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Aliases for ZNF468 Gene

Aliases for ZNF468 Gene

  • Zinc Finger Protein 468 2 3

External Ids for ZNF468 Gene

Summaries for ZNF468 Gene

GeneCards Summary for ZNF468 Gene

ZNF468 (Zinc Finger Protein 468) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF468 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF468 Gene

Genomics for ZNF468 Gene

Genomic Location for ZNF468 Gene

Start:
52,838,008 bp from pter
End:
52,857,649 bp from pter
Size:
19,642 bases
Orientation:
Minus strand

Genomic View for ZNF468 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF468 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF468 Gene

Regulatory Elements for ZNF468 Gene

Proteins for ZNF468 Gene

  • Protein details for ZNF468 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VIY5-ZN468_HUMAN
    Recommended name:
    Zinc finger protein 468
    Protein Accession:
    Q5VIY5
    Secondary Accessions:
    • A8MV20
    • Q5CZB8
    • Q5VIY4
    • Q68DI7

    Protein attributes for ZNF468 Gene

    Size:
    522 amino acids
    Molecular mass:
    60573 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF468 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF468 Gene

Proteomics data for ZNF468 Gene at MOPED

Post-translational modifications for ZNF468 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys496

Other Protein References for ZNF468 Gene

No data available for DME Specific Peptides for ZNF468 Gene

Domains for ZNF468 Gene

Gene Families for ZNF468 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN468_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q5VIY5
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q5VIY5
Similarity:
  • Contains 11 C2H2-type zinc fingers.:
    • Q5VIY5
genes like me logo Genes that share domains with ZNF468: view

Function for ZNF468 Gene

Molecular function for ZNF468 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF468 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF468: view

miRNA for ZNF468 Gene

miRTarBase miRNAs that target ZNF468

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF468 Gene

Localization for ZNF468 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF468 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF468 Gene COMPARTMENTS Subcellular localization image for ZNF468 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF468 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF468: view

Pathways for ZNF468 Gene

SuperPathways for ZNF468 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF468: view

Pathways by source for ZNF468 Gene

2 Reactome pathways for ZNF468 Gene

Interacting Proteins for ZNF468 Gene

Gene Ontology (GO) - Biological Process for ZNF468 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF468: view

Transcripts for ZNF468 Gene

Unigene Clusters for ZNF468 Gene

Zinc finger protein 468:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF468 Gene

No ASD Table

Relevant External Links for ZNF468 Gene

GeneLoc Exon Structure for
ZNF468
ECgene alternative splicing isoforms for
ZNF468

Expression for ZNF468 Gene

mRNA expression in normal human tissues for ZNF468 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF468 Gene

SOURCE GeneReport for Unigene cluster for ZNF468 Gene Hs.467223

mRNA Expression by UniProt/SwissProt for ZNF468 Gene

Q5VIY5-ZN468_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are highly expressed in placenta, pancreas, and small intestine. Lower expression in colon, ovary, testis, prostate, thymus, spleen, kidney, and liver. No expression detected in heart and brain.
genes like me logo Genes that share expressions with ZNF468: view

Orthologs for ZNF468 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF468 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF468 36
  • 98.34 (n)
  • 97.51 (a)
ZNF468 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 49 (a)
ManyToMany
ZNF813 36
  • 65.89 (n)
  • 49.42 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 50 (a)
ManyToMany
Species with no ortholog for ZNF468:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF468 Gene

ENSEMBL:
Gene Tree for ZNF468 (if available)
TreeFam:
Gene Tree for ZNF468 (if available)

Paralogs for ZNF468 Gene

Selected SIMAP similar genes for ZNF468 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF468: view

Variants for ZNF468 Gene

Sequence variations from dbSNP and Humsavar for ZNF468 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1062967 -- 52,838,899(-) AATTG(A/G)GTATA utr-variant-3-prime, nc-transcript-variant
rs2869877 -- 52,858,120(-) ctccc(A/G)cgccc upstream-variant-2KB
rs2904232 -- 52,850,966(+) taaca(A/G)tatat intron-variant
rs3960272 -- 52,849,981(+) AATAA(C/T)AAAAC intron-variant
rs4801939 -- 52,848,448(+) GCACT(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF468 Gene

Variant ID Type Subtype PubMed ID
esv2718786 CNV Deletion 23290073
esv2718787 CNV Deletion 23290073
dgv3980n71 CNV Gain 21882294
dgv3981n71 CNV Gain 21882294
esv2718796 CNV Deletion 23290073
dgv3984n71 CNV Gain 21882294
nsv833875 CNV Loss 17160897
esv2718798 CNV Deletion 23290073
nsv458746 CNV Gain 19166990
esv2445065 CNV Deletion 19546169
esv2718799 CNV Deletion 23290073
nsv817858 CNV Gain 17921354
nsv458747 CNV Gain 19166990
dgv3985n71 CNV Gain 21882294
nsv528436 CNV Loss 19592680
dgv1114e1 CNV Complex 17122850
dgv3986n71 CNV Loss 21882294
dgv570e201 CNV Deletion 23290073
nsv912327 CNV Loss 21882294
dgv3987n71 CNV Gain 21882294
nsv912331 CNV Gain+Loss 21882294
nsv912332 CNV Gain 21882294
dgv3988n71 CNV Gain+Loss 21882294
esv1004256 CNV Deletion 20482838
nsv828619 CNV Gain 20364138
esv21942 CNV Gain 19812545
nsv9744 CNV Gain 18304495
nsv819146 CNV Gain 19587683
nsv436855 CNV Insertion 17901297
esv2421897 OTHER Complex 20811451
nsv828621 CNV Loss 20364138
nsv442470 CNV CNV 18776908
nsv2537 CNV Loss 18451855
dgv18n14 CNV Gain 18776910
dgv3989n71 CNV Loss 21882294
dgv1115e1 CNV Complex 17122850
dgv3990n71 CNV Gain 21882294
dgv426n27 CNV Loss 19166990
nsv817859 CNV Gain 17921354
nsv458750 CNV Loss 19166990
nsv517570 CNV Gain+Loss 19592680
nsv817860 CNV Gain+Loss 17921354
nsv458752 CNV Loss 19166990
nsv524151 CNV Gain 19592680
nsv525329 CNV Loss 19592680
nsv519916 CNV Gain 19592680
nsv819613 CNV Gain 19587683
nsv2538 CNV Insertion 18451855
esv2718803 CNV Deletion 23290073

Relevant External Links for ZNF468 Gene

HapMap Linkage Disequilibrium report
ZNF468

Disorders for ZNF468 Gene

No disorders were found for ZNF468 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF468 Gene

Publications for ZNF468 Gene

  1. A novel zinc finger gene ZNF468 with two co-expressional splice variants, ZNF468.1 and ZNF468.2. (PMID: 16144304) Sun L. … Mao Y. (Biochem. Genet. 2005) 2 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for ZNF468 Gene

Sources for ZNF468 Gene

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