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Aliases for ZNF443 Gene

Aliases for ZNF443 Gene

  • Zinc Finger Protein 443 2 3
  • Krueppel-Type Zinc Finger Protein ZK1 3 4
  • ZK1 3 6
  • Kruppel-Type Zinc Finger (C2H2) 3

External Ids for ZNF443 Gene

Summaries for ZNF443 Gene

Entrez Gene Summary for ZNF443 Gene

  • Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these proteins, see ZNF91 (MIM 603971).[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF443 Gene

ZNF443 (Zinc Finger Protein 443) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF443 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF443 Gene

Genomics for ZNF443 Gene

Genomic Location for ZNF443 Gene

Start:
12,426,896 bp from pter
End:
12,441,112 bp from pter
Size:
14,217 bases
Orientation:
Minus strand

Genomic View for ZNF443 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF443 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF443 Gene

No data available for Regulatory Elements for ZNF443 Gene

Proteins for ZNF443 Gene

  • Protein details for ZNF443 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2A4-ZN443_HUMAN
    Recommended name:
    Zinc finger protein 443
    Protein Accession:
    Q9Y2A4
    Secondary Accessions:

    Protein attributes for ZNF443 Gene

    Size:
    671 amino acids
    Molecular mass:
    77516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF443 Gene

Proteomics data for ZNF443 Gene at MOPED

Post-translational modifications for ZNF443 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF443 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF443 Gene

Domains for ZNF443 Gene

Gene Families for ZNF443 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN443_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q9Y2A4
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9Y2A4
Similarity:
  • Contains 19 C2H2-type zinc fingers.:
    • Q9Y2A4
genes like me logo Genes that share domains with ZNF443: view

Function for ZNF443 Gene

Molecular function for ZNF443 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation
UniProtKB/Swiss-Prot Induction: Induced following exposure to ionizing radiation

Gene Ontology (GO) - Molecular Function for ZNF443 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF443: view

miRNA for ZNF443 Gene

miRTarBase miRNAs that target ZNF443

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF443 Gene

Localization for ZNF443 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF443 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF443 Gene COMPARTMENTS Subcellular localization image for ZNF443 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF443 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF443: view

Pathways for ZNF443 Gene

SuperPathways for ZNF443 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF443: view

Pathways by source for ZNF443 Gene

2 Reactome pathways for ZNF443 Gene

Gene Ontology (GO) - Biological Process for ZNF443 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process TAS 9731181
GO:0006950 response to stress TAS 9731181
genes like me logo Genes that share ontologies with ZNF443: view

Transcripts for ZNF443 Gene

mRNA/cDNA for ZNF443 Gene

Unigene Clusters for ZNF443 Gene

Zinc finger protein 443:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF443 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for ZNF443 Gene

GeneLoc Exon Structure for
ZNF443
ECgene alternative splicing isoforms for
ZNF443

Expression for ZNF443 Gene

mRNA expression in normal human tissues for ZNF443 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF443 Gene

SOURCE GeneReport for Unigene cluster for ZNF443 Gene Hs.720755

genes like me logo Genes that share expressions with ZNF443: view

Orthologs for ZNF443 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF443 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF443 36
  • 98.96 (n)
  • 98.6 (a)
ZNF443 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 50 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp709 36
  • 66.12 (n)
  • 52.85 (a)
rat
(Rattus norvegicus)
Mammalia Zfp709 36
  • 65.27 (n)
  • 53.75 (a)
Species with no ortholog for ZNF443:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF443 Gene

ENSEMBL:
Gene Tree for ZNF443 (if available)
TreeFam:
Gene Tree for ZNF443 (if available)

Paralogs for ZNF443 Gene

Selected SIMAP similar genes for ZNF443 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF443: view

Variants for ZNF443 Gene

Sequence variations from dbSNP and Humsavar for ZNF443 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs706547 -- 12,430,004(+) tcatc(C/G)cttga utr-variant-3-prime
rs1025025 -- 12,429,957(-) atgtc(A/C)agtcc utr-variant-3-prime
rs1056003 -- 12,429,970(-) CACTC(C/T)GTGAG utr-variant-3-prime
rs1056005 -- 12,429,747(-) ATAGT(A/G)TAGTC utr-variant-3-prime
rs1134389 -- 12,431,958(-) GATTT(A/G)TTGAA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF443 Gene

Variant ID Type Subtype PubMed ID
esv2718192 CNV Deletion 23290073
dgv1057e1 CNV Complex 17122850
esv2718194 CNV Deletion 23290073
esv21983 CNV Gain 19812545
dgv3732n71 CNV Loss 21882294
nsv911073 CNV Loss 21882294
nsv442453 CNV CNV 18776908
nsv911075 CNV Loss 21882294

Relevant External Links for ZNF443 Gene

HapMap Linkage Disequilibrium report
ZNF443

Disorders for ZNF443 Gene

No disorders were found for ZNF443 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF443 Gene

Publications for ZNF443 Gene

  1. ZK1, a novel Kruppel-type zinc finger gene, is induced following exposure to ionizing radiation and enhances apoptotic cell death on hematopoietic cells. (PMID: 9731181) Katoh O. … Watanabe H. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Analysis of BCL6-interacting proteins by tandem mass spectrometry. (PMID: 16147992) Miles R.R. … Elenitoba-Johnson K.S. (Mol. Cell Proteomics 2005) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF443 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF443
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF443
  • Block miRNA regulation of ZNF443 using miScript Target Protectors

Sources for ZNF443 Gene

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