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Aliases for ZNF44 Gene

Aliases for ZNF44 Gene

  • Zinc Finger Protein 44 2 3 5
  • Zinc Finger Protein 58 2 3 4
  • Zinc Finger Protein 55 2 3 4
  • Gonadotropin-Inducible Ovary Transcription Repressor 2 3 4
  • Zinc Finger Protein KOX7 3 4
  • GIOT-2 3 4
  • ZNF55 3 4
  • ZNF58 3 4
  • KOX7 3 4
  • Gonadotropin Inducible Transcription Repressor-2 3
  • Gonadotropin-Inducible Transcription Repressor 2 3
  • Zinc Finger Protein 44 (KOX 7) 2
  • Zinc Finger Protein ZnFP12 3
  • ZNF504 3
  • GIOT2 4
  • ZNF 3

External Ids for ZNF44 Gene

Previous HGNC Symbols for ZNF44 Gene

  • ZNF58
  • ZNF55

Previous GeneCards Identifiers for ZNF44 Gene

  • GC16U990063
  • GC19M012190
  • GC19M012214
  • GC19M012118
  • GC19M012196
  • GC19M012243
  • GC19M012354
  • GC19M011957
  • GC19M012336

Summaries for ZNF44 Gene

GeneCards Summary for ZNF44 Gene

ZNF44 (Zinc Finger Protein 44) is a Protein Coding gene. Diseases associated with ZNF44 include enamel erosion and tooth erosion. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF44 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF44 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF44 Gene

Genomics for ZNF44 Gene

Regulatory Elements for ZNF44 Gene

Promoters for ZNF44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF44 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF44 Gene

Chromosome:
19
Start:
12,224,686 bp from pter
End:
12,294,899 bp from pter
Size:
70,214 bases
Orientation:
Minus strand

Genomic View for ZNF44 Gene

Genes around ZNF44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF44 Gene

Proteins for ZNF44 Gene

  • Protein details for ZNF44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15621-ZNF44_HUMAN
    Recommended name:
    Zinc finger protein 44
    Protein Accession:
    P15621
    Secondary Accessions:
    • B4DML9
    • B9EGJ5
    • B9ZVM2
    • P17018
    • Q9ULZ7

    Protein attributes for ZNF44 Gene

    Size:
    663 amino acids
    Molecular mass:
    76524 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA34357.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF44 Gene

Proteomics data for ZNF44 Gene at MOPED

Post-translational modifications for ZNF44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF44 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF44 Gene

Domains & Families for ZNF44 Gene

Gene Families for ZNF44 Gene

Protein Domains for ZNF44 Gene

Suggested Antigen Peptide Sequences for ZNF44 Gene

Graphical View of Domain Structure for InterPro Entry

P15621

UniProtKB/Swiss-Prot:

ZNF44_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 17 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 17 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF44: view

Function for ZNF44 Gene

Molecular function for ZNF44 Gene

GENATLAS Biochemistry:
zinc finger protein 44 (KOX7) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF44: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF44 Gene

Localization for ZNF44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF44 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF44 Gene COMPARTMENTS Subcellular localization image for ZNF44 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF44 Gene

Pathways & Interactions for ZNF44 Gene

SuperPathways for ZNF44 Gene

No Data Available

Interacting Proteins for ZNF44 Gene

Gene Ontology (GO) - Biological Process for ZNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF44: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF44 Gene

Drugs & Compounds for ZNF44 Gene

(1) Drugs for ZNF44 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF44: view

Transcripts for ZNF44 Gene

Unigene Clusters for ZNF44 Gene

Zinc finger protein 44:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF44 Gene

No ASD Table

Relevant External Links for ZNF44 Gene

GeneLoc Exon Structure for
ZNF44
ECgene alternative splicing isoforms for
ZNF44

Expression for ZNF44 Gene

mRNA expression in normal human tissues for ZNF44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF44 Gene



SOURCE GeneReport for Unigene cluster for ZNF44 Gene Hs.296731

genes like me logo Genes that share expression patterns with ZNF44: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF44 Gene

Orthologs for ZNF44 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF44 35
  • 99.35 (n)
  • 98.79 (a)
ZNF44 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
ManyToMany
Species with no ortholog for ZNF44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF44 Gene

ENSEMBL:
Gene Tree for ZNF44 (if available)
TreeFam:
Gene Tree for ZNF44 (if available)

Paralogs for ZNF44 Gene

(497) SIMAP similar genes for ZNF44 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF44 Gene

genes like me logo Genes that share paralogs with ZNF44: view

Variants for ZNF44 Gene

Sequence variations from dbSNP and Humsavar for ZNF44 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11882046 - 12,275,033(+) TCATT(C/G)CTAAA intron-variant, reference, missense, utr-variant-5-prime
rs11879168 - 12,273,765(+) TCCAG(C/T)GTGAG intron-variant, reference, missense
rs382112 -- 12,295,593(+) ggcag(G/T)gcgtg upstream-variant-2KB
rs1064330 -- 12,271,861(-) ATTCT(C/T)CTGTA intron-variant, utr-variant-3-prime
rs1533389 -- 12,285,405(+) CGCCC(A/G)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF44 Gene

Variant ID Type Subtype PubMed ID
nsv911068 CNV Gain 21882294
nsv911069 CNV Loss 21882294
nsv833753 CNV Loss 17160897
nsv911070 CNV Gain 21882294
esv2667434 CNV Deletion 23128226
esv2718192 CNV Deletion 23290073

Variation tolerance for ZNF44 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.06; 80.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF44 Gene

HapMap Linkage Disequilibrium report
ZNF44
Human Gene Mutation Database (HGMD)
ZNF44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF44 Gene

Disorders for ZNF44 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF44 Gene - From: DISEASES

Disorder Aliases PubMed IDs
enamel erosion
tooth erosion
  • generalized erosion
- elite association - COSMIC cancer census association via MalaCards
Search ZNF44 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZNF44

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF44
genes like me logo Genes that share disorders with ZNF44: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF44 Gene

Publications for ZNF44 Gene

  1. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3 67
  2. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P.L. … Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3
  3. Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263. (PMID: 19887448) Frietze S. … Farnham P.J. (J. Biol. Chem. 2010) 23
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. (PMID: 18656483) Karvonen U. … Palvimo J.J. (J. Mol. Biol. 2008) 23

Products for ZNF44 Gene

Sources for ZNF44 Gene

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