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Aliases for ZNF445 Gene

Aliases for ZNF445 Gene

  • Zinc Finger Protein 445 2 3 5
  • Zinc Finger Protein 168 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 15 3 4
  • ZKSCAN15 3 4
  • ZNF168 3 4
  • ZSCAN47 3

External Ids for ZNF445 Gene

Previous HGNC Symbols for ZNF445 Gene

  • ZNF168

Previous GeneCards Identifiers for ZNF445 Gene

  • GC03U900303
  • GC03M044448
  • GC03M044462
  • GC03M044481

Summaries for ZNF445 Gene

GeneCards Summary for ZNF445 Gene

ZNF445 (Zinc Finger Protein 445) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF445 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF445 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF445 Gene

Genomics for ZNF445 Gene

Regulatory Elements for ZNF445 Gene

Enhancers for ZNF445 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H044337 1.1 ENCODE 26.8 +138.6 138602 3 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF660 ZNF445 ZNF197 ZNF502 ENSG00000271941 LOC105377055 LINC01988
GH03H043689 1.4 ENCODE dbSUPER 16.1 +783.3 783251 10 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 SP5 ZNF197 ZNF445 ZNF662 ZNF660 ZNF35 MPRIPP1 KRBOX1 ENSG00000227245 ZNF852 ABHD5
GH03H044974 1.3 ENCODE dbSUPER 16.6 -498.2 -498153 3 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 SP3 SP5 ZHX2 MXD4 ZNF445 EXOSC7 RN7SL145P CLEC3B ZNF502 ZKSCAN7 ZNF852 RNU5B-3P KIAA1143 ZNF197
GH03H045130 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 -658.3 -658322 11 HDGF PKNOX1 ARNT ZNF766 CBX5 FOS REST SMARCB1 ZNF592 MEF2D ZNF502 ZNF852 RN7SL145P ZNF35 ZNF197 RNU5B-3P CLEC3B TMEM158 SACM1L ZDHHC3
GH03H045052 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 -581.9 -581860 13 HDGF PKNOX1 ARNT YY1 ZNF766 ZNF143 FOS REST ZNF592 MEF2D ZNF502 RN7SL145P ZNF852 ZNF197 ZNF35 EXOSC7 CLEC3B ZDHHC3 CDCP1 ZNF660
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF445 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF445 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151581 570 1801 HDGF TBP RB1 TBL1XR1 ZSCAN4 ARID4B RAD21 EGR1 ZNF143 ATF7

Genomic Location for ZNF445 Gene

Chromosome:
3
Start:
44,431,720 bp from pter
End:
44,477,670 bp from pter
Size:
45,951 bases
Orientation:
Minus strand

Genomic View for ZNF445 Gene

Genes around ZNF445 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF445 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF445 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF445 Gene

Proteins for ZNF445 Gene

  • Protein details for ZNF445 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59923-ZN445_HUMAN
    Recommended name:
    Zinc finger protein 445
    Protein Accession:
    P59923
    Secondary Accessions:
    • Q3MJD1

    Protein attributes for ZNF445 Gene

    Size:
    1031 amino acids
    Molecular mass:
    118963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF445 Gene

Post-translational modifications for ZNF445 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF445 Gene

Domains & Families for ZNF445 Gene

Gene Families for ZNF445 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF445 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59923

UniProtKB/Swiss-Prot:

ZN445_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF445: view

Function for ZNF445 Gene

Molecular function for ZNF445 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF445 Gene

Gene Ontology (GO) - Molecular Function for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF445: view
genes like me logo Genes that share phenotypes with ZNF445: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF445
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF445 Gene

Localization for ZNF445 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF445 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF445 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ZNF445: view

Pathways & Interactions for ZNF445 Gene

SuperPathways for ZNF445 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF445: view

Pathways by source for ZNF445 Gene

2 Reactome pathways for ZNF445 Gene

Gene Ontology (GO) - Biological Process for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF445: view

No data available for SIGNOR curated interactions for ZNF445 Gene

Drugs & Compounds for ZNF445 Gene

No Compound Related Data Available

Transcripts for ZNF445 Gene

Unigene Clusters for ZNF445 Gene

Zinc finger protein 445:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF445
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF445 Gene

No ASD Table

Relevant External Links for ZNF445 Gene

GeneLoc Exon Structure for
ZNF445
ECgene alternative splicing isoforms for
ZNF445

Expression for ZNF445 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF445 Gene

Protein differential expression in normal tissues from HIPED for ZNF445 Gene

This gene is overexpressed in Urine (24.9), Vitreous humor (23.4), and Heart (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF445 Gene



Protein tissue co-expression partners for ZNF445 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF445 Gene:

ZNF445

SOURCE GeneReport for Unigene cluster for ZNF445 Gene:

Hs.250481

Evidence on tissue expression from TISSUES for ZNF445 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF445: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF445 Gene

Orthologs for ZNF445 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF445 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF445 33 34
  • 88.08 (n)
dog
(Canis familiaris)
Mammalia ZNF445 33 34
  • 85.54 (n)
cow
(Bos Taurus)
Mammalia ZNF445 33 34
  • 83.61 (n)
rat
(Rattus norvegicus)
Mammalia Zfp445 33
  • 75.95 (n)
mouse
(Mus musculus)
Mammalia Zfp445 33 16 34
  • 75.37 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF445 34
  • 37 (a)
OneToOne
Species where no ortholog for ZNF445 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF445 Gene

ENSEMBL:
Gene Tree for ZNF445 (if available)
TreeFam:
Gene Tree for ZNF445 (if available)

Paralogs for ZNF445 Gene

genes like me logo Genes that share paralogs with ZNF445: view

No data available for Paralogs for ZNF445 Gene

Variants for ZNF445 Gene

Sequence variations from dbSNP and Humsavar for ZNF445 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000138890 -- 44,439,464(+) CTCAT(C/T)GTGAC downstream-variant-500B
rs1000146830 -- 44,475,600(+) AATTT(C/G)TCATA intron-variant
rs1000248826 -- 44,444,126(+) GGCAA(A/C)CCTGT utr-variant-3-prime
rs1000297945 -- 44,444,376(+) CTCAG(A/G)AATCA utr-variant-3-prime
rs1000327244 -- 44,457,549(+) GAGCC(A/G)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF445 Gene

Variant ID Type Subtype PubMed ID
esv3568716 CNV loss 25503493

Variation tolerance for ZNF445 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF445 Gene

Human Gene Mutation Database (HGMD)
ZNF445
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF445

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF445 Gene

Disorders for ZNF445 Gene

Relevant External Links for ZNF445

Genetic Association Database (GAD)
ZNF445
Human Genome Epidemiology (HuGE) Navigator
ZNF445
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF445

No disorders were found for ZNF445 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF445 Gene

Publications for ZNF445 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PMID: 7814019) Calabrò V … Lania L (Human genetics 1995) 2 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ZNF445 Gene

Sources for ZNF445 Gene

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