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ZNF468 Gene

protein-coding   GIFtS: 50
GCID: GC19M053341

Zinc Finger Protein 468

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4681 2
Zinc Finger Protein ZNF4682

External Ids:    HGNC: 331051   Entrez Gene: 903332   Ensembl: ENSG000002046047   UniProtKB: Q5VIY53   

Export aliases for ZNF468 gene to outside databases

Previous GC identifers: GC19M058034 GC19M049669


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF468 Gene:
ZNF468 (zinc finger protein 468) is a protein-coding gene. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF468 gene promoter:
         POU2F1   HTF   POU2F1a   Ik-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF468 promoter sequence
   Search Chromatin IP Primers for ZNF468

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF468


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF468 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF468 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M053341:  view genomic region     (about GC identifiers)

Start:
53,341,261 bp from pter      End:
53,360,902 bp from pter
Size:
19,642 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5 (See protein sequence)
Recommended Name: Zinc finger protein 468  
Size: 522 amino acids; 60573 Da
Secondary accessions: A8MV20 Q5CZB8 Q5VIY4 Q68DI7
Alternative splicing: 2 isoforms:  Q5VIY5-1   Q5VIY5-2   

Explore the universe of human proteins at neXtProt for ZNF468: NX_Q5VIY5

Explore proteomics data for ZNF468 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys496
  • Modification sites at PhosphoSitePlus

  • See ZNF468 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008801.1  NP_001264049.1  

    ENSEMBL proteins: 
     ENSP00000470381   ENSP00000243639   ENSP00000469779   ENSP00000470717   ENSP00000471675  
     ENSP00000469733   ENSP00000379690   ENSP00000445669  
    Reactome Protein details: Q5VIY5

    ZNF468 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF468

     
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    Search eBioscience for ELISAs for ZNF468 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5VIY5

    ProtoNet protein and cluster: Q5VIY5

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF468           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN468_HUMAN, Q5VIY5
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF468           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF468
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    miRNA
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    miRTarBase miRNAs that target ZNF468:
    hsa-mir-26b-5p (MIRT030117)

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    5 qRT-PCR Assays for microRNAs that regulate ZNF468:
    hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidZNF468 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN468_HUMAN, Q5VIY5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF468           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF468 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF468           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF468
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF468
    Interactions:

        Search GeneGlobe Interaction Network for ZNF468

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF468 (ENSP000002436394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AATFENSP000002254024STRING: ENSP00000225402
    SLC9A3R1ENSP000002626134STRING: ENSP00000262613
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF468           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF468 (ZN468)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF468 gene (3 alternative transcripts): 
    NM_199132.1  NM_001008801.1  NM_001277120.1  

    Unigene Cluster for ZNF468:

    Zinc finger protein 468
    Hs.467223  [show with all ESTs]
    Unigene Representative Sequence: CR936695
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595646 ENST00000243639 ENST00000597924 ENST00000601847 ENST00000602144
    ENST00000601980 ENST00000396409(uc002qae.3) ENST00000390651(uc002qaf.3)

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ZNF468:
    hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidZNF468 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF468 (NM_199132)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF468
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF468
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF468
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF468
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF468
      QuantiFast Probe-based Assays in human, mouse, rat ZNF468

    Additional mRNA sequence: 

    AK023558.1 AK025501.1 AK289841.1 AK292449.1 AY117438.1 AY442330.1 AY442331.1 BC008480.1 
    BC037409.1 BC063143.1 CR749381.1 CR936599.1 CR936695.1 

    11 DOTS entries:

    DT.411280  DT.97846900  DT.121462060  DT.101955519  DT.40206943  DT.100657976  DT.121461766  DT.121462218 
    DT.121462350  DT.92038504  DT.95132340 

    Selected AceView cDNA sequences (see all 47):

    BC008480 BX952497 BX106193 AI872737 CA394881 BX955314 R78627 BF438910 
    AK025501 BG056504 AA354849 CF593393 BC063143 BC037409 CR749381 H04753 
    AK023558 BG391851 BG623517 CA389954 BX509654 AW189935 BX497090 CF593840 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF468 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCTACAA
    ZNF468 Expression
    About this image

