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Aliases for ZNF445 Gene

Aliases for ZNF445 Gene

  • Zinc Finger Protein 445 2 3
  • Zinc Finger Protein 168 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 15 3 4
  • ZKSCAN15 3 4
  • ZNF168 3 4
  • ZSCAN47 3

External Ids for ZNF445 Gene

Previous HGNC Symbols for ZNF445 Gene

  • ZNF168

Previous GeneCards Identifiers for ZNF445 Gene

  • GC03U900303
  • GC03M044448
  • GC03M044462
  • GC03M044481

Summaries for ZNF445 Gene

GeneCards Summary for ZNF445 Gene

ZNF445 (Zinc Finger Protein 445) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for ZNF445 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF445 Gene

Genomics for ZNF445 Gene

Regulatory Elements for ZNF445 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF445 Gene

Start:
44,439,770 bp from pter
End:
44,477,670 bp from pter
Size:
37,901 bases
Orientation:
Minus strand

Genomic View for ZNF445 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF445 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF445 Gene

Proteins for ZNF445 Gene

  • Protein details for ZNF445 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59923-ZN445_HUMAN
    Recommended name:
    Zinc finger protein 445
    Protein Accession:
    P59923
    Secondary Accessions:
    • Q3MJD1

    Protein attributes for ZNF445 Gene

    Size:
    1031 amino acids
    Molecular mass:
    118963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF445 Gene

Proteomics data for ZNF445 Gene at MOPED

Post-translational modifications for ZNF445 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF445 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF445 Gene

Domains for ZNF445 Gene

Gene Families for ZNF445 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF445 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59923

UniProtKB/Swiss-Prot:

ZN445_HUMAN :
  • P59923
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF445: view

Function for ZNF445 Gene

Molecular function for ZNF445 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF445: view

Animal Model Products

CRISPR Products

miRNA for ZNF445 Gene

miRTarBase miRNAs that target ZNF445

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF445 Gene

Localization for ZNF445 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF445 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF445 Gene COMPARTMENTS Subcellular localization image for ZNF445 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ZNF445: view

Pathways for ZNF445 Gene

SuperPathways for ZNF445 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF445: view

Pathways by source for ZNF445 Gene

2 Reactome pathways for ZNF445 Gene

Interacting Proteins for ZNF445 Gene

Gene Ontology (GO) - Biological Process for ZNF445 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF445: view

Transcripts for ZNF445 Gene

Unigene Clusters for ZNF445 Gene

Zinc finger protein 445:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF445

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF445

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF445 Gene

No ASD Table

Relevant External Links for ZNF445 Gene

GeneLoc Exon Structure for
ZNF445
ECgene alternative splicing isoforms for
ZNF445

Expression for ZNF445 Gene

mRNA expression in normal human tissues for ZNF445 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF445 Gene

SOURCE GeneReport for Unigene cluster for ZNF445 Gene Hs.250481

genes like me logo Genes that share expressions with ZNF445: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF445 Gene

Orthologs for ZNF445 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF445 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF445 35
  • 88.08 (n)
  • 83.83 (a)
ZNF445 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF445 35
  • 83.61 (n)
  • 77.56 (a)
ZNF445 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF445 35
  • 85.54 (n)
  • 80.28 (a)
ZNF445 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp445 35
  • 75.37 (n)
  • 63.25 (a)
Zfp445 16
Zfp445 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF445 36
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp445 35
  • 75.95 (n)
  • 63.88 (a)
Species with no ortholog for ZNF445:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF445 Gene

ENSEMBL:
Gene Tree for ZNF445 (if available)
TreeFam:
Gene Tree for ZNF445 (if available)

Paralogs for ZNF445 Gene

genes like me logo Genes that share paralogs with ZNF445: view

No data available for Paralogs for ZNF445 Gene

Variants for ZNF445 Gene

Sequence variations from dbSNP and Humsavar for ZNF445 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2886 -- 44,441,714(+) CCTGT(A/T)AAAAT utr-variant-3-prime
rs1106499 -- 44,453,949(+) CCAGC(A/T)CTGCC intron-variant
rs1578989 -- 44,444,901(+) ACATT(C/T)TATCC utr-variant-3-prime
rs1806579 -- 44,467,789(+) TTTAA(C/T)AAAAA intron-variant
rs1881916 -- 44,454,502(+) AATCA(C/T)GGCTC intron-variant

Relevant External Links for ZNF445 Gene

HapMap Linkage Disequilibrium report
ZNF445
Human Gene Mutation Database (HGMD)
ZNF445

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF445 Gene

Disorders for ZNF445 Gene

Relevant External Links for ZNF445

Genetic Association Database (GAD)
ZNF445
Human Genome Epidemiology (HuGE) Navigator
ZNF445
genes like me logo Genes that share disorders with ZNF445: view

No data available for UniProtKB/Swiss-Prot for ZNF445 Gene

Publications for ZNF445 Gene

  1. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PMID: 7814019) CalabrA^ V. … Lania L. (Hum. Genet. 1995) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF445 Gene

Sources for ZNF445 Gene

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