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Aliases for ZNF454 Gene

Aliases for ZNF454 Gene

  • Zinc Finger Protein 454 2 3 5

External Ids for ZNF454 Gene

Previous GeneCards Identifiers for ZNF454 Gene

  • GC05P178436
  • GC05P178481
  • GC05P178300
  • GC05P178368
  • GC05P173094

Summaries for ZNF454 Gene

GeneCards Summary for ZNF454 Gene

ZNF454 (Zinc Finger Protein 454) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF879.

UniProtKB/Swiss-Prot for ZNF454 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF454 Gene

Genomics for ZNF454 Gene

Regulatory Elements for ZNF454 Gene

Enhancers for ZNF454 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F178203 1.1 ENCODE 34.5 -731.4 -731363 12.1 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZFP2 LOC100130798 ZNF454 ZNF879 ENSG00000247679 ZNF354C ZNF354B HNRNPAB LOC202181 CLK4
GH05F178729 1 ENCODE 33.4 -210.8 -210757 1.8 ATF1 CREB3L1 ZFP64 ARID4B SIN3A ZNF2 ETS1 GLIS2 ZNF143 KLF7 ZNF354B ZNF354A ZNF879 ZNF454 LOC105377763 LOC100130798 ZFP2 ADAMTS2 HNRNPAB ENSG00000272431
GH05F178777 1.1 Ensembl 26.3 -163.2 -163173 1.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS ZFP2 LOC100130798 ZNF454 LOC105377763 ZNF354C GRM6 ZNF879 AACSP1 LOC101928445 PIR60108
GH05F179696 1.2 ENCODE 23.6 +757.8 757754 4.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MAML1 ZNF354B ZNF879 LOC105377763 ZNF454 CANX LOC100996419 MGAT4B LOC101928445 ZFP2
GH05F179619 1.2 ENCODE 22.7 +681.1 681097 6.1 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZFP2 ZNF879 LOC100130798 LOC100996419 ZNF454 ZNF354C LOC100502572 LOC100289470 ENSG00000253652 ENSG00000250674
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF454 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF454 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417014 -190 1999 SMARCA4 POLR2A FOS ETS1

Genomic Location for ZNF454 Gene

Chromosome:
5
Start:
178,941,191 bp from pter
End:
178,966,433 bp from pter
Size:
25,243 bases
Orientation:
Plus strand

Genomic View for ZNF454 Gene

Genes around ZNF454 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF454 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF454 Gene

Proteins for ZNF454 Gene

  • Protein details for ZNF454 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9F8-ZN454_HUMAN
    Recommended name:
    Zinc finger protein 454
    Protein Accession:
    Q8N9F8
    Secondary Accessions:
    • Q2M1P2
    • Q2M323

    Protein attributes for ZNF454 Gene

    Size:
    522 amino acids
    Molecular mass:
    60008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF454 Gene

Post-translational modifications for ZNF454 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF454 Gene

Domains & Families for ZNF454 Gene

Gene Families for ZNF454 Gene

Suggested Antigen Peptide Sequences for ZNF454 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N9F8

UniProtKB/Swiss-Prot:

ZN454_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF454: view

Function for ZNF454 Gene

Molecular function for ZNF454 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF454: view
genes like me logo Genes that share phenotypes with ZNF454: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF454 Gene

Localization for ZNF454 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF454 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF454 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF454: view

Pathways & Interactions for ZNF454 Gene

SuperPathways for ZNF454 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF454: view

Pathways by source for ZNF454 Gene

2 Reactome pathways for ZNF454 Gene

Gene Ontology (GO) - Biological Process for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF454: view

No data available for SIGNOR curated interactions for ZNF454 Gene

Transcripts for ZNF454 Gene

mRNA/cDNA for ZNF454 Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF454 Gene

Zinc finger protein 454:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF454 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for ZNF454 Gene

GeneLoc Exon Structure for
ZNF454
ECgene alternative splicing isoforms for
ZNF454

Expression for ZNF454 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF454 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF454 Gene:

ZNF454

SOURCE GeneReport for Unigene cluster for ZNF454 Gene:

Hs.259441
genes like me logo Genes that share expression patterns with ZNF454: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF454 Gene

Orthologs for ZNF454 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF454 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF454 34 35
  • 98.85 (n)
cow
(Bos Taurus)
Mammalia ZNF454 34 35
  • 90 (n)
dog
(Canis familiaris)
Mammalia ZNF454 34 35
  • 88.29 (n)
mouse
(Mus musculus)
Mammalia Zfp454 34 16 35
  • 81.35 (n)
rat
(Rattus norvegicus)
Mammalia LOC102555919 34
  • 80.03 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
OneToMany
Species where no ortholog for ZNF454 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF454 Gene

ENSEMBL:
Gene Tree for ZNF454 (if available)
TreeFam:
Gene Tree for ZNF454 (if available)

Paralogs for ZNF454 Gene

Paralogs for ZNF454 Gene

(509) SIMAP similar genes for ZNF454 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF454 Gene

genes like me logo Genes that share paralogs with ZNF454: view

Variants for ZNF454 Gene

Sequence variations from dbSNP and Humsavar for ZNF454 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10042386 -- 178,957,891(+) GTAAT(A/G)TAAAA intron-variant, utr-variant-3-prime
rs10043049 -- 178,957,530(+) TCAGC(C/T)TCCCG intron-variant, utr-variant-3-prime
rs10053392 -- 178,961,092(+) caccc(A/G)gctaa intron-variant, downstream-variant-500B
rs10053707 -- 178,961,526(+) TAACA(A/G)CATTT intron-variant
rs10060386 -- 178,948,232(+) TCTTA(A/G)CTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF454 Gene

Variant ID Type Subtype PubMed ID
nsv980769 CNV duplication 23825009
nsv823356 CNV loss 20364138
nsv600489 CNV loss 21841781
nsv525129 CNV loss 19592680
nsv328942 CNV deletion 16902084
nsv1120062 OTHER inversion 24896259
esv3890769 CNV gain 25118596
esv3607732 CNV loss 21293372
esv2731267 CNV deletion 23290073
dgv1065e199 CNV deletion 23128226

Variation tolerance for ZNF454 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF454 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF454

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF454 Gene

Disorders for ZNF454 Gene

Relevant External Links for ZNF454

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF454

No disorders were found for ZNF454 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF454 Gene

Publications for ZNF454 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64

Products for ZNF454 Gene

Sources for ZNF454 Gene

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