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Aliases for ZNF440 Gene

Aliases for ZNF440 Gene

  • Zinc Finger Protein 440 2 3 5

External Ids for ZNF440 Gene

Previous GeneCards Identifiers for ZNF440 Gene

  • GC19P011770
  • GC19P011786
  • GC19P011658
  • GC19P011925
  • GC19P011499

Summaries for ZNF440 Gene

GeneCards Summary for ZNF440 Gene

ZNF440 (Zinc Finger Protein 440) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF700.

UniProtKB/Swiss-Prot for ZNF440 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF440 Gene

Genomics for ZNF440 Gene

Regulatory Elements for ZNF440 Gene

Enhancers for ZNF440 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F011534 1 Ensembl ENCODE 14.7 -278.6 -278647 2.9 HDGF PKNOX1 ARNT ARID4B YBX1 ZNF2 ZNF143 FOS KLF13 SP3 ZNF700 ZNF44 ZNF799 ZNF136 ZNF763 ZNF627 ZNF878 TIMM29 ZNF442 YIPF2
GH19F011528 0.6 ENCODE 14.7 -285.3 -285343 1.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF700 ZNF44 ZNF136 PRKCSH ZNF799 ZNF878 ZNF763 ZNF627 SWSAP1 ZNF440
GH19F011337 0.2 ENCODE 14.7 -475.4 -475434 2.9 SIN3A KLF17 RAD21 ZNF121 GTF3C2 GLIS2 ZNF366 EGR2 SP3 SP5 ZNF700 ZNF44 ZNF440 TIMM29 ZNF878 ZNF136 YIPF2 ZNF823 ENSG00000266936 SWSAP1
GH19F012695 1.1 ENCODE 14.7 +882.4 882364 2.1 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF791 ZNF136 ZNF700 ZNF44 WDR83OS ZNF440 ZNF564 ZNF442 ZNF878 ZNF799
GH19F011261 0.6 ENCODE 14.7 -552.2 -552208 1.8 ATF1 PKNOX1 BMI1 ZBTB40 GTF3C2 GLIS2 SCRT2 ZNF143 CREM EGR2 ENSG00000267174 ZNF700 ZNF440 RAVER1 TIMM29 ZNF878 ZNF136 YIPF2 ZNF823 ENSG00000266936
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF440 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF440 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000343579 716 2801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for ZNF440 Gene

Chromosome:
19
Start:
11,814,284 bp from pter
End:
11,835,617 bp from pter
Size:
21,334 bases
Orientation:
Plus strand

Genomic View for ZNF440 Gene

Genes around ZNF440 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF440 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF440 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF440 Gene

Proteins for ZNF440 Gene

  • Protein details for ZNF440 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYI8-ZN440_HUMAN
    Recommended name:
    Zinc finger protein 440
    Protein Accession:
    Q8IYI8
    Secondary Accessions:
    • Q8N1R9

    Protein attributes for ZNF440 Gene

    Size:
    595 amino acids
    Molecular mass:
    69106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF440 Gene

Post-translational modifications for ZNF440 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF440 Gene

No data available for DME Specific Peptides for ZNF440 Gene

Domains & Families for ZNF440 Gene

Gene Families for ZNF440 Gene

Suggested Antigen Peptide Sequences for ZNF440 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYI8

UniProtKB/Swiss-Prot:

ZN440_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF440: view

Function for ZNF440 Gene

Molecular function for ZNF440 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF440: view
genes like me logo Genes that share phenotypes with ZNF440: view

Animal Model Products

miRNA for ZNF440 Gene

miRTarBase miRNAs that target ZNF440

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF440 Gene

Localization for ZNF440 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF440 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF440 Gene COMPARTMENTS Subcellular localization image for ZNF440 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF440: view

Pathways & Interactions for ZNF440 Gene

SuperPathways for ZNF440 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF440: view

Pathways by source for ZNF440 Gene

2 Reactome pathways for ZNF440 Gene

Gene Ontology (GO) - Biological Process for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF440: view

No data available for SIGNOR curated interactions for ZNF440 Gene

Transcripts for ZNF440 Gene

Unigene Clusters for ZNF440 Gene

Zinc finger protein 440:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF440 Gene

No ASD Table

Relevant External Links for ZNF440 Gene

GeneLoc Exon Structure for
ZNF440
ECgene alternative splicing isoforms for
ZNF440

Expression for ZNF440 Gene

mRNA expression in normal human tissues for ZNF440 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF440 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF440 Gene:

ZNF440

SOURCE GeneReport for Unigene cluster for ZNF440 Gene:

Hs.418192
genes like me logo Genes that share expression patterns with ZNF440: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF440 Gene

Orthologs for ZNF440 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF440 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF440 34 35
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 46 (a)
ManyToMany
Species where no ortholog for ZNF440 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF440 Gene

ENSEMBL:
Gene Tree for ZNF440 (if available)
TreeFam:
Gene Tree for ZNF440 (if available)

Paralogs for ZNF440 Gene

(443) SIMAP similar genes for ZNF440 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF440: view

Variants for ZNF440 Gene

Sequence variations from dbSNP and Humsavar for ZNF440 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402456 -- 11,823,315(+) ttaat(A/G)tgtga intron-variant
rs10403941 -- 11,820,268(+) ctgga(C/G)tgcag intron-variant
rs10405249 -- 11,820,087(+) TTTCC(C/T)GAGAA intron-variant
rs10411612 -- 11,821,341(+) TCCTA(C/G)TATAC intron-variant
rs10411874 -- 11,833,455(+) TTTCA(A/C/T)AGACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF440 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv2718185 CNV deletion 23290073
esv3643677 CNV gain 21293372
esv3643678 CNV gain 21293372
nsv458356 CNV gain 19166990
nsv525966 CNV gain 19592680
nsv578618 CNV gain 21841781
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF440 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF440 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF440

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF440 Gene

Disorders for ZNF440 Gene

Relevant External Links for ZNF440

Genetic Association Database (GAD)
ZNF440
Human Genome Epidemiology (HuGE) Navigator
ZNF440
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF440

No disorders were found for ZNF440 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF440 Gene

Publications for ZNF440 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF440 Gene

Sources for ZNF440 Gene

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