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Aliases for ZNF467 Gene

Aliases for ZNF467 Gene

  • Zinc Finger Protein 467 2 3 5
  • Zinc Finger Protein EZI 3
  • Zfp467 3
  • EZI 3

External Ids for ZNF467 Gene

Previous GeneCards Identifiers for ZNF467 Gene

  • GC00U920638
  • GC07M148900
  • GC07M149094
  • GC07M149461
  • GC07M143537

Summaries for ZNF467 Gene

GeneCards Summary for ZNF467 Gene

ZNF467 (Zinc Finger Protein 467) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF467 Gene

  • Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5-CTTCTGGGAAGA-3 of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF467 Gene

Genomics for ZNF467 Gene

Regulatory Elements for ZNF467 Gene

Genomic Location for ZNF467 Gene

Chromosome:
7
Start:
149,764,182 bp from pter
End:
149,776,323 bp from pter
Size:
12,142 bases
Orientation:
Minus strand

Genomic View for ZNF467 Gene

Genes around ZNF467 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF467 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF467 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF467 Gene

Proteins for ZNF467 Gene

  • Protein details for ZNF467 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7K2-ZN467_HUMAN
    Recommended name:
    Zinc finger protein 467
    Protein Accession:
    Q7Z7K2

    Protein attributes for ZNF467 Gene

    Size:
    595 amino acids
    Molecular mass:
    65124 Da
    Quaternary structure:
    • Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus (By similarity).

neXtProt entry for ZNF467 Gene

Proteomics data for ZNF467 Gene at MOPED

Post-translational modifications for ZNF467 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF467 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF467 Gene

Domains & Families for ZNF467 Gene

Gene Families for ZNF467 Gene

Protein Domains for ZNF467 Gene

Suggested Antigen Peptide Sequences for ZNF467 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7K2

UniProtKB/Swiss-Prot:

ZN467_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF467: view

Function for ZNF467 Gene

Molecular function for ZNF467 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5-CTTCTGGGAAGA-3 of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).
genes like me logo Genes that share phenotypes with ZNF467: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF467 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF467
  • Consensus sequence: TGGGGAAGGGCM Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF467 Gene

Localization for ZNF467 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF467 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF467 Gene COMPARTMENTS Subcellular localization image for ZNF467 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF467 Gene

Pathways & Interactions for ZNF467 Gene

SuperPathways for ZNF467 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF467 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF467 Gene

Drugs & Compounds for ZNF467 Gene

No Compound Related Data Available

Transcripts for ZNF467 Gene

Unigene Clusters for ZNF467 Gene

Zinc finger protein 467:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF467 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for ZNF467 Gene

GeneLoc Exon Structure for
ZNF467
ECgene alternative splicing isoforms for
ZNF467

Expression for ZNF467 Gene

mRNA expression in normal human tissues for ZNF467 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF467 Gene

This gene is overexpressed in Whole Blood (x16.9).

Protein differential expression in normal tissues from HIPED for ZNF467 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF467 Gene



SOURCE GeneReport for Unigene cluster for ZNF467 Gene Hs.726477

genes like me logo Genes that share expression patterns with ZNF467: view

Protein tissue co-expression partners for ZNF467 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF467 Gene

Orthologs for ZNF467 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF467 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF467 35
  • 85.41 (n)
  • 81.77 (a)
ZNF467 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF467 35
  • 86.77 (n)
  • 84.92 (a)
ZNF467 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp467 35
  • 82.86 (n)
  • 84.99 (a)
Zfp467 16
Zfp467 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF467 35
  • 99.05 (n)
  • 98.82 (a)
ZNF467 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp467 35
  • 82.8 (n)
  • 84.49 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF467 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
Species with no ortholog for ZNF467:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF467 Gene

ENSEMBL:
Gene Tree for ZNF467 (if available)
TreeFam:
Gene Tree for ZNF467 (if available)

Paralogs for ZNF467 Gene

(249) SIMAP similar genes for ZNF467 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF467: view

No data available for Paralogs for ZNF467 Gene

Variants for ZNF467 Gene

Sequence variations from dbSNP and Humsavar for ZNF467 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6965332 - 149,765,532(+) GGCCG(A/C/T)CTGGT reference, missense
rs41550 -- 149,765,872(+) CCGCG(A/G)TGGCT reference, synonymous-codon
rs41551 -- 149,765,881(+) CTGCG(A/C)TGATG reference, missense
rs41552 -- 149,765,921(+) TGCGG(A/C/T)CGCAG reference, missense
rs41553 -- 149,772,542(+) CGCGG(C/G)GCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF467 Gene

Variant ID Type Subtype PubMed ID
nsv469576 CNV Complex 16826518
nsv831184 CNV Gain 17160897
dgv2151e1 CNV Complex 17122850
dgv844n27 CNV Loss 19166990
dgv7529n71 CNV Loss 21882294
nsv517242 CNV Loss 19592680
dgv7530n71 CNV Loss 21882294
nsv521861 CNV Loss 19592680
nsv889409 CNV Loss 21882294

Variation tolerance for ZNF467 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF467 Gene

HapMap Linkage Disequilibrium report
ZNF467

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF467 Gene

Disorders for ZNF467 Gene

Relevant External Links for ZNF467

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF467

No disorders were found for ZNF467 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF467 Gene

Publications for ZNF467 Gene

  1. A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3. (PMID: 12426389) Nakayama K. … Miyajima A. (EMBO J. 2002) 2 3 23 67
  2. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. (PMID: 17848547) Saijou E. … Miyajima A. (J. Biol. Chem. 2007) 3 23
  3. Altered DNA methylation profile in idiopathic pulmonary fibrosis. (PMID: 22700861) Sanders Y.Y. … Hagood J.S. (Am. J. Respir. Crit. Care Med. 2012) 3
  4. Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment. (PMID: 21123171) Quach J.M. … Martin T.J. (J. Biol. Chem. 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for ZNF467 Gene

Sources for ZNF467 Gene

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