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Aliases for ZNF449 Gene

Aliases for ZNF449 Gene

  • Zinc Finger Protein 449 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 19 3 4
  • ZSCAN19 3 4

External Ids for ZNF449 Gene

Previous GeneCards Identifiers for ZNF449 Gene

  • GC00U911638
  • GC0XP134204
  • GC0XP134306
  • GC0XP134478
  • GC0XP123837

Summaries for ZNF449 Gene

Entrez Gene Summary for ZNF449 Gene

  • This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]

GeneCards Summary for ZNF449 Gene

ZNF449 (Zinc Finger Protein 449) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN25.

UniProtKB/Swiss-Prot for ZNF449 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF449 Gene

Genomics for ZNF449 Gene

Regulatory Elements for ZNF449 Gene

Enhancers for ZNF449 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG134999 1 Ensembl ENCODE 10.3 -344.3 -344314 2.1 ELK4 CTCF ZNF654 CEBPB REST CEBPG RAD21 GATA3 GLIS1 CEBPA RTL8B ZNF449 LOC728470 SMIM10
GH0XG135351 0.3 FANTOM5 2 +6.9 6922 0.0 CT45A6 ZNF449 PIR39715
GH0XG135347 0.7 Ensembl ENCODE 0.7 +2.6 2567 0.6 ZBTB2 CEBPB ID3 ZNF449 PIR39715
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF449 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF449 Gene

Chromosome:
X
Start:
135,344,757 bp from pter
End:
135,363,413 bp from pter
Size:
18,657 bases
Orientation:
Plus strand

Genomic View for ZNF449 Gene

Genes around ZNF449 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF449 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF449 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF449 Gene

Proteins for ZNF449 Gene

  • Protein details for ZNF449 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9G9-ZN449_HUMAN
    Recommended name:
    Zinc finger protein 449
    Protein Accession:
    Q6P9G9
    Secondary Accessions:
    • Q5JRZ7
    • Q5JRZ8
    • Q6NZX2
    • Q8N3Q1
    • Q8TED7

    Protein attributes for ZNF449 Gene

    Size:
    518 amino acids
    Molecular mass:
    59932 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF449 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF449 Gene

Post-translational modifications for ZNF449 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF449 Gene

No data available for DME Specific Peptides for ZNF449 Gene

Domains & Families for ZNF449 Gene

Gene Families for ZNF449 Gene

Suggested Antigen Peptide Sequences for ZNF449 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P9G9

UniProtKB/Swiss-Prot:

ZN449_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF449: view

Function for ZNF449 Gene

Molecular function for ZNF449 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF449: view
genes like me logo Genes that share phenotypes with ZNF449: view

Animal Models for ZNF449 Gene

MGI Knock Outs for ZNF449:

Animal Model Products

CRISPR Products

miRNA for ZNF449 Gene

miRTarBase miRNAs that target ZNF449

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF449 Gene

Localization for ZNF449 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF449 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF449 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF449: view

Pathways & Interactions for ZNF449 Gene

SuperPathways for ZNF449 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF449: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF449 Gene

Drugs & Compounds for ZNF449 Gene

No Compound Related Data Available

Transcripts for ZNF449 Gene

Unigene Clusters for ZNF449 Gene

Zinc finger protein 449:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF449 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: -

Relevant External Links for ZNF449 Gene

GeneLoc Exon Structure for
ZNF449
ECgene alternative splicing isoforms for
ZNF449

Expression for ZNF449 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF449 Gene

Protein differential expression in normal tissues from HIPED for ZNF449 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF449 Gene



Protein tissue co-expression partners for ZNF449 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF449 Gene:

ZNF449

SOURCE GeneReport for Unigene cluster for ZNF449 Gene:

Hs.28780
genes like me logo Genes that share expression patterns with ZNF449: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF449 Gene

Orthologs for ZNF449 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF449 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF449 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia ZNF449 34 35
  • 91.44 (n)
rat
(Rattus norvegicus)
Mammalia Zfp449 34
  • 89.25 (n)
dog
(Canis familiaris)
Mammalia ZNF449 34 35
  • 89.19 (n)
mouse
(Mus musculus)
Mammalia Zfp449 34 16 35
  • 88.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF449 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF449 Gene

ENSEMBL:
Gene Tree for ZNF449 (if available)
TreeFam:
Gene Tree for ZNF449 (if available)

Paralogs for ZNF449 Gene

Paralogs for ZNF449 Gene

(468) SIMAP similar genes for ZNF449 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF449 Gene

genes like me logo Genes that share paralogs with ZNF449: view

Variants for ZNF449 Gene

Sequence variations from dbSNP and Humsavar for ZNF449 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000067138 -- 135,356,472(+) ATTTT(C/T)ATAGA intron-variant
rs1000125013 -- 135,345,515(+) GACAA(A/G)CAATA intron-variant, upstream-variant-2KB
rs1001105754 -- 135,347,916(+) TTTAC(C/T)ATTTG intron-variant, utr-variant-5-prime
rs1001304964 -- 135,344,850(+) CGAGC(G/T)GCCAG intron-variant, upstream-variant-2KB
rs1001437664 -- 135,355,207(+) TTTTT(G/T)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF449 Gene

Variant ID Type Subtype PubMed ID
esv2758894 CNV gain 17122850
nsv469871 CNV loss 16826518
nsv528014 CNV gain 19592680

Variation tolerance for ZNF449 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF449 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF449

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF449 Gene

Disorders for ZNF449 Gene

Relevant External Links for ZNF449

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF449

No disorders were found for ZNF449 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF449 Gene

Publications for ZNF449 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF449 Gene

Sources for ZNF449 Gene

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