Aliases for ZNF451 Gene
Aliases for ZNF451 Gene
External Ids for ZNF451 Gene
- HGNC: 21091
- Entrez Gene: 26036
- Ensembl: ENSG00000112200
- OMIM: 615708
- UniProtKB: Q9Y4E5
Previous GeneCards Identifiers for ZNF451 Gene
- GC06P056957
- GC06P057001
- GC06P056788
- GC06P056951
Summaries for ZNF451 Gene
GeneCards Summary for ZNF451 Gene
ZNF451 (Zinc Finger Protein 451) is a Protein Coding gene. Diseases associated with ZNF451 include Brown-Sequard Syndrome and Carotid Artery Dissection.
UniProtKB/Swiss-Prot for ZNF451 Gene
-
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site Lys-11 (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at Lys-9 (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF451 Gene
Genomics for ZNF451 Gene
Regulatory Elements for ZNF451 Gene
Enhancers for ZNF451 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G057171 | 1.1 | ENCODE | 15.6 | +87.0 | 86966 | 5.0 | HNRNPUL1 PKNOX1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 | KIAA1586 ZNF451 LOC101927211 BAG2 |
| GH06G057045 | 1.4 | ENCODE dbSUPER | 11.4 | -40.4 | -40383 | 1.0 | HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 | BEND6 KIAA1586 ZNF451 LOC101927211 BAG2 ENSG00000272316 GC06M057041 |
| GH06G057181 | 1.1 | ENCODE | 11 | +95.3 | 95262 | 2.0 | HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 | KIAA1586 RAB23 ZNF451 ENSG00000272316 LOC101927211 |
| GH06G057176 | 0.7 | Ensembl ENCODE | 11 | +90.7 | 90745 | 2.2 | PRDM6 HLF ZNF266 | KIAA1586 ZNF451 LOC101927211 RAB23 |
| GH06G056226 | 0.8 | ENCODE | 5.1 | -859.5 | -859532 | 1.5 | ELF3 FOXA2 ATF1 ARID4B RARA ZNF335 ZNF366 CREM CEBPB NFIL3 | COL21A1 ZNF451 GC06M056228 LOC105375100 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ZNF451 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZNF451 gene promoter:
Regulatory Element Products
Genomic Location for ZNF451 Gene
- Chromosome:
- 6
- Start:
- 57,086,844 bp from pter
- End:
- 57,170,307 bp from pter
- Size:
- 83,464 bases
- Orientation:
- Plus strand
Genomic View for ZNF451 Gene
Genes around ZNF451 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.1 by Ensembl
- 6p12.1 by Entrez Gene
- 6p12.1 by HGNC
ZNF451 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF451 Gene
Proteins for ZNF451 Gene
-
Protein details for ZNF451 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4E5-ZN451_HUMAN
- Recommended name:
- E3 SUMO-protein ligase ZNF451
- Protein Accession:
- Q9Y4E5
- Q5VVE9
- Q5VVF1
- Q86YE4
- Q8N380
- Q8TD15
- Q9C0G1
- Q9NQM1
Protein attributes for ZNF451 Gene
- Size:
- 1061 amino acids
- Molecular mass:
- 121484 Da
- Quaternary structure:
-
- Homooligomer. Interacts (via N-terminal region) with SUMO1 (PubMed:18656483). Interacts (via N-terminal region) with SUMO2 (PubMed:18656483, PubMed:26524494). Interacts simultaneously with two SUMO2 chains (PubMed:26524493, PubMed:26524494). Identified in a complex with SUMO2 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule (PubMed:26524493, PubMed:26524494). Interacts (via C-terminus) with ubiquitin (PubMed:18656483). Interacts (via N-terminal zinc-finger domains) with SMAD4 (via MH2 domain). Interacts with SMAD2 and SMAD3. Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4. Interacts with EP300. Inhibits interaction between EP300 and the SMAD4 complex (PubMed:24324267).
- SequenceCaution:
-
- Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH42450.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=AAH58853.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAA25502.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21793.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZNF451 Gene
Post-translational modifications for ZNF451 Gene
- Sumoylated. Predominantly sumoylated on the N-terminal region that is important for interaction with SUMO1 and SUMO2 (PubMed:18656483, PubMed:26524493, PubMed:26524494). Sumoylation is important for localization in nuclear granules; desumoylation leads to diffuse nucleoplasmic location (PubMed:18656483). Autosumoylated (in vitro) (PubMed:26524493, PubMed:26524494). Sumoylation enhances E3 SUMO-protein ligase activity (PubMed:26524494).
