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Aliases for ZNF444 Gene

Aliases for ZNF444 Gene

  • Zinc Finger Protein 444 2 3
  • EZF2 3 4 6
  • Zinc Finger And SCAN Domain-Containing Protein 17 3 4
  • Endothelial Zinc Finger Protein 2 3 4
  • ZSCAN17 3 4
  • EZF-2 3 4

External Ids for ZNF444 Gene

Previous GeneCards Identifiers for ZNF444 Gene

  • GC19P061328
  • GC19P061344
  • GC19P056652
  • GC19P052962

Summaries for ZNF444 Gene

Entrez Gene Summary for ZNF444 Gene

  • This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZNF444 Gene

ZNF444 (Zinc Finger Protein 444) is a Protein Coding gene. Diseases associated with ZNF444 include epithelial-myoepithelial carcinoma. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZKSCAN5.

UniProtKB/Swiss-Prot for ZNF444 Gene

  • Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF444 Gene

Genomics for ZNF444 Gene

Regulatory Elements for ZNF444 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF444 Gene

Start:
56,132,599 bp from pter
End:
56,160,893 bp from pter
Size:
28,295 bases
Orientation:
Plus strand

Genomic View for ZNF444 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF444 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF444 Gene

Proteins for ZNF444 Gene

  • Protein details for ZNF444 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y2-ZN444_HUMAN
    Recommended name:
    Zinc finger protein 444
    Protein Accession:
    Q8N0Y2
    Secondary Accessions:
    • Q8TEQ9
    • Q8WU35
    • Q9NUU1

    Protein attributes for ZNF444 Gene

    Size:
    327 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84889.1; Type=Frameshift; Positions=99; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF444 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF444 Gene

Proteomics data for ZNF444 Gene at MOPED

Post-translational modifications for ZNF444 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF444 Gene

Domains for ZNF444 Gene

Gene Families for ZNF444 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF444 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Y2

UniProtKB/Swiss-Prot:

ZN444_HUMAN :
  • Q8N0Y2
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF444: view

Function for ZNF444 Gene

Molecular function for ZNF444 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator. Binds to the 5-flanking critical region of the SCARF1 promoter

Gene Ontology (GO) - Molecular Function for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF444: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF444 Gene

Localization for ZNF444 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF444 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF444 Gene COMPARTMENTS Subcellular localization image for ZNF444 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF444: view

Pathways for ZNF444 Gene

SuperPathways for ZNF444 Gene

No Data Available

Interacting Proteins for ZNF444 Gene

Gene Ontology (GO) - Biological Process for ZNF444 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF444: view

No data available for Pathways by source for ZNF444 Gene

Transcripts for ZNF444 Gene

Unigene Clusters for ZNF444 Gene

Zinc finger protein 444:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF444

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF444 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - -
SP13: -
SP14:
SP15:

ExUns: 11b · 11c · 11d ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ZNF444 Gene

GeneLoc Exon Structure for
ZNF444
ECgene alternative splicing isoforms for
ZNF444

Expression for ZNF444 Gene

mRNA expression in normal human tissues for ZNF444 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF444 Gene

SOURCE GeneReport for Unigene cluster for ZNF444 Gene Hs.24545

genes like me logo Genes that share expressions with ZNF444: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF444 Gene

Orthologs for ZNF444 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF444 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF444 35
  • 99.34 (n)
  • 99.34 (a)
ZNF444 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF444 35
  • 84.86 (n)
  • 83.99 (a)
ZNF444 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF444 35
  • 84.29 (n)
  • 84.71 (a)
ZNF444 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp444 35
  • 84.3 (n)
  • 89.08 (a)
Zfp444 16
Zfp444 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp444 35
  • 83.67 (n)
  • 87.07 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
OneToMany
-- 36
  • 9 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 14 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 17 (a)
OneToMany
-- 36
  • 14 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 12 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 13 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7368 36
  • 8 (a)
ManyToMany
l(3)neo38 36
  • 11 (a)
ManyToMany
Species with no ortholog for ZNF444:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF444 Gene

ENSEMBL:
Gene Tree for ZNF444 (if available)
TreeFam:
Gene Tree for ZNF444 (if available)

Paralogs for ZNF444 Gene

Paralogs for ZNF444 Gene

genes like me logo Genes that share paralogs with ZNF444: view

Variants for ZNF444 Gene

Sequence variations from dbSNP and Humsavar for ZNF444 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8419 -- 56,160,612(-) CGCCC(A/G)AGCTC utr-variant-3-prime
rs274152 -- 56,161,380(-) CGGAG(C/T)CCCCC downstream-variant-500B
rs274153 -- 56,161,186(-) TAGGT(C/T)CCCAG downstream-variant-500B
rs274154 -- 56,160,467(-) TTAGG(A/G)AGAGG utr-variant-3-prime
rs274176 -- 56,150,535(-) CCGTC(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF444 Gene

Variant ID Type Subtype PubMed ID
dgv206n21 CNV Loss 19592680
nsv912513 CNV Loss 21882294
dgv207n21 CNV Loss 19592680
nsv912516 CNV Gain 21882294
nsv528361 CNV Loss 19592680
esv2719020 CNV Deletion 23290073
esv2719021 CNV Deletion 23290073
dgv586e201 CNV Deletion 23290073
esv2719024 CNV Deletion 23290073

Relevant External Links for ZNF444 Gene

HapMap Linkage Disequilibrium report
ZNF444

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF444 Gene

Disorders for ZNF444 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNF444 Gene including...

Search for ZNF444 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ZNF444 Gene

genes like me logo Genes that share disorders with ZNF444: view

No data available for UniProtKB/Swiss-Prot for ZNF444 Gene

Publications for ZNF444 Gene

  1. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. (PMID: 11978792) Adachi H. … Tsujimoto M. (J. Biol. Chem. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. (PMID: 19760602) Brandal P. … Heim S. (Genes Chromosomes Cancer 2009) 2 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for ZNF444 Gene

Sources for ZNF444 Gene

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