ZNF440 Gene
protein-coding GIFtS: 46
GCID: GC19P011925
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|
zinc finger protein 440
| |
Aliases
for ZNF440 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4401 2 | | FLJ379331 |
Export aliases for ZNF440 gene to outside databasesPrevious GC identifers: GC19P011770 GC19P011786 GC19P011658 GC19P011499 |
Summaries
for ZNF440 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN440_HUMAN, Q8IYI8Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF440 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF440
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF440
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF440 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.13ZNF440 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P011925: view genomic region
(about GC identifiers)
Start:
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11,925,099 bp from pter |
End:
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11,946,016 bp from pter |
Size:
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20,918 bases |
Orientation:
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plus strand |
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Proteins
for ZNF440 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN440_HUMAN, Q8IYI8 (See
protein sequence)Recommended Name: Zinc finger protein 440 Size: 595 amino acids; 69106 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q8N1R9Explore the universe of human proteins at neXtProt for ZNF440: NX_Q8IYI8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYI8
ZNF440 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689570.2
ENSEMBL proteins: ENSP00000305373 ENSP00000404425 ENSP00000393489 ENSP00000465030 ENSP00000411974 Reactome Protein details: Q8IYI8
Human Recombinant Protein Products for ZNF440:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF440 for ontologies About GeneDecksing
ZNF440 Antibody Products:
Assay Products for ZNF440: |
Protein
Domains /
Families
for ZNF440 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF440 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYI8ProtoNet protein and cluster: Q8IYI8 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN440_HUMAN, Q8IYI8Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF440 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN440_HUMAN, Q8IYI8Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF440 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for ZNF440:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF440
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF440
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF440 (NM_152357) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF440 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF440 |
|
Pathways & Interactions
for ZNF440 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF440
ZNF440 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF440
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for ZNF440 (Q8IYI82, 3 ENSP000003053734) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF440 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF440 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF440
Search CenterWatch for drugs/clinical trials and news about ZNF440 / ZN440
|
Transcripts
for ZNF440 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF440 gene: NM_152357.2 Unigene Cluster for ZNF440: Zinc finger protein 440 Hs.418192 [show with all ESTs]Unigene Representative Sequence: AK0952526 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304060(uc002msp.1) ENST00000457526 ENST00000427505 ENST00000588954
ENST00000587795 ENST00000414255
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF440
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF440
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF440 (NM_152357) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF440 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF440 |
Additional cDNA sequence: AK021474.1 AK092559.1 AK095252.1 BC016371.1 BC035760.1 9 DOTS entries: DT.432463 DT.100724397 DT.100721204 DT.101959323 DT.100022039 DT.404909 DT.97808567 DT.92414483 DT.100759209 18 AceView cDNA sequences: BU178807 BC016371 BM905938 BV192947 BP872770 CD656919 BF671558 BV193515 BC035760 BQ686357 BX645129 NM_152357 AK095252 BG109145 AW393394 BF771220 AL540601 AW856830
GeneLoc Exon Structure
|
Expression
for ZNF440 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF440 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF440 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF440
SOURCE GeneReport for Unigene cluster: Hs.418192
SABiosciences Custom PCR Arrays for ZNF440
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF440
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ZNF440 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF440 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF440 |
Orthologs
for ZNF440 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF440 (if available)
TreeFam Gene Tree for ZNF440 (if available) |
Paralogs
for ZNF440 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF440 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ZNF142 ENSG000001968262
- ZNF7002 ZNF692 ZNF4432 ZNF442 ZNF4392 ZNF8232 ZNF4912 ENSG000001884742
- ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912 ZNF4422
- ZNF4332 ZNF572 ZNF5632 ZNF6272 ENSG000002573552 ZNF1362 ZNF5562 ZNF6702
- ZNF7632 ZNF1242 ZNF6992 ZNF8442 ZNF772
18/451 SIMAP similar genes for ZNF440 using alignment to 6 protein entries: ZN440_HUMAN (see all proteins)
(see all similar genes):ZNF69 ZNF439 ZNF763 ZNF700 MGC12518 ZNF738
ZNF300P1 ZNF81 POM121C ZNF625 ZNF669 ZNF844
ZNF248 ZNF273 ZNF55 ZNF493 ZNF627 ZKSCAN4
ZNF440 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF440 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF440 (11925099 - 11946016 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF440: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF440 |
|
Disorders
/ Diseases
for ZNF440 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF440 for disorders About MalaCards
ZNF440 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZNF440 (1 document)
Export disorders for ZNF440 gene to outside databases
|
Publications
for ZNF440 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF440 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF440) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF440 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF440 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF440 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF440 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF440 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF440 gene:
Search GeneIP for patents involving ZNF440
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF440 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF440 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF440 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF440 | | OriGene 3'-UTR Clone for ZNF440 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF440 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF440 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF440 | | OriGene Custom Protein Services for ZNF440 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF440 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF440 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF440 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF440 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF440 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF440 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF440 |
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 | | | ZNF440 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF440 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF440 |
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