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ZNF444 Gene(Protein Coding)

Zinc Finger Protein 444

GCID:
GC19P056132
GIFtS:
49
Genes Participants
UDN Logo

Aliases for ZNF444 Gene

Aliases for ZNF444 Gene

  • Zinc Finger Protein 444 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 17 3 4
  • Endothelial Zinc Finger Protein 2 3 4
  • ZSCAN17 3 4
  • EZF-2 3 4
  • EZF2 3 4

External Ids for ZNF444 Gene

Previous GeneCards Identifiers for ZNF444 Gene

  • GC19P061328
  • GC19P061344
  • GC19P056652
  • GC19P052962

Summaries for ZNF444 Gene

Entrez Gene Summary for ZNF444 Gene

  • This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZNF444 Gene

ZNF444 (Zinc Finger Protein 444) is a Protein Coding gene. Diseases associated with ZNF444 include Chondrosarcoma, Extraskeletal Myxoid. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZKSCAN5.

UniProtKB/Swiss-Prot for ZNF444 Gene

  • Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF444 Gene

Genomics for ZNF444 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZNF444 Gene

Enhancers for ZNF444 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F056171 1.1 Ensembl ENCODE 12.2 +39.4 39402 0.4 ELF3 CTCF TFAP4 SAP130 ZNF133 ARID4B CEBPG ZNF48 RAD21 TEAD3 ZNF444 GALP ENSG00000279794
GH19F056252 1.2 Ensembl ENCODE 10.2 +120.3 120332 0.3 ATF1 CBX3 NFRKB RAD21 CHAMP1 YY1 CBX5 ZNF143 KLF13 ZHX1 U2AF2 ZNF580 NAT14 ENSG00000269696 ZNF582-AS1 FIZ1 ZNF667 MIMT1 KMT5C ZNF470
GH19F056170 1 ENCODE 12.2 +37.9 37898 0.1 MLX ARID4B DMAP1 SLC30A9 SP5 NFYC MXD4 MIER2 KAT8 MAFF ZNF444 GALP ENSG00000279794
GH19F056066 0.8 ENCODE 11.6 -66.0 -65990 0.2 CTCF ZNF48 ZIC2 RAD21 ZBTB40 ZEB1 RFX5 GLIS2 ZNF143 SMC3 ZNF444 LINC01864 GC19M056051
GH19F056324 0.7 FANTOM5 ENCODE 10.9 +192.2 192173 0.5 PAF1 ZNF444 ZSCAN5A LOC729999 PIR48946
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF444 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF444 gene promoter:

Genomic Location for ZNF444 Gene

Chromosome:
19
Start:
56,132,599 bp from pter
End:
56,160,893 bp from pter
Size:
28,295 bases
Orientation:
Plus strand

Genomic View for ZNF444 Gene

Genes around ZNF444 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF444 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF444 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF444 Gene

Proteins for ZNF444 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF444 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y2-ZN444_HUMAN
    Recommended name:
    Zinc finger protein 444
    Protein Accession:
    Q8N0Y2
    Secondary Accessions:
    • Q8TEQ9
    • Q8WU35
    • Q9NUU1

    Protein attributes for ZNF444 Gene

    Size:
    327 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84889.1; Type=Frameshift; Positions=99; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF444 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF444 Gene

Protein Expression for ZNF444 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF444 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF444 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF444 Gene

Domains & Families for ZNF444 Gene

Gene Families for ZNF444 Gene

HGNC:

Protein Domains for ZNF444 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF444 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Y2

UniProtKB/Swiss-Prot:

ZN444_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF444: view

Function for ZNF444 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ZNF444 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter.

Gene Ontology (GO) - Molecular Function for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF444: view
genes like me logo Genes that share phenotypes with ZNF444: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF444 Gene

Localization for ZNF444 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF444 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF444 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF444: view

Pathways & Interactions for ZNF444 Gene

SuperPathways for ZNF444 Gene

PathCards logo More details on SuperPathways for ZNF444
No Data Available

Gene Ontology (GO) - Biological Process for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF444: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF444 Gene

Drugs & Compounds for ZNF444 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF444 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ZNF444 Gene

(12) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF444 Gene

Zinc finger protein 444:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF444 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - -
SP13: -
SP14:
SP15:

ExUns: 11b · 11c · 11d ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ZNF444 Gene

GeneLoc Exon Structure for
ZNF444
ECgene alternative splicing isoforms for
ZNF444

Expression for ZNF444 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF444 Gene

mRNA expression in normal human tissues for ZNF444 Gene
mRNA expression by BioGPS for ZNF444 GenemRNA expression by GTEx for ZNF444 Gene

Protein differential expression in normal tissues from HIPED for ZNF444 Gene

This gene is overexpressed in Fetal ovary (45.0), CD8 Tcells (13.7), and Retina (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF444 Gene



Protein tissue co-expression partners for ZNF444 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF444 Gene:

ZNF444

SOURCE GeneReport for Unigene cluster for ZNF444 Gene:

