Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF444 Gene

Aliases for ZNF444 Gene

  • Zinc Finger Protein 444 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 17 3 4
  • Endothelial Zinc Finger Protein 2 3 4
  • ZSCAN17 3 4
  • EZF-2 3 4
  • EZF2 3 4

External Ids for ZNF444 Gene

Previous GeneCards Identifiers for ZNF444 Gene

  • GC19P061328
  • GC19P061344
  • GC19P056652
  • GC19P052962

Summaries for ZNF444 Gene

Entrez Gene Summary for ZNF444 Gene

  • This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZNF444 Gene

ZNF444 (Zinc Finger Protein 444) is a Protein Coding gene. Diseases associated with ZNF444 include myoepithelial carcinoma and chondrosarcoma, extraskeletal myxoid. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZKSCAN5.

UniProtKB/Swiss-Prot for ZNF444 Gene

  • Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF444 Gene

Genomics for ZNF444 Gene

Regulatory Elements for ZNF444 Gene

Genomic Location for ZNF444 Gene

Chromosome:
19
Start:
56,132,599 bp from pter
End:
56,160,893 bp from pter
Size:
28,295 bases
Orientation:
Plus strand

Genomic View for ZNF444 Gene

Genes around ZNF444 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF444 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF444 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF444 Gene

Proteins for ZNF444 Gene

  • Protein details for ZNF444 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y2-ZN444_HUMAN
    Recommended name:
    Zinc finger protein 444
    Protein Accession:
    Q8N0Y2
    Secondary Accessions:
    • Q8TEQ9
    • Q8WU35
    • Q9NUU1

    Protein attributes for ZNF444 Gene

    Size:
    327 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84889.1; Type=Frameshift; Positions=99; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF444 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF444 Gene

Proteomics data for ZNF444 Gene at MOPED

Post-translational modifications for ZNF444 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF444 Gene

Domains & Families for ZNF444 Gene

Gene Families for ZNF444 Gene

Suggested Antigen Peptide Sequences for ZNF444 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Y2

UniProtKB/Swiss-Prot:

ZN444_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF444: view

Function for ZNF444 Gene

Molecular function for ZNF444 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter.

Gene Ontology (GO) - Molecular Function for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF444: view
genes like me logo Genes that share phenotypes with ZNF444: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF444 Gene

Localization for ZNF444 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF444 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF444 Gene COMPARTMENTS Subcellular localization image for ZNF444 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF444 Gene

Pathways & Interactions for ZNF444 Gene

SuperPathways for ZNF444 Gene

No Data Available

Interacting Proteins for ZNF444 Gene

Gene Ontology (GO) - Biological Process for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF444: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF444 Gene

Drugs & Compounds for ZNF444 Gene

No Compound Related Data Available

Transcripts for ZNF444 Gene

Unigene Clusters for ZNF444 Gene

Zinc finger protein 444:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF444 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - -
SP13: -
SP14:
SP15:

ExUns: 11b · 11c · 11d ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ZNF444 Gene

GeneLoc Exon Structure for
ZNF444
ECgene alternative splicing isoforms for
ZNF444

Expression for ZNF444 Gene

mRNA expression in normal human tissues for ZNF444 Gene

Protein differential expression in normal tissues from HIPED for ZNF444 Gene

This gene is overexpressed in Fetal ovary (45.0), CD8 Tcells (13.7), and Retina (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF444 Gene



SOURCE GeneReport for Unigene cluster for ZNF444 Gene Hs.24545

genes like me logo Genes that share expression patterns with ZNF444: view

Protein tissue co-expression partners for ZNF444 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF444 Gene

Orthologs for ZNF444 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF444 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF444 35
  • 84.86 (n)
  • 83.99 (a)
ZNF444 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF444 35
  • 84.29 (n)
  • 84.71 (a)
ZNF444 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp444 35
  • 84.3 (n)
  • 89.08 (a)
Zfp444 16
Zfp444 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF444 35
  • 99.34 (n)
  • 99.34 (a)
ZNF444 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp444 35
  • 83.67 (n)
  • 87.07 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
OneToMany
-- 36
  • 9 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 14 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 17 (a)
OneToMany
-- 36
  • 14 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 12 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 13 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7368 36
  • 8 (a)
ManyToMany
l(3)neo38 36
  • 11 (a)
ManyToMany
Species with no ortholog for ZNF444:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF444 Gene

ENSEMBL:
Gene Tree for ZNF444 (if available)
TreeFam:
Gene Tree for ZNF444 (if available)

Paralogs for ZNF444 Gene

Paralogs for ZNF444 Gene

genes like me logo Genes that share paralogs with ZNF444: view

Variants for ZNF444 Gene

Sequence variations from dbSNP and Humsavar for ZNF444 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8419 -- 56,160,612(-) CGCCC(A/G)AGCTC utr-variant-3-prime
rs274152 -- 56,161,380(-) CGGAG(C/T)CCCCC downstream-variant-500B
rs274153 -- 56,161,186(-) TAGGT(C/T)CCCAG downstream-variant-500B
rs274154 -- 56,160,467(-) TTAGG(A/G)AGAGG utr-variant-3-prime
rs274179 -- 56,146,019(-) GGAGA(C/T)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF444 Gene

Variant ID Type Subtype PubMed ID
dgv206n21 CNV Loss 19592680
nsv912513 CNV Loss 21882294
dgv207n21 CNV Loss 19592680
nsv912516 CNV Gain 21882294
nsv528361 CNV Loss 19592680
esv2719020 CNV Deletion 23290073
esv2719021 CNV Deletion 23290073
dgv586e201 CNV Deletion 23290073
esv2719024 CNV Deletion 23290073

Variation tolerance for ZNF444 Gene

Gene Damage Index Score: 2.99; 49.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF444 Gene

HapMap Linkage Disequilibrium report
ZNF444

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF444 Gene

Disorders for ZNF444 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF444 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myoepithelial carcinoma
  • malignant myoepithelioma
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF444

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF444
genes like me logo Genes that share disorders with ZNF444: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF444 Gene

Publications for ZNF444 Gene

  1. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. (PMID: 11978792) Adachi H. … Tsujimoto M. (J. Biol. Chem. 2002) 2 3 4 67
  2. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. (PMID: 19760602) Brandal P. … Heim S. (Genes Chromosomes Cancer 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF444 Gene

Sources for ZNF444 Gene

Back to Top

Content