ZNF468 Gene
protein-coding GIFtS: 47
GCID: GC19M053341
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|
zinc finger protein 468
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Aliases
for ZNF468 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4681 2 | | Zinc Finger Protein ZNF4682 |
Export aliases for ZNF468 gene to outside databasesPrevious GC identifers: GC19M058034 GC19M049669 |
Summaries
for ZNF468 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF468 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF468 gene promoter:
POU2F1 HTF POU2F1a Ik-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF468
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF468 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41ZNF468 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M053341: view genomic region
(about GC identifiers)
Start:
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53,341,785 bp from pter |
End:
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53,360,902 bp from pter |
Size:
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19,118 bases |
Orientation:
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minus strand |
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Proteins
for ZNF468 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5 (See
protein sequence)Recommended Name: Zinc finger protein 468 Size: 522 amino acids; 60573 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A8MV20 Q5CZB8 Q5VIY4 Q68DI7Alternative splicing: 2 isoforms: Q5VIY5-1 Q5VIY5-2 Explore the universe of human proteins at neXtProt for ZNF468: NX_Q5VIY5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VIY5
ZNF468 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001008801.1 NP_954583.1
ENSEMBL proteins: ENSP00000243639 ENSP00000379690 ENSP00000445669 Reactome Protein details: Q5VIY5
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF468 for ontologies About GeneDecksing
ZNF468 Antibody Products:
Assay Products for ZNF468: |
Protein
Domains /
Families
for ZNF468 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF468 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VIY5ProtoNet protein and cluster: Q5VIY5 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF468 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF468 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF468 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF468 (NM_199132) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF468 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF468 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF468 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF468 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF468 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF468
ZNF468 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF468
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZNF468 (ENSP000002436394) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF468 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF468 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF468
Search CenterWatch for drugs/clinical trials and news about ZNF468 / ZN468
|
Transcripts
for ZNF468 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF468 gene (2 alternative transcripts): NM_001008801.1 NM_199132.1 Unigene Cluster for ZNF468: Zinc finger protein 468 Hs.467223 [show with all ESTs]Unigene Representative Sequence: CR9366953 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000243639 ENST00000396409(uc002qae.3) ENST00000390651(uc002qaf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF468 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF468 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF468 (NM_199132) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF468 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF468 |
Additional cDNA sequence: AK023558.1 AK025501.1 AK289841.1 AK292449.1 AY117438.1 AY442330.1 AY442331.1 BC008480.1 BC037409.1 BC063143.1 CR749381.1 CR936599.1 CR936695.1 11 DOTS entries: DT.411280 DT.97846900 DT.121462060 DT.101955519 DT.40206943 DT.100657976 DT.121461766 DT.121462218 DT.121462350 DT.92038504 DT.95132340 24/47 AceView cDNA sequences (see all 47): BF438910 CA394881 BX952497 AK025501 BC008480 BX106193 AI872737 R78627 BX955314 BG056504 CA392690 H04753 BX497090 BX509654 AW664160 CR749381 AK023558 AU136526 BC063143 AA984824 BM828200 CA313711 AW189935 BI334272
GeneLoc Exon Structure
|
Expression
for ZNF468 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF468 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATCTACAA
About this image
See ZNF468 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF468
SOURCE GeneReport for Unigene cluster: Hs.467223
UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5Tissue specificity: Isoform 1 and isoform 2 are highly expressed in placenta, pancreas, and small intestine. Lowerexpression in colon, ovary, testis, prostate, thymus, spleen, kidney, and liver. No expression detected in heart andbrain
SABiosciences Custom PCR Arrays for ZNF468
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF468
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF468 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF468 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF468 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF468 |
Orthologs
for ZNF468 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF468 (if available)
TreeFam Gene Tree for ZNF468 (if available) |
Paralogs
for ZNF468 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF468 gene
- ZNF5342 ZNF321P2 ZNF5782 ZNF8802 ZNF7662 ZNF3202 ZNF5252 ZNF8602
- ZNF4152 ZNF6002 ZNF282 ZNF5282 ZNF6112 ZNF6772 ZNF832 ZNF8162
- ZNF6102 ZNF7012 ZNF7652 ZNF4802 ZNF8132
18/554 SIMAP similar genes for ZNF468 using alignment to 6 protein entries: ZN468_HUMAN (see all proteins)
(see all similar genes):ZNF702P ZNF28 ZNF845 ZNF761 ZNF321P ZNF860
ZNF578 ZNF701 ZSCAN22 ZNF78L1 FLJ00301 ZFP41
ZNF300P1 ZNF813 ZNF808 DKFZp686M04222 DKFZp762K012 ZFS-4
ZNF468 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF468 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF468 (53341785 - 53360902 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for ZNF468
15/17 CNVs (see all 17): 35673 9809 38938 9807 3196 50201 59602 58888 78256 53448 37637 30916 9808 67596 37596 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF468 |
|
Disorders
/ Diseases
for ZNF468 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF468 for disorders About GeneDecksing
1  disease for ZNF468: About MalaCardsprostatitis
Export disorders for ZNF468 gene to outside databases
|
Publications
for ZNF468 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF468 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF468) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel zinc finger gene ZNF468 with two co-expressional splice variants, ZNF468.1 and ZNF468.2. (PubMed id 16144304)1, 2, 3, 9 Sun L....Mao Y. (2005)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF468 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF468 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF468 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF468 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF468 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF468 gene:
Search GeneIP for patents involving ZNF468
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF468 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF468 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF468 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF468 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF468 | | OriGene 3'-UTR Clone for ZNF468 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF468 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF468 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF468 | | OriGene Custom Protein Services for ZNF468 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF468 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF468 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF468 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF468 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF468 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF468 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF468 |
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 | | | ZNF468 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF468 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF468 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF468 |
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