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Aliases for ZNF454 Gene

Aliases for ZNF454 Gene

  • Zinc Finger Protein 454 2 3

External Ids for ZNF454 Gene

Previous GeneCards Identifiers for ZNF454 Gene

  • GC05P178436
  • GC05P178481
  • GC05P178300
  • GC05P178368
  • GC05P173094

Summaries for ZNF454 Gene

GeneCards Summary for ZNF454 Gene

ZNF454 (Zinc Finger Protein 454) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF454 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF454 Gene

Genomics for ZNF454 Gene

Regulatory Elements for ZNF454 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF454 Gene

Start:
178,941,191 bp from pter
End:
178,966,433 bp from pter
Size:
25,243 bases
Orientation:
Plus strand

Genomic View for ZNF454 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF454 Gene

Proteins for ZNF454 Gene

  • Protein details for ZNF454 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9F8-ZN454_HUMAN
    Recommended name:
    Zinc finger protein 454
    Protein Accession:
    Q8N9F8
    Secondary Accessions:
    • Q2M1P2
    • Q2M323

    Protein attributes for ZNF454 Gene

    Size:
    522 amino acids
    Molecular mass:
    60008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF454 Gene

Proteomics data for ZNF454 Gene at MOPED

Post-translational modifications for ZNF454 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF454 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF454 Gene

Domains for ZNF454 Gene

Gene Families for ZNF454 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF454 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N9F8

UniProtKB/Swiss-Prot:

ZN454_HUMAN :
  • Q8N9F8
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF454: view

Function for ZNF454 Gene

Molecular function for ZNF454 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF454: view
genes like me logo Genes that share phenotypes with ZNF454: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF454

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF454 Gene

Localization for ZNF454 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF454 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF454 Gene COMPARTMENTS Subcellular localization image for ZNF454 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF454: view

Pathways for ZNF454 Gene

SuperPathways for ZNF454 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF454: view

Pathways by source for ZNF454 Gene

2 Reactome pathways for ZNF454 Gene

Interacting Proteins for ZNF454 Gene

Gene Ontology (GO) - Biological Process for ZNF454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF454: view

Transcripts for ZNF454 Gene

mRNA/cDNA for ZNF454 Gene

(10) Selected AceView cDNA sequences:
(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF454 Gene

Zinc finger protein 454:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF454

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF454 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for ZNF454 Gene

GeneLoc Exon Structure for
ZNF454
ECgene alternative splicing isoforms for
ZNF454

Expression for ZNF454 Gene

mRNA expression in normal human tissues for ZNF454 Gene

SOURCE GeneReport for Unigene cluster for ZNF454 Gene Hs.259441

genes like me logo Genes that share expressions with ZNF454: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ZNF454 Gene

Orthologs for ZNF454 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF454 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF454 35
  • 90 (n)
  • 90.19 (a)
ZNF454 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF454 35
  • 88.29 (n)
  • 88.49 (a)
ZNF454 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp454 35
  • 81.35 (n)
  • 81.48 (a)
Zfp454 16
Zfp454 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF454 35
  • 98.85 (n)
  • 97.7 (a)
ZNF454 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102555919 35
  • 80.03 (n)
  • 78.6 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
Species with no ortholog for ZNF454:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF454 Gene

ENSEMBL:
Gene Tree for ZNF454 (if available)
TreeFam:
Gene Tree for ZNF454 (if available)

Paralogs for ZNF454 Gene

Selected SIMAP similar genes for ZNF454 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF454: view

Variants for ZNF454 Gene

Sequence variations from dbSNP and Humsavar for ZNF454 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs903981 -- 178,963,236(-) AAAAC(A/C)ACTAG intron-variant
rs954733 -- 178,962,792(+) CTCTA(G/T)ATGTT intron-variant
rs1826862 -- 178,963,406(-) CAGGC(A/G)CATTT intron-variant
rs2016198 -- 178,942,212(+) CAGTC(C/T)GACCA intron-variant
rs2016212 -- 178,942,299(+) TACTC(C/G)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF454 Gene

Variant ID Type Subtype PubMed ID
nsv328942 CNV Loss 16902084
nsv525129 CNV Loss 19592680
dgv1065e199 CNV Deletion 23128226
esv2731267 CNV Deletion 23290073
nsv823356 CNV Loss 20364138
dgv6389n71 CNV Gain 21882294

Relevant External Links for ZNF454 Gene

HapMap Linkage Disequilibrium report
ZNF454

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF454 Gene

Disorders for ZNF454 Gene

No disorders were found for ZNF454 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF454 Gene

Publications for ZNF454 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for ZNF454 Gene

Sources for ZNF454 Gene

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