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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF451 Gene

protein-coding   GIFtS: 50
GCID: GC06P056951

zinc finger protein 451

 Explore 4 diseases affiliated with
ZNF451 via our new
 Human Malady Compendium 
Biological research products
for ZNF451
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 4511 2
COASTER1 2 3
DJ417I1.11
KIAA05761 3
KIAA17021 3
Coactivator For Steroid Receptors2 3

External Ids:    HGNC: 210911   Entrez Gene: 260362   Ensembl: ENSG000001122007   UniProtKB: Q9Y4E53   

Export aliases for ZNF451 gene to outside databases

Previous GC identifers: GC06P056957 GC06P057001 GC06P057062 GC06P056788


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5
Function: May be involved in transcriptional regulation. Coactivator for steroid receptors

Gene Wiki entry for ZNF451


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF451 gene promoter:
         ATF-2   Lmo2   POU3F2 (N-Oct-5b)   CUTL1   E4BP4   GATA-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF451 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF451

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF451


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.1

ZNF451 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF451 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P056951:  view genomic region     (about GC identifiers)

Start:
56,951,642 bp from pter      End:
57,035,105 bp from pter
Size:
83,464 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5 (See protein sequence)
Recommended Name: Zinc finger protein 451  
Size: 1061 amino acids; 121484 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH42450.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=AAH58853.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence; Sequence=BAA25502.1; Type=Erroneous initiation; Sequence=BAB21793.1; Type=Erroneous
initiation;
Secondary accessions: Q5VVE9 Q5VVF1 Q86YE4 Q8N380 Q8TD15 Q9C0G1 Q9NQM1
Alternative splicing: 3 isoforms:  Q9Y4E5-1   Q9Y4E5-2   Q9Y4E5-4   

Explore the universe of human proteins at neXtProt for ZNF451: NX_Q9Y4E5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y4E5

  • ZNF451 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001026794.1  NP_001244202.1  NP_056370.2  

    ENSEMBL proteins: 
     ENSP00000424723   ENSP00000427558   ENSP00000359740   ENSP00000350083   ENSP00000359742  
     ENSP00000359736   ENSP00000421786   ENSP00000421645   ENSP00000359744   ENSP00000424329  
     ENSP00000425047  

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    Uscn Proteins for ZNF451

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    ZNF451 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF451 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y4E5

    ProtoNet protein and cluster: Q9Y4E5

    UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN451_HUMAN, Q9Y4E5
    Function: May be involved in transcriptional regulation. Coactivator for steroid receptors

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF451 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF451

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/23 Interacting proteins for ZNF451 (Q9Y4E52, 3 ENSP000003597404) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FXR2P511162, 3, ENSP000002501134MINT-67534 I2D: score=5 STRING: ENSP00000250113
    RNF40O751502, 3, ENSP000003256774MINT-68396 I2D: score=5 STRING: ENSP00000325677
    PRPF40AO754002, 3MINT-61860 I2D: score=3 
    SNIP1Q8TAD82, 3MINT-62156 I2D: score=3 
    CALCOCO2Q131372, 3, ENSP000002589474MINT-67025 I2D: score=5 STRING: ENSP00000258947
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF451 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF451
    Search CenterWatch for drugs/clinical trials and news about ZNF451 / ZN451 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF451 gene (3 alternative transcripts): 
    NM_001031623.2  NM_001257273.1  NM_015555.2  

    Unigene Cluster for ZNF451:

    Zinc finger protein 451
    Hs.485628  [show with all ESTs]
    Unigene Representative Sequence: NM_001257273
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000515290 ENST00000510483 ENST00000370706(uc003pdl.3 uc003pdm.1 uc003pdn.1)
    ENST00000357489 ENST00000370708(uc011dxn.2 uc003pdo.3) ENST00000370702
    ENST00000444273(uc003pdk.1) ENST00000370711 ENST00000508603 ENST00000491832
    ENST00000370710 ENST00000502749 ENST00000504603 ENST00000477046 ENST00000509071
    ENST00000510989 ENST00000509251 ENST00000508548

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    hsa-miR-4307 hsa-miR-607 hsa-miR-495 hsa-miR-3133 hsa-miR-570 hsa-miR-3908 hsa-miR-889 hsa-miR-630
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB011148.1 AB051489.1 AK000983.1 AK023072.1 AK027074.1 AK027805.1 AK075174.1 AK096186.1 
    AK225806.1 AK302577.1 AY055204.1 BC021712.2 BC042450.1 BC058853.1 BC098382.1 BX648081.1 
    BX648336.1 

