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ZNF451 Gene

protein-coding   GIFtS: 52
GCID: GC06P056951

Zinc Finger Protein 451
  See related diseases
at
MalaCards
 

Aliases
for ZNF451 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4511 2
COASTER2 3 5
Coactivator For Steroid Receptors2 3
dJ417I1.12
KIAA05763
KIAA17023

External Ids:    HGNC: 210911   Entrez Gene: 260362   Ensembl: ENSG000001122007   OMIM: 6157085   UniProtKB: Q9Y4E53   

Export aliases for ZNF451 gene to outside databases

Previous GC identifers: GC06P056957 GC06P057001 GC06P057062 GC06P056788


Summaries
for ZNF451 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF451 Gene:
ZNF451 (zinc finger protein 451) is a protein-coding gene. Diseases associated with ZNF451 include benign paroxysmal positional nystagmus, and angelman syndrome.

UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5
Function: May be involved in transcriptional regulation. Coactivator for steroid receptors

Gene Wiki entry for ZNF451 Gene


Genomic Views
for ZNF451 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF451 gene promoter:
         ATF-2   Lmo2   POU3F2 (N-Oct-5b)   CUTL1   E4BP4   GATA-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF451 promoter sequence
   Search Chromatin IP Primers for ZNF451

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF451


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.1

ZNF451 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF451 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P056951:  view genomic region     (about GC identifiers)

Start:
 56,951,642 bp from pter      End:
 57,035,105 bp from pter
Size:
 83,464 bases      Orientation:
 plus strand

Proteins
for ZNF451 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5 (See protein sequence)
Recommended Name: Zinc finger protein 451  
Size: 1061 amino acids; 121484 Da
Sequence caution: Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH42450.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=AAH58853.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence; Sequence=BAA25502.1; Type=Erroneous initiation; Sequence=BAB21793.1; Type=Erroneous
initiation;
Secondary accessions: Q5VVE9 Q5VVF1 Q86YE4 Q8N380 Q8TD15 Q9C0G1 Q9NQM1
Alternative splicing: 3 isoforms:  Q9Y4E5-1   Q9Y4E5-2   Q9Y4E5-4   

Explore the universe of human proteins at neXtProt for ZNF451: NX_Q9Y4E5

Explore proteomics data for ZNF451 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106, Lys139, Lys144, Lys153, Lys316, Lys357, Lys387, Lys423, Lys434, Lys452,
                                 Lys454, Lys464, Lys585, Lys706, Lys779, Lys790, Lys817, Lys827, Lys832, Lys845 (see all 21)
  • Modification sites at PhosphoSitePlus

    • See ZNF451 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001026794.1  NP_001244202.1  NP_056370.2  

    ENSEMBL proteins: 
     ENSP00000424723   ENSP00000427558   ENSP00000359740   ENSP00000350083   ENSP00000359742  
     ENSP00000359736   ENSP00000476915   ENSP00000421786   ENSP00000421645   ENSP00000359744  
     ENSP00000424329   ENSP00000425047  

    ZNF451 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ZNF451

    ZNF451 Antibody Products:

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    Abcam antibodies for ZNF451
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    LSBio Antibodies in human, mouse, rat for ZNF451

    ZNF451 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ZNF451
    Cloud-Clone Corp. CLIAs for ZNF451

    Domains /
    Families
    for ZNF451 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y4E5

    ProtoNet protein and cluster: Q9Y4E5

    UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    ZNF451 for domains           About GeneDecksing


    Function
    for ZNF451 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN451_HUMAN, Q9Y4E5
    Function: May be involved in transcriptional regulation. Coactivator for steroid receptors

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0046872metal ion binding IEA--
         
    ZNF451 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF451
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF451

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF451
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF451

    miRNA
    Products:            		miRTarBase miRNAs that target ZNF451:
    hsa-mir-335-5p (MIRT017501), hsa-mir-124-3p (MIRT022431), hsa-let-7e-5p (MIRT051672)

