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Aliases for ZNF460 Gene

Aliases for ZNF460 Gene

  • Zinc Finger Protein 460 2 3 5
  • Zinc Finger Protein 272 2 3 4
  • Zinc Finger Protein HZF8 3 4
  • ZNF272 3 4
  • HZF8 3

External Ids for ZNF460 Gene

Previous HGNC Symbols for ZNF460 Gene

  • ZNF272

Previous GeneCards Identifiers for ZNF460 Gene

  • GC19P062484
  • GC19P057793
  • GC19P054104

Summaries for ZNF460 Gene

Entrez Gene Summary for ZNF460 Gene

  • Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]

GeneCards Summary for ZNF460 Gene

ZNF460 (Zinc Finger Protein 460) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF543.

UniProtKB/Swiss-Prot for ZNF460 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF460 Gene

Genomics for ZNF460 Gene

Regulatory Elements for ZNF460 Gene

Enhancers for ZNF460 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F057103 1.1 Ensembl ENCODE 10.2 -175.5 -175508 1.0 CBX3 ARID4B SIN3A RAD21 ZNF335 CBX5 SCRT2 ZNF143 ZNF548 THAP11 ZNF805 ZNF256 ZNF134 ZNF550 ZNF773 ZNF264 ZNF417 ENSG00000268392 ZNF543 ZIM3
GH19F057171 0.5 Ensembl ENCODE 10.2 -107.0 -107008 2.0 ZNF48 ZNF2 ZNF366 ZNF548 SP3 CEBPB ZFP69B ZNF585B ZNF341 GLIS1 LOC100132009 ZNF17 ZNF134 ZNF773 ZNF417 ZNF805 ZNF606 ZNF549 AURKC ZNF256
GH19F058181 0.5 ENCODE 10.1 +903.8 903829 2.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF134 ZNF773 ZNF550 ZNF256 ZNF543 ZNF551 ZNF549 ZNF17 ZNF417 ZNF776
GH19F057613 0.6 ENCODE 10.1 +335.0 334969 1.5 ATF1 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ETS1 YY1 GLIS2 ELK1 ZNF805 ZNF134 ZNF256 ZNF550 ZNF773 ZNF264 ENSG00000268392 ZNF417 ZNF543 TRIM28
GH19F057809 1.2 FANTOM5 ENCODE 10.1 +533.8 533810 7.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF805 ZNF264 TRIM28 ZNF256 ZNF543 ZNF417 ZNF773 ZNF17 ENSG00000269867
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF460 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF460 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000349179 1192 2801 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ZNF460 Gene

Chromosome:
19
Start:
57,279,408 bp from pter
End:
57,294,075 bp from pter
Size:
14,668 bases
Orientation:
Plus strand

Genomic View for ZNF460 Gene

Genes around ZNF460 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF460 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF460 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF460 Gene

Proteins for ZNF460 Gene

  • Protein details for ZNF460 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14592-ZN460_HUMAN
    Recommended name:
    Zinc finger protein 460
    Protein Accession:
    Q14592
    Secondary Accessions:
    • A4FU64
    • B4DNX9
    • Q2VPC7
    • Q6VSF8

    Protein attributes for ZNF460 Gene

    Size:
    562 amino acids
    Molecular mass:
    63665 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF460 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF460 Gene

Post-translational modifications for ZNF460 Gene

  • Ubiquitination at Lys 194 and Lys 287
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF460 Gene

No data available for DME Specific Peptides for ZNF460 Gene

Domains & Families for ZNF460 Gene

Gene Families for ZNF460 Gene

Suggested Antigen Peptide Sequences for ZNF460 Gene

Graphical View of Domain Structure for InterPro Entry

Q14592

UniProtKB/Swiss-Prot:

ZN460_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF460: view

Function for ZNF460 Gene

Molecular function for ZNF460 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF460: view
genes like me logo Genes that share phenotypes with ZNF460: view

Animal Model Products

miRNA for ZNF460 Gene

miRTarBase miRNAs that target ZNF460

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF460 Gene

Localization for ZNF460 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF460 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF460 Gene COMPARTMENTS Subcellular localization image for ZNF460 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF460: view

Pathways & Interactions for ZNF460 Gene

SuperPathways for ZNF460 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF460: view

Pathways by source for ZNF460 Gene

2 Reactome pathways for ZNF460 Gene

Gene Ontology (GO) - Biological Process for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF460: view

No data available for SIGNOR curated interactions for ZNF460 Gene

Transcripts for ZNF460 Gene

Unigene Clusters for ZNF460 Gene

Zinc finger protein 460:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF460 Gene

No ASD Table

Relevant External Links for ZNF460 Gene

GeneLoc Exon Structure for
ZNF460
ECgene alternative splicing isoforms for
ZNF460

Expression for ZNF460 Gene

mRNA expression in normal human tissues for ZNF460 Gene

Protein differential expression in normal tissues from HIPED for ZNF460 Gene

This gene is overexpressed in Lymph node (35.6), Placenta (26.3), and Ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF460 Gene



Protein tissue co-expression partners for ZNF460 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF460 Gene:

ZNF460

SOURCE GeneReport for Unigene cluster for ZNF460 Gene:

Hs.99971

mRNA Expression by UniProt/SwissProt for ZNF460 Gene:

Q14592-ZN460_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.
genes like me logo Genes that share expression patterns with ZNF460: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF460 Gene

Orthologs for ZNF460 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF460 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF460 34 35
  • 99.53 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 35
  • 46 (a)
ManyToMany
CU138542.3 35
  • 39 (a)
ManyToMany
Species where no ortholog for ZNF460 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF460 Gene

ENSEMBL:
Gene Tree for ZNF460 (if available)
TreeFam:
Gene Tree for ZNF460 (if available)

Paralogs for ZNF460 Gene

Paralogs for ZNF460 Gene

(516) SIMAP similar genes for ZNF460 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF460: view

Variants for ZNF460 Gene

Sequence variations from dbSNP and Humsavar for ZNF460 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10153479 -- 57,297,491(+) tatca(C/T)gacca utr-variant-3-prime
rs10403733 -- 57,278,919(+) aggcc(A/G)aggtg intron-variant, upstream-variant-2KB
rs10403953 -- 57,278,975(+) TGGAA(A/G)AACCC intron-variant, upstream-variant-2KB
rs10404485 -- 57,278,695(+) gtctt(C/T)atgat intron-variant, upstream-variant-2KB
rs10404949 -- 57,278,923(+) CGAGG(C/T)GGGTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF460 Gene

Variant ID Type Subtype PubMed ID
nsv580400 CNV gain 21841781

Variation tolerance for ZNF460 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF460 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF460

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF460 Gene

Disorders for ZNF460 Gene

Relevant External Links for ZNF460

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF460

No disorders were found for ZNF460 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF460 Gene

Publications for ZNF460 Gene

  1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-q13.4. (PMID: 15004467) Dai J. … Mao Y. (Cytogenet. Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZNF460 Gene

Sources for ZNF460 Gene

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