ZNF446 Gene
protein-coding GIFtS: 50
GCID: GC19P059192
|
|
zinc finger protein 446
| |
Aliases
for ZNF446 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4461 2 | | ZKSCAN201 2 3 | | ZSCAN521 2 | | Zinc Finger Protein With KRAB And SCAN Domains 202 3 | | FLJ206261 | | ZSCAN302 |
Export aliases for ZNF446 gene to outside databasesPrevious GC identifers: GC00U911635 GC19P063680 GC19P059044 GC19P059050 GC19P055296 GC19P059067 GC19P059082 GC19P059099 GC19P059136 |
Summaries
for ZNF446 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF446 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF446 gene promoter:
NF-1 NF-1/L AP-1 Bach2 ATF-2 STAT5A c-Jun E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF446
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF446 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF446 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P059192: view genomic region
(about GC identifiers)
Start:
|
58,987,795 bp from pter |
End:
|
58,992,597 bp from pter |
Size:
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4,803 bases |
Orientation:
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plus strand |
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Proteins
for ZNF446 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9 (See
protein sequence)Recommended Name: Zinc finger protein 446 Size: 450 amino acids; 48957 Da
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZNF446: NX_Q9NWS9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWS9
ZNF446 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060378.1
ENSEMBL proteins: ENSP00000336565 ENSP00000375576 Reactome Protein details: Q9NWS9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF446 for ontologies About GeneDecksing
ZNF446 Antibody Products:
Assay Products for ZNF446: |
Protein
Domains /
Families
for ZNF446 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF446 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9NWS9ProtoNet protein and cluster: Q9NWS9 2 Blocks protein families: IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 3 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Function
for ZNF446 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF446 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF446
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF446 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF446 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF446 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF446 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF446:
|
Pathways & Interactions
for ZNF446 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF446
ZNF446 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF446
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/17 Interacting proteins for ZNF446 (Q9NWS93 ENSP000003365654) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZNF446 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF446 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF446
Search CenterWatch for drugs/clinical trials and news about ZNF446 / ZN446
|
Transcripts
for ZNF446 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF446 gene: NM_017908.2 Unigene Cluster for ZNF446: Zinc finger protein 446 Hs.710284 [show with all ESTs]Unigene Representative Sequence: AK0553592 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335841(uc002qsz.3 uc002qta.3) ENST00000391694(uc010eur.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF446 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF446
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF446 (NM_017908) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF446 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF446 |
Additional cDNA sequence: AK000633.1 AK026153.1 AK055359.1 AK310384.1 AL122108.1 AL833955.1 AY279351.1 AY280800.1 BC017206.2 8 DOTS entries: DT.95155673 DT.100779523 DT.97839687 DT.91980096 DT.100779525 DT.102840965 DT.121457189 DT.75172544 24/60 AceView cDNA sequences (see all 60): BU151642 BF724990 BQ441187 AW070519 CB131805 BP375489 BF194745 BG819435 CA422428 BE743568 BU527229 AL122108 AW249600 AK026153 BI160944 AI436448 AW902283 AW198009 NM_017908 BG748470 BM016815 AW246135 CB049975 AA335574
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF446 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF446
|
Expression
for ZNF446 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF446 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGGGCTG
About this image
See ZNF446 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF446
SOURCE GeneReport for Unigene cluster: Hs.710284
SABiosciences Custom PCR Arrays for ZNF446
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF446
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF446 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF446 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF446 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF446 |
Orthologs
for ZNF446 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF446 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZNF446 (if available)
TreeFam Gene Tree for ZNF446 (if available) |
Paralogs
for ZNF446 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF446 gene
- ZNF4962 ZNF4492 ZSCAN92 ZKSCAN12 ZNF3972 ZNF5002 ZNF2132 ZSCAN302
- ZNF2322 ZNF2632 ZNF2022 ZKSCAN42 ZNF1742 ZSCAN252 ZNF3962 ZSCAN122
- ZNF3942 ZSCAN212 ZSCAN232 ZNF1652 ZSCAN162 ZKSCAN82 ZSCAN312 ZSCAN222
- ZKSCAN32 ZNF242 ZNF182
12 SIMAP similar genes for ZNF446 using alignment to 4 protein entries: ZN446_HUMAN (see all proteins):DKFZp434L2027 DKFZp434K202 ZNF397 LOC100128510 SCAND1 MZF1
ZNF697 ZSCAN18 ZNF18 ZNF434 ZNF78L1 ZNF844
ZNF446 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF446
PGOHUM00000234457
|
Genomic Variants
for ZNF446 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF446 (58987795 - 58992597 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF446
4 CNVs: 50240 50238 50239 5119 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF446 |
|
Disorders
/ Diseases
for ZNF446 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF446 for disorders About GeneDecksing
1  disease for ZNF446: About MalaCardsosteoporosis
Export disorders for ZNF446 gene to outside databases
|
Publications
for ZNF446 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF446 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF446) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. (PubMed id 15936718)1, 9 Liu F....Liu M. (2005)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis. (PubMed id 18433299)9 Xiao P....Deng H.W. (2008)
|
External Searches for ZNF446 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF446 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF446 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF446 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF446 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF446 gene:
Search GeneIP for patents involving ZNF446
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF446 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF446 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF446 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF446 | | | OriGene Protein Over-expression Lysate for ZNF446 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF446 | | OriGene 3'-UTR Clone for ZNF446 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF446 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF446 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF446 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF446 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF446 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF446 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF446 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF446 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF446 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF446 |
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