    ZNF468 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF468 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467223

    UniProtKB/Swiss-Prot: ZN468_HUMAN, Q5VIY5
    Tissue specificity: Isoform 1 and isoform 2 are highly expressed in placenta, pancreas, and small intestine. Lower
    expression in colon, ovary, testis, prostate, thymus, spleen, kidney, and liver. No expression detected in heart
    and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF468

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF468 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    50(a)
    many ↔ many
    1(104870859-104886591)


    ENSEMBL Gene Tree for ZNF468 (if available)
    TreeFam Gene Tree for ZNF468 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF468 gene
    ZNF5342  ZNF321P2  ZNF5782  ZNF8802  ZNF7662  ZNF3202  ZNF5252  ZNF8602  
    ZNF4152  ZNF6002  ZNF282  ZNF5282  ZNF6112  ZNF6772  ZNF832  ZNF8162  
    ZNF6102  ZNF7012  ZNF7652  ZNF4802  ZNF8132  
    Selected SIMAP similar genes for ZNF468 using alignment to 6 protein entries:     ZN468_HUMAN (see all proteins) (see all similar genes):
    ZNF28    ZNF702P    ZNF91    ZNF208    ZNF321P    ZNF625-ZNF20
    ZNF845    ZNF761    ZNF616    ZNF738    ZNF695    ZNF860
    ZNF611    ZNF415    ZNF677    ZNF675    ZNF525    LOC101928664

    Find genes that share paralogs with ZNF468           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF468 (see all 696)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563288901,2
    C,F--53341314(+) TCATGT/CGCAAT 5 -- ds5001 int16Minor allele frequency- C:0.07WA NA CSA EA 364
    rs1889152321,2
    --53341321(+) CAATTA/TTCACA 5 -- ds5001 int10--------
    rs1813631861,2
    C--53341388(+) TCAAGA/GGGATA 5 -- ds5001 int10--------
    rs1424633041,2
    --53341430(+) TATTTA/CTGGGA 5 -- ds5001 int10--------
    rs1461142171,2
    --53341461(+) GTCAAA/GCAAAT 5 -- ds5001 int10--------
    rs1864617761,2
    --53341711(+) TCTCAC/TCCCTT 5 -- ds5001 int10--------
    rs605508751,2
    C--53341727(+) CAATCA/CATACT 5 -- ds5001 int10--------
    rs72472711,2
    C,F,A,H--53341838(+) TCTGTA/GAAGAA 5 -- ut31 nc-transcript-variantese324Minor allele frequency- G:0.37NS EA NA WA CSA 2482
    rs1910559871,2
    --53341867(+) AAAATA/GCAACT 5 -- ut31 nc-transcript-variant0--------
    rs10629671,2
    C,F,A,H--53342152(-) AATTGG/AGTATA 5 -- ut31 nc-transcript-variantese331Minor allele frequency- A:0.43NS EA NA WA CSA 2977

    HapMap Linkage Disequilibrium report for ZNF468 (53341261 - 53360902 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF468 (see all 49):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718787CNV Deletion23290073
    esv2718796CNV Deletion23290073
    esv1004256CNV Deletion20482838
    esv2718803CNV Deletion23290073
    esv2718799CNV Deletion23290073
    esv2445065CNV Deletion19546169
    dgv570e201CNV Deletion23290073
    esv2718798CNV Deletion23290073
    esv2718786CNV Deletion23290073
    nsv2538CNV Insertion18451855

    Human Gene Mutation Database (HGMD): ZNF468
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF468
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF468

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF468           About GenesLikeMe


    Export disorders for ZNF468 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF468 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF468)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel zinc finger gene ZNF468 with two co-expressional splice variants, ZNF468.1 and ZNF468.2. (PubMed id 16144304)1, 2, 3, 9 Sun L....Mao Y. (Biochem. Genet. 2005)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90333 HGNC: 33105 AceView: LOC90333 Ensembl:ENSG00000204604 euGenes: HUgn90333
    ECgene: ZNF468 H-InvDB: ZNF468

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF468 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF468 gene:
    Search GeneIP for patents involving ZNF468

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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