Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF440 Gene

Aliases for ZNF440 Gene

  • Zinc Finger Protein 440 2 3 5

External Ids for ZNF440 Gene

Previous GeneCards Identifiers for ZNF440 Gene

  • GC19P011770
  • GC19P011786
  • GC19P011658
  • GC19P011925
  • GC19P011499

Summaries for ZNF440 Gene

GeneCards Summary for ZNF440 Gene

ZNF440 (Zinc Finger Protein 440) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF440 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF440 Gene

Genomics for ZNF440 Gene

Regulatory Elements for ZNF440 Gene

Enhancers for ZNF440 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF440 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF440 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF440 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF440 Gene

11,814,284 bp from pter
11,835,617 bp from pter
21,334 bases
Plus strand

Genomic View for ZNF440 Gene

Genes around ZNF440 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF440 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF440 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF440 Gene

Proteins for ZNF440 Gene

  • Protein details for ZNF440 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 440
    Protein Accession:
    Secondary Accessions:
    • Q8N1R9

    Protein attributes for ZNF440 Gene

    595 amino acids
    Molecular mass:
    69106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF440 Gene

Proteomics data for ZNF440 Gene at MOPED

Post-translational modifications for ZNF440 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF440 Gene

No data available for DME Specific Peptides for ZNF440 Gene

Domains & Families for ZNF440 Gene

Gene Families for ZNF440 Gene

Protein Domains for ZNF440 Gene

Suggested Antigen Peptide Sequences for ZNF440 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF440: view

Function for ZNF440 Gene

Molecular function for ZNF440 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF440: view

Animal Model Products

CRISPR Products

miRNA for ZNF440 Gene

miRTarBase miRNAs that target ZNF440

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF440 Gene

Localization for ZNF440 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF440 Gene

Subcellular locations from

Jensen Localization Image for ZNF440 Gene COMPARTMENTS Subcellular localization image for ZNF440 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF440 Gene

Pathways & Interactions for ZNF440 Gene

SuperPathways for ZNF440 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF440: view

Pathways by source for ZNF440 Gene

2 Reactome pathways for ZNF440 Gene

Gene Ontology (GO) - Biological Process for ZNF440 Gene


No data available for SIGNOR curated interactions for ZNF440 Gene

Drugs & Compounds for ZNF440 Gene

No Compound Related Data Available

Transcripts for ZNF440 Gene

mRNA/cDNA for ZNF440 Gene

Unigene Clusters for ZNF440 Gene

Zinc finger protein 440:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF440 Gene

No ASD Table

Relevant External Links for ZNF440 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF440 Gene

mRNA expression in normal human tissues for ZNF440 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF440 Gene

SOURCE GeneReport for Unigene cluster for ZNF440 Gene Hs.418192

genes like me logo Genes that share expression patterns with ZNF440: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF440 Gene

Orthologs for ZNF440 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF440 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF440 35
  • 98.99 (n)
  • 97.98 (a)
ZNF440 36
  • 80 (a)
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
Species with no ortholog for ZNF440:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF440 Gene

Gene Tree for ZNF440 (if available)
Gene Tree for ZNF440 (if available)

Paralogs for ZNF440 Gene

(443) SIMAP similar genes for ZNF440 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF440: view

Variants for ZNF440 Gene

Sequence variations from dbSNP and Humsavar for ZNF440 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs448446 - 11,831,439(+) AGTTC(C/G)AGATG reference, missense
rs400106 - 11,832,882(+) GAGAA(A/G)CCCTA reference, missense
rs424132 - 11,830,406(+) CCTCT(A/G/T)TAGGT reference, missense
rs427880 - 11,831,547(+) TATGA(A/G)CATCA reference, missense
rs12978559 -- 11,824,276(+) AACTT(A/G)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF440 Gene

Variant ID Type Subtype PubMed ID
nsv525966 CNV Gain 19592680
nsv911068 CNV Gain 21882294
nsv458356 CNV Gain 19166990
esv2718185 CNV Deletion 23290073

Variation tolerance for ZNF440 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF440 Gene

Disorders for ZNF440 Gene

Relevant External Links for ZNF440

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF440 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF440 Gene

Publications for ZNF440 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3

Products for ZNF440 Gene

Sources for ZNF440 Gene