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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF444 Gene

protein-coding   GIFtS: 45
GCID: GC19P056652

zinc finger protein 444

 Explore 5 diseases affiliated with
ZNF444 via our new
 Human Malady Compendium 
Biological research products
for ZNF444
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 4441 2     Zinc Finger And SCAN Domain-Containing Protein 172 3
EZF21 2 3 5     EZF-22 3
ZSCAN171 2 3     FLJ111371
Endothelial Zinc Finger Protein 22 3     

External Ids:    HGNC: 160521   Entrez Gene: 553112   Ensembl: ENSG000001676857   OMIM: 6078745   UniProtKB: Q8N0Y23   

Export aliases for ZNF444 gene to outside databases

Previous GC identifers: GC19P061328 GC19P061344 GC19P052962


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF444:
This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the
degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc
finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: ZN444_HUMAN, Q8N0Y2
Function: Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF444 gene promoter:
         E2F-3a   E2F-4   STAT1   E2F-5   E2F-2   Tal-1beta   STAT1alpha   E47   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF444 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF444

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF444


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF444 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF444 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056652:  view genomic region     (about GC identifiers)

Start:
56,643,968 bp from pter      End:
56,672,262 bp from pter
Size:
28,295 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN444_HUMAN, Q8N0Y2 (See protein sequence)
Recommended Name: Zinc finger protein 444  
Size: 327 amino acids; 35204 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAB84889.1; Type=Frameshift; Positions=99;
Secondary accessions: Q8TEQ9 Q8WU35 Q9NUU1
Alternative splicing: 2 isoforms:  Q8N0Y2-1   Q8N0Y2-2   

Explore the universe of human proteins at neXtProt for ZNF444: NX_Q8N0Y2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N0Y2

  • ZNF444 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001240721.1  NP_060807.2  

    ENSEMBL proteins: 
     ENSP00000465171   ENSP00000466287   ENSP00000338860   ENSP00000466666   ENSP00000468069  
     ENSP00000465070   ENSP00000465466   ENSP00000468762  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF444

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF444 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF444 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003309 Tscrpt_reg_SCAN

    Graphical View of Domain Structure for InterPro Entry Q8N0Y2

    ProtoNet protein and cluster: Q8N0Y2

    1 Blocks protein family: IPB003309 Transcriptional regulator SCAN

    UniProtKB/Swiss-Prot: ZN444_HUMAN, Q8N0Y2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN444_HUMAN, Q8N0Y2
    Function: Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF444:
    hsa-miR-138
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    Inhib. RNA
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    In Situ Assay
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZNF444

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    ZNF444 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF444

    1 Interacting protein for ZNF444 (Q8N0Y23) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL3Q929973I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016032viral reproduction IEA--


    ZNF444 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF444
    Search CenterWatch for drugs/clinical trials and news about ZNF444 / ZN444 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF444 gene (2 alternative transcripts): 
    NM_001253792.1  NM_018337.3  

    Unigene Cluster for ZNF444:

    Zinc finger protein 444
    Hs.24545  [show with all ESTs]
    Unigene Representative Sequence: NM_018337
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587467 ENST00000588358 ENST00000337080(uc002qmn.2 uc002qmm.3)
    ENST00000587195 ENST00000586123 ENST00000587664 ENST00000592949 ENST00000593100
    ENST00000588203 ENST00000591564 ENST00000587236 ENST00000592171 ENST00000592382


    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF444:
    hsa-miR-138
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB052954.1 AB052955.1 AF074985.1 AK001999.1 AK223408.1 AL834130.1 BC021282.2 

    9 DOTS entries:

    DT.209968  DT.95319332  DT.100778630  DT.101958133  DT.99954439  DT.95273876  DT.99968402  DT.92427034 
    DT.95273871 

    24/139 AceView cDNA sequences (see all 139):

