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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF444 Gene

protein-coding GIFtS: 47
GCID: GC19P056652

Zinc Finger Protein 444

Microbiology & Infectious Diseases Congress

5 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Zinc Finger Protein 444¹ ²
EZF2² ³ ⁵
Endothelial Zinc Finger Protein 2² ³
Zinc Finger And SCAN Domain-Containing Protein 17² ³
EZF-2² ³
ZSCAN17² ³

External Ids:	HGNC: 16052¹	Entrez Gene: 55311²	Ensembl: ENSG00000167685⁷	OMIM: 607874⁵	UniProtKB: Q8N0Y2³

Export aliases for ZNF444 gene to outside databases

Previous GC identifers: GC19P061328 GC19P061344 GC19P052962

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF444 Gene:

This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the

degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc

finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for ZNF444 Gene:

ZNF444 (zinc finger protein 444) is a protein-coding gene. Diseases associated with ZNF444 include epithelial-myoepithelial carcinoma, and myoepithelial carcinoma. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ZN444_HUMAN, Q8N0Y2

Function: Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NT_011109.16 NC_018930.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF444 gene promoter:
E2F-3a E2F-4 STAT1 E2F-5 E2F-2 Tal-1beta STAT1alpha E47 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF444 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF444

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF444

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

ZNF444 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF444 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P056652: view genomic region (about GC identifiers)

Start:	56,643,968 bp from pter	End:	56,672,262 bp from pter
Size:	28,295 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN444_HUMAN, Q8N0Y2 (See protein sequence)

Recommended Name: Zinc finger protein 444

Size: 327 amino acids; 35204 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=BAB84889.1; Type=Frameshift; Positions=99;

Secondary accessions: Q8TEQ9 Q8WU35 Q9NUU1

Alternative splicing: 2 isoforms: Q8N0Y2-1 Q8N0Y2-2

Explore the universe of human proteins at neXtProt for ZNF444: NX_Q8N0Y2

Explore proteomics data for ZNF444 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8N0Y2

ZNF444 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001240721.1 NP_060807.2

ENSEMBL proteins:

ENSP00000465171 ENSP00000466287 ENSP00000338860 ENSP00000466666 ENSP00000468069

ENSP00000465070 ENSP00000465466 ENSP00000468762

Human Recombinant Protein Products for ZNF444:

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	Cloud-Clone Corp. Proteins for ZNF444

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IBA	--

ZNF444 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

5 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR008916 Retrov_capsid_C

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

IPR003309 Tscrpt_reg_SCAN

Graphical View of Domain Structure for InterPro Entry Q8N0Y2

ProtoNet protein and cluster: Q8N0Y2

1 Blocks protein domain: IPB003309 Transcriptional regulator SCAN

UniProtKB/Swiss-Prot: ZN444_HUMAN, Q8N0Y2

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 4 C2H2-type zinc fingers

Similarity: Contains 1 SCAN box domain

ZNF444 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN444_HUMAN, Q8N0Y2

Function: Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	IBA	--
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0008270	zinc ion binding	--	--
GO:0046872	metal ion binding	IEA	--

ZNF444 for ontologies About GeneDecksing

Animal Models:

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		hsa-miR-138
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF444

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF444

1 Interacting protein for ZNF444 (Q8N0Y2³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DVL3	Q92997³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IBA	--
GO:0006366	transcription from RNA polymerase II promoter	IBA	--
GO:0016032	viral process	--	--

ZNF444 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF444 (ZN444)

Search CenterWatch for drugs/clinical trials and news about ZNF444 / ZN444

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF444 gene (2 alternative transcripts):

NM_001253792.1 NM_018337.3

Unigene Cluster for ZNF444:

Zinc finger protein 444

Hs.24545 [show with all ESTs]

Unigene Representative Sequence: NM_018337

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000587467 ENST00000588358 ENST00000337080(uc002qmn.2 uc002qmm.3)

ENST00000587195 ENST00000586123 ENST00000587664 ENST00000592949 ENST00000593100

ENST00000588203 ENST00000591564 ENST00000587236 ENST00000592171

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF444:
		hsa-miR-138
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Additional mRNA sequence:

AB052954.1 AB052955.1 AF074985.1 AK001999.1 AK223408.1 AL834130.1 BC021282.2

9 DOTS entries:

DT.209968 DT.95319332 DT.100778630 DT.101958133 DT.99954439 DT.95273876 DT.99968402 DT.92427034

DT.95273871

24/139 AceView cDNA sequences (see all 139):

CR590232 AL834130 BQ889394 AI858670 BQ025503 AW955650 BX415164 BM980144

AA297241 BE395510 BF436611 CR626120 CK823295 AB052954 BM920816 AI609372

AI573292 AL520692 BM966791 BM702299 BI962599 AL522825 BU618006 BM451961

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF444 (see all 15) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	·	7g	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·
SP1:													-		-		-		-																		-		-		-		-		-
SP2:													-		-		-		-																		-		-		-		-		-
SP3:											-		-		-		-		-																		-
SP4:													-				-		-
SP5:													-		-		-		-																-		-		-		-		-		-

