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Aliases for ZNF440 Gene

Aliases for ZNF440 Gene

  • Zinc Finger Protein 440 2 3 5

External Ids for ZNF440 Gene

Previous GeneCards Identifiers for ZNF440 Gene

  • GC19P011770
  • GC19P011786
  • GC19P011658
  • GC19P011925
  • GC19P011499

Summaries for ZNF440 Gene

GeneCards Summary for ZNF440 Gene

ZNF440 (Zinc Finger Protein 440) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF700.

UniProtKB/Swiss-Prot for ZNF440 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF440 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF440 Gene

Genomics for ZNF440 Gene

Regulatory Elements for ZNF440 Gene

Enhancers for ZNF440 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H011534 1.6 Ensembl ENCODE dbSUPER 14.7 -278.3 -278316 2 HDGF PKNOX1 ARNT ARID4B YBX1 ZNF2 ZNF766 ZNF207 ZNF143 FOS ZNF136 ILF3 ZNF627 KRI1 ZNF442 ZNF700 ZNF625 ZNF763 ZNF44 ZNF799
GH19H011150 1.6 Ensembl ENCODE dbSUPER 14.7 -660.5 -660462 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KRI1 ILF3 TIMM29 ZNF20 ZNF700 ZNF627 ZNF433 ZNF878 ZNF763 ZNF440
GH19H011343 1.2 ENCODE 18.5 -468.5 -468538 4 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ILF3 ZNF136 KRI1 ZNF627 ZNF844 ZNF44 TIMM29 ZNF20 ZNF763 ZNF433
GH19H012781 1.9 FANTOM5 ENCODE dbSUPER 10.4 +975.0 975014 15 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 ZNF136 CCDC130 ZNF791 ZNF44 ZNF442 ZNF564 TRMT1 ZNF844 TRIR ZNF700
GH19H011478 1.8 FANTOM5 Ensembl ENCODE 10.4 -332.7 -332659 5 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF416 ILF3 ZNF627 ZNF136 KRI1 TIMM29 ZNF844 ENSG00000242615 ZNF441 ZNF44 ZNF625
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF440 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF440 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107226 416 1801 HDGF PKNOX1 SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF143 FOS SP3

Genomic Location for ZNF440 Gene

Chromosome:
19
Start:
11,814,284 bp from pter
End:
11,835,617 bp from pter
Size:
21,334 bases
Orientation:
Plus strand

Genomic View for ZNF440 Gene

Genes around ZNF440 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF440 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF440 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF440 Gene

Proteins for ZNF440 Gene

  • Protein details for ZNF440 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYI8-ZN440_HUMAN
    Recommended name:
    Zinc finger protein 440
    Protein Accession:
    Q8IYI8
    Secondary Accessions:
    • Q8N1R9

    Protein attributes for ZNF440 Gene

    Size:
    595 amino acids
    Molecular mass:
    69106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF440 Gene

Post-translational modifications for ZNF440 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF440 Gene

No data available for DME Specific Peptides for ZNF440 Gene

Domains & Families for ZNF440 Gene

Gene Families for ZNF440 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF440 Gene

Suggested Antigen Peptide Sequences for ZNF440 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYI8

UniProtKB/Swiss-Prot:

ZN440_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF440: view

Function for ZNF440 Gene

Molecular function for ZNF440 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF440 Gene

Gene Ontology (GO) - Molecular Function for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF440: view
genes like me logo Genes that share phenotypes with ZNF440: view

Animal Model Products

CRISPR Products

miRNA for ZNF440 Gene

miRTarBase miRNAs that target ZNF440

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF440
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF440 Gene

Localization for ZNF440 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF440 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF440 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF440: view

Pathways & Interactions for ZNF440 Gene

SuperPathways for ZNF440 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF440: view

Pathways by source for ZNF440 Gene

2 Reactome pathways for ZNF440 Gene

Gene Ontology (GO) - Biological Process for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF440: view

No data available for SIGNOR curated interactions for ZNF440 Gene

Drugs & Compounds for ZNF440 Gene

No Compound Related Data Available

Transcripts for ZNF440 Gene

Unigene Clusters for ZNF440 Gene

Zinc finger protein 440:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF440
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF440 Gene

No ASD Table

Relevant External Links for ZNF440 Gene

GeneLoc Exon Structure for
ZNF440
ECgene alternative splicing isoforms for
ZNF440

Expression for ZNF440 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF440 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF440 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF440 Gene:

ZNF440

SOURCE GeneReport for Unigene cluster for ZNF440 Gene:

Hs.418192
genes like me logo Genes that share expression patterns with ZNF440: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF440 Gene

Orthologs for ZNF440 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF440 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF440 33 34
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 46 (a)
ManyToMany
Species where no ortholog for ZNF440 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF440 Gene

ENSEMBL:
Gene Tree for ZNF440 (if available)
TreeFam:
Gene Tree for ZNF440 (if available)

Paralogs for ZNF440 Gene

(443) SIMAP similar genes for ZNF440 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF440: view

Variants for ZNF440 Gene

Sequence variations from dbSNP and Humsavar for ZNF440 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000153301 -- 11,821,230(+) TTGGA(A/G)GGTCT intron-variant
rs1000821042 -- 11,831,708(+) TATGT(A/G)GAAAA reference, missense
rs1000863354 -- 11,820,608(+) CTGGA(-/G)GGTCT intron-variant
rs1000926537 -- 11,816,483(+) TGTGC(A/G)TCAGT intron-variant
rs1000983691 -- 11,815,434(+) TTTAC(A/G)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF440 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv2718185 CNV deletion 23290073
esv3643677 CNV gain 21293372
esv3643678 CNV gain 21293372
nsv458356 CNV gain 19166990
nsv525966 CNV gain 19592680
nsv578618 CNV gain 21841781
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF440 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF440 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF440

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF440 Gene

Disorders for ZNF440 Gene

Relevant External Links for ZNF440

Genetic Association Database (GAD)
ZNF440
Human Genome Epidemiology (HuGE) Navigator
ZNF440
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF440

No disorders were found for ZNF440 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF440 Gene

Publications for ZNF440 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for ZNF440 Gene

Sources for ZNF440 Gene

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