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Aliases for ZNF440 Gene

Aliases for ZNF440 Gene

  • Zinc Finger Protein 440 2 3

External Ids for ZNF440 Gene

Summaries for ZNF440 Gene

GeneCards Summary for ZNF440 Gene

ZNF440 (Zinc Finger Protein 440) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF440 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF440 Gene

Genomics for ZNF440 Gene

Genomic Location for ZNF440 Gene

Start:
11,814,284 bp from pter
End:
11,835,201 bp from pter
Size:
20,918 bases
Orientation:
Plus strand

Genomic View for ZNF440 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF440 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF440 Gene

No data available for Regulatory Elements for ZNF440 Gene

Proteins for ZNF440 Gene

  • Protein details for ZNF440 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYI8-ZN440_HUMAN
    Recommended name:
    Zinc finger protein 440
    Protein Accession:
    Q8IYI8
    Secondary Accessions:
    • Q8N1R9

    Protein attributes for ZNF440 Gene

    Size:
    595 amino acids
    Molecular mass:
    69106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF440 Gene

Proteomics data for ZNF440 Gene at MOPED

Post-translational modifications for ZNF440 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF440 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF440 Gene

Domains for ZNF440 Gene

Gene Families for ZNF440 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF440 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYI8

UniProtKB/Swiss-Prot:

ZN440_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q8IYI8
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8IYI8
Similarity:
  • Contains 12 C2H2-type zinc fingers.:
    • Q8IYI8
genes like me logo Genes that share domains with ZNF440: view

Function for ZNF440 Gene

Molecular function for ZNF440 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF440: view
genes like me logo Genes that share phenotypes with ZNF440: view

miRNA for ZNF440 Gene

miRTarBase miRNAs that target ZNF440

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF440 Gene

Localization for ZNF440 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF440 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF440 Gene COMPARTMENTS Subcellular localization image for ZNF440 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF440: view

Pathways for ZNF440 Gene

SuperPathways for ZNF440 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF440: view

Pathways by source for ZNF440 Gene

2 Reactome pathways for ZNF440 Gene

Gene Ontology (GO) - Biological Process for ZNF440 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF440: view

Transcripts for ZNF440 Gene

mRNA/cDNA for ZNF440 Gene

Unigene Clusters for ZNF440 Gene

Zinc finger protein 440:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF440 Gene

No ASD Table

Relevant External Links for ZNF440 Gene

GeneLoc Exon Structure for
ZNF440
ECgene alternative splicing isoforms for
ZNF440

Expression for ZNF440 Gene

mRNA expression in normal human tissues for ZNF440 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF440 Gene

SOURCE GeneReport for Unigene cluster for ZNF440 Gene Hs.418192

genes like me logo Genes that share expressions with ZNF440: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF440 Gene

Orthologs for ZNF440 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF440 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF440 35
  • 98.99 (n)
  • 97.98 (a)
ZNF440 36
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
ManyToMany
Species with no ortholog for ZNF440:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF440 Gene

ENSEMBL:
Gene Tree for ZNF440 (if available)
TreeFam:
Gene Tree for ZNF440 (if available)

Paralogs for ZNF440 Gene

Selected SIMAP similar genes for ZNF440 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF440: view

Variants for ZNF440 Gene

Sequence variations from dbSNP and Humsavar for ZNF440 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1549 -- 11,817,553(-) gtggc(A/G)tgtcc intron-variant
rs166970 -- 11,815,720(-) tcacc(A/G)tgttg intron-variant
rs166971 -- 11,817,416(-) gtttc(A/G)ctata intron-variant
rs166972 -- 11,817,997(-) cctaa(C/T)ctcaa intron-variant
rs286247 -- 11,816,790(-) agccg(A/G)gtgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF440 Gene

Variant ID Type Subtype PubMed ID
nsv525966 CNV Gain 19592680
nsv911068 CNV Gain 21882294
nsv458356 CNV Gain 19166990
esv2718185 CNV Deletion 23290073

Relevant External Links for ZNF440 Gene

HapMap Linkage Disequilibrium report
ZNF440

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF440 Gene

Disorders for ZNF440 Gene

Relevant External Links for ZNF440

Genetic Association Database (GAD)
ZNF440
Human Genome Epidemiology (HuGE) Navigator
ZNF440
genes like me logo Genes that share disorders with ZNF440: view

No data available for UniProtKB/Swiss-Prot for ZNF440 Gene

Publications for ZNF440 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF440 Gene

Sources for ZNF440 Gene

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