- Ubiquitination at posLast=106106, posLast=139139, posLast=144144, isoforms=2153, posLast=316316, posLast=357357, posLast=387387, posLast=423423, isoforms=2434, posLast=452452, isoforms=2464, isoforms=2585, isoforms=2779, posLast=790790, isoforms=2817, isoforms=2827, posLast=832832, posLast=845845, posLast=852852, isoforms=286, posLast=356356, and isoforms=522
- Modification sites at PhosphoSitePlus
Other Protein References for ZNF451 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZNF451
- Novus Biologicals Antibodies for ZNF451
-
Abcam antibodies for ZNF451
- antibodies-online Antibodies for ZNF451: See all 21
- Search GeneTex for Antibodies for ZNF451
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF451
Protein Products
-
OriGene Purified Proteins for ZNF451
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF451
- Origene Custom Protein Services for ZNF451
- Search GeneTex for Proteins for ZNF451
No data available for DME Specific Peptides for ZNF451 Gene
Domains & Families for ZNF451 Gene
Gene Families for ZNF451 Gene
Protein Domains for ZNF451 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF451 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y4E5UniProtKB/Swiss-Prot:
ZN451_HUMAN :- Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
- Belongs to the krueppel C2H2-type zinc-finger protein family.
- Domain:
-
- Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF451 Gene
Molecular function for ZNF451 Gene
- UniProtKB/Swiss-Prot Function:
- E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site Lys-11 (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at Lys-9 (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).
Enzyme Numbers (IUBMB) for ZNF451 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001106 | RNA polymerase II transcription corepressor activity | IMP | 24324267 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0016874 | ligase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF451 Gene
- MGI mutant phenotypes for ZNF451:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZNF451:
Animal Models for ZNF451 Gene
- MGI Knock Outs for ZNF451:
-
- Zfp451 tm1b(EUCOMM)Hmgu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF451
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF451 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF451 gene
- Search ViGene Biosciences for ZNF451
CRISPR Products
-
OriGene CRISPR knockouts for ZNF451
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF451
- GenScript: Design CRISPR guide RNA sequences for ZNF451
miRNA for ZNF451 Gene
- miRTarBase miRNAs that target ZNF451
-
- hsa-mir-335-5p (MIRT017501)
- hsa-mir-124-3p (MIRT022431)
- hsa-let-7e-5p (MIRT051672)
- hsa-mir-4452 (MIRT445859)
- hsa-mir-183-3p (MIRT445860)
- hsa-mir-526b-5p (MIRT445861)
- hsa-mir-624-3p (MIRT445862)
- hsa-mir-4790-3p (MIRT449664)
- hsa-mir-548ax (MIRT449665)
- hsa-mir-5582-3p (MIRT449666)
- hsa-mir-548ao-5p (MIRT449667)
- hsa-mir-548f-3p (MIRT449668)
- hsa-mir-548e-3p (MIRT449669)
- hsa-mir-548az-3p (MIRT449670)
- hsa-mir-548ar-3p (MIRT449671)
- hsa-mir-548a-3p (MIRT449672)
- hsa-mir-6516-5p (MIRT463120)
- hsa-mir-455-3p (MIRT463121)
- hsa-mir-7641 (MIRT463122)
- hsa-mir-650 (MIRT463123)
- hsa-mir-3612 (MIRT463124)
- hsa-mir-4327 (MIRT463125)
- hsa-mir-6499-3p (MIRT463126)
- hsa-mir-4695-3p (MIRT463127)
- hsa-mir-1827 (MIRT463128)
- hsa-mir-4537 (MIRT463129)
- hsa-mir-1247-3p (MIRT463130)
- hsa-mir-6511a-5p (MIRT463131)
- hsa-mir-1910-3p (MIRT463132)
- hsa-mir-1273e (MIRT463133)
- hsa-mir-6799-5p (MIRT463134)
- hsa-mir-6851-5p (MIRT463135)
- hsa-mir-3689d (MIRT463136)
- hsa-mir-6134 (MIRT463137)
- hsa-mir-4524a-3p (MIRT463138)
- hsa-mir-219b-3p (MIRT463139)
- hsa-mir-4329 (MIRT463140)
- hsa-mir-6865-5p (MIRT463141)
- hsa-mir-6815-5p (MIRT463142)
