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Aliases for ZNF45 Gene

Aliases for ZNF45 Gene

  • Zinc Finger Protein 45 2 3 5
  • Zinc Finger Protein 13 2 3 4
  • Zinc Finger Protein 45 (A Kruppel-Associated Box (KRAB) Domain Polypeptide) 2 3
  • Zinc Finger Protein KOX5 3 4
  • BRC1744 3 4
  • ZNF13 3 4
  • KOX5 3 4

External Ids for ZNF45 Gene

Previous HGNC Symbols for ZNF45 Gene

  • ZNF13

Previous GeneCards Identifiers for ZNF45 Gene

  • GC19M045062
  • GC19M044808
  • GC19M049092
  • GC19M049108
  • GC19M044416
  • GC19M040849

Summaries for ZNF45 Gene

GeneCards Summary for ZNF45 Gene

ZNF45 (Zinc Finger Protein 45) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot for ZNF45 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF45 Gene

Genomics for ZNF45 Gene

Regulatory Elements for ZNF45 Gene

Promoters for ZNF45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF45 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF45 Gene

Chromosome:
19
Start:
43,912,624 bp from pter
End:
43,935,280 bp from pter
Size:
22,657 bases
Orientation:
Minus strand

Genomic View for ZNF45 Gene

Genes around ZNF45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF45 Gene

Proteins for ZNF45 Gene

  • Protein details for ZNF45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02386-ZNF45_HUMAN
    Recommended name:
    Zinc finger protein 45
    Protein Accession:
    Q02386
    Secondary Accessions:
    • P17016
    • P78472
    • Q9P1U9

    Protein attributes for ZNF45 Gene

    Size:
    682 amino acids
    Molecular mass:
    78242 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF45 Gene

Proteomics data for ZNF45 Gene at MOPED

Post-translational modifications for ZNF45 Gene

  • Ubiquitination at Lys 117
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF45 Gene

No data available for DME Specific Peptides for ZNF45 Gene

Domains & Families for ZNF45 Gene

Gene Families for ZNF45 Gene

Protein Domains for ZNF45 Gene

Suggested Antigen Peptide Sequences for ZNF45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02386

UniProtKB/Swiss-Prot:

ZNF45_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF45: view

Function for ZNF45 Gene

Molecular function for ZNF45 Gene

GENATLAS Biochemistry:
zinc finger 45 with a Kruppel associated box A (KRAB) domain containing,widely expressed,involved in transcription repression
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF45: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF45 Gene

Localization for ZNF45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF45 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF45 Gene COMPARTMENTS Subcellular localization image for ZNF45 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZNF45: view

Pathways & Interactions for ZNF45 Gene

SuperPathways for ZNF45 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF45: view

Pathways by source for ZNF45 Gene

2 Reactome pathways for ZNF45 Gene

Gene Ontology (GO) - Biological Process for ZNF45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with ZNF45: view

No data available for SIGNOR curated interactions for ZNF45 Gene

Drugs & Compounds for ZNF45 Gene

No Compound Related Data Available

Transcripts for ZNF45 Gene

Unigene Clusters for ZNF45 Gene

Zinc finger protein 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5:

Relevant External Links for ZNF45 Gene

GeneLoc Exon Structure for
ZNF45
ECgene alternative splicing isoforms for
ZNF45

Expression for ZNF45 Gene

mRNA expression in normal human tissues for ZNF45 Gene

Protein differential expression in normal tissues from HIPED for ZNF45 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF45 Gene



SOURCE GeneReport for Unigene cluster for ZNF45 Gene Hs.381285

genes like me logo Genes that share expression patterns with ZNF45: view

Protein tissue co-expression partners for ZNF45 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF45 Gene

Orthologs for ZNF45 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF45 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF45 35
  • 85.03 (n)
  • 84.09 (a)
ZNF45 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF45 35
  • 87.09 (n)
  • 85.57 (a)
ZNF45 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF45 35
  • 99.41 (n)
  • 98.97 (a)
ZNF45 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102548695 35
  • 77.28 (n)
  • 72.66 (a)
mouse
(Mus musculus)
Mammalia Zfp94 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS02740.8 37
  • 38 (a)
rgr 37
  • 37 (a)
Species with no ortholog for ZNF45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF45 Gene

ENSEMBL:
Gene Tree for ZNF45 (if available)
TreeFam:
Gene Tree for ZNF45 (if available)

Paralogs for ZNF45 Gene

(429) SIMAP similar genes for ZNF45 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF45 Gene

genes like me logo Genes that share paralogs with ZNF45: view

Variants for ZNF45 Gene

Sequence variations from dbSNP and Humsavar for ZNF45 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_012019 -
VAR_012020 -
VAR_012021 -
VAR_012022 -
VAR_012023 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF45 Gene

Variant ID Type Subtype PubMed ID
nsv912108 CNV Loss 21882294
nsv469650 CNV Gain 16826518
nsv510476 CNV Loss 20534489

Variation tolerance for ZNF45 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.59; 95.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF45 Gene

HapMap Linkage Disequilibrium report
ZNF45
Human Gene Mutation Database (HGMD)
ZNF45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF45 Gene

Disorders for ZNF45 Gene

Relevant External Links for ZNF45

Genetic Association Database (GAD)
ZNF45
Human Genome Epidemiology (HuGE) Navigator
ZNF45
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF45

No disorders were found for ZNF45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF45 Gene

Publications for ZNF45 Gene

  1. Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene. (PMID: 9067431) Constantinou-Deltas C.D. … Lee J.E. (Cytogenet. Cell Genet. 1996) 2 3 4 67
  2. The correlation between reading and mathematics ability at age twelve has a substantial genetic component. (PMID: 25003214) Davis O.S. … Spencer C.C. (Nat Commun 2014) 3
  3. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3
  4. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PMID: 19195718) Bonetti A. … Tienari P.J. (J. Neuroimmunol. 2009) 3
  5. Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. (PMID: 17082780) Zada A.A. … Behre G. (Leukemia 2006) 3

Products for ZNF45 Gene

Sources for ZNF45 Gene

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