Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF462 Gene

Aliases for ZNF462 Gene

  • Zinc Finger Protein 462 2 3 5
  • KIAA1803 4
  • Zfp462 3

External Ids for ZNF462 Gene

Previous GeneCards Identifiers for ZNF462 Gene

  • GC09P105069
  • GC09P106704
  • GC09P108665
  • GC09P109626
  • GC09P079228

Summaries for ZNF462 Gene

GeneCards Summary for ZNF462 Gene

ZNF462 (Zinc Finger Protein 462) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF142.

UniProtKB/Swiss-Prot for ZNF462 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF462 Gene

Genomics for ZNF462 Gene

Regulatory Elements for ZNF462 Gene

Enhancers for ZNF462 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF462 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF462 Gene

106,860,165 bp from pter
107,013,634 bp from pter
153,470 bases
Plus strand

Genomic View for ZNF462 Gene

Genes around ZNF462 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF462 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF462 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF462 Gene

Proteins for ZNF462 Gene

  • Protein details for ZNF462 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 462
    Protein Accession:
    Secondary Accessions:
    • Q5T0T4
    • Q8N408

    Protein attributes for ZNF462 Gene

    2506 amino acids
    Molecular mass:
    284688 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF462 Gene

    Alternative splice isoforms for ZNF462 Gene


neXtProt entry for ZNF462 Gene

Proteomics data for ZNF462 Gene at MOPED

Post-translational modifications for ZNF462 Gene

Other Protein References for ZNF462 Gene

No data available for DME Specific Peptides for ZNF462 Gene

Domains & Families for ZNF462 Gene

Gene Families for ZNF462 Gene

Protein Domains for ZNF462 Gene


Suggested Antigen Peptide Sequences for ZNF462 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 27 C2H2-type zinc fingers.
  • Contains 27 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF462: view

Function for ZNF462 Gene

Molecular function for ZNF462 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF462: view

Animal Model Products

CRISPR Products

miRNA for ZNF462 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF462 Gene

Localization for ZNF462 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF462 Gene

Subcellular locations from

Jensen Localization Image for ZNF462 Gene COMPARTMENTS Subcellular localization image for ZNF462 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF462 Gene

Pathways & Interactions for ZNF462 Gene

SuperPathways for ZNF462 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF462 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF462: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF462 Gene

Drugs & Compounds for ZNF462 Gene

No Compound Related Data Available

Transcripts for ZNF462 Gene

Unigene Clusters for ZNF462 Gene

Zinc finger protein 462:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF462 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP5: - - - - - -
SP7: -
SP9: - - - -

ExUns: 18

Relevant External Links for ZNF462 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF462 Gene

mRNA expression in normal human tissues for ZNF462 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF462 Gene

This gene is overexpressed in Cervix (56.2) and Bone (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF462 Gene

SOURCE GeneReport for Unigene cluster for ZNF462 Gene Hs.370379

genes like me logo Genes that share expression patterns with ZNF462: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF462 Gene

Orthologs for ZNF462 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF462 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF462 35
  • 90.6 (n)
  • 95.12 (a)
ZNF462 36
  • 94 (a)
(Canis familiaris)
Mammalia ZNF462 35
  • 92.08 (n)
  • 96.13 (a)
ZNF462 36
  • 96 (a)
(Mus musculus)
Mammalia Zfp462 35
  • 90.09 (n)
  • 93.97 (a)
Zfp462 16
Zfp462 36
  • 93 (a)
(Pan troglodytes)
Mammalia ZNF462 35
  • 99.71 (n)
  • 99.68 (a)
ZNF462 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp462 35
  • 89.54 (n)
  • 93.61 (a)
(Monodelphis domestica)
Mammalia ZNF462 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF462 36
  • 85 (a)
(Gallus gallus)
Aves ZNF462 35
  • 78.94 (n)
  • 84.56 (a)
ZNF462 36
  • 85 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
-- 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf462 35
  • 67.51 (n)
  • 69.21 (a)
(Danio rerio)
Actinopterygii znf462 35
  • 60.75 (n)
  • 58.22 (a)
ZNF462 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7801 35
fruit fly
(Drosophila melanogaster)
Insecta hb 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea hbl-1 36
  • 15 (a)
Species with no ortholog for ZNF462:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF462 Gene

Gene Tree for ZNF462 (if available)
Gene Tree for ZNF462 (if available)

Paralogs for ZNF462 Gene

Paralogs for ZNF462 Gene

(8) SIMAP similar genes for ZNF462 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF462: view

Variants for ZNF462 Gene

Sequence variations from dbSNP and Humsavar for ZNF462 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs17723637 - 106,925,122(+) GTGCT(A/G)TGGAT reference, missense
rs3814541 - 106,927,471(-) CACAG(A/G)AGGGC intron-variant, reference, missense
rs3814538 - 106,929,395(-) CAAAG(C/T)TGCCT intron-variant, reference, missense
rs7020769 - 106,935,541(+) CCATA(A/G)ACCAT reference, missense
VAR_058305 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF462 Gene

Variant ID Type Subtype PubMed ID
nsv893696 CNV Gain 21882294
nsv831680 CNV Loss 17160897
esv2738890 CNV Deletion 23290073
esv2669661 CNV Deletion 23128226
esv2673055 CNV Deletion 23128226
esv29808 CNV Loss 19812545
nsv893697 CNV Gain 21882294

Variation tolerance for ZNF462 Gene

Residual Variation Intolerance Score: 0.608% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.98; 87.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF462 Gene

Disorders for ZNF462 Gene

Relevant External Links for ZNF462

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF462 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF462 Gene

Publications for ZNF462 Gene

  1. Discovery of O-GlcNAc-6-phosphate modified proteins in large-scale phosphoproteomics data. (PMID: 22826440) Hahne H. … Kuster B. (Mol. Cell. Proteomics 2012) 3 4 67
  2. Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. (PMID: 25752541) Nie J. … Yang X.J. (Structure 2015) 3
  3. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
  4. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (PMID: 24025145) Chung S. … Nakamura Y. (Breast Cancer Res. 2013) 3
  5. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for ZNF462 Gene

Sources for ZNF462 Gene