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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF443 Gene

protein-coding   GIFtS: 49
GCID: GC19M012540

Zinc Finger Protein 443

  Search for ZNF443
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 4431 2
Krueppel-Type Zinc Finger Protein ZK12 3
ZK12 5
Kruppel-Type Zinc Finger (C2H2)2

External Ids:    HGNC: 208781   Entrez Gene: 102242   Ensembl: ENSG000001808557   OMIM: 6066975   UniProtKB: Q9Y2A43   

Export aliases for ZNF443 gene to outside databases

Previous GC identifers: GC19M012385 GC19M012290 GC19M012120 GC19M012401


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF443 Gene:
Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain
conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these
proteins, see ZNF91 (MIM 603971).(supplied by OMIM, Jul 2002)

GeneCards Summary for ZNF443 Gene: 
ZNF443 (zinc finger protein 443) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN443_HUMAN, Q9Y2A4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF443
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF443 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF443

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF443


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

ZNF443 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF443 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012540:  view genomic region     (about GC identifiers)

Start:
12,540,520 bp from pter      End:
12,551,926 bp from pter
Size:
11,407 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN443_HUMAN, Q9Y2A4 (See protein sequence)
Recommended Name: Zinc finger protein 443  
Size: 671 amino acids; 77516 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF443: NX_Q9Y2A4

Explore proteomics data for ZNF443 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2A4

  • ZNF443 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF443 Protein Expression
    REFSEQ proteins: NP_005806.2  
    ENSEMBL proteins: 
     ENSP00000301547   ENSP00000389105  
    Reactome Protein details: Q9Y2A4
    Human Recombinant Protein Products for ZNF443: 
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    Cloud-Clone Corp. Proteins for ZNF443 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF443 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ZNF443


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y2A4

    ProtoNet protein and cluster: Q9Y2A4

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN443_HUMAN, Q9Y2A4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 19 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF443 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN443_HUMAN, Q9Y2A4
    Function: May be involved in transcriptional regulation
    Induction: Induced following exposure to ionizing radiation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF443 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-188-3p
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF443 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF443
        Generic Transcription Pathway
    Gene Expression



    ZNF443 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF443

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF443 (Q9Y2A43 ENSP000003015474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006915apoptotic process TAS9731181
    GO:0006950response to stress TAS9731181

    ZNF443 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF443 (ZN443)

    Search CenterWatch for drugs/clinical trials and news about ZNF443 / ZN443

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF443 gene: 
    NM_005815.4  

    Unigene Cluster for ZNF443:

    Zinc finger protein 443
    Hs.720755  [show with all ESTs]
    Unigene Representative Sequence: NM_005815
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301547(uc002mtu.3) ENST00000436821
    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF443:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF443 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF443
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF443
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF443

    Additional mRNA sequence: 

    AB011414.1 AK023025.1 AK299532.1 BC032753.1 

    4 DOTS entries:

    DT.100749418  DT.65285526  DT.121421354  DT.100020380 

    24/45 AceView cDNA sequences (see all 45):

    BU181851 BM993011 AL832890 AK027660 CB136136 BM764861 AW173649 BQ647436 
    AI613104 AU118781 AL556986 BM728490 BQ644911 BV199532 CB321847 BF000618 
    BE394804 AW302249 BM799437 CB988846 AW299851 AI858923 BM456982 AW770326 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF443    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for ZNF443

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF443 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF443 Expression
    About this image


    See ZNF443 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF443

    SOURCE GeneReport for Unigene cluster: Hs.720755
        SABiosciences Expression via Pathway-Focused PCR Array including ZNF443: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF443

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF443 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    48(a)
    possible ortholog
    20(49458696-49539566)


    ENSEMBL Gene Tree for ZNF443 (if available)
    TreeFam Gene Tree for ZNF443 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF443 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF442  ZNF4392  ZNF8232  
    ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  ZNF202  
    ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF5632  ZNF6272  
    ENSG000002573552  ZNF1362  ZNF5562  ZNF6702  ZNF7632  ZNF1242  ENSG000002687442  ZNF6992  
    ZNF8442  ZNF772  
    18/493 SIMAP similar genes for ZNF443 using alignment to 2 protein entries:     ZN443_HUMAN (see all proteins) (see all similar genes):
    ZNF799    ZNF823    ZNF226    ZNF442    ZNF44    ZNF55
    ZNF625    ZNF669    ZNF846    FIK    HZF36    ZNF230
    DKFZp434J0650    ZNF627    ZNF155    ZNF20    ZNF596    ZNF83

    ZNF443 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/487 SNPs in ZNF443 are shown (see all 487)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0599184
    ----see VAR_0599182 C F mis40--------
    rs1395168211,2
    --12540052(+) AGGTAC/TGATCC 1 -- int10--------
    rs42920251,2
    C,F,H--12540103(+) AGAAAC/TAACAT 1 -- int113Minor allele frequency- T:0.47NS EA NA WA 1222
    rs2002676151,2
    C--12540127(+) TTTTT-/TAATGA 1 -- int10--------
    rs568285491,2
    C,F--12540509(+) AAACAG/AAAGAA 1 -- int18Minor allele frequency- A:0.42NA WA EA 368
    rs1809228461,2
    --12540512(+) CAGAAC/GAAATA 1 -- int10--------
    rs1851443551,2
    --12540576(+) ATAGGC/TTCACA 1 -- ut310--------
    rs667089071,2
    C,F--12540578(+) AGGCTC/GACAAT 1 -- ut316Minor allele frequency- G:0.20NA WA EA 364
    rs31786771,2
    C--12540714(-) GTATAC/GTCTCA 1 -- ut310--------
    rs284888631,2
    C--12540748(+) ACAAAT/CATGTC 1 -- ut31 ese33Minor allele frequency- C:0.17NA 6

    HapMap Linkage Disequilibrium report for ZNF443 (12540520 - 12551926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF443:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718192CNV Deletion23290073
    esv2718194CNV Deletion23290073
    nsv911073CNV Loss21882294
    dgv3732n71CNV Loss21882294
    nsv911075CNV Loss21882294
    esv21983CNV Gain19812545
    nsv442453CNV CNV18776908
    dgv1057e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF443 for disorders           About MalaCards
    OMIM gene information: 606697    OMIM disorders: --


    ZNF443 for disorders           About GeneDecksing


    Export disorders for ZNF443 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF443 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF443)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZK1, a novel Kruppel-type zinc finger gene, is induced following exposure to ionizing radiation and enhances apoptotic cell death on hematopoietic cells. (PubMed id 9731181)1, 2, 3, 9 Katoh O.... Watanabe H. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Analysis of BCL6-interacting proteins by tandem mass spectrometry. (PubMed id 16147992)1 Miles R.R....Elenitoba-Johnson K.S. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    8. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. (PubMed id 12215374)1 Lee S.M....Waye M.M. (2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10224 HGNC: 20878 AceView: ZNF443 Ensembl:ENSG00000180855 euGenes: HUgn10224
    ECgene: ZNF443 H-InvDB: ZNF443

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF443 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF443 gene:
    Search GeneIP for patents involving ZNF443

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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