    Block miRNA regulation of human, mouse, rat ZNF451 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF451 (see all 18):
    hsa-miR-4307 hsa-miR-607 hsa-miR-495 hsa-miR-3133 hsa-miR-570 hsa-miR-3908 hsa-miR-889 hsa-miR-630
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF451 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for ZNF451
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF451

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ZNF451
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF451 (NM_015555)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF451
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF451

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF451 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF451


    Localization
    for ZNF451 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN451_HUMAN, Q9Y4E5: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF451 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ZNF451 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF451
    Interactions:

        Search GeneGlobe Interaction Network for ZNF451

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for ZNF451 (Q9Y4E51, 2, 3 ENSP000003597404) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632791, 3, ENSP000003248974EBI-747230,EBI-80168 I2D: score=6 STRING: ENSP00000324897
    FXR2P511162, 3, ENSP000002501134MINT-67534 I2D: score=5 STRING: ENSP00000250113
    RNF40O751502, 3, ENSP000003256774MINT-68396 I2D: score=5 STRING: ENSP00000325677
    PRPF40AO754002, 3MINT-61860 I2D: score=3 
    SNIP1Q8TAD82, 3MINT-62156 I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF451 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF451 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF451 (ZN451)



    Transcripts
    for ZNF451 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF451 gene (3 alternative transcripts): 
    NM_001031623.2  NM_001257273.1  NM_015555.2  

    Unigene Cluster for ZNF451:

    Zinc finger protein 451
    Hs.485628  [show with all ESTs]
    Unigene Representative Sequence: NM_001257273
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515290 ENST00000510483 ENST00000370706(uc003pdl.3 uc003pdm.1 uc003pdn.1)
    ENST00000357489 ENST00000370708(uc011dxn.2 uc003pdo.3) ENST00000370702
    ENST00000444273(uc003pdk.1) ENST00000370711 ENST00000508603 ENST00000491832
    ENST00000370710 ENST00000502749 ENST00000504603 ENST00000509071 ENST00000510989
    ENST00000509251 ENST00000508548 ENST00000504364
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat ZNF451 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF451 (see all 18):
    hsa-miR-4307 hsa-miR-607 hsa-miR-495 hsa-miR-3133 hsa-miR-570 hsa-miR-3908 hsa-miR-889 hsa-miR-630
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF451 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for ZNF451
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF451
    Clone
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    OriGene ORF clones in mouse, rat for ZNF451
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF451 (NM_015555)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF451
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF451
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF451
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF451
      QuantiFast Probe-based Assays in human, mouse, rat ZNF451

    Additional mRNA sequence: 

    AB011148.1 AB051489.1 AK000983.1 AK023072.1 AK027074.1 AK027805.1 AK075174.1 AK096186.1 
    AK225806.1 AK302577.1 AY055204.1 BC021712.2 BC042450.1 BC058853.1 BC098382.1 BX648081.1 
    BX648336.1 

    21 DOTS entries:

    DT.446327  DT.95196572  DT.100776855  DT.109953  DT.97775114  DT.92432129  DT.97786078  DT.218270 
    DT.100637749  DT.121366082  DT.65285369  DT.75127324  DT.121366113  DT.75193084  DT.75195288  DT.92024035 
    DT.95198742  DT.95313296  DT.121366153  DT.95102529  DT.95229832 

    Selected AceView cDNA sequences (see all 305):

    BP368891 AI621298 BU172465 AW571656 AA846521 AK000983 AI377651 BE502606 
    AA361558 AI656597 AA732009 AI914234 AA102087 AA343058 AW129544 BQ717205 
    BC021712 BE674628 CR623945 AI078498 AW173052 T11228 AI631132 BC058853 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF451 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                -           -     -     -                                                     -                 -               
    SP2:                                -           -     -     -                                                     -                                 
    SP3:                                -           -     -     -                                                                                       
    SP4:                                -                                                                                                               
    SP5:                          -     -                                                                                                               


    ECgene alternative splicing isoforms for ZNF451

    Expression
    for ZNF451 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF451 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTTAAGA
    ZNF451 Expression
    About this image