ExUns:	11b	·	11c	·	11d	^	12
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ZNF444

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF444 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGATGGACAG

About this image

See ZNF444 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF444

SOURCE GeneReport for Unigene cluster: Hs.24545

SABiosciences Custom PCR Arrays for ZNF444

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF444 gene from 4/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp444^{1 , 5}	zinc finger protein 444^{1, 5}	82.91(n)¹ 88.05(a)¹		7 (3.58 cM)⁵ 72667¹ NM_001146024.1¹ NP_001139496.1¹ 6172226⁵
lizard (Anolis carolinensis)	Reptilia	ZNF467⁶	Uncharacterized protein	13(a)	1 → many	GL343790.1(8739-53919)
zebrafish (Danio rerio)	Actinopterygii	--	--	15(a)	possible ortholog	11(2231155-2276000)
fruit fly (Drosophila melanogaster)	Insecta	CG7368⁶ l(3)neo38⁶	lethal (3) neo38	9(a) 14(a)	many ↔ many many ↔ many	3L(11590302-11598474) 3R(7590760-7604886)

ENSEMBL Gene Tree for ZNF444 (if available)
TreeFam Gene Tree for ZNF444 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF444 gene

18/36 SIMAP similar genes for ZNF444 using alignment to 7 protein entries: ZN444_HUMAN (see all proteins) (see all similar genes):

ZNF167 ZSCAN21 ZKSCAN8 ZSCAN31 ZNF263 ZKSCAN1

ZNF24 ZKSCAN7 ZNF202 ZNF397 ZNF197 ZNF174

ZSCAN29 ZNF394 ZSCAN10 ZNF18 LOC100128510 ZNF396

ZNF444 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188698700^1,2		--	56650613(+)	`AGAGGC/TGAGAG`	2	--	us2k¹		0	--	--	--	--
rs73615800^1,2	C,F	--	56650670(+)	`TGGTAG/ACCATA`	2	--	us2k¹		3		WA	122
rs148716734^1,2		--	56650701(+)	`ATTCTC/GCATCT`	2	--	us2k¹		0	--	--	--	--
rs112572899^1,2	C	--	56650710(+)	`CTATTC/G/TTGAAG`	2	--	us2k¹		1		CSA	2
rs191929060^1,2		--	56650736(+)	`CCTGAC/TGATAG`	2	--	us2k¹		0	--	--	--	--
rs667523^1,2	C,H	--	56650783(+)	`tgggcG/Atggtg`	2	--	us2k¹ tfbs³		10		NA WA EA	374
rs184842995^1,2		--	56650794(+)	`GTTCAC/TGCTTG`	2	--	us2k¹		0	--	--	--	--
rs142288256^1,2		--	56650871(+)	`GCCAAC/TATGGC`	2	--	us2k¹		0	--	--	--	--
rs190116656^1,2		--	56650927(+)	`GTGCAC/TGCCTG`	2	--	us2k¹		0	--	--	--	--
rs4801294^1,2	C,F,A,H	--	56650956(+)	`aggatG/Tcagca`	2	--	us2k¹		13		NS EA NA WA	788

HapMap Linkage Disequilibrium report for ZNF444 (56643968 - 56672262 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for ZNF444: About this table

Variant ID	Type	Subtype	PubMed ID
esv2719020	CNV	Deletion	23290073
esv2719021	CNV	Deletion	23290073
dgv586e201	CNV	Deletion	23290073
esv2719024	CNV	Deletion	23290073
nsv912513	CNV	Loss	21882294
dgv207n21	CNV	Loss	19592680
nsv528361	CNV	Loss	19592680
dgv206n21	CNV	Loss	19592680
nsv912516	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF444 for disorders           About GeneDecksing

OMIM gene information: 607874    OMIM disorders: --

5 diseases for ZNF444:    About MalaCards

epithelial-myoepithelial carcinoma myoepithelial carcinoma peutz-jeghers syndrome mucoepidermoid carcinoma

endotheliitis

2 diseases from the University of Copenhagen DISEASES database for ZNF444:

Myoepithelial carcinoma epithelial-myoepithelial carcinoma

Export disorders for ZNF444 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF444 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF444)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. (PubMed id 11978792)^{1, 2, 3} Adachi H. and Tsujimoto M. (2002)
t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. (PubMed id 19760602)^{1, 3} Brandal P....Heim S. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55311	HGNC: 16052	AceView: ZNF444	Ensembl:ENSG00000167685	euGenes: HUgn55311
ECgene: ZNF444	H-InvDB: ZNF444

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZNF444	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF444 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZNF444 gene:
Search GeneIP for patents involving ZNF444

GeneCards and IP:
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Zinc Finger Protein 444

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Zinc Finger Protein 444

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