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Aliases for ZNF442 Gene

Aliases for ZNF442 Gene

  • Zinc Finger Protein 442 2 3 5

External Ids for ZNF442 Gene

Previous GeneCards Identifiers for ZNF442 Gene

  • GC19M012305
  • GC19M012321
  • GC19M012119
  • GC19M012460
  • GC19M012035

Summaries for ZNF442 Gene

GeneCards Summary for ZNF442 Gene

ZNF442 (Zinc Finger Protein 442) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF443.

UniProtKB/Swiss-Prot for ZNF442 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF442 Gene

Genomics for ZNF442 Gene

Regulatory Elements for ZNF442 Gene

Enhancers for ZNF442 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF442 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF442 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF442 Gene

Chromosome:
19
Start:
12,345,949 bp from pter
End:
12,365,985 bp from pter
Size:
20,037 bases
Orientation:
Minus strand

Genomic View for ZNF442 Gene

Genes around ZNF442 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF442 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF442 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF442 Gene

Proteins for ZNF442 Gene

  • Protein details for ZNF442 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7R0-ZN442_HUMAN
    Recommended name:
    Zinc finger protein 442
    Protein Accession:
    Q9H7R0
    Secondary Accessions:
    • B4DJ48

    Protein attributes for ZNF442 Gene

    Size:
    627 amino acids
    Molecular mass:
    72863 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF442 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF442 Gene

Post-translational modifications for ZNF442 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF442 Gene

No data available for DME Specific Peptides for ZNF442 Gene

Domains & Families for ZNF442 Gene

Gene Families for ZNF442 Gene

Protein Domains for ZNF442 Gene

Suggested Antigen Peptide Sequences for ZNF442 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7R0

UniProtKB/Swiss-Prot:

ZN442_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF442: view

Function for ZNF442 Gene

Molecular function for ZNF442 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF442: view
genes like me logo Genes that share phenotypes with ZNF442: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF442 Gene

Localization for ZNF442 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF442 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF442 Gene COMPARTMENTS Subcellular localization image for ZNF442 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF442: view

Pathways & Interactions for ZNF442 Gene

SuperPathways for ZNF442 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF442: view

Pathways by source for ZNF442 Gene

2 Reactome pathways for ZNF442 Gene

Interacting Proteins for ZNF442 Gene

Gene Ontology (GO) - Biological Process for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF442: view

No data available for SIGNOR curated interactions for ZNF442 Gene

Drugs & Compounds for ZNF442 Gene

No Compound Related Data Available

Transcripts for ZNF442 Gene

mRNA/cDNA for ZNF442 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF442 Gene

Zinc finger protein 442:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF442 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for ZNF442 Gene

GeneLoc Exon Structure for
ZNF442
ECgene alternative splicing isoforms for
ZNF442

Expression for ZNF442 Gene

mRNA expression in normal human tissues for ZNF442 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF442 Gene:

ZNF442

SOURCE GeneReport for Unigene cluster for ZNF442 Gene:

Hs.253193
genes like me logo Genes that share expression patterns with ZNF442: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF442 Gene

Orthologs for ZNF442 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF442 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm14325 34
  • 63.1 (n)
  • 58.18 (a)
Zfp971 16
chimpanzee
(Pan troglodytes)
Mammalia ZNF442 34
  • 98.94 (n)
  • 98.09 (a)
ZNF442 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909622 34
  • 64.24 (n)
  • 52.96 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
ManyToMany
Species where no ortholog for ZNF442 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF442 Gene

ENSEMBL:
Gene Tree for ZNF442 (if available)
TreeFam:
Gene Tree for ZNF442 (if available)

Paralogs for ZNF442 Gene

(507) SIMAP similar genes for ZNF442 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF442 Gene

genes like me logo Genes that share paralogs with ZNF442: view

Variants for ZNF442 Gene

Sequence variations from dbSNP and Humsavar for ZNF442 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10415207 - 12,351,257(+) AGGAG(G/T)TTTTT reference, missense
rs10500210 - 12,350,258(+) AATAC(A/G)GAAGG reference, missense
rs10414971 A colorectal cancer sample 12,351,131(+) ATGTG(A/G)CTTCT reference, missense
rs757755988 A colorectal cancer sample 12,350,857(+) CTTTA(C/G/T)AACAC reference, missense
rs10423273 - 12,351,308(+) CTCTA(C/T)GATAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF442 Gene

Variant ID Type Subtype PubMed ID
esv1086965 CNV deletion 17803354
esv2718192 CNV deletion 23290073
nsv961181 CNV duplication 23825009

Variation tolerance for ZNF442 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF442 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF442

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF442 Gene

Disorders for ZNF442 Gene

Relevant External Links for ZNF442

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF442

No disorders were found for ZNF442 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF442 Gene

Publications for ZNF442 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4 65
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 65
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 65

Products for ZNF442 Gene

Sources for ZNF442 Gene

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