Aliases for ZNF451 Gene
External Ids for ZNF451 Gene
Previous GeneCards Identifiers for ZNF451 Gene
GeneCards Summary for ZNF451 Gene
UniProtKB/Swiss-Prot for ZNF451 Gene
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site Lys-11 (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at Lys-9 (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).