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Aliases for ZNF442 Gene

Aliases for ZNF442 Gene

  • Zinc Finger Protein 442 2 3

External Ids for ZNF442 Gene

Previous GeneCards Identifiers for ZNF442 Gene

  • GC19M012305
  • GC19M012321
  • GC19M012119
  • GC19M012460
  • GC19M012035

Summaries for ZNF442 Gene

GeneCards Summary for ZNF442 Gene

ZNF442 (Zinc Finger Protein 442) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF442 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF442 Gene

Genomics for ZNF442 Gene

Regulatory Elements for ZNF442 Gene

Genomic Location for ZNF442 Gene

Chromosome:
19
Start:
12,345,949 bp from pter
End:
12,365,985 bp from pter
Size:
20,037 bases
Orientation:
Minus strand

Genomic View for ZNF442 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ZNF442 Gene

Proteins for ZNF442 Gene

  • Protein details for ZNF442 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7R0-ZN442_HUMAN
    Recommended name:
    Zinc finger protein 442
    Protein Accession:
    Q9H7R0
    Secondary Accessions:
    • B4DJ48

    Protein attributes for ZNF442 Gene

    Size:
    627 amino acids
    Molecular mass:
    72863 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF442 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF442 Gene

Proteomics data for ZNF442 Gene at MOPED

Post-translational modifications for ZNF442 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF442 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF442 Gene

Domains & Families for ZNF442 Gene

Gene Families for ZNF442 Gene

Protein Domains for ZNF442 Gene

Suggested Antigen Peptide Sequences for ZNF442 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7R0

UniProtKB/Swiss-Prot:

ZN442_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF442: view

Function for ZNF442 Gene

Molecular function for ZNF442 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF442: view

Phenotypes for ZNF442 Gene

genes like me logo Genes that share phenotypes with ZNF442: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF442

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF442 Gene

Localization for ZNF442 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF442 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF442 Gene COMPARTMENTS Subcellular localization image for ZNF442 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF442: view

Pathways & Interactions for ZNF442 Gene

SuperPathways for ZNF442 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF442: view

Pathways by source for ZNF442 Gene

2 Reactome pathways for ZNF442 Gene

Interacting Proteins for ZNF442 Gene

Gene Ontology (GO) - Biological Process for ZNF442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF442: view

No data available for SIGNOR curated interactions for ZNF442 Gene

Drugs & Compounds for ZNF442 Gene

No Compound Related Data Available

Transcripts for ZNF442 Gene

mRNA/cDNA for ZNF442 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF442 Gene

Zinc finger protein 442:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF442

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF442 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for ZNF442 Gene

GeneLoc Exon Structure for
ZNF442
ECgene alternative splicing isoforms for
ZNF442

Expression for ZNF442 Gene

mRNA expression in normal human tissues for ZNF442 Gene

SOURCE GeneReport for Unigene cluster for ZNF442 Gene Hs.253193

genes like me logo Genes that share expression patterns with ZNF442: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF442 Gene

Orthologs for ZNF442 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF442 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm14325 35
  • 63.1 (n)
  • 58.18 (a)
chimpanzee
(Pan troglodytes)
Mammalia ZNF442 35
  • 98.94 (n)
  • 98.09 (a)
ZNF442 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909622 35
  • 64.24 (n)
  • 52.96 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
ManyToMany
Species with no ortholog for ZNF442:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF442 Gene

ENSEMBL:
Gene Tree for ZNF442 (if available)
TreeFam:
Gene Tree for ZNF442 (if available)

Paralogs for ZNF442 Gene

(507) SIMAP similar genes for ZNF442 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF442 Gene

genes like me logo Genes that share paralogs with ZNF442: view

Variants for ZNF442 Gene

Sequence variations from dbSNP and Humsavar for ZNF442 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3745654 -- 12,353,270(-) CTGTG(C/T)TGGAG intron-variant
rs3833249 -- 12,365,765(-) TCCCT(-/G)GGGGG upstream-variant-2KB, intron-variant
rs4804178 -- 12,365,394(+) actga(A/G)ggccg intron-variant
rs4804661 -- 12,367,732(+) ggcac(A/G)atctc upstream-variant-2KB
rs5827145 -- 12,357,350(+) TTTCT(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF442 Gene

Variant ID Type Subtype PubMed ID
nsv911068 CNV Gain 21882294
nsv911069 CNV Loss 21882294
esv2718192 CNV Deletion 23290073
nsv911071 CNV Gain 21882294
esv1086965 CNV Deletion 17803354

Variation tolerance for ZNF442 Gene

Residual Variation Intolerance Score: 96.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF442 Gene

HapMap Linkage Disequilibrium report
ZNF442

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF442 Gene

Disorders for ZNF442 Gene

Relevant External Links for ZNF442

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF442
genes like me logo Genes that share disorders with ZNF442: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF442 Gene

Publications for ZNF442 Gene

  1. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67

Products for ZNF442 Gene

Sources for ZNF442 Gene

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