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Aliases for ZNF446 Gene

Aliases for ZNF446 Gene

  • Zinc Finger Protein 446 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 20 3 4
  • ZKSCAN20 3 4
  • ZSCAN30 3
  • ZSCAN52 3

External Ids for ZNF446 Gene

Previous GeneCards Identifiers for ZNF446 Gene

  • GC00U911635
  • GC19P063680
  • GC19P059044
  • GC19P059050
  • GC19P055296
  • GC19P059067
  • GC19P059082
  • GC19P059099
  • GC19P059136
  • GC19P059192
  • GC19P059232
  • GC19P059283

Summaries for ZNF446 Gene

GeneCards Summary for ZNF446 Gene

ZNF446 (Zinc Finger Protein 446) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF18.

UniProtKB/Swiss-Prot for ZNF446 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF446 Gene

Genomics for ZNF446 Gene

Regulatory Elements for ZNF446 Gene

Enhancers for ZNF446 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G058517 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +45.7 45692 4.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF324B ZNF549 CENPBD1P1 MZF1 ZNF134 ZNF606 LOC100128398 ZNF324 ZBTB45 ZNF418
GH19G058571 1.4 ENCODE dbSUPER 10.8 +100.1 100096 4.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZSCAN18 LOC100128398 TRIM28 ZNF418 ENSG00000268201 LOC105372482 ZNF606 LOC105372483 MZF1 ENSG00000268049
GH19G058580 1.2 Ensembl ENCODE 11.1 +107.2 107248 1.5 PKNOX1 ATF1 CREB3L1 GTF3C2 ZNF766 ZNF143 KDM4B REST ZNF592 MEF2D TRIM28 ZNF587B ZNF324B ZNF134 ZNF587 CENPBD1P1 ZBTB45 UBE2M CHMP2A ZNF417
GH19G058379 1.2 ENCODE 10.7 -92.9 -92932 2.9 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZSCAN18 ZNF584 LOC100128398 TRIM28 ZNF548 ZNF606 ZNF134 RPS5 ZNF132 ZNF549
GH19G058304 1.2 ENCODE 10.4 -168.5 -168491 2.3 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 ZNF324B ERVK3-1 ZNF549 ZNF17 ZBTB45 ZNF606 MZF1 ZNF544 LOC100506634 ZNF324
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF446 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF446 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111880 1657 1201 HNRNPUL1 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for ZNF446 Gene

Chromosome:
19
Start:
58,474,017 bp from pter
End:
58,489,533 bp from pter
Size:
15,517 bases
Orientation:
Plus strand

Genomic View for ZNF446 Gene

Genes around ZNF446 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF446 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF446 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF446 Gene

Proteins for ZNF446 Gene

  • Protein details for ZNF446 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWS9-ZN446_HUMAN
    Recommended name:
    Zinc finger protein 446
    Protein Accession:
    Q9NWS9

    Protein attributes for ZNF446 Gene

    Size:
    450 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF446 Gene

Post-translational modifications for ZNF446 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF446 Gene

Domains & Families for ZNF446 Gene

Gene Families for ZNF446 Gene

Suggested Antigen Peptide Sequences for ZNF446 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWS9

UniProtKB/Swiss-Prot:

ZN446_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF446: view

Function for ZNF446 Gene

Molecular function for ZNF446 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with ZNF446: view
genes like me logo Genes that share phenotypes with ZNF446: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF446 Gene

Localization for ZNF446 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF446 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF446 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with ZNF446: view

Pathways & Interactions for ZNF446 Gene

SuperPathways for ZNF446 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF446: view

Pathways by source for ZNF446 Gene

2 Reactome pathways for ZNF446 Gene

Gene Ontology (GO) - Biological Process for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF446: view

No data available for SIGNOR curated interactions for ZNF446 Gene

Transcripts for ZNF446 Gene

Unigene Clusters for ZNF446 Gene

Zinc finger protein 446:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF446 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:
SP3: -
SP4: - - - -
SP5: - -

Relevant External Links for ZNF446 Gene

GeneLoc Exon Structure for
ZNF446
ECgene alternative splicing isoforms for
ZNF446

Expression for ZNF446 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF446 Gene

Protein differential expression in normal tissues from HIPED for ZNF446 Gene

This gene is overexpressed in Fetal ovary (33.7), Blymphocyte (24.3), and Testis (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF446 Gene



Protein tissue co-expression partners for ZNF446 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF446 Gene:

ZNF446

SOURCE GeneReport for Unigene cluster for ZNF446 Gene:

Hs.710284

Evidence on tissue expression from TISSUES for ZNF446 Gene

  • Liver(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ZNF446: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF446 Gene

Orthologs for ZNF446 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF446 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF446 34 35
  • 98.81 (n)
dog
(Canis familiaris)
Mammalia ZNF446 34 35
  • 80.29 (n)
cow
(Bos Taurus)
Mammalia ZNF446 34 35
  • 75.51 (n)
mouse
(Mus musculus)
Mammalia Zfp446 34 16 35
  • 69.49 (n)
rat
(Rattus norvegicus)
Mammalia LOC102552463 34
  • 69.45 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF446 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF446 35
  • 24 (a)
OneToOne
Species where no ortholog for ZNF446 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF446 Gene

ENSEMBL:
Gene Tree for ZNF446 (if available)
TreeFam:
Gene Tree for ZNF446 (if available)

Paralogs for ZNF446 Gene

Paralogs for ZNF446 Gene

Pseudogenes.org Pseudogenes for ZNF446 Gene

genes like me logo Genes that share paralogs with ZNF446: view

Variants for ZNF446 Gene

Sequence variations from dbSNP and Humsavar for ZNF446 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000230786 -- 58,484,643(+) CCTGG(A/G)CAACA intron-variant
rs1000430399 -- 58,475,937(+) ACCCT(C/G)GGACT upstream-variant-2KB, utr-variant-5-prime
rs1000538068 -- 58,489,220(+) TCACG(A/C)AGCTG intron-variant
rs1000583549 -- 58,484,984(+) GCCTT(A/G)GGAGG intron-variant
rs1000760193 -- 58,476,534(+) TCAGG(A/G)CCGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF446 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1116353 CNV deletion 24896259
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv833888 CNV loss 17160897
nsv952156 CNV deletion 24416366

Variation tolerance for ZNF446 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.95; 83.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF446 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF446

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF446 Gene

Disorders for ZNF446 Gene

Relevant External Links for ZNF446

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF446

No disorders were found for ZNF446 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF446 Gene

Publications for ZNF446 Gene

  1. A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. (PMID: 15936718) Liu F. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF446 Gene

Sources for ZNF446 Gene

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