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Aliases for ZNF460 Gene

Aliases for ZNF460 Gene

  • Zinc Finger Protein 460 2 3
  • Zinc Finger Protein 272 2 3 4
  • ZNF272 3 4 6
  • Zinc Finger Protein HZF8 3 4
  • HZF8, 6
  • HZF8 3

External Ids for ZNF460 Gene

Previous HGNC Symbols for ZNF460 Gene

  • ZNF272

Previous GeneCards Identifiers for ZNF460 Gene

  • GC19P062484
  • GC19P057793
  • GC19P054104

Summaries for ZNF460 Gene

Entrez Gene Summary for ZNF460 Gene

  • Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]

GeneCards Summary for ZNF460 Gene

ZNF460 (Zinc Finger Protein 460) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot for ZNF460 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF460 Gene

Genomics for ZNF460 Gene

Genomic Location for ZNF460 Gene

Start:
57,279,408 bp from pter
End:
57,294,068 bp from pter
Size:
14,661 bases
Orientation:
Plus strand

Genomic View for ZNF460 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF460 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF460 Gene

No data available for Regulatory Elements for ZNF460 Gene

Proteins for ZNF460 Gene

  • Protein details for ZNF460 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14592-ZN460_HUMAN
    Recommended name:
    Zinc finger protein 460
    Protein Accession:
    Q14592
    Secondary Accessions:
    • A4FU64
    • B4DNX9
    • Q2VPC7
    • Q6VSF8

    Protein attributes for ZNF460 Gene

    Size:
    562 amino acids
    Molecular mass:
    63665 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF460 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF460 Gene

Proteomics data for ZNF460 Gene at MOPED

Post-translational modifications for ZNF460 Gene

  • Ubiquitination at Lys194, Lys287, and Lys474
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF460 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF460 Gene

Domains for ZNF460 Gene

Gene Families for ZNF460 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF460 Gene

Graphical View of Domain Structure for InterPro Entry

Q14592

UniProtKB/Swiss-Prot:

ZN460_HUMAN :
  • Q14592
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF460: view

Function for ZNF460 Gene

Molecular function for ZNF460 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF460: view

miRNA for ZNF460 Gene

miRTarBase miRNAs that target ZNF460

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF460 Gene

Localization for ZNF460 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF460 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF460 Gene COMPARTMENTS Subcellular localization image for ZNF460 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF460: view

Pathways for ZNF460 Gene

SuperPathways for ZNF460 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF460: view

Pathways by source for ZNF460 Gene

2 Reactome pathways for ZNF460 Gene

Gene Ontology (GO) - Biological Process for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF460: view

Transcripts for ZNF460 Gene

mRNA/cDNA for ZNF460 Gene

Unigene Clusters for ZNF460 Gene

Zinc finger protein 460:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF460 Gene

No ASD Table

Relevant External Links for ZNF460 Gene

GeneLoc Exon Structure for
ZNF460
ECgene alternative splicing isoforms for
ZNF460

Expression for ZNF460 Gene

mRNA expression in normal human tissues for ZNF460 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF460 Gene

SOURCE GeneReport for Unigene cluster for ZNF460 Gene Hs.99971

mRNA Expression by UniProt/SwissProt for ZNF460 Gene

Q14592-ZN460_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.
genes like me logo Genes that share expressions with ZNF460: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF460 Gene

Orthologs for ZNF460 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF460 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF460 35
  • 99.53 (n)
  • 99.82 (a)
ZNF460 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU138542.3 36
  • 39 (a)
ManyToMany
si:dkey-7j22.3 36
  • 46 (a)
ManyToMany
Species with no ortholog for ZNF460:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF460 Gene

ENSEMBL:
Gene Tree for ZNF460 (if available)
TreeFam:
Gene Tree for ZNF460 (if available)

Paralogs for ZNF460 Gene

Paralogs for ZNF460 Gene

Selected SIMAP similar genes for ZNF460 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF460: view

Variants for ZNF460 Gene

Sequence variations from dbSNP and Humsavar for ZNF460 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2041109 -- 57,291,438(+) CATAA(C/T)AAGAG reference, synonymous-codon
rs2041110 -- 57,291,456(+) GAGAA(A/G)AAACC synonymous-codon, reference
rs2108527 -- 57,283,667(+) TGGCT(A/G)ATTTT intron-variant
rs3746227 -- 57,293,156(-) GTAAA(A/G)AAGCT utr-variant-3-prime
rs3746228 -- 57,292,994(-) ACACA(C/T)GGAGA utr-variant-3-prime

Relevant External Links for ZNF460 Gene

HapMap Linkage Disequilibrium report
ZNF460

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF460 Gene

Disorders for ZNF460 Gene

No disorders were found for ZNF460 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF460 Gene

Publications for ZNF460 Gene

  1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-q13.4. (PMID: 15004467) Dai J. … Mao Y. (Cytogenet. Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF460 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF460
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF460
  • Block miRNA regulation of ZNF460 using miScript Target Protectors
  • antibodies-online peptides for ZNF460
  • antibodies-online antibodies for ZNF460
  • antibodies-online kits for ZNF460

Sources for ZNF460 Gene

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