- hsa-mir-302f (MIRT463143)
- hsa-mir-4666a-5p (MIRT505036)
- hsa-mir-203a-3p (MIRT505037)
- hsa-mir-4277 (MIRT532882)
- hsa-mir-9-3p (MIRT532883)
- hsa-mir-584-3p (MIRT532884)
- hsa-mir-3622b-3p (MIRT532885)
- hsa-mir-3622a-3p (MIRT532886)
- hsa-mir-6854-5p (MIRT532887)
- hsa-mir-4429 (MIRT532888)
- hsa-mir-320d (MIRT532889)
- hsa-mir-320c (MIRT532890)
- hsa-mir-320b (MIRT532891)
- hsa-mir-320a (MIRT532892)
- hsa-mir-4465 (MIRT532893)
- hsa-mir-26b-5p (MIRT532894)
- hsa-mir-26a-5p (MIRT532895)
- hsa-mir-1297 (MIRT532896)
- hsa-mir-4756-3p (MIRT532897)
- hsa-mir-5697 (MIRT532898)
- hsa-mir-5692a (MIRT532899)
- hsa-mir-6830-5p (MIRT532900)
- hsa-mir-4293 (MIRT532901)
- hsa-mir-4423-3p (MIRT671728)
- hsa-mir-6787-5p (MIRT671729)
- hsa-mir-663a (MIRT671730)
- hsa-mir-1908-5p (MIRT671731)
- hsa-mir-566 (MIRT671732)
- hsa-mir-4767 (MIRT671733)
- hsa-mir-6720-3p (MIRT671734)
- hsa-mir-3188 (MIRT671735)
- hsa-mir-20b-3p (MIRT671736)
- hsa-mir-3664-3p (MIRT671737)
- hsa-mir-6499-5p (MIRT671738)
- hsa-mir-4433a-3p (MIRT671739)
- hsa-mir-4459 (MIRT671740)
- hsa-mir-4768-3p (MIRT671741)
- hsa-mir-5690 (MIRT671742)
- hsa-mir-2114-5p (MIRT671743)
- hsa-mir-5588-3p (MIRT671744)
- hsa-mir-449c-5p (MIRT671745)
- hsa-mir-34b-5p (MIRT671746)
- hsa-mir-2682-5p (MIRT671747)
- hsa-mir-940 (MIRT671748)
- hsa-mir-6893-5p (MIRT671749)
- hsa-mir-6808-5p (MIRT671750)
- hsa-mir-4695-5p (MIRT671751)
- hsa-mir-510-5p (MIRT671752)
- hsa-mir-512-5p (MIRT671753)
- hsa-mir-6513-5p (MIRT674717)
- hsa-mir-887-5p (MIRT674718)
- hsa-mir-6780a-5p (MIRT674719)
- hsa-mir-6779-5p (MIRT674720)
- hsa-mir-3689c (MIRT674721)
- hsa-mir-3689b-3p (MIRT674722)
- hsa-mir-3689a-3p (MIRT674723)
- hsa-mir-30b-3p (MIRT674724)
- hsa-mir-1273h-5p (MIRT674725)
- hsa-mir-6788-5p (MIRT674726)
- hsa-mir-30c-2-3p (MIRT674727)
- hsa-mir-30c-1-3p (MIRT674728)
- hsa-mir-7977 (MIRT674729)
- hsa-mir-6802-5p (MIRT674730)
- hsa-mir-6883-5p (MIRT674731)
- hsa-mir-6785-5p (MIRT674732)
- hsa-mir-4728-5p (MIRT674733)
- hsa-mir-149-3p (MIRT674734)
- hsa-mir-7106-5p (MIRT674735)
- hsa-mir-383-3p (MIRT674736)
- hsa-mir-3913-5p (MIRT676862)
- hsa-mir-3122 (MIRT676863)
- hsa-mir-450a-1-3p (MIRT676864)
- hsa-mir-4474-3p (MIRT676865)
- hsa-mir-24-3p (MIRT676866)
- hsa-mir-4284 (MIRT676867)
- hsa-mir-4318 (MIRT676868)
- hsa-mir-5195-3p (MIRT686199)
- hsa-mir-145-5p (MIRT686200)
- hsa-mir-770-5p (MIRT686201)
- hsa-mir-4712-5p (MIRT686202)
- hsa-mir-1285-5p (MIRT686203)
- hsa-mir-101-5p (MIRT686204)
- hsa-mir-513c-3p (MIRT686205)
- hsa-mir-513a-3p (MIRT686206)
- hsa-mir-3606-3p (MIRT686207)
- hsa-mir-6500-3p (MIRT697348)
- hsa-mir-3614-5p (MIRT697349)
miRNA Products
- Search ViGene Biosciences for ZNF451
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ZNF451
- Browse OriGene Inhibitory RNA Products For ZNF451
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF451 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZNF451
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF451
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ZNF451
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNF451 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF451 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF451 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF451 Gene
Localization for ZNF451 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF451 Gene
- Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. {ECO:0000269 PubMed:18656483}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 24324267 |
| GO:0005654 | nucleoplasm | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016605 | PML body | IEA | -- |
Pathways & Interactions for ZNF451 Gene
No Data Available
UniProtKB/Swiss-Prot Q9Y4E5-ZN451_HUMAN
- Pathway: Protein modification; protein sumoylation.
