ZNF445 Gene
protein-coding GIFtS: 43
GCID: GC03M044481
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zinc finger protein 445(Previous name: zinc finger protein 168 )
(Previous symbol: ZNF168)
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Aliases
for ZNF445 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4451 2 | | Zinc Finger Protein 1681 2 3 | | ZKSCAN151 2 3 | | ZNF1681 2 3 | | ZSCAN471 2 | | Zinc Finger Protein With KRAB And SCAN Domains 152 3 |
Export aliases for ZNF445 gene to outside databasesPrevious GC identifers: GC03U900303 GC03M044448 GC03M044462 |
Summaries
for ZNF445 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN445_HUMAN, P59923Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF445 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF445 gene promoter:
c-Fos AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF445
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF445 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.32 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.32ZNF445 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M044481: view genomic region
(about GC identifiers)
Start:
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44,481,262 bp from pter |
End:
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44,519,162 bp from pter |
Size:
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37,901 bases |
Orientation:
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minus strand |
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Proteins
for ZNF445 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN445_HUMAN, P59923 (See
protein sequence)Recommended Name: Zinc finger protein 445 Size: 1031 amino acids; 118963 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q3MJD1Explore the universe of human proteins at neXtProt for ZNF445: NX_P59923
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P59923
ZNF445 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_852466.1
ENSEMBL proteins: ENSP00000379387 ENSP00000413073 Reactome Protein details: P59923
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF445 for ontologies About GeneDecksing
ZNF445 Antibody Products:
Assay Products for ZNF445: |
Protein
Domains /
Families
for ZNF445 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF445 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P59923ProtoNet protein and cluster: P59923 2 Blocks protein families: IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZN445_HUMAN, P59923Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 14 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Function
for ZNF445 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN445_HUMAN, P59923Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF445 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF445
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF445 (NM_181489) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF445 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF445 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF445 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF445 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF445 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF445
ZNF445 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF445
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZNF445 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF445 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF445
Search CenterWatch for drugs/clinical trials and news about ZNF445 / ZN445
|
Transcripts
for ZNF445 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF445 gene: NM_181489.5 Unigene Cluster for ZNF445: Zinc finger protein 445 Hs.250481 [show with all ESTs]Unigene Representative Sequence: NM_1814894 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396077 ENST00000460529 ENST00000474600(uc021wwo.1) ENST00000425708(uc011azv.1 uc003cnf.2 uc011azw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF445 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF445
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF445 (NM_181489) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF445 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF445 |
Additional cDNA sequence: AF024702.1 AF027137.1 AK026891.1 AK310588.1 AL832553.1 AY262260.1 AY279350.1 AY295873.2 BC052953.1 BC101486.1 BC143439.1 L32162.1 6 DOTS entries: DT.95333334 DT.421189 DT.91994520 DT.100813239 DT.65286113 DT.100813246 16 AceView cDNA sequences: AY262260 AY295873 NM_181489 AL596634 BX489727 AI636407 AY279350 AU077105 AF027137 BI050552 BG015829 BF772210 T05639 BI055629 L32162 AF024702
GeneLoc Exon Structure
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Expression
for ZNF445 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF445 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF445 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF445
SOURCE GeneReport for Unigene cluster: Hs.250481
SABiosciences Custom PCR Arrays for ZNF445
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF445
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF445 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF445 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF445 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF445 |
Orthologs
for ZNF445 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZNF445 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZNF445 (if available)
TreeFam Gene Tree for ZNF445 (if available) |
Paralogs
for ZNF445 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNF445 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF445 (44481262 - 44519162 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF445: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF445 |
|
Disorders
/ Diseases
for ZNF445 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF445 for disorders About MalaCards
ZNF445 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZNF445 (1 document)
Export disorders for ZNF445 gene to outside databases
|
Publications
for ZNF445 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF445 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF445) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PubMed id 7814019)1, 3 Calabro V....Lania L. (1995)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445. (PubMed id 16368201)1 Luo K....Yu L. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for ZNF445 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF445 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF445 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF445 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF445 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF445 gene:
Search GeneIP for patents involving ZNF445
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF445 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF445 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF445 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF445 | | | OriGene Protein Over-expression Lysate for ZNF445 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF445 | | OriGene 3'-UTR Clone for ZNF445 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF445 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF445 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF445 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF445 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF445 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF445 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF445 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF445 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF445 |
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 | | | ZNF445 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF445 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF445 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF445 |
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