    ZNF451 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZNF451 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485628
        Custom PCR Arrays for ZNF451
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF451

    Orthologs
    for ZNF451 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF451 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp4511 , 5 zinc finger protein 4511, 5 82.87(n)1
    79.77(a)1    		   1 (12.81 cM)5
    984031  NM_133817.21  NP_598578.11 
     337604725 
    chicken
    (Gallus gallus)    		 Aves ZNF4511 zinc finger protein 451 67.08(n)
    59.9(a)    		   421881  XM_004940458.1  XP_004940515.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ZNF4516
    		 zinc finger protein 451
    		 51(a)
    		 1 ↔ 1
    		 1(162892731-162947846)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.35492 Transcribed sequence with weak similarity to protein more 78.15(n)    AL860524.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii znf4511 zinc finger protein 451 50.78(n)
    42.47(a)    		   557758  XM_001923135.3  XP_001923170.1 


    ENSEMBL Gene Tree for ZNF451 (if available)
    TreeFam Gene Tree for ZNF451 (if available)

    Paralogs
    for ZNF451 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF451 gene
    2 SIMAP similar genes for ZNF451 using alignment to 10 protein entries:     ZN451_HUMAN (see all proteins):
    KIAA1586    ZNF844

    ZNF451 for paralogs           About GeneDecksing



    Genomic Variants
    for ZNF451 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ZNF451 (see all 1230)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1462559081,2
    		--56953022(+) ACTGTC/GAGCCA 3 -- us2k10--------
    rs1864975521,2
    		--56953054(+) AATTAC/TGCAGT 3 -- us2k10--------
    rs1908372081,2
    		--56953102(+) AACATA/GGTTCT 3 -- us2k10--------
    rs1823309501,2
    		--56953237(+) TACATC/TCCCCA 3 -- us2k10--------
    rs1393963561,2
    		C--56953329(+) ACAGTA/TACTGA 3 -- us2k10--------
    rs624158791,2
    		C--56953447(+) ACCAGC/TCCACT 3 -- us2k14Minor allele frequency- T:0.08NA WA EA 360
    rs77662341,2
    		C,A--56953543(+) ATGCAC/GGTCTG 3 -- us2k14Minor allele frequency- G:0.12NA WA EA 360
    rs121995731,2
    		C--56953711(+) GGAATC/TTGAGA 3 -- us2k11Minor allele frequency- T:0.50NA 2
    rs797929531,2
    		--56953732(+) TTTGTG/TTTTTT 3 -- us2k10--------
    rs766344601,2
    		C--56953833(+) CTCTCC/GGCCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF451 (56951642 - 57035105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF451:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732127CNV Deletion23290073
    nsv5316CNV Insertion18451855
    nsv462949CNV Loss19166990
    nsv350038CNV Loss16902084

    Human Gene Mutation Database (HGMD): ZNF451
    Site Specific Mutation Identification with PCR Assays
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    Disorders / Diseases
    for ZNF451 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 615708    OMIM disorders: --

    3 diseases for ZNF451:    About MalaCards
    benign paroxysmal positional nystagmus    angelman syndrome    schizophrenia


    ZNF451 for disorders           About GeneDecksing


    Export disorders for ZNF451 gene to outside databases

    Publications
    for ZNF451 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for ZNF451 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ZNF451)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-I^ signaling. (PubMed id 24324267)1 Feng Y....Feng X.H. (J. Biol. Chem. 2014)
    6. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    7. Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. (PubMed id 23718855)1 Waaijers S....Boxem M. (J. Proteome Res. 2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    External Searches for ZNF451 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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    Genome Databases showing ZNF451 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26036 HGNC: 21091 AceView: ZNF451 Ensembl:ENSG00000112200 euGenes: HUgn26036
    ECgene: ZNF451 H-InvDB: ZNF451

    Other Databases showing ZNF451 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1702 KIAA0576

    Specialized Databases showing ZNF451 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZNF451 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF451 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for ZNF451 gene:
    Search GeneIP for patents involving ZNF451

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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