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ZNF451 Gene

protein-coding GIFtS: 52
GCID: GC06P056951

Zinc Finger Protein 451

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Zinc Finger Protein 451¹ ²
COASTER² ³ ⁵
Coactivator For Steroid Receptors² ³
dJ417I1.1²
KIAA0576³
KIAA1702³

External Ids:	HGNC: 21091¹	Entrez Gene: 26036²	Ensembl: ENSG00000112200⁷	OMIM: 615708⁵	UniProtKB: Q9Y4E5³

Export aliases for ZNF451 gene to outside databases

Previous GC identifers: GC06P056957 GC06P057001 GC06P057062 GC06P056788

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF451 Gene:

ZNF451 (zinc finger protein 451) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5

Function: May be involved in transcriptional regulation. Coactivator for steroid receptors

Gene Wiki entry for ZNF451 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11 NT_007592.16 NC_018917.2

Regulatory elements:

Regulatory transcription factor binding sites in the ZNF451 gene promoter:
ATF-2 Lmo2 POU3F2 (N-Oct-5b) CUTL1 E4BP4 GATA-1 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF451 promoter sequence

Search Chromatin IP Primers for ZNF451

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF451

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1 Ensembl cytogenetic band: 6p12.1 HGNC cytogenetic band: 6p12.1

ZNF451 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF451 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P056951: view genomic region (about GC identifiers)

Start:	56,951,642 bp from pter	End:	57,035,105 bp from pter
Size:	83,464 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5 (See protein sequence)

Recommended Name: Zinc finger protein 451

Size: 1061 amino acids; 121484 Da

Sequence caution: Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH42450.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=AAH58853.1; Type=Miscellaneous discrepancy;

Note=Contaminating sequence; Sequence=BAA25502.1; Type=Erroneous initiation; Sequence=BAB21793.1; Type=Erroneous

initiation;

Secondary accessions: Q5VVE9 Q5VVF1 Q86YE4 Q8N380 Q8TD15 Q9C0G1 Q9NQM1

Alternative splicing: 3 isoforms: Q9Y4E5-1 Q9Y4E5-2 Q9Y4E5-4

Explore the universe of human proteins at neXtProt for ZNF451: NX_Q9Y4E5

Explore proteomics data for ZNF451 at MOPED

Post-translational modifications:

Ubiquitination² at Lys106, Lys139, Lys144, Lys153, Lys316, Lys357, Lys387, Lys423, Lys434, Lys452,
Lys454, Lys464, Lys585, Lys706, Lys779, Lys790, Lys817, Lys827, Lys832, Lys845 (see all 21)

Modification sites at PhosphoSitePlus

See ZNF451 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001026794.1 NP_001244202.1 NP_056370.2

ENSEMBL proteins:

ENSP00000424723 ENSP00000427558 ENSP00000359740 ENSP00000350083 ENSP00000359742

ENSP00000359736 ENSP00000476915 ENSP00000421786 ENSP00000421645 ENSP00000359744

ENSP00000424329 ENSP00000425047

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	antibodies-online peptides for ZNF451

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	antibodies-online antibodies for ZNF451 (12 products)

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

2 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9Y4E5

ProtoNet protein and cluster: Q9Y4E5

UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 11 C2H2-type zinc fingers

Find genes that share domains with ZNF451 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN451_HUMAN, Q9Y4E5

Function: May be involved in transcriptional regulation. Coactivator for steroid receptors

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	16189514
GO:0046872	metal ion binding	IEA	--

Find genes that share ontologies with ZNF451 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for ZNF451

miRNA Products:		miRTarBase miRNAs that target ZNF451: hsa-mir-335-5p (MIRT017501), hsa-mir-124-3p (MIRT022431), hsa-let-7e-5p (MIRT051672)

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF451

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ZN451_HUMAN, Q9Y4E5: Nucleus (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	3
cytosol	2
plasma membrane	1

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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ZNF451
Interactions:

Search GeneGlobe Interaction Network for ZNF451

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for ZNF451 (Q9Y4E5^{1, 2, 3} ENSP00000359740⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2I	P63279¹^,³, ENSP00000324897⁴	EBI-747230,EBI-80168 I2D: score=6 STRING: ENSP00000324897
FXR2	P51116²^,³, ENSP00000250113⁴	MINT-67534 I2D: score=5 STRING: ENSP00000250113
RNF40	O75150²^,³, ENSP00000325677⁴	MINT-68396 I2D: score=5 STRING: ENSP00000325677
PRPF40A	O75400²^,³	MINT-61860 I2D: score=3
SNIP1	Q8TAD8²^,³	MINT-62156 I2D: score=3

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ZNF451 (ZN451)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF451 gene (3 alternative transcripts):

NM_001031623.2 NM_001257273.1 NM_015555.2

Unigene Cluster for ZNF451:

Zinc finger protein 451

Hs.485628 [show with all ESTs]

Unigene Representative Sequence: NM_001257273

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000515290 ENST00000510483 ENST00000370706(uc003pdl.3 uc003pdm.1 uc003pdn.1)

ENST00000357489 ENST00000370708(uc011dxn.2 uc003pdo.3) ENST00000370702

ENST00000444273(uc003pdk.1) ENST00000370711 ENST00000508603 ENST00000491832

ENST00000370710 ENST00000502749 ENST00000504603 ENST00000509071 ENST00000510989

ENST00000509251 ENST00000508548 ENST00000504364

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		hsa-miR-4307 hsa-miR-607 hsa-miR-495 hsa-miR-3133 hsa-miR-570 hsa-miR-3908 hsa-miR-889 hsa-miR-630

