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Aliases for ZNF460 Gene

Aliases for ZNF460 Gene

  • Zinc Finger Protein 460 2 3 5
  • Zinc Finger Protein 272 2 3 4
  • Zinc Finger Protein HZF8 3 4
  • ZNF272 3 4
  • HZF8 3

External Ids for ZNF460 Gene

Previous HGNC Symbols for ZNF460 Gene

  • ZNF272

Previous GeneCards Identifiers for ZNF460 Gene

  • GC19P062484
  • GC19P057793
  • GC19P054104

Summaries for ZNF460 Gene

Entrez Gene Summary for ZNF460 Gene

  • Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]

GeneCards Summary for ZNF460 Gene

ZNF460 (Zinc Finger Protein 460) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF80.

UniProtKB/Swiss-Prot for ZNF460 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF460 Gene

Genomics for ZNF460 Gene

Regulatory Elements for ZNF460 Gene

Enhancers for ZNF460 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF460 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF460 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF460 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF460 Gene

Chromosome:
19
Start:
57,279,408 bp from pter
End:
57,294,075 bp from pter
Size:
14,668 bases
Orientation:
Plus strand

Genomic View for ZNF460 Gene

Genes around ZNF460 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF460 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF460 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF460 Gene

Proteins for ZNF460 Gene

  • Protein details for ZNF460 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14592-ZN460_HUMAN
    Recommended name:
    Zinc finger protein 460
    Protein Accession:
    Q14592
    Secondary Accessions:
    • A4FU64
    • B4DNX9
    • Q2VPC7
    • Q6VSF8

    Protein attributes for ZNF460 Gene

    Size:
    562 amino acids
    Molecular mass:
    63665 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF460 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF460 Gene

Proteomics data for ZNF460 Gene at MOPED

Post-translational modifications for ZNF460 Gene

  • Ubiquitination at Lys 194 and Lys 287
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF460 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF460 Gene

Domains & Families for ZNF460 Gene

Gene Families for ZNF460 Gene

Protein Domains for ZNF460 Gene

Suggested Antigen Peptide Sequences for ZNF460 Gene

Graphical View of Domain Structure for InterPro Entry

Q14592

UniProtKB/Swiss-Prot:

ZN460_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF460: view

Function for ZNF460 Gene

Molecular function for ZNF460 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF460 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF460: view
genes like me logo Genes that share phenotypes with ZNF460: view

Animal Model Products

CRISPR Products

miRNA for ZNF460 Gene

miRTarBase miRNAs that target ZNF460

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF460 Gene

Localization for ZNF460 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF460 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF460 Gene COMPARTMENTS Subcellular localization image for ZNF460 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF460 Gene

Pathways & Interactions for ZNF460 Gene

SuperPathways for ZNF460 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF460: view

Pathways by source for ZNF460 Gene

2 Reactome pathways for ZNF460 Gene

Gene Ontology (GO) - Biological Process for ZNF460 Gene

None

No data available for SIGNOR curated interactions for ZNF460 Gene

Drugs & Compounds for ZNF460 Gene

No Compound Related Data Available

Transcripts for ZNF460 Gene

Unigene Clusters for ZNF460 Gene

Zinc finger protein 460:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF460 Gene

No ASD Table

Relevant External Links for ZNF460 Gene

GeneLoc Exon Structure for
ZNF460
ECgene alternative splicing isoforms for
ZNF460

Expression for ZNF460 Gene

mRNA expression in normal human tissues for ZNF460 Gene

Protein differential expression in normal tissues from HIPED for ZNF460 Gene

This gene is overexpressed in Lymph node (35.6), Placenta (26.3), and Ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF460 Gene



SOURCE GeneReport for Unigene cluster for ZNF460 Gene Hs.99971

mRNA Expression by UniProt/SwissProt for ZNF460 Gene

Q14592-ZN460_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.
genes like me logo Genes that share expression patterns with ZNF460: view

Protein tissue co-expression partners for ZNF460 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF460 Gene

Orthologs for ZNF460 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF460 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF460 35
  • 99.53 (n)
  • 99.82 (a)
ZNF460 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU138542.3 36
  • 39 (a)
ManyToMany
si:dkey-7j22.3 36
  • 46 (a)
ManyToMany
Species with no ortholog for ZNF460:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF460 Gene

ENSEMBL:
Gene Tree for ZNF460 (if available)
TreeFam:
Gene Tree for ZNF460 (if available)

Paralogs for ZNF460 Gene

Paralogs for ZNF460 Gene

(516) SIMAP similar genes for ZNF460 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF460: view

Variants for ZNF460 Gene

Sequence variations from dbSNP and Humsavar for ZNF460 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs62131343 -- 57,289,650(+) GGGAT(C/T)TCTAT intron-variant
rs62131344 -- 57,290,410(+) GTCGC(C/T)GGGAT intron-variant
rs8108403 -- 57,286,295(+) atcta(C/T)tgtgg intron-variant
rs71186245 -- 57,283,526(-) GTCTC(-/A/AA)AAAAA intron-variant
rs28397613 -- 57,290,919(+) GAACA(C/T)GAAGG reference, synonymous-codon

Variation tolerance for ZNF460 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZNF460 Gene

Disorders for ZNF460 Gene

Relevant External Links for ZNF460

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF460

No disorders were found for ZNF460 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF460 Gene

Publications for ZNF460 Gene

  1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-q13.4. (PMID: 15004467) Dai J. … Mao Y. (Cytogenet. Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ZNF460 Gene

Sources for ZNF460 Gene

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