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ZNF44 Gene

protein-coding   GIFtS: 50
GCID: GC19M012336

Zinc Finger Protein 44

(Previous names: zinc finger protein 58, zinc finger protein 44 (KOX 7),...)
(Previous symbols: ZNF58, ZNF55)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 441 2     GIOT-22 3
Zinc Finger Protein 551 2 3     Zinc Finger Protein 44 (KOX 7)1
Zinc Finger Protein 581 2 3     ZNF2
ZNF551 2 3     ZNF5042
ZNF581 2 3     Gonadotropin Inducible Transcription Repressor-22
KOX72 3 5     Gonadotropin-Inducible Transcription Repressor 22
Gonadotropin-Inducible Ovary Transcription Repressor 22 3     Zinc Finger Protein ZnFP122
Zinc Finger Protein KOX72 3     GIOT23

External Ids:    HGNC: 131101   Entrez Gene: 517102   Ensembl: ENSG000001978577   OMIM: 1945425   UniProtKB: P156213   

Export aliases for ZNF44 gene to outside databases

Previous GC identifers: GC16U990063 GC19M012190 GC19M012214 GC19M012118 GC19M012196 GC19M012243 GC19M012354 GC19M011957


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF44 Gene:
ZNF44 (zinc finger protein 44) is a protein-coding gene. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZNF44_HUMAN, P15621
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF44 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF44 gene promoter:
         COUP-TF1   RP58   Pax-5   Lmo2   COUP   AP-4   XBP-1   HNF-4alpha2   HNF-4alpha1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF44 promoter sequence
   Search Chromatin IP Primers for ZNF44

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF44 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012336:  view genomic region     (about GC identifiers)

Start:
12,335,501 bp from pter      End:
12,405,714 bp from pter
Size:
70,214 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZNF44_HUMAN, P15621 (See protein sequence)
Recommended Name: Zinc finger protein 44  
Size: 663 amino acids; 76524 Da
Sequence caution: Sequence=CAA34357.1; Type=Frameshift; Positions=Several;
Secondary accessions: B4DML9 B9EGJ5 B9ZVM2 P17018 Q9ULZ7
Alternative splicing: 3 isoforms:  P15621-1   P15621-2   P15621-3   

Explore the universe of human proteins at neXtProt for ZNF44: NX_P15621

Explore proteomics data for ZNF44 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF44 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157748.1  NP_057348.3  

    ENSEMBL proteins: 
     ENSP00000471655   ENSP00000377008   ENSP00000380850   ENSP00000348419   ENSP00000347910  
     ENSP00000346681   ENSP00000395745  

    ZNF44 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF44

     
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    antibodies-online proteins for ZNF44 (5 products) 

     
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    antibodies-online antibodies for ZNF44 (18 products) 

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    antibodies-online kits for ZNF44 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P15621

    ProtoNet protein and cluster: P15621

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZNF44_HUMAN, P15621
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 17 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF44           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF44_HUMAN, P15621
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF44:
    zinc finger protein 44 (KOX7) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF44           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF44

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF44:
    hsa-mir-93-3p (MIRT038754)

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    1 qRT-PCR Assays for microRNA that regulate ZNF44:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF44 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF44_HUMAN, P15621: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0015630microtubule cytoskeleton ----

    Find genes that share ontologies with ZNF44           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF44
    Interactions:

        Search GeneGlobe Interaction Network for ZNF44

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for ZNF44 (P156213 ENSP000003479104) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703, ENSP000003650254I2D: score=1 STRING: ENSP00000365025
    ENSG00000232960P678703, ENSP000003955464I2D: score=1 STRING: ENSP00000395546
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    ENSG00000224774P678703I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF44           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF44

    1 Novoseek inferred chemical compound relationship for ZNF44 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 61.8 5 16606702 (1), 16817023 (1), 19887448 (1), 18656483 (1)



    Find genes that share compounds with ZNF44           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF44 gene (2 alternative transcripts): 
    NM_001164276.1  NM_016264.3  

    Unigene Cluster for ZNF44:

