ZNF449 Gene
protein-coding GIFtS: 44
GCID: GC0XP134478
|
|
zinc finger protein 449
| |
Aliases
for ZNF449 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4491 2 | | ZSCAN191 2 3 5 | | Zinc Finger And SCAN Domain-Containing Protein 192 3 | | FLJ236141 |
Export aliases for ZNF449 gene to outside databasesPrevious GC identifers: GC00U911638 GC0XP134204 GC0XP134306 GC0XP123837 |
Summaries
for ZNF449 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF449:
This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminalSCAN domain, and seven C2H2-type zinc finger motifs. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: ZN449_HUMAN, Q6P9G9Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF449 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF449 gene promoter:
AhR STAT1 Nkx2-2 STAT1beta Arnt STAT1alpha Gfi-1 HEN1 AREB6 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF449
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF449 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3ZNF449 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP134478: view genomic region
(about GC identifiers)
Start:
|
134,478,696 bp from pter |
End:
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134,497,338 bp from pter |
Size:
|
18,643 bases |
Orientation:
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plus strand |
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Proteins
for ZNF449 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN449_HUMAN, Q6P9G9 (See
protein sequence)Recommended Name: Zinc finger protein 449 Size: 518 amino acids; 59932 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5JRZ7 Q5JRZ8 Q6NZX2 Q8N3Q1 Q8TED7Alternative splicing: 3 isoforms: Q6P9G9-1 Q6P9G9-2 Q6P9G9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF449: NX_Q6P9G9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P9G9
ZNF449 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689908.3
ENSEMBL proteins: ENSP00000359797 ENSP00000339585 ENSP00000359796
Human Recombinant Protein Products for ZNF449:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF449 for ontologies About GeneDecksing
ZNF449 Antibody Products:
Assay Products for ZNF449: |
Protein
Domains /
Families
for ZNF449 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF449 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P9G9ProtoNet protein and cluster: Q6P9G9 1 Blocks protein family: IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZN449_HUMAN, Q6P9G9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingersSimilarity: Contains 1 SCAN box domain |
Function
for ZNF449 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN449_HUMAN, Q6P9G9Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF449 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF449 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF449
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF449 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF449 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF449 |
|
Pathways & Interactions
for ZNF449 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF449
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZNF449 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF449 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF449
Search CenterWatch for drugs/clinical trials and news about ZNF449 / ZN449
|
Transcripts
for ZNF449 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF449 gene: NM_152695.5 Unigene Cluster for ZNF449: Zinc finger protein 449 Hs.28780 [show with all ESTs]Unigene Representative Sequence: NM_1526953 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370761(uc004eyr.4) ENST00000339249(uc004eyq.1 uc004eys.3 uc004eyt.3 uc004eyu.3)
ENST00000370760
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF449 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF449
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF449 (NM_152695) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF449 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF449 |
Additional cDNA sequence: AK002078.1 AK314344.1 AL832169.1 AL833109.1 AL833407.1 AY280801.1 AY927530.1 AY927531.1 AY927532.1 BC060768.1 9 DOTS entries: DT.105213 DT.100764958 DT.101977558 DT.97798026 DT.101980776 DT.100669291 DT.121313690 DT.100776955 DT.100804210 24/55 AceView cDNA sequences (see all 55): AL832169 BX499720 BC060768 BP381609 BC065938 AK074194 AU138172 BX537604 AI381234 CB856466 BX095255 AL833407 AY280801 AI263612 CD557359 AL833109 BF576391 NM_152695 BE042720 AK002078 AW084686 AI888786 AV727702 BF195744
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF449 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
|---|
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| SP1: | | | - | | | | | | - | | - | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF449
|
Expression
for ZNF449 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF449 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCAGGCTC
About this image
See ZNF449 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF449
SOURCE GeneReport for Unigene cluster: Hs.28780
SABiosciences Custom PCR Arrays for ZNF449
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF449
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF449 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF449 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF449 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF449 |
Orthologs
for ZNF449 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF449 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZNF449 (if available)
TreeFam Gene Tree for ZNF449 (if available) |
Paralogs
for ZNF449 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF449 gene
- ZNF4962 ZNF4462 ZSCAN92 ZKSCAN12 ZNF3972 ZNF5002 ZNF2132 ZSCAN302
- ZNF2322 ZNF2022 ZNF2632 ZKSCAN42 ZNF1742 ZSCAN252 ZNF3962 ZSCAN122
- ZNF3942 ZSCAN212 ZSCAN232 ZNF1652 ZSCAN162 ZKSCAN82 ZSCAN312 ZSCAN222
- ZKSCAN32 ZNF242 ZNF182
18/470 SIMAP similar genes for ZNF449 using alignment to 2 protein entries: ZN449_HUMAN (see all proteins)
(see all similar genes):SCAND1 LOC100128510 ZNF818P kr-znf3 ZIK1 ZNF485
ZNF70 ZNF78L1 ZNF12 ZNF211 ZNF239 ZNF251
ZNF454 ZNF782 ZNF214 ZNF420 ZNF461 ZNF510
ZNF449 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF449
PGOHUM00000241555 PGOHUM00000242028
|
Genomic Variants
for ZNF449 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF449 (134478696 - 134497338 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF449
2 CNVs: 2280 4173
Locus Specific Mutation Databases (LSDB): ZNF449
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF449 |
|
Disorders
/ Diseases
for ZNF449 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF449 for disorders About MalaCards
ZNF449 for disorders About GeneDecksing
OMIM gene information: 300627
OMIM disorders: --
Export disorders for ZNF449 gene to outside databases
|
Publications
for ZNF449 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF449 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF449) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Identification and characterization of the human SCAN domain zinc-finger gene ZNF449. (PubMed id 16636917)1 Luo K....Yu L. (2006)
- Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807)1 Cheng J....Gingeras T.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ZNF449 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF449 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF449 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF449 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF449 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF449 gene:
Search GeneIP for patents involving ZNF449
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF449 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF449 |
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