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ZNF446 Gene

protein-coding   GIFtS: 50
GCID: GC19P059283

Zinc Finger Protein 446

  Search for ZNF446
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 4461 2
Zinc Finger Protein With KRAB And SCAN Domains 202 3
ZKSCAN202 3
ZSCAN302
ZSCAN522

External Ids:    HGNC: 210361   Entrez Gene: 556632   Ensembl: ENSG000000838387   UniProtKB: Q9NWS93   
ORGUL members:         

Export aliases for ZNF446 gene to outside databases

Previous GC identifers: GC00U911635 GC19P063680 GC19P059044 GC19P059050 GC19P055296 GC19P059067 GC19P059082 GC19P059099 GC19P059136 GC19P059192 GC19P059232


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF446 Gene:
ZNF446 (zinc finger protein 446) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZSCAN9.

UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF446 gene promoter:
         NF-1   NF-1/L   AP-1   Bach2   ATF-2   STAT5A   c-Jun   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF446 promoter sequence
   Search Chromatin IP Primers for ZNF446

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF446


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF446 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF446 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P059283:  view genomic region     (about GC identifiers)

Start:
58,985,384 bp from pter      End:
58,992,597 bp from pter
Size:
7,214 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9 (See protein sequence)
Recommended Name: Zinc finger protein 446  
Size: 450 amino acids; 48957 Da

Explore the universe of human proteins at neXtProt for ZNF446: NX_Q9NWS9

Explore proteomics data for ZNF446 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF446 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060378.1  
    ENSEMBL proteins: 
     ENSP00000472219   ENSP00000470963   ENSP00000472802   ENSP00000336565  
    Reactome Protein details: Q9NWS9

    ZNF446 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 8):
     IPR001909 Krueppel-associated_box
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam

    Graphical View of Domain Structure for InterPro Entry Q9NWS9

    ProtoNet protein and cluster: Q9NWS9

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB003309 Transcriptional regulator SCAN


    UniProtKB/Swiss-Prot: ZN446_HUMAN, Q9NWS9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain
    Similarity: Contains 1 SCAN box domain


    Find genes that share domains with ZNF446           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN446_HUMAN, Q9NWS9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF446           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF446:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF446
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN446_HUMAN, Q9NWS9: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005622intracellular ----
    GO:0005634nucleus IBA--

    Find genes that share ontologies with ZNF446           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF446 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF446           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF446
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF446
    Interactions:

        Search GeneGlobe Interaction Network for ZNF446

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ZNF446 (Q9NWS93 ENSP000003365654) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF263O149783, ENSP000002190694I2D: score=3 STRING: ENSP00000219069
    LINC00921O149783I2D: score=3 
    ZNF232Q9UNY53, ENSP000002500764I2D: score=3 STRING: ENSP00000250076
    ZSCAN32Q9NX653, ENSP000003025024I2D: score=3 STRING: ENSP00000302502
    DGCR6LQ9BY273, ENSP000002488794I2D: score=2 STRING: ENSP00000248879
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with ZNF446           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF446 (ZN446)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF446 gene: 
    NM_017908.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596341 ENST00000599913 ENST00000594468 ENST00000600013 ENST00000594369
    ENST00000335841(uc002qsz.3 uc002qta.3) ENST00000391694(uc010eur.3)

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF446

    Selected AceView cDNA sequences (see all 60):

    BF724990 AL122108 BG819435 BU527229 BP375489 BF194745 CA422428 BU151642 
    AW249600 BE743568 CB131805 AW070519 BQ441187 BM801312 AA357414 BG478804 
    AI286331 NM_017908 AW198009 AA335574 AI436448 BI160944 BX353954 AW246135 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF446    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                              -               
    SP4:              -     -     -     -                                             
    SP5:              -     -                                                         


    ECgene alternative splicing isoforms for ZNF446

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF446 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGGGCTG
    ZNF446 Expression
    About this image

    ZNF446 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF446 Protein Expression
        Custom PCR Arrays for ZNF446
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF446 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp4461 , 5 zinc finger protein 4461, 5 69.49(n)1
    62.23(a)1
      7 (7.71 cM)5
    2698701  NM_175558.41  NP_780767.11 
     129778485 


    ENSEMBL Gene Tree for ZNF446 (if available)
    TreeFam Gene Tree for ZNF446 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF446 gene
    ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  ZNF2322  ZSCAN302  ZNF1742  
    ZNF32  ZKSCAN42  ZNF3962  ZSCAN122  ZNF3942  ZSCAN212  ZSCAN232  ZNF1652  
    ZSCAN162  ZKSCAN82  ZSCAN222  ZSCAN312  ZNF242  ZKSCAN32  ZNF182  
    Selected SIMAP similar genes for ZNF446 using alignment to 4 protein entries:     ZN446_HUMAN (see all proteins) (see all similar genes):
    DKFZp434K202    DKFZp434L2027    ZNF197    ZNF331    ZSCAN10    ZNF202
    ZNF18    ZKSCAN1    ZNF394    ZNF397    LOC100128510    SCAND1
    ZNF483    ZSCAN32    ZKSCAN2    ZNF396    ZNF615    ZSCAN30

    Find genes that share paralogs with ZNF446           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF446
    PGOHUM00000234457


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF446 (see all 257)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877881691,2
    --58985818(+) TCCCAC/GCAGCC 1 -- us2k10--------
    rs37949711,2
    C,F,H--58985866(-) ACAACA/GGGGGC 1 -- us2k116Minor allele frequency- G:0.10EA NS WA NA 3834
    rs766258051,2
    C,F--58985974(+) CCCCTC/TGGCTG 1 -- us2k13Minor allele frequency- T:0.14CSA WA 122
    rs800832781,2
    C,F--58986045(+) CCCTGG/CGCTTC 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1918361531,2
    --58986063(+) AAAGGA/TCAGAC 1 -- us2k10--------
    rs1825050791,2
    --58986142(+) ACCCAC/GAAGTA 1 -- us2k10--------
    rs1468056621,2
    --58986203(+) TGGGTA/GAGAGC 1 -- us2k10--------
    rs1489353891,2
    --58986227(+) GGGAAA/GGCAAA 1 -- us2k10--------
    rs37949701,2
    C,F,H--58986260(-) CTCTCT/CCCTCT 1 -- us2k1 trp324Minor allele frequency- C:0.10EA NS NA WA 4222
    rs116688901,2
    C,H--58986299(+) GAAGGC/TTGAGA 1 -- us2k12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for ZNF446 (58985384 - 58992597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF446:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833888CNV Loss17160897
    nsv515731CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF446
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF446

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF446 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF446)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. (PubMed id 15936718)1, 9 Liu F....Liu M. (Biochem. Biophys. Res. Commun. 2005)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55663 HGNC: 21036 AceView: FLJ20626 Ensembl:ENSG00000083838 euGenes: HUgn55663
    ECgene: ZNF446 H-InvDB: ZNF446

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF446 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF446 gene:
    Search GeneIP for patents involving ZNF446

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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