Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF454 Gene

Aliases for ZNF454 Gene

  • Zinc Finger Protein 454 2 3 5

External Ids for ZNF454 Gene

Previous GeneCards Identifiers for ZNF454 Gene

  • GC05P178436
  • GC05P178481
  • GC05P178300
  • GC05P178368
  • GC05P173094

Summaries for ZNF454 Gene

GeneCards Summary for ZNF454 Gene

ZNF454 (Zinc Finger Protein 454) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF34.

UniProtKB/Swiss-Prot for ZNF454 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF454 Gene

Genomics for ZNF454 Gene

Regulatory Elements for ZNF454 Gene

Enhancers for ZNF454 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF454 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF454 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF454 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF454 Gene

178,941,191 bp from pter
178,966,433 bp from pter
25,243 bases
Plus strand

Genomic View for ZNF454 Gene

Genes around ZNF454 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF454 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF454 Gene

Proteins for ZNF454 Gene

  • Protein details for ZNF454 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 454
    Protein Accession:
    Secondary Accessions:
    • Q2M1P2
    • Q2M323

    Protein attributes for ZNF454 Gene

    522 amino acids
    Molecular mass:
    60008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF454 Gene

Proteomics data for ZNF454 Gene at MOPED

Post-translational modifications for ZNF454 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF454 Gene

Domains & Families for ZNF454 Gene

Gene Families for ZNF454 Gene

Protein Domains for ZNF454 Gene

Suggested Antigen Peptide Sequences for ZNF454 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF454: view

Function for ZNF454 Gene

Molecular function for ZNF454 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF454: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF454 Gene

Localization for ZNF454 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF454 Gene

Subcellular locations from

Jensen Localization Image for ZNF454 Gene COMPARTMENTS Subcellular localization image for ZNF454 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF454 Gene

Pathways & Interactions for ZNF454 Gene

SuperPathways for ZNF454 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF454: view

Pathways by source for ZNF454 Gene

2 Reactome pathways for ZNF454 Gene

Interacting Proteins for ZNF454 Gene

Gene Ontology (GO) - Biological Process for ZNF454 Gene


No data available for SIGNOR curated interactions for ZNF454 Gene

Drugs & Compounds for ZNF454 Gene

No Compound Related Data Available

Transcripts for ZNF454 Gene

mRNA/cDNA for ZNF454 Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF454 Gene

Zinc finger protein 454:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF454 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -

Relevant External Links for ZNF454 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF454 Gene

mRNA expression in normal human tissues for ZNF454 Gene

SOURCE GeneReport for Unigene cluster for ZNF454 Gene Hs.259441

genes like me logo Genes that share expression patterns with ZNF454: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF454 Gene

Orthologs for ZNF454 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF454 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF454 35
  • 90 (n)
  • 90.19 (a)
ZNF454 36
  • 85 (a)
(Canis familiaris)
Mammalia ZNF454 35
  • 88.29 (n)
  • 88.49 (a)
ZNF454 36
  • 88 (a)
(Mus musculus)
Mammalia Zfp454 35
  • 81.35 (n)
  • 81.48 (a)
Zfp454 16
Zfp454 36
  • 77 (a)
(Pan troglodytes)
Mammalia ZNF454 35
  • 98.85 (n)
  • 97.7 (a)
ZNF454 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC102555919 35
  • 80.03 (n)
  • 78.6 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
Species with no ortholog for ZNF454:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF454 Gene

Gene Tree for ZNF454 (if available)
Gene Tree for ZNF454 (if available)

Paralogs for ZNF454 Gene

(509) SIMAP similar genes for ZNF454 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF454: view

Variants for ZNF454 Gene

Sequence variations from dbSNP and Humsavar for ZNF454 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs12719860 - 178,964,901(+) CAGTG(A/C)TCAAA reference, missense
rs6867221 - 178,964,859(+) GGAAT(A/G)TGATG reference, missense
rs903981 -- 178,963,236(-) AAAAC(A/C)ACTAG intron-variant
rs954733 -- 178,962,792(+) CTCTA(G/T)ATGTT intron-variant
rs3857414 -- 178,959,896(-) cgggc(A/G)cggtg intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF454 Gene

Variant ID Type Subtype PubMed ID
nsv328942 CNV Loss 16902084
nsv525129 CNV Loss 19592680
dgv1065e199 CNV Deletion 23128226
esv2731267 CNV Deletion 23290073
nsv823356 CNV Loss 20364138
dgv6389n71 CNV Gain 21882294

Variation tolerance for ZNF454 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF454 Gene

Disorders for ZNF454 Gene

Relevant External Links for ZNF454

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF454 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF454 Gene

Publications for ZNF454 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF454 Gene

Sources for ZNF454 Gene