Hs.24545
genes like me logo Genes that share expression patterns with ZNF444: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF444 Gene

Orthologs for ZNF444 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF444 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF444 34 35
  • 99.34 (n)
cow
(Bos Taurus)
 Mammalia ZNF444 34 35
  • 84.86 (n)
mouse
(Mus musculus)
 Mammalia Zfp444 34 16 35
  • 84.3 (n)
dog
(Canis familiaris)
 Mammalia ZNF444 34 35
  • 84.29 (n)
rat
(Rattus norvegicus)
 Mammalia Zfp444 34
  • 83.67 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 43 (a)
 OneToMany
-- 35
  • 42 (a)
 OneToMany
-- 35
  • 33 (a)
 OneToMany
-- 35
  • 31 (a)
 OneToMany
-- 35
  • 29 (a)
 OneToMany
-- 35
  • 25 (a)
 OneToMany
-- 35
  • 13 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 44 (a)
 OneToMany
-- 35
  • 40 (a)
 OneToMany
-- 35
  • 35 (a)
 OneToMany
-- 35
  • 35 (a)
 OneToMany
-- 35
  • 34 (a)
 OneToMany
-- 35
  • 33 (a)
 OneToMany
-- 35
  • 32 (a)
 OneToMany
-- 35
  • 32 (a)
 OneToMany
-- 35
  • 32 (a)
 OneToMany
-- 35
  • 28 (a)
 OneToMany
-- 35
  • 28 (a)
 OneToMany
-- 35
  • 25 (a)
 OneToMany
-- 35
  • 25 (a)
 OneToMany
-- 35
  • 25 (a)
 OneToMany
-- 35
  • 25 (a)
 OneToMany
-- 35
  • 25 (a)
 OneToMany
-- 35
  • 25 (a)
 OneToMany
-- 35
  • 24 (a)
 OneToMany
-- 35
  • 24 (a)
 OneToMany
-- 35
  • 24 (a)
 OneToMany
-- 35
  • 24 (a)
 OneToMany
-- 35
  • 23 (a)
 OneToMany
-- 35
  • 23 (a)
 OneToMany
-- 35
  • 21 (a)
 OneToMany
-- 35
  • 21 (a)
 OneToMany
-- 35
  • 21 (a)
 OneToMany
-- 35
  • 20 (a)
 OneToMany
-- 35
  • 19 (a)
 OneToMany
-- 35
  • 19 (a)
 OneToMany
-- 35
  • 19 (a)
 OneToMany
-- 35
  • 18 (a)
 OneToMany
-- 35
  • 18 (a)
 OneToMany
-- 35
  • 17 (a)
 OneToMany
-- 35
  • 14 (a)
 OneToMany
-- 35
  • 14 (a)
 OneToMany
-- 35
  • 13 (a)
 OneToMany
-- 35
  • 12 (a)
 OneToMany
-- 35
  • 9 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta l(3)neo38 35
  • 11 (a)
 ManyToMany
CG7368 35
  • 8 (a)
 ManyToMany
Species where no ortholog for ZNF444 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF444 Gene

ENSEMBL:
Gene Tree for ZNF444 (if available)
TreeFam:
Gene Tree for ZNF444 (if available)

Paralogs for ZNF444 Gene

Variants for ZNF444 Gene

Sequence variations from dbSNP and Humsavar for ZNF444 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10407167 -- 56,160,323(+) cctgc(A/G)cctcc utr-variant-3-prime
rs10408574 -- 56,147,674(+) ctccc(A/G)ccccc intron-variant
rs10410564 -- 56,157,157(+) GGGCC(C/T)GAGTG intron-variant, utr-variant-5-prime
rs10413795 -- 56,153,685(+) AGGGC(A/G)TCTGC intron-variant, upstream-variant-2KB
rs10419088 -- 56,145,540(+) aagat(C/G)gcacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF444 Gene

Variant ID Type Subtype PubMed ID
nsv580354 CNV gain 21841781
nsv528361 CNV loss 19592680
nsv1143928 CNV deletion 24896259
nsv1057820 CNV gain 25217958
esv3583591 CNV loss 25503493
esv2719024 CNV deletion 23290073
esv2719021 CNV deletion 23290073
esv2719020 CNV deletion 23290073
dgv545e201 CNV deletion 23290073
dgv3681n100 CNV gain 25217958
dgv207n21 CNV loss 19592680
dgv206n21 CNV loss 19592680

Variation tolerance for ZNF444 Gene

Gene Damage Index Score: 2.99; 49.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF444 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF444

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF444 Gene

Disorders for ZNF444 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF444 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF444

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF444
genes like me logo Genes that share disorders with ZNF444: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF444 Gene

Publications for ZNF444 Gene

  1. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. (PMID: 11978792) Adachi H. … Tsujimoto M. (J. Biol. Chem. 2002) 2 3 4 64
  2. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. (PMID: 19760602) Brandal P. … Heim S. (Genes Chromosomes Cancer 2009) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZNF444 Gene

Sources for ZNF444 Gene

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