Interacting Proteins for ZNF451 Gene
Selected Interacting proteins:
Q9Y4E5-ZN451_HUMAN
ENSP00000359740
for ZNF451 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0016925 | protein sumoylation | IEA | -- |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IMP | 24324267 |
| GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter | IMP | 24324267 |
No data available for Pathways by source and SIGNOR curated interactions for ZNF451 Gene
Transcripts for ZNF451 Gene
mRNA/cDNA for ZNF451 Gene
- (8) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (305) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF451 Gene
- Zinc finger protein 451:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZNF451
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF451
- GenScript: Design CRISPR guide RNA sequences for ZNF451
miRNA Products
- Search ViGene Biosciences for ZNF451
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ZNF451
- Browse OriGene Inhibitory RNA Products For ZNF451
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF451 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZNF451
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF451
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for ZNF451 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Cerebrospinal fluid (67.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF451 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF451 Gene:
ZNF451SOURCE GeneReport for Unigene cluster for ZNF451 Gene:
Hs.485628Evidence on tissue expression from TISSUES for ZNF451 Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for ZNF451
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF451 Gene
Orthologs for ZNF451 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF451 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNF451 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNF451 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp451 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zfp451 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF451 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | ZNF451 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ZNF451 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | znf451 34 |
|
||
| Str.3549 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | znf451 34 35 |
|
- Species where no ortholog for ZNF451 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZNF451 Gene
(2) SIMAP similar genes for ZNF451 Gene using alignment to 10 proteins:
No data available for Paralogs for ZNF451 Gene
Variants for ZNF451 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021965 | -- | 57,115,510(+) | TCCTC(A/G)ATATG | intron-variant, nc-transcript-variant | |
| rs1000038052 | -- | 57,124,258(+) | AGGAT(C/T)ATGTG | intron-variant | |
| rs1000040591 | -- | 57,152,201(+) | TTTTT(-/G)CCTTT | intron-variant | |
| rs1000058192 | -- | 57,167,371(+) | ATTAG(C/T)TACTG | intron-variant | |
| rs1000122505 | -- | 57,149,720(+) | TCATG(A/G)CATGT | intron-variant |
Residual Variation Intolerance Score:
11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.56;
30.14% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ZNF451 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF451 Gene
Disorders for ZNF451 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| brown-sequard syndrome |
|
|
| carotid artery dissection |
|
|
| benign paroxysmal positional nystagmus |
|
|
| peroneal neuropathy |
|
|
Search ZNF451 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ZNF451
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ZNF451
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF451 Gene
Publications for ZNF451 Gene
- A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly. (PMID: 26524493) Eisenhardt N. … Pichler A. (Nat. Struct. Mol. Biol. 2015) 2 3 4 64
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
- Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase. (PMID: 26524494) Cappadocia L. … Lima C.D. (Nat. Struct. Mol. Biol. 2015) 3 4 64
- Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-I^ signaling. (PMID: 24324267) Feng Y. … Feng X.H. (J. Biol. Chem. 2014) 3 4 64
- ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. (PMID: 18656483) Karvonen U. … Palvimo J.J. (J. Mol. Biol. 2008) 3 4 64
Products for ZNF451 Gene
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- Custom Antibody ServicesOriGene Antibodies for ZNF451
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- ViGene Biosciences adenoviral particle packaged cDNA for ZNF451 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for ZNF451
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- Santa Cruz Biotechnology (SCBT) CRISPR for ZNF451
- Horizon Cell Lines for ZNF451
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- VectorBuilder custom plasmid, inducible vectors for ZNF451
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ZNF451 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (50) eBioscience
- (51) Atlas
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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- (77) Proteopedia
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- (100) COMPARTMENTS
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