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Aliases for ZNF445 Gene

Aliases for ZNF445 Gene

  • Zinc Finger Protein 445 2 3 5
  • Zinc Finger Protein 168 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 15 3 4
  • ZKSCAN15 3 4
  • ZNF168 3 4
  • ZSCAN47 3

External Ids for ZNF445 Gene

Previous HGNC Symbols for ZNF445 Gene

  • ZNF168

Previous GeneCards Identifiers for ZNF445 Gene

  • GC03U900303
  • GC03M044448
  • GC03M044462
  • GC03M044481

Summaries for ZNF445 Gene

GeneCards Summary for ZNF445 Gene

ZNF445 (Zinc Finger Protein 445) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF445 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF445 Gene

Genomics for ZNF445 Gene

Regulatory Elements for ZNF445 Gene

Promoters for ZNF445 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF445 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF445 Gene

Chromosome:
3
Start:
44,431,720 bp from pter
End:
44,477,670 bp from pter
Size:
45,951 bases
Orientation:
Minus strand

Genomic View for ZNF445 Gene

Genes around ZNF445 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF445 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF445 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF445 Gene

Proteins for ZNF445 Gene

  • Protein details for ZNF445 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59923-ZN445_HUMAN
    Recommended name:
    Zinc finger protein 445
    Protein Accession:
    P59923
    Secondary Accessions:
    • Q3MJD1

    Protein attributes for ZNF445 Gene

    Size:
    1031 amino acids
    Molecular mass:
    118963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF445 Gene

Proteomics data for ZNF445 Gene at MOPED

Post-translational modifications for ZNF445 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF445 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF445

No data available for DME Specific Peptides for ZNF445 Gene

Domains & Families for ZNF445 Gene

Gene Families for ZNF445 Gene

Suggested Antigen Peptide Sequences for ZNF445 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59923

UniProtKB/Swiss-Prot:

ZN445_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF445: view

Function for ZNF445 Gene

Molecular function for ZNF445 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF445: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF445 Gene

Localization for ZNF445 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF445 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF445 Gene COMPARTMENTS Subcellular localization image for ZNF445 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ZNF445: view

Pathways & Interactions for ZNF445 Gene

SuperPathways for ZNF445 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF445: view

Pathways by source for ZNF445 Gene

2 Reactome pathways for ZNF445 Gene

Interacting Proteins for ZNF445 Gene

Gene Ontology (GO) - Biological Process for ZNF445 Gene

None

No data available for SIGNOR curated interactions for ZNF445 Gene

Drugs & Compounds for ZNF445 Gene

No Compound Related Data Available

Transcripts for ZNF445 Gene

Unigene Clusters for ZNF445 Gene

Zinc finger protein 445:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF445 Gene

No ASD Table

Relevant External Links for ZNF445 Gene

GeneLoc Exon Structure for
ZNF445
ECgene alternative splicing isoforms for
ZNF445

Expression for ZNF445 Gene

mRNA expression in normal human tissues for ZNF445 Gene

Protein differential expression in normal tissues from HIPED for ZNF445 Gene

This gene is overexpressed in Urine (24.9), Vitreous humor (23.4), and Heart (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF445 Gene



SOURCE GeneReport for Unigene cluster for ZNF445 Gene Hs.250481

genes like me logo Genes that share expression patterns with ZNF445: view

Protein tissue co-expression partners for ZNF445 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF445 Gene

Orthologs for ZNF445 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF445 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF445 35
  • 88.08 (n)
  • 83.83 (a)
ZNF445 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF445 36
  • 77 (a)
OneToOne
ZNF445 35
  • 83.61 (n)
  • 77.56 (a)
dog
(Canis familiaris)
Mammalia ZNF445 35
  • 85.54 (n)
  • 80.28 (a)
ZNF445 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp445 16
Zfp445 36
  • 62 (a)
OneToOne
Zfp445 35
  • 75.37 (n)
  • 63.25 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF445 36
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp445 35
  • 75.95 (n)
  • 63.88 (a)
Species with no ortholog for ZNF445:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF445 Gene

ENSEMBL:
Gene Tree for ZNF445 (if available)
TreeFam:
Gene Tree for ZNF445 (if available)

Paralogs for ZNF445 Gene

genes like me logo Genes that share paralogs with ZNF445: view

No data available for Paralogs for ZNF445 Gene

Variants for ZNF445 Gene

Sequence variations from dbSNP and Humsavar for ZNF445 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11710965 - 44,448,388(+) AGTCA(C/T)AGTGG reference, missense
rs1106499 -- 44,453,949(+) CCAGC(A/T)CTGCC intron-variant
rs2372688 -- 44,444,330(+) ACCAC(C/T)TGATG utr-variant-3-prime
rs2372689 -- 44,468,218(+) ataac(C/T)tacac intron-variant
rs2372690 -- 44,471,985(+) GGTGC(A/C/G)TGCCA intron-variant

Variation tolerance for ZNF445 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF445 Gene

HapMap Linkage Disequilibrium report
ZNF445
Human Gene Mutation Database (HGMD)
ZNF445

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF445 Gene

Disorders for ZNF445 Gene

Relevant External Links for ZNF445

Genetic Association Database (GAD)
ZNF445
Human Genome Epidemiology (HuGE) Navigator
ZNF445
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF445

No disorders were found for ZNF445 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF445 Gene

Publications for ZNF445 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PMID: 7814019) CalabrA^ V. … Lania L. (Hum. Genet. 1995) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445. (PMID: 16368201) Luo K. … Yu L. (Gene 2006) 3

Products for ZNF445 Gene

Sources for ZNF445 Gene

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