    Zinc finger protein 44
    Hs.296731  [show with all ESTs]
    Unigene Representative Sequence: BC136502
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600003 ENST00000597563 ENST00000393337(uc010xmi.2 uc002mtn.4)
    ENST00000397742 ENST00000356109(uc010xmj.2 uc010dys.3) ENST00000355684
    ENST00000354656(uc002mtl.3) ENST00000483826(uc002mto.2) ENST00000426973

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ZNF44:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF44 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF44

    Additional mRNA sequence: 

    AF024706.1 AK297528.1 BC136502.1 X16281.1 X52338.1 

    10 DOTS entries:

    DT.121425027  DT.303133  DT.92426317  DT.91699211  DT.92426314  DT.97826459  DT.121425050  DT.40209929 
    DT.121425024  DT.121425048 

    Selected AceView cDNA sequences (see all 105):

    BM126264 CB852522 CB305685 X52338 CK818861 Z41396 AI271935 T27624 
    AI379070 BX283731 AA714971 AL137602 BC001868 AA348316 AI567771 AA137065 
    AA531273 BU615918 CR604609 AA255425 CA865471 BQ016285 CB242000 BX641580 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF44 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCACAAACC
    ZNF44 Expression
    About this image

    ZNF44 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF44 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.296731
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF44 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    cow
    (Bos taurus)
    Mammalia --
    Uncharacterized protein
    49(a)
    many ↔ many
    7(14307682-14311244)


    ENSEMBL Gene Tree for ZNF44 (if available)
    TreeFam Gene Tree for ZNF44 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF44 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF4392  
    ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  
    ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF6272  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF44 using alignment to 5 protein entries:     ZNF44_HUMAN (see all proteins) (see all similar genes):
    LOC101928664    ZNF625-ZNF20    ZNF669    ZNF823    ZNF443    ZNF55
    ZNF799    ZNF78L1    ZFS-4    ZNF442    ZNF    HZF16
    ZNF625    ZNF627    ZNF14    ZNF709    ZNF490    ZNF826P

    Find genes that share paralogs with ZNF44           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZNF44
    PGOHUM00000234160 PGOHUM00000234511


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF44 (see all 555)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151533601,2
    C,F--12382347(+) CTAGTC/TACCTC 2 -- int11Minor allele frequency- T:0.08WA 118
    rs2005316221,2
    C--12382387(+) TCATC-/ATTGTCAT 2 -- int10--------
    rs1416425801,2
    --12382457(+) ACACAC/TTCTTT 2 -- int10--------
    rs1899296051,2
    --12382520(+) ATAGGC/TGATAT 2 -- int10--------
    rs1501619471,2
    --12382563(+) CTGTAA/CTGAAC 2 -- int10--------
    rs1825686481,2
    --12382574(+) ACATAC/TAGATT 2 -- int10--------
    rs1855440401,2
    --12382592(+) TTATGA/GTTCCC 2 -- int10--------
    rs1387782311,2
    C--12382704(+) AATATA/TCCATT 2 -- ut310--------
    rs1881710751,2
    --12382734(+) TGTGGA/TTTTAG 2 -- ut310--------
    rs1113249191,2
    C--12382774(+) CTTGC-/AATATA 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZNF44 (12335501 - 12405714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF44:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718192CNV Deletion23290073
    esv2667434CNV Deletion23128226
    nsv911069CNV Loss21882294
    nsv833753CNV Loss17160897
    nsv911070CNV Gain21882294
    nsv911068CNV Gain21882294

    Human Gene Mutation Database (HGMD): ZNF44
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF44
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF44

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194542    OMIM disorders: --


    Find genes that share disorders with ZNF44           About GenesLikeMe


    Export disorders for ZNF44 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF44 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ZNF44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1, 3 Lichter P.... Ward D.C. (Genomics 1992)
    2. Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1, 3 Bray P.L.... Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    8. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1 Lehner B. and Sanderson C.M. (Genome Res. 2004)
    9. Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. (PubMed id 14667819)1 Lehner B....Sanderson C.M. (Genomics 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51710 HGNC: 13110 AceView: ZNF44 Ensembl:ENSG00000197857 euGenes: HUgn51710
    ECgene: ZNF44 H-InvDB: ZNF44

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF44 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF44 gene:
    Search GeneIP for patents involving ZNF44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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