Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF446 Gene

Aliases for ZNF446 Gene

  • Zinc Finger Protein 446 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 20 3 4
  • ZKSCAN20 3 4
  • ZSCAN30 3
  • ZSCAN52 3

External Ids for ZNF446 Gene

Previous GeneCards Identifiers for ZNF446 Gene

  • GC00U911635
  • GC19P063680
  • GC19P059044
  • GC19P059050
  • GC19P055296
  • GC19P059067
  • GC19P059082
  • GC19P059099
  • GC19P059136
  • GC19P059192
  • GC19P059232
  • GC19P059283

Summaries for ZNF446 Gene

GeneCards Summary for ZNF446 Gene

ZNF446 (Zinc Finger Protein 446) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF500.

UniProtKB/Swiss-Prot for ZNF446 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF446 Gene

Genomics for ZNF446 Gene

Regulatory Elements for ZNF446 Gene

Genomic Location for ZNF446 Gene

Chromosome:
19
Start:
58,474,017 bp from pter
End:
58,489,533 bp from pter
Size:
15,517 bases
Orientation:
Plus strand

Genomic View for ZNF446 Gene

Genes around ZNF446 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF446 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF446 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF446 Gene

Proteins for ZNF446 Gene

  • Protein details for ZNF446 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWS9-ZN446_HUMAN
    Recommended name:
    Zinc finger protein 446
    Protein Accession:
    Q9NWS9

    Protein attributes for ZNF446 Gene

    Size:
    450 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF446 Gene

Proteomics data for ZNF446 Gene at MOPED

Post-translational modifications for ZNF446 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF446 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF446 Gene

Domains & Families for ZNF446 Gene

Gene Families for ZNF446 Gene

Suggested Antigen Peptide Sequences for ZNF446 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWS9

UniProtKB/Swiss-Prot:

ZN446_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF446: view

Function for ZNF446 Gene

Molecular function for ZNF446 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF446: view
genes like me logo Genes that share phenotypes with ZNF446: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF446 Gene

Localization for ZNF446 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF446 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF446 Gene COMPARTMENTS Subcellular localization image for ZNF446 gene
Compartment Confidence
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF446 Gene

Pathways & Interactions for ZNF446 Gene

SuperPathways for ZNF446 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF446: view

Pathways by source for ZNF446 Gene

2 Reactome pathways for ZNF446 Gene

Gene Ontology (GO) - Biological Process for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF446: view

No data available for SIGNOR curated interactions for ZNF446 Gene

Drugs & Compounds for ZNF446 Gene

No Compound Related Data Available

Transcripts for ZNF446 Gene

Unigene Clusters for ZNF446 Gene

Zinc finger protein 446:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF446 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:
SP3: -
SP4: - - - -
SP5: - -

Relevant External Links for ZNF446 Gene

GeneLoc Exon Structure for
ZNF446
ECgene alternative splicing isoforms for
ZNF446

Expression for ZNF446 Gene

mRNA expression in normal human tissues for ZNF446 Gene

Protein differential expression in normal tissues from HIPED for ZNF446 Gene

This gene is overexpressed in Fetal ovary (33.7), Blymphocyte (24.3), and Testis (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF446 Gene



SOURCE GeneReport for Unigene cluster for ZNF446 Gene Hs.710284

genes like me logo Genes that share expression patterns with ZNF446: view

Protein tissue co-expression partners for ZNF446 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF446 Gene

Orthologs for ZNF446 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF446 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF446 35
  • 75.51 (n)
  • 70.15 (a)
ZNF446 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF446 35
  • 80.29 (n)
  • 76.67 (a)
ZNF446 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp446 35
  • 69.49 (n)
  • 62.23 (a)
Zfp446 16
Zfp446 36
  • 47 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF446 35
  • 98.81 (n)
  • 98.66 (a)
ZNF446 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102552463 35
  • 69.45 (n)
  • 65.16 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF446 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF446 36
  • 24 (a)
OneToOne
Species with no ortholog for ZNF446:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF446 Gene

ENSEMBL:
Gene Tree for ZNF446 (if available)
TreeFam:
Gene Tree for ZNF446 (if available)

Paralogs for ZNF446 Gene

Paralogs for ZNF446 Gene

Pseudogenes.org Pseudogenes for ZNF446 Gene

genes like me logo Genes that share paralogs with ZNF446: view

Variants for ZNF446 Gene

Sequence variations from dbSNP and Humsavar for ZNF446 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs893185 - 58,478,128(-) ATGGT(G/T)CCCCT reference, missense
rs36095067 - 58,480,271(+) CCACT(A/C/T)CTGCC intron-variant, reference, missense
rs882610 - 58,480,533(-) GTGAG(C/T)GTCGG intron-variant, reference, missense
rs2011665 -- 58,478,674(-) TTTTT(G/T)TTTGT intron-variant
rs2011666 -- 58,478,678(-) TTTTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF446 Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv833888 CNV Loss 17160897

Variation tolerance for ZNF446 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.95; 83.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF446 Gene

HapMap Linkage Disequilibrium report
ZNF446

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF446 Gene

Disorders for ZNF446 Gene

Relevant External Links for ZNF446

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF446

No disorders were found for ZNF446 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF446 Gene

Publications for ZNF446 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. (PMID: 15936718) Liu F. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZNF446 Gene

Sources for ZNF446 Gene

Back to Top

Content