    21 DOTS entries:

    DT.446327  DT.95196572  DT.100776855  DT.109953  DT.97775114  DT.92432129  DT.97786078  DT.218270 
    DT.100637749  DT.121366082  DT.65285369  DT.75127324  DT.121366113  DT.75193084  DT.75195288  DT.92024035 
    DT.95198742  DT.95313296  DT.121366153  DT.95102529  DT.95229832 

    24/305 AceView cDNA sequences (see all 305):

    AI918048 AA102087 AW965554 BM930986 BF223462 W68279 AW571656 BP371539 
    AA429027 AY055204 AI377651 AA343058 AA199828 AA846521 BE502606 BE674416 
    AA456098 BE501732 AK000983 BM929463 AW665980 AI868226 BP368891 BQ719151 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF451 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                -           -     -     -                                                     -                 -               
    SP2:                                -           -     -     -                                                     -                                 
    SP3:                                -           -     -     -                                                                                       
    SP4:                                -                                                                                                               
    SP5:                          -     -                                                                                                               


    ECgene alternative splicing isoforms for ZNF451

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF451 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGTTAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ZNF451 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZNF451 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF451

    SOURCE GeneReport for Unigene cluster: Hs.485628
        SABiosciences Custom PCR Arrays for ZNF451
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF451

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF451 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp4511 , 5 zinc finger protein 4511, 5 82.87(n)1
    79.77(a)1
      1 (12.81 cM)5
    984031  NM_133817.21  NP_598578.11 
     337604725 
    chicken
    (Gallus gallus)
    Aves ZNF4511 zinc finger protein 451 66.92(n)
    59.52(a)
      421881  XM_419898.3  XP_419898.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF4516
    --
    52(a)
    1 ↔ 1
    1(162900020-162943253)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.35492 Transcribed sequence with weak similarity to protein more 78.15(n)    AL860524.2 
    zebrafish
    (Danio rerio)
    Actinopterygii znf4511 zinc finger protein 451 50.54(n)
    41.98(a)
      557758  XM_001923135.2  XP_001923170.1 


    ENSEMBL Gene Tree for ZNF451 (if available)
    TreeFam Gene Tree for ZNF451 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/992 NCBI SNPs in ZNF451 are shown (see all 992    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462559081,2
    --56953022(+) ACTGTC/GAGCCA 3 -- us2k10--------
    rs1864975521,2
    --56953054(+) AATTAC/TGCAGT 3 -- us2k10--------
    rs1908372081,2
    --56953102(+) AACATA/GGTTCT 3 -- us2k10--------
    rs1823309501,2
    --56953237(+) TACATC/TCCCCA 3 -- us2k10--------
    rs1393963561,2
    --56953329(+) ACAGTA/TACTGA 3 -- us2k10--------
    rs624158791,2
    C,--56953447(+) ACCAGC/TCCACT 3 -- us2k14Minor allele frequency- T:0.08NA WA EA 360
    rs77662341,2
    C,A,--56953543(+) ATGCAC/GGTCTG 3 -- us2k14Minor allele frequency- G:0.12NA WA EA 360
    rs121995731,2
    C--56953711(+) GGAATC/TTGAGA 3 -- us2k11Minor allele frequency- T:0.50NA 2
    rs797929531,2
    --56953732(+) TTTGTG/TTTTTT 3 -- us2k10--------
    rs766344601,2
    C,--56953833(+) CTCTCC/GGCCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF451 (56951642 - 57035105 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF451
         1 CNV: 6495
    Human Gene Mutation Database (HGMD): ZNF451

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF451
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF451

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF451 for disorders           About GeneDecksing

    4 diseases for ZNF451:    About MalaCards
    benign paroxysmal positional nystagmus    nystagmus    angelman syndrome    schizophrenia


    Export disorders for ZNF451 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF451 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with ZNF451)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26036 HGNC: 21091 AceView: ZNF451 Ensembl:ENSG00000112200 euGenes: HUgn26036
    ECgene: ZNF451 H-InvDB: ZNF451

    (According to HUGE)
    About This Section
    HUGE: KIAA1702 KIAA0576

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF451 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF451 gene:
    Search GeneIP for patents involving ZNF451

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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