ZNF45 Gene
protein-coding GIFtS: 54
GCID: GC19M044416
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zinc finger protein 45(Previous names: zinc finger protein 45 (a Kruppel-associated box (KRAB)...)
(Previous symbol: ZNF13)
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Aliases
for ZNF45 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 451 2 | | Zinc Finger Protein 45 (A Kruppel-Associated Box (KRAB) Domain Polypeptide)1 2 | | ZNF131 2 3 5 | | Zinc Finger Protein KOX52 3 | | Zinc Finger Protein 131 2 3 | | BRC17442 3 | | KOX52 3 5 | | |
Export aliases for ZNF45 gene to outside databasesPrevious GC identifers: GC19M045062 GC19M044808 GC19M049092 GC19M049108 GC19M040849 |
Summaries
for ZNF45 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF45_HUMAN, Q02386Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF45 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF45
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF45
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF45 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.2ZNF45 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M044416: view genomic region
(about GC identifiers)
Start:
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44,416,776 bp from pter |
End:
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44,439,430 bp from pter |
Size:
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22,655 bases |
Orientation:
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minus strand |
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Proteins
for ZNF45 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF45_HUMAN, Q02386 (See
protein sequence)Recommended Name: Zinc finger protein 45 Size: 682 amino acids; 78242 Da
Subcellular location: Nucleus
Secondary accessions: P17016 P78472 Q9P1U9Explore the universe of human proteins at neXtProt for ZNF45: NX_Q02386
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q02386
ZNF45 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003416.1
ENSEMBL proteins: ENSP00000269973 ENSP00000468579 ENSP00000467551 Reactome Protein details: Q02386
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- |
ZNF45 for ontologies About GeneDecksing
ZNF45 Antibody Products:
Assay Products for ZNF45: |
Protein
Domains /
Families
for ZNF45 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF45 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q02386ProtoNet protein and cluster: Q02386 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF45_HUMAN, Q02386Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 18 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF45 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF45_HUMAN, Q02386Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF45:zinc finger 45 with a Kruppel associated box A (KRAB) domain containing,widely expressed,involved in transcriptionrepression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF45
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF45 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF45 (NM_003425) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF45 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF45 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF45 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF45 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF45:
|
Pathways & Interactions
for ZNF45 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF45
ZNF45 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF45
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for ZNF45 (Q023863 ENSP000002699734) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
ZNF45 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF45 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF45
Search CenterWatch for drugs/clinical trials and news about ZNF45
|
Transcripts
for ZNF45 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF45 gene: NM_003425.3 Unigene Cluster for ZNF45: Zinc finger protein 45 Hs.381285 [show with all ESTs]Unigene Representative Sequence: NM_0034255 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269973(uc002oxu.2 uc002oxw.2) ENST00000589703 ENST00000588140
ENST00000588432 ENST00000590655
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF45
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF45 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF45 (NM_003425) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF45 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF45 |
Additional cDNA sequence: AF024703.1 AK127739.1 BC037575.1 L75847.1 M67509.1 X52336.1 4 DOTS entries: DT.207324 DT.91708718 DT.121468741 DT.121468740 24/43 AceView cDNA sequences (see all 43): BM463964 AA932811 AI650772 BQ945699 AI967981 AI970418 AW206282 BC037575 M67509 BU656064 AA890648 AI735265 CA428818 AI693119 AK127739 L75847 BU729431 NM_003425 AW590226 BM703520 AA205152 AI808528 AW138229 AL703326
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF45 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
|---|
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| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF45
|
Expression
for ZNF45 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTTCTGAA
About this image
See ZNF45 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF45
SOURCE GeneReport for Unigene cluster: Hs.381285
SABiosciences Custom PCR Arrays for ZNF45
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF45
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF45 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF45 |
Orthologs
for ZNF45 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF45 (if available)
TreeFam Gene Tree for ZNF45 (if available) |
Paralogs
for ZNF45 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF45 gene
- ZNF2292 ZNF2232 ZNF2302 ENSG000000623702 ZNF1552 ZNF6642 ZNF2272 ZNF2342
- ZNF2392 ZNF2242 ZNF2252 ZNF2262 ZNF2142 ZNF2222 ZNF2842 ENSG000002671732
- ZNF2352 ZNF2212 ZNF2852 ENSG000002670222 ZNF2332
18/425 SIMAP similar genes for ZNF45 using alignment to 2 protein entries: ZNF45_HUMAN (see all proteins)
(see all similar genes):ZNF ZNF232 ZSCAN16 ZNF852 ZNF436 ZNF664
DKFZp762K012 HZF36 ZFS-1 ZNF43 ZNF774 ZNF829
DKFZp666M039 ZNF234 ZNF35 DKFZp686N14223 HZF41 ZFP2
ZNF45 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF45
PGOHUM00000260139
|
Genomic Variants
for ZNF45 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF45 (44416776 - 44439430 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF45
1 CNV: 2245 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF45 |
|
Disorders
/ Diseases
for ZNF45 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF45 for disorders About GeneDecksing
OMIM gene information: 194554
OMIM disorders: --
1  disease for ZNF45: About MalaCardsmultiple sclerosis
Human Genome Epidemiology (HuGE) Navigator: ZNF45 (1 document)
Export disorders for ZNF45 gene to outside databases
|
Publications
for ZNF45 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF45 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZNF45) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene. (PubMed id 9067431)1, 2, 3 Constantinou-Deltas C.D.... Lee J.E. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The identification and characterization of KRAB-domain-containing zinc finger proteins. (PubMed id 1559709)1, 2 Constantinou-Deltas C.D.... Lee J.E. (1992)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
- A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PubMed id 19195718)1 Bonetti A....Tienari P.J. (2009)
- Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. (PubMed id 17082780)1 Zada A.A....Behre G. (2006)
|
External Searches for ZNF45 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF45 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF45 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF45 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF45 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF45 gene:
Search GeneIP for patents involving ZNF45
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF45 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF45 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF45 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF45 | | | OriGene Protein Over-expression Lysate for ZNF45 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF45 | | OriGene 3'-UTR Clone for ZNF45 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF45 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF45 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF45 |
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