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Aliases for ZNF45 Gene

Aliases for ZNF45 Gene

  • Zinc Finger Protein 45 2 3
  • Zinc Finger Protein 13 2 3 4
  • ZNF13 3 4 6
  • KOX5 3 4 6
  • Zinc Finger Protein 45 (A Kruppel-Associated Box (KRAB) Domain Polypeptide) 2 3
  • Zinc Finger Protein KOX5 3 4
  • BRC1744 3 4

External Ids for ZNF45 Gene

Previous Symbols for ZNF45 Gene

  • ZNF13

Summaries for ZNF45 Gene

GeneCards Summary for ZNF45 Gene

ZNF45 (Zinc Finger Protein 45) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF155.

UniProtKB/Swiss-Prot for ZNF45 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF45 Gene

Genomics for ZNF45 Gene

Genomic Location for ZNF45 Gene

Start:
43,912,624 bp from pter
End:
43,935,278 bp from pter
Size:
22,655 bases
Orientation:
Minus strand

Genomic View for ZNF45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF45 Gene

No data available for Regulatory Elements for ZNF45 Gene

Proteins for ZNF45 Gene

  • Protein details for ZNF45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02386-ZNF45_HUMAN
    Recommended name:
    Zinc finger protein 45
    Protein Accession:
    Q02386
    Secondary Accessions:
    • P17016
    • P78472
    • Q9P1U9

    Protein attributes for ZNF45 Gene

    Size:
    682 amino acids
    Molecular mass:
    78242 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF45 Gene

Proteomics data for ZNF45 Gene at MOPED

Post-translational modifications for ZNF45 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys117, Lys358, and Lys361

Other Protein References for ZNF45 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF45 Gene

Domains for ZNF45 Gene

Gene Families for ZNF45 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZNF45_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q02386
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q02386
Similarity:
  • Contains 18 C2H2-type zinc fingers.:
    • Q02386
genes like me logo Genes that share domains with ZNF45: view

Function for ZNF45 Gene

Molecular function for ZNF45 Gene

GENATLAS Biochemistry: zinc finger 45 with a Kruppel associated box A (KRAB) domain containing,widely expressed,involved in transcription repression
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF45: view

Phenotypes for ZNF45 Gene

GenomeRNAi human phenotypes for ZNF45:
genes like me logo Genes that share phenotypes with ZNF45: view

miRNA for ZNF45 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF45 Gene

Localization for ZNF45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF45 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF45 Gene COMPARTMENTS Subcellular localization image for ZNF45 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZNF45: view

Pathways for ZNF45 Gene

SuperPathways for ZNF45 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF45: view

Pathways by source for ZNF45 Gene

2 Reactome pathways for ZNF45 Gene

Gene Ontology (GO) - Biological Process for ZNF45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007275 multicellular organismal development TAS 1559709
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with ZNF45: view

Transcripts for ZNF45 Gene

Unigene Clusters for ZNF45 Gene

Zinc finger protein 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5:

Relevant External Links for ZNF45 Gene

GeneLoc Exon Structure for
ZNF45
ECgene alternative splicing isoforms for
ZNF45

Expression for ZNF45 Gene

mRNA expression in normal human tissues for ZNF45 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF45 Gene

SOURCE GeneReport for Unigene cluster for ZNF45 Gene Hs.381285

genes like me logo Genes that share expressions with ZNF45: view

Orthologs for ZNF45 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF45 36
  • 99.41 (n)
  • 98.97 (a)
ZNF45 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF45 36
  • 85.03 (n)
  • 84.09 (a)
ZNF45 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF45 36
  • 87.09 (n)
  • 85.57 (a)
ZNF45 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp94 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102548695 36
  • 77.28 (n)
  • 72.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS02740.8 38
  • 38 (a)
rgr 38
  • 37 (a)
Species with no ortholog for ZNF45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF45 Gene

ENSEMBL:
Gene Tree for ZNF45 (if available)
TreeFam:
Gene Tree for ZNF45 (if available)

Paralogs for ZNF45 Gene

Selected SIMAP similar genes for ZNF45 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF45 Gene

genes like me logo Genes that share paralogs with ZNF45: view

Variants for ZNF45 Gene

Sequence variations from dbSNP and Humsavar for ZNF45 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs365769 -- 43,934,947(+) GAAGC(G/T)ACAGA utr-variant-5-prime
rs366431 -- 43,933,786(+) TTAAG(A/G)AAATT intron-variant
rs367741 -- 43,925,028(-) TCCCA(A/G)TAACA intron-variant
rs368316 -- 43,927,742(+) AAGAA(A/C)ATAGA intron-variant
rs368492 -- 43,931,395(-) ACCAC(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF45 Gene

Variant ID Type Subtype PubMed ID
nsv912108 CNV Loss 21882294
nsv469650 CNV Gain 16826518
nsv510476 CNV Loss 20534489

Relevant External Links for ZNF45 Gene

HapMap Linkage Disequilibrium report
ZNF45
Human Gene Mutation Database (HGMD)
ZNF45

Disorders for ZNF45 Gene

Relevant External Links for ZNF45

Genetic Association Database (GAD)
ZNF45
Human Genome Epidemiology (HuGE) Navigator
ZNF45
genes like me logo Genes that share disorders with ZNF45: view

No data available for UniProtKB/Swiss-Prot for ZNF45 Gene

Publications for ZNF45 Gene

  1. Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene. (PMID: 9067431) Constantinou-Deltas C.D. … Lee J.E. (Cytogenet. Cell Genet. 1996) 2 3 4
  2. The identification and characterization of KRAB-domain-containing zinc finger proteins. (PMID: 1559709) Constantinou-Deltas C.D. … Lee J.E. (Genomics 1992) 3 4
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4
  4. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PMID: 19195718) Bonetti A. … Tienari P.J. (J. Neuroimmunol. 2009) 3 49
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4

Products for ZNF45 Gene

Sources for ZNF45 Gene

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