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Aliases for ZNF446 Gene

Aliases for ZNF446 Gene

  • Zinc Finger Protein 446 2 3
  • Zinc Finger Protein With KRAB And SCAN Domains 20 3 4
  • ZKSCAN20 3 4
  • ZSCAN30 3
  • ZSCAN52 3

External Ids for ZNF446 Gene

Summaries for ZNF446 Gene

GeneCards Summary for ZNF446 Gene

ZNF446 (Zinc Finger Protein 446) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZNF446 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF446 Gene

Genomics for ZNF446 Gene

Genomic Location for ZNF446 Gene

58,474,017 bp from pter
58,489,533 bp from pter
15,517 bases
Plus strand

Genomic View for ZNF446 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF446 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF446 Gene

Regulatory Elements for ZNF446 Gene

Proteins for ZNF446 Gene

  • Protein details for ZNF446 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 446
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ZNF446 Gene

    450 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF446 Gene

Proteomics data for ZNF446 Gene at MOPED

Post-translational modifications for ZNF446 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF446 Gene

No data available for DME Specific Peptides for ZNF446 Gene

Domains for ZNF446 Gene

Gene Families for ZNF446 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF446 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.:
    • Q9NWS9
  • Contains 1 SCAN box domain.:
    • Q9NWS9
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9NWS9
  • Contains 3 C2H2-type zinc fingers.:
    • Q9NWS9
genes like me logo Genes that share domains with ZNF446: view

Function for ZNF446 Gene

Molecular function for ZNF446 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF446: view

Phenotypes for ZNF446 Gene

GenomeRNAi human phenotypes for ZNF446:
genes like me logo Genes that share phenotypes with ZNF446: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF446 Gene

Localization for ZNF446 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF446 Gene

Subcellular locations from

Jensen Localization Image for ZNF446 Gene COMPARTMENTS Subcellular localization image for ZNF446 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF446: view

Pathways for ZNF446 Gene

SuperPathways for ZNF446 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF446: view

Pathways by source for ZNF446 Gene

2 Reactome pathways for ZNF446 Gene

Gene Ontology (GO) - Biological Process for ZNF446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF446: view

Transcripts for ZNF446 Gene

Unigene Clusters for ZNF446 Gene

Zinc finger protein 446:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF446 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP3: -
SP4: - - - -
SP5: - -

Relevant External Links for ZNF446 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF446 Gene

mRNA expression in normal human tissues for ZNF446 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF446 Gene

SOURCE GeneReport for Unigene cluster for ZNF446 Gene Hs.710284

genes like me logo Genes that share expressions with ZNF446: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF446 Gene

Orthologs for ZNF446 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF446 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF446 35
  • 98.81 (n)
  • 98.66 (a)
ZNF446 36
  • 99 (a)
(Bos Taurus)
Mammalia ZNF446 35
  • 75.51 (n)
  • 70.15 (a)
ZNF446 36
  • 52 (a)
(Canis familiaris)
Mammalia ZNF446 35
  • 80.29 (n)
  • 76.67 (a)
ZNF446 36
  • 58 (a)
(Mus musculus)
Mammalia Zfp446 35
  • 69.49 (n)
  • 62.23 (a)
Zfp446 16
Zfp446 36
  • 47 (a)
(Monodelphis domestica)
Mammalia ZNF446 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF446 36
  • 24 (a)
(Rattus norvegicus)
Mammalia LOC102552463 35
  • 69.45 (n)
  • 65.16 (a)
Species with no ortholog for ZNF446:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF446 Gene

Gene Tree for ZNF446 (if available)
Gene Tree for ZNF446 (if available)

Paralogs for ZNF446 Gene Pseudogenes for ZNF446 Gene

genes like me logo Genes that share paralogs with ZNF446: view

Variants for ZNF446 Gene

Sequence variations from dbSNP and Humsavar for ZNF446 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs731259 -- 58,478,057(+) CCTGA(C/T)ACCAC intron-variant
rs882047 -- 58,479,589(+) AACCA(A/G)ACAGG intron-variant
rs882609 -- 58,480,112(-) GTGGC(C/T)GTGGC intron-variant
rs882610 - 58,480,533(-) GTGAG(C/T)GTCGG missense, reference, intron-variant
rs893185 - 58,478,128(-) ATGGT(G/T)CCCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF446 Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv833888 CNV Loss 17160897

Relevant External Links for ZNF446 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF446 Gene

Disorders for ZNF446 Gene

No disorders were found for ZNF446 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF446 Gene

Publications for ZNF446 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. (PMID: 15936718) Liu F. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis. (PMID: 18433299) Xiao P. … Deng H.W. (J. Bone Miner. Res. 2008) 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ZNF446 Gene

Sources for ZNF446 Gene

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