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Aliases for ZNF461 Gene

Aliases for ZNF461 Gene

  • Zinc Finger Protein 461 2 3 5
  • Gonadotropin-Inducible Ovary Transcription Repressor 1 3 4
  • GIOT-1 3 4
  • GIOT1 3 4
  • Zinc Finger Protein 28 3
  • HZF28 3

External Ids for ZNF461 Gene

Previous GeneCards Identifiers for ZNF461 Gene

  • GC19M041822
  • GC19M037128
  • GC19M033596
  • GC19M036678
  • GC19M036705

Summaries for ZNF461 Gene

GeneCards Summary for ZNF461 Gene

ZNF461 (Zinc Finger Protein 461) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF461 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF461 Gene

Genomics for ZNF461 Gene

Regulatory Elements for ZNF461 Gene

Enhancers for ZNF461 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF461 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF461 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF461 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF461 Gene

36,636,683 bp from pter
36,667,131 bp from pter
30,449 bases
Minus strand

Genomic View for ZNF461 Gene

Genes around ZNF461 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF461 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF461 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF461 Gene

Proteins for ZNF461 Gene

  • Protein details for ZNF461 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 461
    Protein Accession:
    Secondary Accessions:
    • A8K9W9
    • Q6VSF7
    • Q9ULZ8

    Protein attributes for ZNF461 Gene

    563 amino acids
    Molecular mass:
    66214 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF461 Gene


neXtProt entry for ZNF461 Gene

Proteomics data for ZNF461 Gene at MOPED

Post-translational modifications for ZNF461 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF461 Gene

Domains & Families for ZNF461 Gene

Gene Families for ZNF461 Gene

Protein Domains for ZNF461 Gene

Suggested Antigen Peptide Sequences for ZNF461 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF461: view

Function for ZNF461 Gene

Molecular function for ZNF461 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF461 Gene

genes like me logo Genes that share phenotypes with ZNF461: view

Animal Model Products

CRISPR Products

miRNA for ZNF461 Gene

miRTarBase miRNAs that target ZNF461

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF461 Gene

Localization for ZNF461 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF461 Gene

Subcellular locations from

Jensen Localization Image for ZNF461 Gene COMPARTMENTS Subcellular localization image for ZNF461 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF461 Gene

Pathways & Interactions for ZNF461 Gene

SuperPathways for ZNF461 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF461: view

Pathways by source for ZNF461 Gene

2 Reactome pathways for ZNF461 Gene

Gene Ontology (GO) - Biological Process for ZNF461 Gene


No data available for SIGNOR curated interactions for ZNF461 Gene

Drugs & Compounds for ZNF461 Gene

No Compound Related Data Available

Transcripts for ZNF461 Gene

Unigene Clusters for ZNF461 Gene

Zinc finger protein 461:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF461 Gene

No ASD Table

Relevant External Links for ZNF461 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF461 Gene

mRNA expression in normal human tissues for ZNF461 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF461 Gene

SOURCE GeneReport for Unigene cluster for ZNF461 Gene Hs.590972

mRNA Expression by UniProt/SwissProt for ZNF461 Gene

Tissue specificity: Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine.
genes like me logo Genes that share expression patterns with ZNF461: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF461 Gene

Orthologs for ZNF461 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF461 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF461 35
  • 81.79 (n)
  • 73.36 (a)
ZNF461 36
  • 63 (a)
(Pan troglodytes)
Mammalia ZNF461 35
  • 99.75 (n)
  • 100 (a)
-- 36
  • 54 (a)
Species with no ortholog for ZNF461:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF461 Gene

Gene Tree for ZNF461 (if available)
Gene Tree for ZNF461 (if available)

Paralogs for ZNF461 Gene

(550) SIMAP similar genes for ZNF461 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF461: view

Variants for ZNF461 Gene

Sequence variations from dbSNP and Humsavar for ZNF461 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10419469 - 36,643,835(+) aatta(C/T)tgtga intron-variant, upstream-variant-2KB, reference, missense
rs7259195 -- 36,645,157(+) TGAGA(C/G)GTCCA intron-variant, upstream-variant-2KB
rs7260233 -- 36,654,373(+) TGATT(A/G)ATTGA intron-variant
rs12976893 -- 36,646,132(+) ttgtt(A/G)ttatt intron-variant
rs7507224 -- 36,642,146(+) AGGCC(A/G)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF461 Gene

Variant ID Type Subtype PubMed ID
nsv833817 CNV Loss 17160897
nsv469794 CNV Complex 16826518
esv34384 CNV Loss 17911159
nsv817833 CNV Loss 17921354
nsv2475 CNV Insertion 18451855

Variation tolerance for ZNF461 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF461 Gene

Disorders for ZNF461 Gene

Relevant External Links for ZNF461

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF461 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF461 Gene

Publications for ZNF461 Gene

  1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-q13.4. (PMID: 15004467) Dai J. … Mao Y. (Cytogenet. Genome Res. 2003) 2 3 4 23 67
  2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. (PMID: 11579202) Mizutani T. … Miyamoto K. (Mol. Endocrinol. 2001) 2 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Mono-(2-ethylhexyl) phthalate induces NR4A subfamily and GIOT-1 gene expression, and suppresses CYP19 expression in human granulosa-like tumor cell line KGN. (PMID: 19822197) Ohno S. … Nakajin S. (Toxicol. Lett. 2009) 23
  5. Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2. (PMID: 16595694) Song K.H. … Choi H.S. (J. Biol. Chem. 2006) 3

Products for ZNF461 Gene

Sources for ZNF461 Gene