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Aliases for ZNF468 Gene

Aliases for ZNF468 Gene

  • Zinc Finger Protein 468 2 3 5

External Ids for ZNF468 Gene

Previous GeneCards Identifiers for ZNF468 Gene

  • GC19M058034
  • GC19M053341
  • GC19M049669

Summaries for ZNF468 Gene

GeneCards Summary for ZNF468 Gene

ZNF468 (Zinc Finger Protein 468) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF468 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF468 Gene

Genomics for ZNF468 Gene

Regulatory Elements for ZNF468 Gene

Enhancers for ZNF468 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF468 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF468 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF468 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF468 Gene

52,838,008 bp from pter
52,857,649 bp from pter
19,642 bases
Minus strand

Genomic View for ZNF468 Gene

Genes around ZNF468 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF468 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF468 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF468 Gene

Proteins for ZNF468 Gene

  • Protein details for ZNF468 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 468
    Protein Accession:
    Secondary Accessions:
    • A8MV20
    • Q5CZB8
    • Q5VIY4
    • Q68DI7

    Protein attributes for ZNF468 Gene

    522 amino acids
    Molecular mass:
    60573 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF468 Gene


neXtProt entry for ZNF468 Gene

Proteomics data for ZNF468 Gene at MOPED

Post-translational modifications for ZNF468 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF468 Gene

Domains & Families for ZNF468 Gene

Gene Families for ZNF468 Gene

Protein Domains for ZNF468 Gene

Suggested Antigen Peptide Sequences for ZNF468 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF468: view

Function for ZNF468 Gene

Molecular function for ZNF468 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF468: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF468 Gene

Localization for ZNF468 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF468 Gene

Subcellular locations from

Jensen Localization Image for ZNF468 Gene COMPARTMENTS Subcellular localization image for ZNF468 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF468 Gene

Pathways & Interactions for ZNF468 Gene

SuperPathways for ZNF468 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF468: view

Pathways by source for ZNF468 Gene

2 Reactome pathways for ZNF468 Gene

Interacting Proteins for ZNF468 Gene

Gene Ontology (GO) - Biological Process for ZNF468 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF468: view

No data available for SIGNOR curated interactions for ZNF468 Gene

Drugs & Compounds for ZNF468 Gene

No Compound Related Data Available

Transcripts for ZNF468 Gene

Unigene Clusters for ZNF468 Gene

Zinc finger protein 468:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF468 Gene

No ASD Table

Relevant External Links for ZNF468 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF468 Gene

mRNA expression in normal human tissues for ZNF468 Gene

Protein differential expression in normal tissues from HIPED for ZNF468 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF468 Gene

SOURCE GeneReport for Unigene cluster for ZNF468 Gene Hs.467223

mRNA Expression by UniProt/SwissProt for ZNF468 Gene

Tissue specificity: Isoform 1 and isoform 2 are highly expressed in placenta, pancreas, and small intestine. Lower expression in colon, ovary, testis, prostate, thymus, spleen, kidney, and liver. No expression detected in heart and brain.
genes like me logo Genes that share expression patterns with ZNF468: view

Protein tissue co-expression partners for ZNF468 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF468 Gene

Orthologs for ZNF468 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF468 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF813 35
  • 65.89 (n)
  • 49.42 (a)
-- 36
  • 49 (a)
(Pan troglodytes)
Mammalia ZNF468 35
  • 98.34 (n)
  • 97.51 (a)
ZNF468 36
  • 98 (a)
(Canis familiaris)
Mammalia -- 36
  • 50 (a)
Species with no ortholog for ZNF468:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF468 Gene

Gene Tree for ZNF468 (if available)
Gene Tree for ZNF468 (if available)

Paralogs for ZNF468 Gene

(593) SIMAP similar genes for ZNF468 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF468: view

Variants for ZNF468 Gene

Sequence variations from dbSNP and Humsavar for ZNF468 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12462929 - 52,841,173(+) GTCTA(C/T)GATGG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs10419826 - 52,840,865(+) CTGAC(A/C/G/T)GAAGG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs7256165 -- 52,848,013(+) AAATA(C/T)CCACA intron-variant
rs7256559 -- 52,847,570(+) GAATG(C/T)CTCGG intron-variant
rs7256825 -- 52,857,045(+) CAACG(A/C)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF468 Gene

Variant ID Type Subtype PubMed ID
esv2718786 CNV Deletion 23290073
esv2718787 CNV Deletion 23290073
dgv3980n71 CNV Gain 21882294
dgv3981n71 CNV Gain 21882294
esv2718796 CNV Deletion 23290073
dgv3984n71 CNV Gain 21882294
nsv833875 CNV Loss 17160897
esv2718798 CNV Deletion 23290073
nsv458746 CNV Gain 19166990
esv2445065 CNV Deletion 19546169
esv2718799 CNV Deletion 23290073
nsv817858 CNV Gain 17921354
nsv458747 CNV Gain 19166990
dgv3985n71 CNV Gain 21882294
nsv528436 CNV Loss 19592680
dgv1114e1 CNV Complex 17122850
dgv3986n71 CNV Loss 21882294
dgv570e201 CNV Deletion 23290073
nsv912327 CNV Loss 21882294
dgv3987n71 CNV Gain 21882294
nsv912331 CNV Gain+Loss 21882294
nsv912332 CNV Gain 21882294
dgv3988n71 CNV Gain+Loss 21882294
esv1004256 CNV Deletion 20482838
nsv828619 CNV Gain 20364138
esv21942 CNV Gain 19812545
nsv9744 CNV Gain 18304495
nsv819146 CNV Gain 19587683
nsv436855 CNV Insertion 17901297
esv2421897 OTHER Complex 20811451
nsv828621 CNV Loss 20364138
nsv442470 CNV CNV 18776908
nsv2537 CNV Loss 18451855
dgv18n14 CNV Gain 18776910
dgv3989n71 CNV Loss 21882294
dgv1115e1 CNV Complex 17122850
dgv3990n71 CNV Gain 21882294
dgv426n27 CNV Loss 19166990
nsv817859 CNV Gain 17921354
nsv458750 CNV Loss 19166990
nsv517570 CNV Gain+Loss 19592680
nsv817860 CNV Gain+Loss 17921354
nsv458752 CNV Loss 19166990
nsv524151 CNV Gain 19592680
nsv525329 CNV Loss 19592680
nsv519916 CNV Gain 19592680
nsv819613 CNV Gain 19587683
nsv2538 CNV Insertion 18451855
esv2718803 CNV Deletion 23290073

Variation tolerance for ZNF468 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF468 Gene

Disorders for ZNF468 Gene

Relevant External Links for ZNF468

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF468 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF468 Gene

Publications for ZNF468 Gene

  1. A novel zinc finger gene ZNF468 with two co-expressional splice variants, ZNF468.1 and ZNF468.2. (PMID: 16144304) Sun L. … Mao Y. (Biochem. Genet. 2005) 2 3 4 23 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF468 Gene

Sources for ZNF468 Gene