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Aliases for ZNF441 Gene

Aliases for ZNF441 Gene

  • Zinc Finger Protein 441 2 3 5

External Ids for ZNF441 Gene

Previous GeneCards Identifiers for ZNF441 Gene

  • GC19P011723
  • GC19P011659
  • GC19P011878
  • GC19P011452

Summaries for ZNF441 Gene

GeneCards Summary for ZNF441 Gene

ZNF441 (Zinc Finger Protein 441) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF441 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF441 Gene

Genomics for ZNF441 Gene

Regulatory Elements for ZNF441 Gene

Promoters for ZNF441 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF441 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF441 Gene

Chromosome:
19
Start:
11,767,000 bp from pter
End:
11,784,078 bp from pter
Size:
17,079 bases
Orientation:
Plus strand

Genomic View for ZNF441 Gene

Genes around ZNF441 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF441 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF441 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF441 Gene

Proteins for ZNF441 Gene

  • Protein details for ZNF441 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Z8-ZN441_HUMAN
    Recommended name:
    Zinc finger protein 441
    Protein Accession:
    Q8N8Z8

    Protein attributes for ZNF441 Gene

    Size:
    693 amino acids
    Molecular mass:
    80136 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04661.1; Type=Frameshift; Positions=2; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF441 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF441 Gene

Proteomics data for ZNF441 Gene at MOPED

Post-translational modifications for ZNF441 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF441 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF441 Gene

Domains & Families for ZNF441 Gene

Gene Families for ZNF441 Gene

Protein Domains for ZNF441 Gene

Suggested Antigen Peptide Sequences for ZNF441 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8Z8

UniProtKB/Swiss-Prot:

ZN441_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF441: view

Function for ZNF441 Gene

Molecular function for ZNF441 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF441: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF441 Gene

Localization for ZNF441 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF441 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF441 Gene COMPARTMENTS Subcellular localization image for ZNF441 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF441 Gene

Pathways & Interactions for ZNF441 Gene

SuperPathways for ZNF441 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF441: view

Pathways by source for ZNF441 Gene

2 Reactome pathways for ZNF441 Gene

Interacting Proteins for ZNF441 Gene

Gene Ontology (GO) - Biological Process for ZNF441 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF441: view

No data available for SIGNOR curated interactions for ZNF441 Gene

Drugs & Compounds for ZNF441 Gene

No Compound Related Data Available

Transcripts for ZNF441 Gene

mRNA/cDNA for ZNF441 Gene

Unigene Clusters for ZNF441 Gene

Zinc finger protein 441:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF441 Gene

No ASD Table

Relevant External Links for ZNF441 Gene

GeneLoc Exon Structure for
ZNF441
ECgene alternative splicing isoforms for
ZNF441

Expression for ZNF441 Gene

mRNA expression in normal human tissues for ZNF441 Gene

Protein differential expression in normal tissues from HIPED for ZNF441 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF441 Gene



SOURCE GeneReport for Unigene cluster for ZNF441 Gene Hs.675132

genes like me logo Genes that share expression patterns with ZNF441: view

Protein tissue co-expression partners for ZNF441 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF441 Gene

Orthologs for ZNF441 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF441 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF441 35
  • 99.54 (n)
  • 99.23 (a)
ZNF441 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 47 (a)
ManyToMany
Species with no ortholog for ZNF441:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF441 Gene

ENSEMBL:
Gene Tree for ZNF441 (if available)
TreeFam:
Gene Tree for ZNF441 (if available)

Paralogs for ZNF441 Gene

(496) SIMAP similar genes for ZNF441 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF441: view

Variants for ZNF441 Gene

Sequence variations from dbSNP and Humsavar for ZNF441 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs440848 -- 11,769,188(-) GGTTT(C/T)GTTTT intron-variant
rs441052 -- 11,776,039(-) CATAA(A/G)AAACC intron-variant
rs384148 -- 11,767,280(+) ccagg(G/T)cttcc intron-variant
rs394542 -- 11,772,141(-) gtcca(C/T)tggac intron-variant
rs400020 -- 11,771,792(+) tgtca(A/G)ggaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF441 Gene

Variant ID Type Subtype PubMed ID
nsv525966 CNV Gain 19592680
nsv911068 CNV Gain 21882294
esv33306 CNV Gain 17666407

Variation tolerance for ZNF441 Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF441 Gene

HapMap Linkage Disequilibrium report
ZNF441

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF441 Gene

Disorders for ZNF441 Gene

Relevant External Links for ZNF441

Genetic Association Database (GAD)
ZNF441
Human Genome Epidemiology (HuGE) Navigator
ZNF441
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF441

No disorders were found for ZNF441 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF441 Gene

Publications for ZNF441 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF441 Gene

Sources for ZNF441 Gene

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