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Aliases for ZNF449 Gene

Aliases for ZNF449 Gene

  • Zinc Finger Protein 449 2 3
  • ZSCAN19 3 4 6
  • Zinc Finger And SCAN Domain-Containing Protein 19 3 4

External Ids for ZNF449 Gene

Previous GeneCards Identifiers for ZNF449 Gene

  • GC00U911638
  • GC0XP134204
  • GC0XP134306
  • GC0XP134478
  • GC0XP123837

Summaries for ZNF449 Gene

Entrez Gene Summary for ZNF449 Gene

  • This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]

GeneCards Summary for ZNF449 Gene

ZNF449 (Zinc Finger Protein 449) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SCAND1.

UniProtKB/Swiss-Prot for ZNF449 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF449 Gene

Genomics for ZNF449 Gene

Regulatory Elements for ZNF449 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF449 Gene

Start:
135,344,771 bp from pter
End:
135,363,413 bp from pter
Size:
18,643 bases
Orientation:
Plus strand

Genomic View for ZNF449 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF449 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF449 Gene

Proteins for ZNF449 Gene

  • Protein details for ZNF449 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9G9-ZN449_HUMAN
    Recommended name:
    Zinc finger protein 449
    Protein Accession:
    Q6P9G9
    Secondary Accessions:
    • Q5JRZ7
    • Q5JRZ8
    • Q6NZX2
    • Q8N3Q1
    • Q8TED7

    Protein attributes for ZNF449 Gene

    Size:
    518 amino acids
    Molecular mass:
    59932 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF449 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF449 Gene

Proteomics data for ZNF449 Gene at MOPED

Post-translational modifications for ZNF449 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF449 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF449 Gene

Domains for ZNF449 Gene

Gene Families for ZNF449 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF449 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P9G9

UniProtKB/Swiss-Prot:

ZN449_HUMAN :
  • Q6P9G9
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF449: view

Function for ZNF449 Gene

Molecular function for ZNF449 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF449: view

Animal Model Products

CRISPR Products

miRNA for ZNF449 Gene

miRTarBase miRNAs that target ZNF449

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF449

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF449 Gene

Localization for ZNF449 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF449 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF449 Gene COMPARTMENTS Subcellular localization image for ZNF449 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF449: view

Pathways for ZNF449 Gene

SuperPathways for ZNF449 Gene

No Data Available

Interacting Proteins for ZNF449 Gene

Gene Ontology (GO) - Biological Process for ZNF449 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF449: view

No data available for Pathways by source for ZNF449 Gene

Transcripts for ZNF449 Gene

Unigene Clusters for ZNF449 Gene

Zinc finger protein 449:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF449

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF449 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: -

Relevant External Links for ZNF449 Gene

GeneLoc Exon Structure for
ZNF449
ECgene alternative splicing isoforms for
ZNF449

Expression for ZNF449 Gene

mRNA expression in normal human tissues for ZNF449 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF449 Gene

SOURCE GeneReport for Unigene cluster for ZNF449 Gene Hs.28780

genes like me logo Genes that share expressions with ZNF449: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF449 Gene

Orthologs for ZNF449 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF449 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF449 35
  • 99.74 (n)
  • 99.61 (a)
ZNF449 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF449 35
  • 91.44 (n)
  • 91.7 (a)
ZNF449 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF449 35
  • 89.19 (n)
  • 91.31 (a)
ZNF449 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp449 35
  • 88.55 (n)
  • 90.15 (a)
Zfp449 16
Zfp449 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp449 35
  • 89.25 (n)
  • 90.35 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for ZNF449:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF449 Gene

ENSEMBL:
Gene Tree for ZNF449 (if available)
TreeFam:
Gene Tree for ZNF449 (if available)

Paralogs for ZNF449 Gene

Paralogs for ZNF449 Gene

Selected SIMAP similar genes for ZNF449 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF449 Gene

genes like me logo Genes that share paralogs with ZNF449: view

Variants for ZNF449 Gene

Sequence variations from dbSNP and Humsavar for ZNF449 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1046642 -- 135,363,139(+) ATGTA(C/T)GTGCT utr-variant-3-prime
rs2286479 -- 135,349,226(-) ACTGG(A/G)GCCTC reference, synonymous-codon
rs2531372 -- 135,359,460(+) ATTCA(A/G)AAGAC intron-variant, upstream-variant-2KB
rs2883328 -- 135,354,739(-) TTATG(C/T)ACAGC intron-variant
rs3834998 -- 135,346,795(-) TCAAA(-/A)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF449 Gene

Variant ID Type Subtype PubMed ID
dgv2476e1 CNV Complex 17122850
nsv469871 CNV Loss 16826518
nsv528014 CNV Gain 19592680

Relevant External Links for ZNF449 Gene

HapMap Linkage Disequilibrium report
ZNF449
Locus Specific Mutation Databases (LSDB)
ZNF449

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF449 Gene

Disorders for ZNF449 Gene

No disorders were found for ZNF449 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF449 Gene

Publications for ZNF449 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PMID: 15790807) Cheng J. … Gingeras T.R. (Science 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF449 Gene

Sources for ZNF449 Gene

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