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Aliases for ZNF461 Gene

Aliases for ZNF461 Gene

  • Zinc Finger Protein 461 2 3
  • GIOT1 3 4 6
  • Gonadotropin-Inducible Ovary Transcription Repressor 1 3 4
  • GIOT-1 3 4
  • Gonadotropin Inducible Transcription Repressor 1 3

External Ids for ZNF461 Gene

Summaries for ZNF461 Gene

GeneCards Summary for ZNF461 Gene

ZNF461 (Zinc Finger Protein 461) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF461 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF461 Gene

Genomics for ZNF461 Gene

Genomic Location for ZNF461 Gene

Start:
36,637,192 bp from pter
End:
36,666,853 bp from pter
Size:
29,662 bases
Orientation:
Minus strand

Genomic View for ZNF461 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF461 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF461 Gene

Regulatory Elements for ZNF461 Gene

Proteins for ZNF461 Gene

  • Protein details for ZNF461 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAF7-ZN461_HUMAN
    Recommended name:
    Zinc finger protein 461
    Protein Accession:
    Q8TAF7
    Secondary Accessions:
    • A8K9W9
    • Q6VSF7
    • Q9ULZ8

    Protein attributes for ZNF461 Gene

    Size:
    563 amino acids
    Molecular mass:
    66214 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF461 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF461 Gene

Proteomics data for ZNF461 Gene at MOPED

Post-translational modifications for ZNF461 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF461 Gene

No data available for DME Specific Peptides for ZNF461 Gene

Domains for ZNF461 Gene

Gene Families for ZNF461 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF461 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAF7

UniProtKB/Swiss-Prot:

ZN461_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q8TAF7
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8TAF7
Similarity:
  • Contains 12 C2H2-type zinc fingers.:
    • Q8TAF7
genes like me logo Genes that share domains with ZNF461: view

Function for ZNF461 Gene

Molecular function for ZNF461 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF461 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF461: view

miRNA for ZNF461 Gene

miRTarBase miRNAs that target ZNF461

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF461 Gene

Localization for ZNF461 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF461 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF461 Gene COMPARTMENTS Subcellular localization image for ZNF461 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF461 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF461: view

Pathways for ZNF461 Gene

SuperPathways for ZNF461 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF461: view

Pathways by source for ZNF461 Gene

2 Reactome pathways for ZNF461 Gene

Gene Ontology (GO) - Biological Process for ZNF461 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF461: view

Transcripts for ZNF461 Gene

Unigene Clusters for ZNF461 Gene

Zinc finger protein 461:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF461 Gene

No ASD Table

Relevant External Links for ZNF461 Gene

GeneLoc Exon Structure for
ZNF461
ECgene alternative splicing isoforms for
ZNF461

Expression for ZNF461 Gene

mRNA expression in normal human tissues for ZNF461 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF461 Gene

SOURCE GeneReport for Unigene cluster for ZNF461 Gene Hs.590972

mRNA Expression by UniProt/SwissProt for ZNF461 Gene

Q8TAF7-ZN461_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine.
genes like me logo Genes that share expressions with ZNF461: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF461 Gene

Orthologs for ZNF461 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF461 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 54 (a)
ManyToMany
ZNF461 35
  • 99.75 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ZNF461 35
  • 81.79 (n)
  • 73.36 (a)
ZNF461 36
  • 63 (a)
OneToOne
Species with no ortholog for ZNF461:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF461 Gene

ENSEMBL:
Gene Tree for ZNF461 (if available)
TreeFam:
Gene Tree for ZNF461 (if available)

Paralogs for ZNF461 Gene

Selected SIMAP similar genes for ZNF461 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF461: view

Variants for ZNF461 Gene

Sequence variations from dbSNP and Humsavar for ZNF461 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1464830 -- 36,641,978(+) GAGCG(C/T)AGTGG intron-variant
rs1464831 -- 36,642,085(+) ACTAT(A/G)CCCTG intron-variant
rs1880563 -- 36,637,173(-) ACCAA(C/T)AGATA downstream-variant-500B
rs2885744 -- 36,644,307(+) tctgt(C/T)gccca intron-variant
rs3108172 -- 36,642,902(-) tggtg(A/G)gcacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF461 Gene

Variant ID Type Subtype PubMed ID
nsv833817 CNV Loss 17160897
nsv469794 CNV Complex 16826518
esv34384 CNV Loss 17911159
nsv817833 CNV Loss 17921354
nsv2475 CNV Insertion 18451855

Relevant External Links for ZNF461 Gene

HapMap Linkage Disequilibrium report
ZNF461

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF461 Gene

Disorders for ZNF461 Gene

Relevant External Links for ZNF461

Genetic Association Database (GAD)
ZNF461
genes like me logo Genes that share disorders with ZNF461: view

No data available for UniProtKB/Swiss-Prot for ZNF461 Gene

Publications for ZNF461 Gene

  1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-q13.4. (PMID: 15004467) Dai J. … Mao Y. (Cytogenet. Genome Res. 2003) 2 3 4 23
  2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. (PMID: 11579202) Mizutani T. … Miyamoto K. (Mol. Endocrinol. 2001) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2. (PMID: 16595694) Song K.H. … Choi H.S. (J. Biol. Chem. 2006) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZNF461 Gene

Sources for ZNF461 Gene

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