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ZNF45 Gene

protein-coding   GIFtS: 58
GCID: GC19M044416

Zinc Finger Protein 45

(Previous names: zinc finger protein 45 (a Kruppel-associated box (KRAB)...)
(Previous symbol: ZNF13)
  Search for ZNF45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 451 2     Zinc Finger Protein 45 (A Kruppel-Associated Box (KRAB) Domain
Polypeptide)1 2
ZNF131 2 3 5     Zinc Finger Protein KOX52 3
Zinc Finger Protein 131 2 3     BRC17442 3
KOX52 3 5     

External Ids:    HGNC: 131111   Entrez Gene: 75962   Ensembl: ENSG000001244597   OMIM: 1945545   UniProtKB: Q023863   

Export aliases for ZNF45 gene to outside databases

Previous GC identifers: GC19M045062 GC19M044808 GC19M049092 GC19M049108 GC19M040849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF45 Gene:
ZNF45 (zinc finger protein 45) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZNF45_HUMAN, Q02386
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF45
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF45 promoter sequence
   Search Chromatin IP Primers for ZNF45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

ZNF45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF45 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044416:  view genomic region     (about GC identifiers)

Start:
44,416,776 bp from pter      End:
44,439,430 bp from pter
Size:
22,655 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNF45_HUMAN, Q02386 (See protein sequence)
Recommended Name: Zinc finger protein 45  
Size: 682 amino acids; 78242 Da
Secondary accessions: P17016 P78472 Q9P1U9

Explore the universe of human proteins at neXtProt for ZNF45: NX_Q02386

Explore proteomics data for ZNF45 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys117, Lys358, Lys361
  • Modification sites at PhosphoSitePlus

  • See ZNF45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003416.1  
    ENSEMBL proteins: 
     ENSP00000269973   ENSP00000468579   ENSP00000467551  
    Reactome Protein details: Q02386

    ZNF45 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q02386

    ProtoNet protein and cluster: Q02386

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF45_HUMAN, Q02386
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF45           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF45_HUMAN, Q02386
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF45:
    zinc finger 45 with a Kruppel associated box A (KRAB) domain containing,widely expressed,involved in transcription
    repression

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF45           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF45:
     Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF45
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    miRTarBase miRNAs that target ZNF45:
    hsa-mir-27b-3p (MIRT046226), hsa-mir-29c-3p (MIRT020361), hsa-mir-192-5p (MIRT026769), hsa-mir-215-5p (MIRT024670)

    Block miRNA regulation of human, mouse, rat ZNF45 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidZNF45 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF45_HUMAN, Q02386: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with ZNF45           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF45 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF45           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF45
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF45
    Interactions:

        Search GeneGlobe Interaction Network for ZNF45

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF45 (Q023863 ENSP000002699734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEBPAP497153I2D: score=1 
    ZNF347Q96SE73I2D: score=1 
    TRIM28ENSP000002530244STRING: ENSP00000253024
    CPEB1ENSP000004141874STRING: ENSP00000414187
    CBX5ENSP000002098754STRING: ENSP00000209875
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007275multicellular organismal development TAS1559709
    GO:0010467gene expression TAS--

    Find genes that share ontologies with ZNF45           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF45



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF45 gene: 
    NM_003425.3  

    Unigene Cluster for ZNF45:

    Zinc finger protein 45
    Hs.381285  [show with all ESTs]
    Unigene Representative Sequence: NM_003425
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269973(uc002oxu.2 uc002oxw.2) ENST00000589703 ENST00000588140
    ENST00000588432 ENST00000590655
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ZNF45:
    hsa-miR-217 hsa-miR-942 hsa-miR-298 hsa-miR-3065-3p hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidZNF45 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF45
      QuantiFast Probe-based Assays in human, mouse, rat ZNF45

    Additional mRNA sequence: 

    AF024703.1 AK127739.1 BC037575.1 L75847.1 M67509.1 X52336.1 

    4 DOTS entries:

    DT.207324  DT.91708718  DT.121468741  DT.121468740 

    Selected AceView cDNA sequences (see all 43):

