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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF441 Gene

protein-coding GIFtS: 44
GCID: GC19P011878

zinc finger protein 441

Search for ZNF441
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 441¹ ²
FLJ38637¹

External Ids:	HGNC: 20875¹	Entrez Gene: 126068²	Ensembl: ENSG00000197044⁷	UniProtKB: Q8N8Z8³

Export aliases for ZNF441 gene to outside databases

Previous GC identifers: GC19P011723 GC19P011738 GC19P011659 GC19P011452

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN441_HUMAN, Q8N8Z8

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF441
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF441 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF441

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF441

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.13

ZNF441 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF441 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P011878: view genomic region (about GC identifiers)

Start:	11,877,815 bp from pter	End:	11,894,893 bp from pter
Size:	17,079 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN441_HUMAN, Q8N8Z8 (See protein sequence)

Recommended Name: Zinc finger protein 441

Size: 693 amino acids; 80136 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=BAC04661.1; Type=Frameshift; Positions=2;

Alternative splicing: 2 isoforms: Q8N8Z8-1 Q8N8Z8-2

Explore the universe of human proteins at neXtProt for ZNF441: NX_Q8N8Z8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N8Z8

ZNF441 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689568.2

ENSEMBL proteins:

ENSP00000386658 ENSP00000350576 ENSP00000403738

Reactome Protein details: Q8N8Z8
Human Recombinant Protein Products:

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	Uscn Proteins for ZNF441

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF441 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ZNF441

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF441 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8N8Z8

ProtoNet protein and cluster: Q8N8Z8

UniProtKB/Swiss-Prot: ZN441_HUMAN, Q8N8Z8

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 19 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN441_HUMAN, Q8N8Z8

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF441 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for ZNF441:

Decreased Wnt reporter activit

Increased HPV18 LCR reporter a

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF441

	Generic Transcription Pathway
	Gene Expression

ZNF441 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF441

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF441 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF441
Search CenterWatch for drugs/clinical trials and news about ZNF441 / ZN441

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF441 gene:

NM_152355.2

Unigene Cluster for ZNF441:

Zinc finger protein 441

Hs.675132 [show with all ESTs]

Unigene Representative Sequence: NM_152355

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000462251 ENST00000409902 ENST00000357901(uc010dyj.3 uc002msn.4)

ENST00000454339

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Additional cDNA sequence:

AK092721.1 AK095956.1 BC144217.1 BX649086.1

1 DOTS entry:

DT.100027156

24/32 AceView cDNA sequences (see all 32):

AA836290 BU783332 AK092721 BX649086 AI797710 BQ002549 AI861891 AI373552

BG286420 AA035079 AW292547 BU783088 AA424356 NM_152355 BG399973 BU783925

AK095956 BU532083 BU159782 AI678174 AI378454 BQ006032 BQ003442 CN478653

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF441 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTACCTTAT

About this image
See ZNF441 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF441

SOURCE GeneReport for Unigene cluster: Hs.675132

SABiosciences Custom PCR Arrays for ZNF441

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF441 (if available)
TreeFam Gene Tree for ZNF441 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF441 gene

ZNF669² ZNF490² ZNF564² ZNF878² ENSG00000267179² ZNF14² ENSG00000196826² ZNF700²

ZNF69² ZNF440² ZNF443² ZNF44² ZNF439² ZNF823² ZNF491² ENSG00000188474²

ZNF555² ZNF709² ZNF625² ZNF799² ZNF20² ZNF101² ZNF791² ZNF442²

ZNF433² ZNF57² ZNF563² ZNF627² ENSG00000257355² ZNF136² ZNF556² ZNF670²

ZNF763² ZNF124² ZNF699² ZNF844² ZNF77²

18/493 SIMAP similar genes for ZNF441 using alignment to 2 protein entries: ZN441_HUMAN (see all proteins) (see all similar genes):

ZNF55 ZNF78L1 HZF16 ZFS-4 ZNF833P HZF36

kr-znf3 ZNF ZNF397 ZNF826P DKFZp666C237 DKFZp686D2168

DKFZp686M04222 ZNF2 ZNF436 ZNF844 ZNF823 DKFZp434J0650

ZNF441 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191153713^1,2		--	11875866(+)	`TCTTAA/GTCTTG`	1	--	us2k¹		0	--	--	--	--
rs78378412^1,2	C,F,	--	11876001(+)	`GTGGTC/GAGGAG`	1	--	us2k¹		3		WA CSA	5
rs115907087^1,2	F,	--	11876033(+)	`TTTGGG/ATGGAA`	1	--	us2k¹		1		WA	118
rs114581902^1,2	F,	--	11876116(+)	`ATGGCG/AGCAGG`	1	--	us2k¹		1		WA	118
rs147146586^1,2		--	11876209(+)	`GAAAA-/CCCGCC`	1	--	us2k¹		0	--	--	--	--
rs77613742^1,2	C,	--	11876227(+)	`TTCAAT/CTACCT`	1	--	us2k¹		3		WA CSA	121
rs147864346^1,2	C,	--	11876386(+)	`TTTTG-/CTCCTCCT`	1	--	us2k¹		0	--	--	--	--
rs139655017^1,2		--	11876409(+)	`ACCATG/TATTGT`	1	--	us2k¹		0	--	--	--	--
rs2871867^1,2	C,F,	--	11876500(+)	`AATAAC/TGCTTT`	1	--	us2k¹		3		WA CSA	122
rs5827136^1,2	C,	--	11876503(+)	`ttttt-/Tgtttg`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF441 (11877815 - 11894893 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF441
1 Indel: 11139

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF441 for disorders About MalaCards

ZNF441 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: ZNF441 (1 document)

Export disorders for ZNF441 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF441 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF441)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 126068	HGNC: 20875	AceView: ZNF441	Ensembl:ENSG00000197044	euGenes: HUgn126068
ECgene: ZNF441	H-InvDB: ZNF441

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF441	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF441 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF441 gene:
Search GeneIP for patents involving ZNF441

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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ZNF441 Gene

zinc finger protein 441

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ZNF441 Gene

zinc finger protein 441

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for ZNF441 gene

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for ZNF441 gene

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for ZNF441 gene

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for ZNF441 gene

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for ZNF441 gene

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