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Aliases for ZNF439 Gene

Aliases for ZNF439 Gene

  • Zinc Finger Protein 439 2 3 5

External Ids for ZNF439 Gene

Previous GeneCards Identifiers for ZNF439 Gene

  • GC19P011804
  • GC19P011960
  • GC19P011552

Summaries for ZNF439 Gene

GeneCards Summary for ZNF439 Gene

ZNF439 (Zinc Finger Protein 439) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF440.

UniProtKB/Swiss-Prot for ZNF439 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF439 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF439 Gene

Genomics for ZNF439 Gene

Regulatory Elements for ZNF439 Gene

Enhancers for ZNF439 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H011531 1.5 FANTOM5 Ensembl ENCODE 49.2 -316.1 -316092 1 PKNOX1 ATF1 ZNF493 ZFP64 FOS ZNF202 ZC3H11A REST ZNF623 ZNF518A ZNF627 ZNF136 ILF3 ZNF442 ZNF844 ZNF625 ZNF44 KRI1 ZNF20 ZNF763
GH19H010975 1.2 Ensembl ENCODE 51 -871.9 -871892 3 FOXA2 NFIB ZNF195 ZEB1 RARA EGR2 ZIK1 OVOL3 TSHZ1 ZNF662 ZNF627 ZNF441 ZNF439 ILF3 ILF3-AS1 QTRT1 RPL18AP13 HNRNPA1P10 ZNF823 ZNF763
GH19H012781 1.9 FANTOM5 ENCODE dbSUPER 31.5 +940.8 940768 15 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 ZNF136 CCDC130 ZNF791 ZNF44 ZNF442 ZNF564 TRMT1 ZNF844 TRIR ZNF700
GH19H011478 1.8 FANTOM5 Ensembl ENCODE 21.1 -366.9 -366905 5 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF416 ILF3 ZNF627 ZNF136 KRI1 TIMM29 ZNF844 ENSG00000242615 ZNF441 ZNF44 ZNF625
GH19H010870 1.6 FANTOM5 ENCODE dbSUPER 22.1 -976.5 -976523 3 HDGF ARNT DMAP1 ZNF2 ZNF143 SP3 SP5 ZNF592 KAT8 ZNF610 ZNF439 ZNF627 RAVER1 HNRNPA1P10 KRI1 ILF3 ZNF491 ZNF441 PRKCSH EIF3G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF439 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF439 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107229 570 1001 ELF3 DRAP1 MXI1 PKNOX1 SAP130 ARID4B MAX DMAP1 KMT2B TEAD3

Genomic Location for ZNF439 Gene

Chromosome:
19
Start:
11,848,530 bp from pter
End:
11,883,750 bp from pter
Size:
35,221 bases
Orientation:
Plus strand

Genomic View for ZNF439 Gene

Genes around ZNF439 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF439 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF439 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF439 Gene

Proteins for ZNF439 Gene

  • Protein details for ZNF439 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDP4-ZN439_HUMAN
    Recommended name:
    Zinc finger protein 439
    Protein Accession:
    Q8NDP4
    Secondary Accessions:
    • Q8IYZ7
    • Q96SU1

    Protein attributes for ZNF439 Gene

    Size:
    499 amino acids
    Molecular mass:
    58395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55187.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF439 Gene

Post-translational modifications for ZNF439 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF439 Gene

Domains & Families for ZNF439 Gene

Gene Families for ZNF439 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF439 Gene

Suggested Antigen Peptide Sequences for ZNF439 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDP4

UniProtKB/Swiss-Prot:

ZN439_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF439: view

Function for ZNF439 Gene

Molecular function for ZNF439 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF439 Gene

Gene Ontology (GO) - Molecular Function for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF439: view
genes like me logo Genes that share phenotypes with ZNF439: view

Animal Model Products

CRISPR Products

miRNA for ZNF439 Gene

miRTarBase miRNAs that target ZNF439

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF439
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF439 Gene

Localization for ZNF439 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF439 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF439 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF439: view

Pathways & Interactions for ZNF439 Gene

SuperPathways for ZNF439 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF439: view

Pathways by source for ZNF439 Gene

2 Reactome pathways for ZNF439 Gene

Gene Ontology (GO) - Biological Process for ZNF439 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF439: view

No data available for SIGNOR curated interactions for ZNF439 Gene

Drugs & Compounds for ZNF439 Gene

No Compound Related Data Available

Transcripts for ZNF439 Gene

Unigene Clusters for ZNF439 Gene

Zinc finger protein 439:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF439
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF439 Gene

No ASD Table

Relevant External Links for ZNF439 Gene

GeneLoc Exon Structure for
ZNF439
ECgene alternative splicing isoforms for
ZNF439

Expression for ZNF439 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF439 Gene

Protein differential expression in normal tissues from HIPED for ZNF439 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF439 Gene



Protein tissue co-expression partners for ZNF439 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF439 Gene:

ZNF439

SOURCE GeneReport for Unigene cluster for ZNF439 Gene:

Hs.528731

Evidence on tissue expression from TISSUES for ZNF439 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF439: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF439 Gene

Orthologs for ZNF439 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF439 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF439 33 34
  • 93.44 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 36
Species where no ortholog for ZNF439 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF439 Gene

ENSEMBL:
Gene Tree for ZNF439 (if available)
TreeFam:
Gene Tree for ZNF439 (if available)

Paralogs for ZNF439 Gene

(447) SIMAP similar genes for ZNF439 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF439: view

Variants for ZNF439 Gene

Sequence variations from dbSNP and Humsavar for ZNF439 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000086154 -- 11,864,541(+) AACCA(C/G)CTACC upstream-variant-2KB
rs1001291508 -- 11,869,625(+) TTTTC(-/T)TTTTT downstream-variant-500B
rs1002332748 -- 11,867,893(+) GGAAT(A/G)TGGGA reference, missense
rs1002955192 -- 11,864,546(+) CCTAC(C/T)TTGGC upstream-variant-2KB
rs1003389248 -- 11,869,932(+) ATTTA(A/C)AGACA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF439 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
esv2718185 CNV deletion 23290073
esv3643677 CNV gain 21293372
nsv458356 CNV gain 19166990
nsv482214 CNV gain 20164927
nsv525966 CNV gain 19592680
nsv578618 CNV gain 21841781
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF439 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF439 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF439

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF439 Gene

Disorders for ZNF439 Gene

Relevant External Links for ZNF439

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF439

No disorders were found for ZNF439 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF439 Gene

Publications for ZNF439 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 60
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60

Products for ZNF439 Gene

Sources for ZNF439 Gene

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