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Aliases for ZNF444 Gene

Aliases for ZNF444 Gene

  • Zinc Finger Protein 444 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 17 3 4
  • Endothelial Zinc Finger Protein 2 3 4
  • ZSCAN17 3 4
  • EZF-2 3 4
  • EZF2 3 4

External Ids for ZNF444 Gene

Previous GeneCards Identifiers for ZNF444 Gene

  • GC19P061328
  • GC19P061344
  • GC19P056652
  • GC19P052962

Summaries for ZNF444 Gene

Entrez Gene Summary for ZNF444 Gene

  • This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZNF444 Gene

ZNF444 (Zinc Finger Protein 444) is a Protein Coding gene. Diseases associated with ZNF444 include Chondrosarcoma, Extraskeletal Myxoid. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZKSCAN5.

UniProtKB/Swiss-Prot for ZNF444 Gene

  • Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter.

Additional gene information for ZNF444 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF444 Gene

Genomics for ZNF444 Gene

Regulatory Elements for ZNF444 Gene

Enhancers for ZNF444 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H055519 1.6 FANTOM5 Ensembl ENCODE 9.7 -612.4 -612390 0 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 FOS ZNF548 ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
GH19H056171 1.1 Ensembl ENCODE 12.3 +39.4 39382 0 ELF3 ARNT ZNF133 ARID4B RAD21 ZNF143 RUNX3 IKZF2 THAP11 MXD4 ZNF444 GALP ENSG00000279794
GH19H056066 1.1 Ensembl ENCODE 11.6 -65.9 -65919 0 CTCF MXI1 RB1 ZIC2 RAD21 ZEB1 RFX5 GLIS2 SCRT2 SMC3 ZNF444 LINC01864 GC19M056051
GH19H055503 1.3 Ensembl ENCODE 9.7 -628.6 -628631 1 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF416 ZNF143 ZNF548 U2AF2 FIZ1 ZNF667 ZNF582-AS1 NAT14 ZNF667-AS1 ZNF542P ZNF582 ZNF583 ENSG00000267523
GH19H056170 1 ENCODE 12.3 +37.9 37898 0 MLX ARID4B DMAP1 SLC30A9 ATF7 SP5 ZHX2 MXD4 NFYC MIER2 ZNF444 GALP ENSG00000279794
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF444 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF444 Gene

Chromosome:
19
Start:
56,132,599 bp from pter
End:
56,160,893 bp from pter
Size:
28,295 bases
Orientation:
Plus strand

Genomic View for ZNF444 Gene

Genes around ZNF444 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF444 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF444 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF444 Gene

Proteins for ZNF444 Gene

  • Protein details for ZNF444 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y2-ZN444_HUMAN
    Recommended name:
    Zinc finger protein 444
    Protein Accession:
    Q8N0Y2
    Secondary Accessions:
    • Q8TEQ9
    • Q8WU35
    • Q9NUU1

    Protein attributes for ZNF444 Gene

    Size:
    327 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84889.1; Type=Frameshift; Positions=99; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF444 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF444 Gene

Post-translational modifications for ZNF444 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF444 Gene

Domains & Families for ZNF444 Gene

Gene Families for ZNF444 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF444 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Y2

UniProtKB/Swiss-Prot:

ZN444_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF444: view

Function for ZNF444 Gene

Molecular function for ZNF444 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter.

Phenotypes From GWAS Catalog for ZNF444 Gene

Gene Ontology (GO) - Molecular Function for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF444: view
genes like me logo Genes that share phenotypes with ZNF444: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF444
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF444 Gene

Localization for ZNF444 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF444 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF444 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF444: view

Pathways & Interactions for ZNF444 Gene

SuperPathways for ZNF444 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF444: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF444 Gene

Drugs & Compounds for ZNF444 Gene

No Compound Related Data Available

Transcripts for ZNF444 Gene

Unigene Clusters for ZNF444 Gene

Zinc finger protein 444:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF444
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF444 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - -
SP13: -
SP14:
SP15:

ExUns: 11b · 11c · 11d ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ZNF444 Gene

GeneLoc Exon Structure for
ZNF444
ECgene alternative splicing isoforms for
ZNF444

Expression for ZNF444 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF444 Gene

Protein differential expression in normal tissues from HIPED for ZNF444 Gene

This gene is overexpressed in Fetal ovary (45.0), CD8 Tcells (13.7), and Retina (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF444 Gene



Protein tissue co-expression partners for ZNF444 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF444 Gene:

ZNF444

SOURCE GeneReport for Unigene cluster for ZNF444 Gene:

Hs.24545

Evidence on tissue expression from TISSUES for ZNF444 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with ZNF444: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF444 Gene

Orthologs for ZNF444 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF444 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF444 33 34
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia ZNF444 33 34
  • 84.86 (n)
mouse
(Mus musculus)
Mammalia Zfp444 33 16 34
  • 84.3 (n)
dog
(Canis familiaris)
Mammalia ZNF444 33 34
  • 84.29 (n)
rat
(Rattus norvegicus)
Mammalia Zfp444 33
  • 83.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
-- 34
  • 33 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 13 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
-- 34
  • 34 (a)
OneToMany
-- 34
  • 33 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 20 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
-- 34
  • 17 (a)
OneToMany
-- 34
  • 14 (a)
OneToMany
-- 34
  • 14 (a)
OneToMany
-- 34
  • 13 (a)
OneToMany
-- 34
  • 12 (a)
OneToMany
-- 34
  • 9 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo38 34
  • 11 (a)
ManyToMany
CG7368 34
  • 8 (a)
ManyToMany
Species where no ortholog for ZNF444 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF444 Gene

ENSEMBL:
Gene Tree for ZNF444 (if available)
TreeFam:
Gene Tree for ZNF444 (if available)

Paralogs for ZNF444 Gene

Variants for ZNF444 Gene

Sequence variations from dbSNP and Humsavar for ZNF444 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000018935 -- 56,160,709(+) GGGTT(-/G)GGGGA utr-variant-3-prime
rs1000155870 -- 56,160,488(+) TTCCC(C/G)CCTCT utr-variant-3-prime
rs1000228577 -- 56,152,622(+) CTGCT(A/G)TAACA intron-variant
rs1000307036 -- 56,159,380(+) CTACC(C/T)ACGCA intron-variant
rs1000317050 -- 56,156,689(+) AAGAC(C/T)GTAAC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF444 Gene

Variant ID Type Subtype PubMed ID
dgv206n21 CNV loss 19592680
dgv207n21 CNV loss 19592680
dgv3681n100 CNV gain 25217958
dgv545e201 CNV deletion 23290073
esv2719020 CNV deletion 23290073
esv2719021 CNV deletion 23290073
esv2719024 CNV deletion 23290073
esv3583591 CNV loss 25503493
nsv1057820 CNV gain 25217958
nsv1143928 CNV deletion 24896259
nsv528361 CNV loss 19592680
nsv580354 CNV gain 21841781

Variation tolerance for ZNF444 Gene

Gene Damage Index Score: 2.99; 49.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF444 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF444

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF444 Gene

Disorders for ZNF444 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF444 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF444

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF444
genes like me logo Genes that share disorders with ZNF444: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF444 Gene

Publications for ZNF444 Gene

  1. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. (PMID: 11978792) Adachi H … Tsujimoto M (The Journal of biological chemistry 2002) 2 3 4 60
  2. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. (PMID: 19760602) Brandal P … Heim S (Genes, chromosomes & cancer 2009) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for ZNF444 Gene

Sources for ZNF444 Gene

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