    AI650772 AA932811 BM463964 AW590226 BQ945699 AI735265 BU656064 AK127739 
    AW138229 NM_003425 AI808528 CD656193 AA205152 AA890648 M67509 AW206282 
    L75847 BC037575 AI635658 CA428818 BX643219 AI967981 AI970418 AL703326 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF45    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                                -     -                             -           -                                 
    SP2:              -                 -     -                                                                           
    SP3:              -                                                                                                   
    SP4:                                                                                -                                 
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ZNF45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTCTGAA
    ZNF45 Expression
    About this image

    ZNF45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF45 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381285
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ZNF45 (if available)
    TreeFam Gene Tree for ZNF45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF45 gene
    ZNF2292  ZNF2232  ZNF2302  ZNF1552  ZNF2272  ZNF2242  ZNF2342  ZNF2252  
    ZNF2262  ZNF2142  ZNF2222  ZNF2842  ENSG000002671732  ZNF2352  ZNF2212  ZNF2852  
    ENSG000002670222  ZNF1122  ZNF2332  
    Selected SIMAP similar genes for ZNF45 using alignment to 2 protein entries:     ZNF45_HUMAN (see all proteins) (see all similar genes):
    ZNF    ZNF232    ZNF852    ZSCAN16    ZKSCAN7    ZNF436
    ZNF664    DKFZp762K012    HZF36    ZFS-1    ZNF43    ZNF774
    ZNF829    DKFZp666M039    ZNF234    ZNF35    DKFZp686N14223    HZF41

    Find genes that share paralogs with ZNF45           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF45
    PGOHUM00000260139


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF45 (see all 549)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs590861541,2
    C--44416436(+) GGGGTA/CCTAGA 1 -- ds50012Minor allele frequency- C:0.22WA EA 122
    rs772345901,2
    C,F--44416478(+) TTCACA/GTAACA 1 -- ds50011Minor allele frequency- G:0.07EA 120
    rs621146491,2
    C,F--44416567(+) TATGAT/CTTTCA 1 -- ds50019Minor allele frequency- C:0.26NA WA CSA EA 369
    rs612800171,2
    C--44416593(+) TTGAA-/GAATTTTT 1 -- ds50010--------
    rs1833209961,2
    --44416937(+) CTGTTA/GACATA 1 -- ut310--------
    rs413228451,2
    C,F,H--44417055(-) TCATAT/CGGCCT 1 -- ut3113Minor allele frequency- C:0.01NS EA NA 1542
    rs1381995561,2
    C--44417096(+) ATTCT-/TCTGAGT 1 -- ut310--------
    rs1397929051,2
    C--44417139(+) AAAATA/GTCAAA 1 -- ut310--------
    rs118833111,2
    C,F,H--44417146(+) CAAATA/GTTACT 1 -- ut317Minor allele frequency- G:0.02NS EA NA CSA WA 514
    rs1496647031,2
    C--44417199(+) TACAAC/TGTATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF45 (44416776 - 44439430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF45:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510476CNV Loss20534489
    nsv912108CNV Loss21882294
    nsv469650CNV Gain16826518

    Human Gene Mutation Database (HGMD): ZNF45
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF45
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF45

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194554    OMIM disorders: --


    Find genes that share disorders with ZNF45           About GenesLikeMe

    Genetic Association Database (GAD): ZNF45
    Human Genome Epidemiology (HuGE) Navigator: ZNF45 (1 document)

    Export disorders for ZNF45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF45 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene. (PubMed id 9067431)1, 2, 3 Constantinou-Deltas C.D.... Lee J.E. (Cytogenet. Cell Genet. 1996)
    2. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PubMed id 19195718)1, 4 Bonetti A....Tienari P.J. (J. Neuroimmunol. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. The identification and characterization of KRAB-domain-containing zinc finger proteins. (PubMed id 1559709)1, 2 Constantinou-Deltas C.D.... Lee J.E. (Genomics 1992)
    6. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    10. Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. (PubMed id 17082780)1 Zada A.A....Behre G. (Leukemia 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7596 HGNC: 13111 AceView: ZNF45 Ensembl:ENSG00000124459 euGenes: HUgn7596
    ECgene: ZNF45 H-InvDB: ZNF45

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF45 gene:
    Search GeneIP for patents involving ZNF45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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