZNF471 gene

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for ZNF471 gene

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for ZNF471 gene

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for ZNF471 gene

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for ZNF471 gene

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for ZNF471 gene

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for ZNF471 gene

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