    CR622776 AL520692 AL834130 BE395510 AB052955 AA297241 AB052954 AI573292 
    CD674794 AI609372 BU618006 BM966886 NM_018337 BQ889394 BM920816 BM451961 
    AI131205 BI962599 AW955650 BM980144 R32522 BX094029 BM966791 BQ277759 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF444 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a ·
    SP1:                                      -     -     -     -                                                     -     -     -     -     -                     
    SP2:                                      -     -     -     -                                                     -     -     -     -     -                     
    SP3:                                -     -     -     -     -                                                     -                                             
    SP4:                                      -           -     -                                                                                                   
    SP5:                                      -     -     -     -                                               -     -     -     -     -     -                     

    ExUns: 11b · 11c · 11d ^ 12
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ZNF444

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF444 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGATGGACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF444 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF444

    SOURCE GeneReport for Unigene cluster: Hs.24545
        SABiosciences Custom PCR Arrays for ZNF444
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZNF444

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF444 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    ZNF1746
    (see all 37)
    --
    43(a)
    43(a)
    (see all 37)
    many ↔ many
    many ↔ many
    (see all 37)
    GL344026.1(77049-77538)
    GL343514.1(204568-205088)


    ENSEMBL Gene Tree for ZNF444 (if available)
    TreeFam Gene Tree for ZNF444 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF444 gene
    ZKSCAN52  ZSCAN102  MZF12  
    18/36 SIMAP similar genes for ZNF444 using alignment to 7 protein entries:     ZN444_HUMAN (see all proteins) (see all similar genes):
    ZNF167    ZSCAN31    ZSCAN21    ZKSCAN8    ZNF263    ZKSCAN1
    ZNF24    ZKSCAN7    ZNF202    ZNF197    ZNF174    ZNF397
    ZSCAN29    ZNF394    ZSCAN10    ZNF18    LOC100128510    ZNF396

    ZNF444 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/465 NCBI SNPs in ZNF444 are shown (see all 465    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886987001,2
    --56650613(+) AGAGGC/TGAGAG 2 -- us2k10--------
    rs736158001,2
    C,F,--56650670(+) TGGTAG/ACCATA 2 -- us2k13Minor allele frequency- A:0.11WA 122
    rs1487167341,2
    --56650701(+) ATTCTC/GCATCT 2 -- us2k10--------
    rs1919290601,2
    --56650736(+) CCTGAC/TGATAG 2 -- us2k10--------
    rs6675231,2
    C,H,--56650783(+) TGGGCG/ATGGTG 2 -- us2k1 tfbs310Minor allele frequency- A:0.19NA WA EA 374
    rs1848429951,2
    --56650794(+) GTTCAC/TGCTTG 2 -- us2k10--------
    rs1422882561,2
    --56650871(+) GCCAAC/TATGGC 2 -- us2k10--------
    rs1901166561,2
    --56650927(+) GTGCAC/TGCCTG 2 -- us2k10--------
    rs48012941,2
    C,F,A,H,--56650956(+) AGGATG/TCAGCA 2 -- us2k113Minor allele frequency- T:0.28NS EA NA WA 788
    rs1476377331,2
    --56651061(+) AAAAAC/GAAAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF444 (56643968 - 56672262 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF444
         1 CNV: 50229

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF444 for disorders           About GeneDecksing

    OMIM gene information: 607874    OMIM disorders: --

    5 diseases for ZNF444:    About MalaCards
    peutz-jeghers syndrome    epithelial-myoepithelial carcinoma    myoepithelial carcinoma    mucoepidermoid carcinoma
    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for ZNF444:
    Myoepithelial carcinoma     epithelial-myoepithelial carcinoma

    Export disorders for ZNF444 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF444 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF444)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. (PubMed id 11978792)1, 2, 3 Adachi H. and Tsujimoto M. (2002)
    2. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. (PubMed id 19760602)1, 3 Brandal P....Heim S. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55311 HGNC: 16052 AceView: ZNF444 Ensembl:ENSG00000167685 euGenes: HUgn55311
    ECgene: ZNF444 H-InvDB: ZNF444

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF444 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF444 gene:
    Search GeneIP for patents involving ZNF444

    GeneCards and IP:
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