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Aliases for ZNF449 Gene

Aliases for ZNF449 Gene

  • Zinc Finger Protein 449 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 19 3 4
  • ZSCAN19 3 4

External Ids for ZNF449 Gene

Previous GeneCards Identifiers for ZNF449 Gene

  • GC00U911638
  • GC0XP134204
  • GC0XP134306
  • GC0XP134478
  • GC0XP123837

Summaries for ZNF449 Gene

Entrez Gene Summary for ZNF449 Gene

  • This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]

GeneCards Summary for ZNF449 Gene

ZNF449 (Zinc Finger Protein 449) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SCAND1.

UniProtKB/Swiss-Prot for ZNF449 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF449 Gene

Genomics for ZNF449 Gene

Regulatory Elements for ZNF449 Gene

Enhancers for ZNF449 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF449 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF449 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF449 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF449 Gene

135,344,757 bp from pter
135,363,413 bp from pter
18,657 bases
Plus strand

Genomic View for ZNF449 Gene

Genes around ZNF449 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF449 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF449 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF449 Gene

Proteins for ZNF449 Gene

  • Protein details for ZNF449 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 449
    Protein Accession:
    Secondary Accessions:
    • Q5JRZ7
    • Q5JRZ8
    • Q6NZX2
    • Q8N3Q1
    • Q8TED7

    Protein attributes for ZNF449 Gene

    518 amino acids
    Molecular mass:
    59932 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF449 Gene


neXtProt entry for ZNF449 Gene

Proteomics data for ZNF449 Gene at MOPED

Post-translational modifications for ZNF449 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF449 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF449 Gene

Domains & Families for ZNF449 Gene

Gene Families for ZNF449 Gene

Suggested Antigen Peptide Sequences for ZNF449 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF449: view

Function for ZNF449 Gene

Molecular function for ZNF449 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF449: view
genes like me logo Genes that share phenotypes with ZNF449: view

Animal Models for ZNF449 Gene

MGI Knock Outs for ZNF449:

Animal Model Products

CRISPR Products

miRNA for ZNF449 Gene

miRTarBase miRNAs that target ZNF449

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF449 Gene

Localization for ZNF449 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF449 Gene

Subcellular locations from

Jensen Localization Image for ZNF449 Gene COMPARTMENTS Subcellular localization image for ZNF449 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF449 Gene

Pathways & Interactions for ZNF449 Gene

SuperPathways for ZNF449 Gene

No Data Available

Interacting Proteins for ZNF449 Gene

Gene Ontology (GO) - Biological Process for ZNF449 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF449 Gene

Drugs & Compounds for ZNF449 Gene

No Compound Related Data Available

Transcripts for ZNF449 Gene

Unigene Clusters for ZNF449 Gene

Zinc finger protein 449:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF449 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP4: -
SP6: -

Relevant External Links for ZNF449 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF449 Gene

mRNA expression in normal human tissues for ZNF449 Gene

Protein differential expression in normal tissues from HIPED for ZNF449 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF449 Gene

SOURCE GeneReport for Unigene cluster for ZNF449 Gene Hs.28780

genes like me logo Genes that share expression patterns with ZNF449: view

Protein tissue co-expression partners for ZNF449 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF449 Gene

Orthologs for ZNF449 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF449 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF449 35
  • 91.44 (n)
  • 91.7 (a)
ZNF449 36
  • 92 (a)
(Canis familiaris)
Mammalia ZNF449 35
  • 89.19 (n)
  • 91.31 (a)
ZNF449 36
  • 91 (a)
(Mus musculus)
Mammalia Zfp449 35
  • 88.55 (n)
  • 90.15 (a)
Zfp449 16
Zfp449 36
  • 90 (a)
(Pan troglodytes)
Mammalia ZNF449 35
  • 99.74 (n)
  • 99.61 (a)
ZNF449 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp449 35
  • 89.25 (n)
  • 90.35 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
-- 36
  • 34 (a)
-- 36
  • 40 (a)
-- 36
  • 30 (a)
-- 36
  • 37 (a)
-- 36
  • 36 (a)
Species with no ortholog for ZNF449:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF449 Gene

Gene Tree for ZNF449 (if available)
Gene Tree for ZNF449 (if available)

Paralogs for ZNF449 Gene

Paralogs for ZNF449 Gene

(468) SIMAP similar genes for ZNF449 Gene using alignment to 2 proteins: Pseudogenes for ZNF449 Gene

genes like me logo Genes that share paralogs with ZNF449: view

Variants for ZNF449 Gene

Sequence variations from dbSNP and Humsavar for ZNF449 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1046642 -- 135,363,139(+) ATGTA(C/T)GTGCT utr-variant-3-prime
rs2286479 -- 135,349,226(-) ACTGG(A/G)GCCTC reference, synonymous-codon
rs2531372 -- 135,359,460(+) ATTCA(A/G)AAGAC intron-variant
rs2883328 -- 135,354,739(-) TTATG(C/T)ACAGC intron-variant
rs3834998 -- 135,346,795(-) TCAAA(-/A)GTTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF449 Gene

Variant ID Type Subtype PubMed ID
dgv2476e1 CNV Complex 17122850
nsv469871 CNV Loss 16826518
nsv528014 CNV Gain 19592680

Variation tolerance for ZNF449 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF449 Gene

Disorders for ZNF449 Gene

Relevant External Links for ZNF449

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF449 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF449 Gene

Publications for ZNF449 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. (PMID: 25546433) Okada K. … Saito T. (PLoS ONE 2014) 3
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3

Products for ZNF449 Gene

Sources for ZNF449 Gene