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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF460 Gene

protein-coding   GIFtS: 45
GCID: GC19P057793

Zinc Finger Protein 460

(Previous name: zinc finger protein 272)
(Previous symbol: ZNF272)
  Search for ZNF460
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 4601 2
ZNF2721 2 3 5
Zinc Finger Protein 2721 2 3
Zinc Finger Protein HZF82 3
HZF82 5

External Ids:    HGNC: 216281   Entrez Gene: 107942   Ensembl: ENSG000001977147   OMIM: 6047555   UniProtKB: Q145923   

Export aliases for ZNF460 gene to outside databases

Previous GC identifers: GC19P062484 GC19P054104


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF460 Gene:
Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger
domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines
that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93
(MIM 604749) for additional information on zinc finger proteins.(supplied by OMIM, May 2004)

GeneCards Summary for ZNF460 Gene: 
ZNF460 (zinc finger protein 460) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF80.

UniProtKB/Swiss-Prot: ZN460_HUMAN, Q14592
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF460
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF460 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF460

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF460


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.4

ZNF460 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF460 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P057793:  view genomic region     (about GC identifiers)

Start:
57,791,419 bp from pter      End:
57,805,436 bp from pter
Size:
14,018 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN460_HUMAN, Q14592 (See protein sequence)
Recommended Name: Zinc finger protein 460  
Size: 562 amino acids; 63665 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A4FU64 Q2VPC7 Q6VSF8

Explore the universe of human proteins at neXtProt for ZNF460: NX_Q14592

Explore proteomics data for ZNF460 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14592

  • ZNF460 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF460 Protein Expression
    REFSEQ proteins: NP_006626.3  
    ENSEMBL proteins: 
     ENSP00000446167   ENSP00000353491   ENSP00000471285  
    Reactome Protein details: Q14592
    Human Recombinant Protein Products for ZNF460: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF460 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF460 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q14592

    ProtoNet protein and cluster: Q14592

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN460_HUMAN, Q14592
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF460 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN460_HUMAN, Q14592
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF460 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF460 
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    hsa-miR-125a-5p hsa-miR-125b hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidZNF460 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF460


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF460 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF460
        Generic Transcription Pathway
    Gene Expression



    ZNF460 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF460

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF460 (ENSP000003534914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX5ENSP000002098754STRING: ENSP00000209875
    CBX3ENSP000003366874STRING: ENSP00000336687
    SMARCAD1ENSP000003519474STRING: ENSP00000351947
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF460 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF460 (ZN460)

    Search CenterWatch for drugs/clinical trials and news about ZNF460 / ZN460

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF460 gene: 
    NM_006635.3  

    Unigene Cluster for ZNF460:

    Zinc finger protein 460
    Hs.99971  [show with all ESTs]
    Unigene Representative Sequence: NM_006635
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537645 ENST00000360338(uc010ygv.1 uc002qog.2) ENST00000599602

    miRNA
    Products:
         
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF460:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidZNF460 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF460
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF460
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF460
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF460 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF460 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF460
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF460

    Additional mRNA sequence: 

    AF113692.1 AK074582.1 AK090816.1 AK292144.1 AK298106.1 AY329492.1 BC109018.1 BC109019.1 
    BC118625.1 X78931.1 

    5 DOTS entries:

    DT.40119888  DT.121465344  DT.97779168  DT.91748829  DT.121465343 

    24/28 AceView cDNA sequences (see all 28):

    CB268371 NM_006635 AK090816 X78931 AK074582 AX746630 AW892749 BQ352852 
    BM543039 AY329492 AI811056 BV173744 AA319154 AW293116 BI047079 BQ225968 
    BE882666 BQ361241 BQ314505 BF740796 BF368571 BQ352776 BF368749 BF368612 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF460 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTTTCT
    ZNF460 Expression
    About this image


    See ZNF460 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF460

    SOURCE GeneReport for Unigene cluster: Hs.99971

    UniProtKB/Swiss-Prot: ZN460_HUMAN, Q14592
    Tissue specificity: Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver

        SABiosciences Custom PCR Arrays for ZNF460
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF460

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF460 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF4601 zinc finger protein 460 99.53(n)
    99.82(a)
      100615257  XM_003316698.2  XP_003316746.1 


    ENSEMBL Gene Tree for ZNF460 (if available)
    TreeFam Gene Tree for ZNF460 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF460 gene
    ZNF802  ZNF5992  ZNF5432  ZNF5502  ZNF8052  ZNF2642  
    18/516 SIMAP similar genes for ZNF460 using alignment to 3 protein entries:     ZN460_HUMAN (see all proteins) (see all similar genes):
    kr-znf3    ZNF78L1    ZNF805    DKFZp313M0722    DKFZp666C237    HZF30
    ZFS-4    ZNF24    ZNF323    ZSCAN31    HZF16    ZNF146
    ZNF397    ZNF542    ZNF543    ZNF697    ZNF678    HZF36

    ZNF460 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/338 SNPs in ZNF460 are shown (see all 338)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451909411,2
    --57793779(+) CTAGTA/GGGACT 1 -- int10--------
    rs783915651,2
    F--57793788(+) CTTAGG/ATAGAA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1886626851,2
    --57793867(+) CACCAC/TGTCAG 1 -- int10--------
    rs1811481351,2
    --57793868(+) ACCACA/GTCAGG 1 -- int10--------
    rs1378893071,2
    --57793931(+) TGGGAA/GTGGCT 1 -- int10--------
    rs1860342411,2
    --57794140(+) ACTGCC/TTGAGC 1 -- int10--------
    rs1430523331,2
    --57794217(+) AGACCA/GGCATG 1 -- int10--------
    rs1904997841,2
    --57794223(+) GCATGA/GCATCA 1 -- int10--------
    rs770541961,2
    C,F--57794368(+) AAAAAG/AAGAGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1461672691,2
    C--57794409(+) CTGGTA/GGAGCG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF460 (57791419 - 57805436 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF460: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF460
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF460

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF460 for disorders           About MalaCards
    OMIM gene information: 604755    OMIM disorders: --


    ZNF460 for disorders           About GeneDecksing


    Export disorders for ZNF460 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF460 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF460)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-q13.4. (PubMed id 15004467)1, 2, 3 Dai J.... Mao Y. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2 Abrink M.... Hellman L. (1995)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    8. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10794 HGNC: 21628 AceView: ZNF272 Ensembl:ENSG00000197714 euGenes: HUgn10794
    ECgene: ZNF460 H-InvDB: ZNF460

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF460 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF460 gene:
    Search GeneIP for patents involving ZNF460

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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