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Aliases for ZNF439 Gene

Aliases for ZNF439 Gene

  • Zinc Finger Protein 439 2 3

External Ids for ZNF439 Gene

Previous GeneCards Identifiers for ZNF439 Gene

  • GC19P011804
  • GC19P011960
  • GC19P011552

Summaries for ZNF439 Gene

GeneCards Summary for ZNF439 Gene

ZNF439 (Zinc Finger Protein 439) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF439 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF439 Gene

Genomics for ZNF439 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF439 Gene

Chromosome:
19
Start:
11,848,530 bp from pter
End:
11,883,750 bp from pter
Size:
35,221 bases
Orientation:
Plus strand

Genomic View for ZNF439 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF439 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF439 Gene

No data available for Regulatory Elements for ZNF439 Gene

Proteins for ZNF439 Gene

  • Protein details for ZNF439 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDP4-ZN439_HUMAN
    Recommended name:
    Zinc finger protein 439
    Protein Accession:
    Q8NDP4
    Secondary Accessions:
    • Q8IYZ7
    • Q96SU1

    Protein attributes for ZNF439 Gene

    Size:
    499 amino acids
    Molecular mass:
    58395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55187.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF439 Gene

Proteomics data for ZNF439 Gene at MOPED

Post-translational modifications for ZNF439 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF439 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF439 Gene

Domains & Families for ZNF439 Gene

Gene Families for ZNF439 Gene

Protein Domains for ZNF439 Gene

Suggested Antigen Peptide Sequences for ZNF439 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDP4

UniProtKB/Swiss-Prot:

ZN439_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF439: view

Function for ZNF439 Gene

Molecular function for ZNF439 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF439: view

Phenotypes for ZNF439 Gene

GenomeRNAi human phenotypes for ZNF439:
genes like me logo Genes that share phenotypes with ZNF439: view

miRNA for ZNF439 Gene

miRTarBase miRNAs that target ZNF439

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF439

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF439 Gene

Localization for ZNF439 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF439 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF439 Gene COMPARTMENTS Subcellular localization image for ZNF439 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF439: view

Pathways & Interactions for ZNF439 Gene

SuperPathways for ZNF439 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF439: view

Pathways by source for ZNF439 Gene

2 Reactome pathways for ZNF439 Gene

Gene Ontology (GO) - Biological Process for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF439: view

No data available for SIGNOR curated interactions for ZNF439 Gene

Drugs & Compounds for ZNF439 Gene

No Compound Related Data Available

Transcripts for ZNF439 Gene

Unigene Clusters for ZNF439 Gene

Zinc finger protein 439:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF439

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF439 Gene

No ASD Table

Relevant External Links for ZNF439 Gene

GeneLoc Exon Structure for
ZNF439
ECgene alternative splicing isoforms for
ZNF439

Expression for ZNF439 Gene

mRNA expression in normal human tissues for ZNF439 Gene

Protein differential expression in normal tissues from HIPED for ZNF439 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF439 Gene



SOURCE GeneReport for Unigene cluster for ZNF439 Gene Hs.528731

genes like me logo Genes that share expression patterns with ZNF439: view

Protein tissue co-expression partners for ZNF439 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF439 Gene

Orthologs for ZNF439 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF439 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF439 35
  • 93.44 (n)
  • 87.93 (a)
ZNF439 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 38
Species with no ortholog for ZNF439:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF439 Gene

ENSEMBL:
Gene Tree for ZNF439 (if available)
TreeFam:
Gene Tree for ZNF439 (if available)

Paralogs for ZNF439 Gene

(447) SIMAP similar genes for ZNF439 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF439: view

Variants for ZNF439 Gene

Sequence variations from dbSNP and Humsavar for ZNF439 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs279207 -- 11,857,002(+) tgtta(A/C)tggga intron-variant
rs279208 -- 11,857,623(+) ctttg(A/G)tcaat intron-variant
rs279209 -- 11,858,420(+) gagat(C/T)gcacc intron-variant
rs279210 -- 11,860,870(+) gcagg(C/T)gcaga intron-variant
rs279211 -- 11,861,684(+) aagaa(A/G)aggaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF439 Gene

Variant ID Type Subtype PubMed ID
nsv525966 CNV Gain 19592680
nsv911068 CNV Gain 21882294
nsv458356 CNV Gain 19166990
esv2718185 CNV Deletion 23290073
nsv482214 CNV Gain 20164927

Variation tolerance for ZNF439 Gene

Residual Variation Intolerance Score: 73.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF439 Gene

HapMap Linkage Disequilibrium report
ZNF439

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF439 Gene

Disorders for ZNF439 Gene

Relevant External Links for ZNF439

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF439
genes like me logo Genes that share disorders with ZNF439: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF439 Gene

Publications for ZNF439 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 67
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for ZNF439 Gene

Sources for ZNF439 Gene

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