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Additional mRNA sequence:

AB011148.1 AB051489.1 AK000983.1 AK023072.1 AK027074.1 AK027805.1 AK075174.1 AK096186.1

AK225806.1 AK302577.1 AY055204.1 BC021712.2 BC042450.1 BC058853.1 BC098382.1 BX648081.1

BX648336.1

21 DOTS entries:

DT.446327 DT.95196572 DT.100776855 DT.109953 DT.97775114 DT.92432129 DT.97786078 DT.218270

DT.100637749 DT.121366082 DT.65285369 DT.75127324 DT.121366113 DT.75193084 DT.75195288 DT.92024035

DT.95198742 DT.95313296 DT.121366153 DT.95102529 DT.95229832

Selected AceView cDNA sequences (see all 305):

BP368891 AI621298 BU172465 AW571656 AA846521 AK000983 AI377651 BE502606

AA361558 AI656597 AA732009 AI914234 AA102087 AA343058 AW129544 BQ717205

BC021712 BE674628 CR623945 AI078498 AW173052 T11228 AI631132 BC058853

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF451 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17
SP1:											-				-		-		-																		-						-
SP2:											-				-		-		-																		-
SP3:											-				-		-		-
SP4:											-
SP5:									-		-

ECgene alternative splicing isoforms for ZNF451

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF451 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACTGTTAAGA

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ZNF451 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZNF451 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.485628

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF451

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF451 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp451^{1 , 5}	zinc finger protein 451^{1, 5}	82.87(n)¹ 79.77(a)¹		1 (12.81 cM)⁵ 98403¹ NM_133817.2¹ NP_598578.1¹ 33760472⁵
chicken (Gallus gallus)	Aves	ZNF451¹	zinc finger protein 451	67.08(n) 59.9(a)		421881 XM_004940458.1 XP_004940515.1
lizard (Anolis carolinensis)	Reptilia	ZNF451⁶	zinc finger protein 451	51(a)	1 ↔ 1	1(162892731-162947846)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.3549²	Transcribed sequence with weak similarity to protein more	78.15(n)		AL860524.2
zebrafish (Danio rerio)	Actinopterygii	znf451¹	zinc finger protein 451	50.78(n) 42.47(a)		557758 XM_001923135.3 XP_001923170.1

ENSEMBL Gene Tree for ZNF451 (if available)
TreeFam Gene Tree for ZNF451 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ZNF451 gene

2 SIMAP similar genes for ZNF451 using alignment to 10 protein entries: ZN451_HUMAN (see all proteins):

KIAA1586 ZNF844

Find genes that share paralogs with ZNF451 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146255908^1,2		--	56953022(+)	`ACTGTC/GAGCCA`	3	--	us2k¹		0	--	--	--	--
rs186497552^1,2		--	56953054(+)	`AATTAC/TGCAGT`	3	--	us2k¹		0	--	--	--	--
rs190837208^1,2		--	56953102(+)	`AACATA/GGTTCT`	3	--	us2k¹		0	--	--	--	--
rs182330950^1,2		--	56953237(+)	`TACATC/TCCCCA`	3	--	us2k¹		0	--	--	--	--
rs139396356^1,2	C	--	56953329(+)	`ACAGTA/TACTGA`	3	--	us2k¹		0	--	--	--	--
rs62415879^1,2	C	--	56953447(+)	`ACCAGC/TCCACT`	3	--	us2k¹		4		NA WA EA	360
rs7766234^1,2	C,A	--	56953543(+)	`ATGCAC/GGTCTG`	3	--	us2k¹		4		NA WA EA	360
rs12199573^1,2	C	--	56953711(+)	`GGAATC/TTGAGA`	3	--	us2k¹		1		NA	2
rs79792953^1,2		--	56953732(+)	`TTTGTG/TTTTTT`	3	--	us2k¹		0	--	--	--	--
rs76634460^1,2	C	--	56953833(+)	`CTCTCC/GGCCTC`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF451 (56951642 - 57035105 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for ZNF451: About this table

Variant ID	Type	Subtype	PubMed ID
esv2732127	CNV	Deletion	23290073
nsv5316	CNV	Insertion	18451855
nsv462949	CNV	Loss	19166990
nsv350038	CNV	Loss	16902084

Human Gene Mutation Database (HGMD): ZNF451

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF451

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF451

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615708 OMIM disorders: --

Find genes that share disorders with ZNF451 About GenesLikeMe

Export disorders for ZNF451 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ZNF451 gene, integrated from 10 sources (see all 36):
(articles sorted by number of sources associating them with ZNF451)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2, 3} Nagase T....Ohara O. (DNA Res. 1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2} Nagase T.... Ohara O. (DNA Res. 2000)
Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-I^ signaling. (PubMed id 24324267)¹ Feng Y....Feng X.H. (J. Biol. Chem. 2014)
Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)¹ Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. (PubMed id 23718855)¹ Waaijers S....Boxem M. (J. Proteome Res. 2013)
A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)¹ Weimann M.... Stelzl U. (Nat. Methods 2013)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26036	HGNC: 21091	AceView: ZNF451	Ensembl:ENSG00000112200	euGenes: HUgn26036
ECgene: ZNF451	H-InvDB: ZNF451

(According to HUGE)
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HUGE: KIAA1702 KIAA0576

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZNF451	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF451 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZNF451 gene:
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