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Aliases for ZNF462 Gene

Aliases for ZNF462 Gene

  • Zinc Finger Protein 462 2 3
  • KIAA1803 4
  • Zfp462 3

External Ids for ZNF462 Gene

Summaries for ZNF462 Gene

GeneCards Summary for ZNF462 Gene

ZNF462 (Zinc Finger Protein 462) is a Protein Coding gene. An important paralog of this gene is ZNF142.

UniProtKB/Swiss-Prot for ZNF462 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF462 Gene

Genomics for ZNF462 Gene

Genomic Location for ZNF462 Gene

Start:
106,860,159 bp from pter
End:
107,013,634 bp from pter
Size:
153,476 bases
Orientation:
Plus strand

Genomic View for ZNF462 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF462 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF462 Gene

Regulatory Elements for ZNF462 Gene

Proteins for ZNF462 Gene

  • Protein details for ZNF462 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JM2-ZN462_HUMAN
    Recommended name:
    Zinc finger protein 462
    Protein Accession:
    Q96JM2
    Secondary Accessions:
    • Q5T0T4
    • Q8N408

    Protein attributes for ZNF462 Gene

    Size:
    2506 amino acids
    Molecular mass:
    284688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF462 Gene

    Alternative splice isoforms for ZNF462 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF462 Gene

Proteomics data for ZNF462 Gene at MOPED

Post-translational modifications for ZNF462 Gene

Other Protein References for ZNF462 Gene

No data available for DME Specific Peptides for ZNF462 Gene

Domains for ZNF462 Gene

Gene Families for ZNF462 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF462 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF462 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JM2

UniProtKB/Swiss-Prot:

ZN462_HUMAN
Similarity:
  • Contains 27 C2H2-type zinc fingers.:
    • Q96JM2
genes like me logo Genes that share domains with ZNF462: view

Function for ZNF462 Gene

Molecular function for ZNF462 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF462 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF462: view
genes like me logo Genes that share phenotypes with ZNF462: view

miRNA for ZNF462 Gene

miRTarBase miRNAs that target ZNF462

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF462 Gene

Localization for ZNF462 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF462 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF462 Gene COMPARTMENTS Subcellular localization image for ZNF462 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF462 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF462: view

Pathways for ZNF462 Gene

SuperPathways for ZNF462 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF462 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0043392 negative regulation of DNA binding IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF462: view

No data available for Pathways by source for ZNF462 Gene

Transcripts for ZNF462 Gene

Unigene Clusters for ZNF462 Gene

Zinc finger protein 462:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF462 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - - - - - -
SP6:
SP7: -
SP8:
SP9: - - - -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ZNF462 Gene

GeneLoc Exon Structure for
ZNF462
ECgene alternative splicing isoforms for
ZNF462

Expression for ZNF462 Gene

mRNA expression in normal human tissues for ZNF462 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF462 Gene

SOURCE GeneReport for Unigene cluster for ZNF462 Gene Hs.370379

genes like me logo Genes that share expressions with ZNF462: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF462 Gene

Orthologs for ZNF462 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF462 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF462 35
  • 99.71 (n)
  • 99.68 (a)
ZNF462 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF462 35
  • 90.6 (n)
  • 95.12 (a)
ZNF462 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF462 35
  • 92.08 (n)
  • 96.13 (a)
ZNF462 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp462 35
  • 90.09 (n)
  • 93.97 (a)
Zfp462 16
Zfp462 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF462 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF462 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp462 35
  • 89.54 (n)
  • 93.61 (a)
chicken
(Gallus gallus)
Aves ZNF462 35
  • 78.94 (n)
  • 84.56 (a)
ZNF462 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf462 35
  • 67.51 (n)
  • 69.21 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7801 35
zebrafish
(Danio rerio)
Actinopterygii znf462 35
  • 60.75 (n)
  • 58.22 (a)
ZNF462 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hb 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hbl-1 36
  • 15 (a)
OneToMany
Species with no ortholog for ZNF462:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF462 Gene

ENSEMBL:
Gene Tree for ZNF462 (if available)
TreeFam:
Gene Tree for ZNF462 (if available)

Paralogs for ZNF462 Gene

Paralogs for ZNF462 Gene

Selected SIMAP similar genes for ZNF462 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF462: view

Variants for ZNF462 Gene

Sequence variations from dbSNP and Humsavar for ZNF462 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs907064 -- 106,896,052(-) AAGTA(A/C)AGAGA intron-variant
rs954584 -- 106,880,655(+) AATGG(G/T)TTAAG intron-variant
rs954585 -- 106,880,415(+) TTTGA(A/G)GTGGT intron-variant
rs954852 -- 106,884,548(+) CACCT(C/G)TGCCC intron-variant
rs957017 -- 106,917,404(+) CTTCA(A/G)ACTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF462 Gene

Variant ID Type Subtype PubMed ID
nsv893696 CNV Gain 21882294
nsv831680 CNV Loss 17160897
esv2738890 CNV Deletion 23290073
esv2669661 CNV Deletion 23128226
esv2673055 CNV Deletion 23128226
esv29808 CNV Loss 19812545
nsv893697 CNV Gain 21882294

Relevant External Links for ZNF462 Gene

HapMap Linkage Disequilibrium report
ZNF462

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF462 Gene

Disorders for ZNF462 Gene

(1) University of Copenhagen DISEASES for ZNF462 Gene

Relevant External Links for ZNF462

Genetic Association Database (GAD)
ZNF462
Human Genome Epidemiology (HuGE) Navigator
ZNF462
genes like me logo Genes that share disorders with ZNF462: view

No data available for UniProtKB/Swiss-Prot for ZNF462 Gene

Publications for ZNF462 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48

Products for ZNF462 Gene

Sources for ZNF462 Gene

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