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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF467 Gene

protein-coding GIFtS: 47
GCID: GC07M149461

zinc finger protein 467

Search for ZNF467
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 467¹ ²
EZI¹ ²
Zfp467¹ ²
Zinc Finger Protein EZI²

External Ids:	HGNC: 23154¹	Entrez Gene: 168544²	Ensembl: ENSG00000181444⁷	OMIM: 614040⁵	UniProtKB: Q7Z7K2³

Export aliases for ZNF467 gene to outside databases

Previous GC identifers: GC00U920638 GC07M148900 GC07M149094 GC07M143537

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN467_HUMAN, Q7Z7K2

Function: Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the

bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence

5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and

PPARG. Recruits a histone deacetylase complex (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF467 gene promoter:
Nkx2-5 C/EBPalpha c-Ets-1 HEN1 Max FAC1 STAT3 Zic3 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF467 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF467

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF467

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1

ZNF467 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF467 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M149461: view genomic region (about GC identifiers)

Start:	149,461,271 bp from pter	End:	149,470,568 bp from pter
Size:	9,298 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 148,799,466-148,808,309

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN467_HUMAN, Q7Z7K2 (See protein sequence)

Recommended Name: Zinc finger protein 467

Size: 595 amino acids; 65124 Da

Subunit: Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus (By similarity)

Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for ZNF467: NX_Q7Z7K2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z7K2

ZNF467 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_997219.1

ENSEMBL proteins:

ENSP00000418011 ENSP00000304769

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	Uscn Proteins for ZNF467

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF467 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF467 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q7Z7K2

ProtoNet protein and cluster: Q7Z7K2

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN467_HUMAN, Q7Z7K2

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN467_HUMAN, Q7Z7K2

Function: Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the

bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence

5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and

PPARG. Recruits a histone deacetylase complex (By similarity)

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In Situ Assay
Products:

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--

ZNF467 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF467

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for ZNF467 (Q7Z7K2³ ENSP00000304769⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAT1	P42224³, ENSP00000354394⁴	I2D: score=2 STRING: ENSP00000354394
STAT3	P40763³, ENSP00000264657⁴	I2D: score=3 STRING: ENSP00000264657
STAT4	Q14765³, ENSP00000351255⁴	I2D: score=2 STRING: ENSP00000351255
MYOCD	Q8IZQ8³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF467 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF467
Search CenterWatch for drugs/clinical trials and news about ZNF467 / ZN467

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF467 gene:

NM_207336.1

Unigene Cluster for ZNF467:

Zinc finger protein 467

Hs.726477 [show with all ESTs]

Unigene Representative Sequence: AK131441

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000484747(uc003wgc.3) ENST00000302017(uc003wgd.2)

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Additional cDNA sequence:

AK131441.1 BC029296.1 BC038972.1 BC052625.1

3 DOTS entries:

DT.100021748 DT.112473 DT.86845157

24/140 AceView cDNA sequences (see all 140):

AI291401 BG164108 AW205625 AW024430 AI700746 BF438122 BE671331 BQ898676

BF110093 BF224256 BF223769 BF438049 AI681709 AI672902 BM727378 BE328892

BE326412 BE042924 BM707784 AI365683 AW027001 CA454547 BE220303 AI422183

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF467 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6
SP1:
SP2:											-

ECgene alternative splicing isoforms for ZNF467

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF467 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACCGCCTG

About this image

ZNF467 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF467 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF467

SOURCE GeneReport for Unigene cluster: Hs.726477

SABiosciences Custom PCR Arrays for ZNF467

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF467 gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ZNF467⁶	--	29(a)	1 → many	GL343790.1(8739-53919)
fruit fly (Drosophila melanogaster)	Insecta	jim⁶	jim	15(a)	1 → many	3L(22782333-22828294)

ENSEMBL Gene Tree for ZNF467 (if available)
TreeFam Gene Tree for ZNF467 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF467 gene

ZNF497² ZNF835²

18/263 SIMAP similar genes for ZNF467 using alignment to 2 protein entries: ZN467_HUMAN (see all proteins) (see all similar genes):

ZNF75A DKFZp547L155 ZNF ZNF16 ZNF323 ZNF793

ZNF814 ZNF605 ZNF697 ZNF713 ZFP2 ZNF135

ZNF160 ZNF184 ZNF271 ZNF304 ZNF347 ZNF569

ZNF467 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs855665^1,2	C,F,A,H,	--	149460973(+)	`CCTGCG/CTGGGC`	1	--	int¹		14		MN NS EA NA WA CSA	968
rs185152616^1,2		--	149460986(+)	`GAGAAA/GGGCAA`	1	--	int¹		0	--	--	--	--
rs190080622^1,2		--	149461047(+)	`CGATGC/TGAAAG`	1	--	int¹		0	--	--	--	--
rs182211189^1,2		--	149461115(+)	`CCCCCA/GGGAGA`	1	--	int¹		0	--	--	--	--
rs185593718^1,2		--	149461140(+)	`ACAGAC/GCTCCC`	1	--	int¹		0	--	--	--	--
rs189484186^1,2		--	149461255(+)	`AGCAGA/GAGCCA`	1	--	int¹		0	--	--	--	--
rs180763629^1,2		--	149461368(+)	`GGGGGA/GTGGTC`	1	--	int¹		0	--	--	--	--
rs117383860^1,2	F,	--	149461399(+)	`ACAGTG/CGCTAA`	1	--	int¹		1		NA	120
rs73168052^1,2	C,	--	149461428(+)	`TCCCCC/TAATTC`	1	--	int¹		0	--	--	--	--
rs73168053^1,2	C,F,	--	149461487(+)	`GTACAT/GAAATA`	1	--	ut3¹		4		WA NA EA EU	951

HapMap Linkage Disequilibrium report for ZNF467 (149461271 - 149470568 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZNF467
3 CNVs: 53471 3709 52146

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF467 for disorders About MalaCards

ZNF467 for disorders About GeneDecksing

OMIM gene information: 614040 OMIM disorders: --

Export disorders for ZNF467 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF467 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF467)

Utopia: connect your pdf to the dynamic
world of online information

A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3. (PubMed id 12426389)^{1, 3, 9} Nakayama K....Miyajima A. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. (PubMed id 17848547)^{1, 9} Saijou E....Miyajima A. (2007)
Altered DNA methylation profile in idiopathic pulmonar y fibrosis. (PubMed id 22700861)¹ Sanders Y.Y....Hagood J.S. (2012)
Zinc finger protein 467 is a novel regulator of osteo blast and adipocyte commitment. (PubMed id 21123171)¹ Quach J.M....Martin T.J. (2011)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 168544	HGNC: 23154	AceView: EZI	Ensembl:ENSG00000181444	euGenes: HUgn168544
ECgene: ZNF467	H-InvDB: ZNF467

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF467	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF467 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF467 gene:
Search GeneIP for patents involving ZNF467

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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ZNF467 Gene

zinc finger protein 467

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ZNF467 Gene

zinc finger protein 467

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