ZNF470 Gene
protein-coding GIFtS: 40
GCID: GC19P057078
|
|
zinc finger protein 470
| |
Aliases
for ZNF470 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4701 2 | | CZF-11 2 3 | | Chondrogenesis Zinc Finger Protein 12 3 | | FLJ261751 | | CZF13 |
Export aliases for ZNF470 gene to outside databasesPrevious GC identifers: GC19P061768 GC19P053388 |
Summaries
for ZNF470 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN470_HUMAN, Q6ECI4Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF470 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF470 gene promoter:
STAT1 C/EBPbeta CUTL1 Cdc5
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF470
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF470 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF470 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P057078: view genomic region
(about GC identifiers)
Start:
|
57,078,890 bp from pter |
End:
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57,094,262 bp from pter |
Size:
|
15,373 bases |
Orientation:
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plus strand |
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Proteins
for ZNF470 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN470_HUMAN, Q6ECI4 (See
protein sequence)Recommended Name: Zinc finger protein 470 Size: 717 amino acids; 82650 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAC85218.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MTW0 B9EGU1 Q6ZPA1 Q9Y2N9Alternative splicing: 2 isoforms: Q6ECI4-1 Q6ECI4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF470: NX_Q6ECI4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ECI4
ZNF470 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001668.3
ENSEMBL proteins: ENSP00000375590 ENSP00000333223
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF470 for ontologies About GeneDecksing
ZNF470 Antibody Products:
Assay Products for ZNF470: |
Protein
Domains /
Families
for ZNF470 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF470 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ECI4ProtoNet protein and cluster: Q6ECI4 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN470_HUMAN, Q6ECI4Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 17 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF470 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN470_HUMAN, Q6ECI4Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF470
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF470
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF470 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF470 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF470 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF470 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF470:
|
Pathways & Interactions
for ZNF470 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF470
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF470 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF470 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF470
Search CenterWatch for drugs/clinical trials and news about ZNF470 / ZN470
|
Transcripts
for ZNF470 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF470 gene: NM_001001668.3 Unigene Cluster for ZNF470: Zinc finger protein 470 Hs.204449 [show with all ESTs]Unigene Representative Sequence: NM_0010016682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000391709(uc002qnl.4) ENST00000330619(uc010etn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF470
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF470
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF470 (NM_001001668) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF470 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF470 |
Additional cDNA sequence: AK129686.1 AK130356.1 AY484591.1 BC136762.1 BC142627.1 BC150188.1 BX641145.1 7 DOTS entries: DT.402703 DT.101979345 DT.97817642 DT.100743916 DT.99985172 DT.40278510 DT.97768516 24/50 AceView cDNA sequences (see all 50): BU742177 BM696952 CN480707 AA977233 AI376230 AA938134 AA364195 AA676761 BE218640 BU618289 AI913658 AA325029 AA018700 CN482212 BX430098 AI275125 AW296418 BX463345 AL119995 T83348 AW104615 BX641145 BU688158 AI887328
GeneLoc Exon Structure
|
Expression
for ZNF470 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF470 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCACAGAGG
About this image
See ZNF470 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF470
SOURCE GeneReport for Unigene cluster: Hs.204449
UniProtKB/Swiss-Prot: ZN470_HUMAN, Q6ECI4Tissue specificity: Highly expressed in testis. Very low expression in thymus. No expression in other tissues tested.Expressed in a differentiation stage-specific manner in mesenchymal chondrogenic progenitor cells
SABiosciences Custom PCR Arrays for ZNF470
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF470
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF470 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF470 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF470 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF470 |
Orthologs
for ZNF470 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF470 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
BX320054.12 |
-- |
74.51(n) |
|
BX320054.1 |
ENSEMBL Gene Tree for ZNF470 (if available)
TreeFam Gene Tree for ZNF470 (if available) |
Paralogs
for ZNF470 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF470 gene
- ZNF5702 ZNF2872 ZNF1812 ZFP282 ZNF4712 ZNF72 ZNF2502 ZNF8792
- ZNF3022 ZNF354C2 ZNF742 ZNF5832 ZFP902 ZNF1892 ZNF354A2 ZNF354B2
- ZNF1352 ZNF5682 ZNF342 ZNF5272 ZNF82 ZNF5692
18/477 SIMAP similar genes for ZNF470 using alignment to 3 protein entries: ZN470_HUMAN (see all proteins)
(see all similar genes):ZNF818P ZNF78L1 kr-znf3 ZNF24 MGC12518 ZFS-6
ZNF738 HZF36 ZFP41 ZFS-1 ZNF391 DKFZp313M0722
HZF30 ZNF146 ZNF323 ZNF660 zf30 ZNF
ZNF470 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ZNF470
PGOHUM00000259256 PGOHUM00000263003 PGOHUM00000234804 PGOHUM00000259436
|
Genomic Variants
for ZNF470 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF470 (57078890 - 57094262 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF470: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF470 |
|
Disorders
/ Diseases
for ZNF470 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF470 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF470 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF470) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization and chondrocyte differentiation stage-specific expression of KRAB zinc-finger protein gene ZNF470. (PubMed id 15302581)1, 2, 3 Hering T.M....Johnstone B. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF470 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF470 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF470 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF470 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF470 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF470 gene:
Search GeneIP for patents involving ZNF470
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF470 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF470 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF470 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF470 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF470 | | OriGene 3'-UTR Clone for ZNF470 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF470 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF470 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF470 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF470 |
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