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Aliases for ZNF438 Gene

Aliases for ZNF438 Gene

  • Zinc Finger Protein 438 2 3
  • BA330O11.1 3

External Ids for ZNF438 Gene

Previous GeneCards Identifiers for ZNF438 Gene

  • GC10M031174
  • GC10M030852
  • GC10M031133
  • GC10M031111

Summaries for ZNF438 Gene

GeneCards Summary for ZNF438 Gene

ZNF438 (Zinc Finger Protein 438) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for ZNF438 Gene

  • Isoform 1 acts as a transcriptional repressor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF438 Gene

Genomics for ZNF438 Gene

Regulatory Elements for ZNF438 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF438 Gene

Start:
30,820,207 bp from pter
End:
31,031,937 bp from pter
Size:
211,731 bases
Orientation:
Minus strand

Genomic View for ZNF438 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF438 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF438 Gene

Proteins for ZNF438 Gene

  • Protein details for ZNF438 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4V0-ZN438_HUMAN
    Recommended name:
    Zinc finger protein 438
    Protein Accession:
    Q7Z4V0
    Secondary Accessions:
    • A2A3J4
    • A8K9L5
    • Q5T426
    • Q658Q4
    • Q6ZN65

    Protein attributes for ZNF438 Gene

    Size:
    828 amino acids
    Molecular mass:
    91836 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF438 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF438 Gene

Proteomics data for ZNF438 Gene at MOPED

Post-translational modifications for ZNF438 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF438 Gene

Domains for ZNF438 Gene

Gene Families for ZNF438 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF438 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4V0

UniProtKB/Swiss-Prot:

ZN438_HUMAN :
  • Q7Z4V0
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF438: view

Function for ZNF438 Gene

Molecular function for ZNF438 Gene

UniProtKB/Swiss-Prot Function: Isoform 1 acts as a transcriptional repressor

Gene Ontology (GO) - Molecular Function for ZNF438 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 17669267
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF438: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF438 Gene

Localization for ZNF438 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF438 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF438 Gene COMPARTMENTS Subcellular localization image for ZNF438 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF438 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17669267
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF438: view

Pathways for ZNF438 Gene

SuperPathways for ZNF438 Gene

No Data Available

Interacting Proteins for ZNF438 Gene

Gene Ontology (GO) - Biological Process for ZNF438 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 17669267
genes like me logo Genes that share ontologies with ZNF438: view

No data available for Pathways by source for ZNF438 Gene

Transcripts for ZNF438 Gene

Unigene Clusters for ZNF438 Gene

Zinc finger protein 438:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF438

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF438 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: - - - - - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for ZNF438 Gene

GeneLoc Exon Structure for
ZNF438
ECgene alternative splicing isoforms for
ZNF438

Expression for ZNF438 Gene

mRNA expression in normal human tissues for ZNF438 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF438 Gene

This gene is overexpressed in Whole Blood (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF438 Gene

SOURCE GeneReport for Unigene cluster for ZNF438 Gene Hs.660642

mRNA Expression by UniProt/SwissProt for ZNF438 Gene

Q7Z4V0-ZN438_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with ZNF438: view

In Situ Assay Products

Orthologs for ZNF438 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF438 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF438 35
  • 99.24 (n)
  • 98.43 (a)
ZNF438 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF438 35
  • 69.98 (n)
  • 60.3 (a)
ZNF438 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF438 35
  • 76.39 (n)
  • 66.95 (a)
ZNF438 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp438 35
  • 74.61 (n)
  • 65.32 (a)
Zfp438 16
Zfp438 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF438 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF438 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp438 35
  • 74.92 (n)
  • 65.78 (a)
chicken
(Gallus gallus)
Aves ZNF438 35
  • 57.76 (n)
  • 46.58 (a)
ZNF438 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf438 35
  • 51.81 (n)
  • 41.74 (a)
zebrafish
(Danio rerio)
Actinopterygii znf438 35
  • 49.71 (n)
  • 40.41 (a)
znf438 36
  • 34 (a)
OneToOne
Species with no ortholog for ZNF438:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF438 Gene

ENSEMBL:
Gene Tree for ZNF438 (if available)
TreeFam:
Gene Tree for ZNF438 (if available)

Paralogs for ZNF438 Gene

Selected SIMAP similar genes for ZNF438 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF438: view

No data available for Paralogs for ZNF438 Gene

Variants for ZNF438 Gene

Sequence variations from dbSNP and Humsavar for ZNF438 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8586 -- 30,844,842(+) ATTTC(C/T)GTTCA utr-variant-3-prime, nc-transcript-variant
rs870165 -- 30,860,235(-) TTGCT(A/G)TTGAC intron-variant
rs870166 -- 30,860,186(-) GGACC(C/T)TCTCT intron-variant
rs923902 -- 30,855,292(-) ATACC(A/G)GTCGT intron-variant
rs957714 -- 30,915,050(-) TCACC(A/C)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF438 Gene

Variant ID Type Subtype PubMed ID
nsv894995 CNV Gain 21882294
nsv510215 CNV Loss 20534489
esv2325923 CNV Deletion 18987734
esv2556462 CNV Deletion 19546169
esv2669719 CNV Deletion 23128226
nsv508575 CNV Loss 20534489
nsv6243 CNV Loss 18451855
nsv819044 CNV Gain 19587683
dgv23n17 CNV Loss 16327808
nsv821086 CNV Deletion 20802225
nsv825333 CNV Loss 20364138
esv21784 CNV Gain 19812545
nsv498724 CNV Loss 21111241
dgv126e199 CNV Deletion 23128226
nsv514551 CNV Loss 21397061
esv2421350 CNV Deletion 20811451
dgv629n71 CNV Loss 21882294
nsv831823 CNV Gain 17160897
nsv819898 CNV Loss 19587683

Relevant External Links for ZNF438 Gene

HapMap Linkage Disequilibrium report
ZNF438

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF438 Gene

Disorders for ZNF438 Gene

Relevant External Links for ZNF438

Genetic Association Database (GAD)
ZNF438
Human Genome Epidemiology (HuGE) Navigator
ZNF438
genes like me logo Genes that share disorders with ZNF438: view

No data available for UniProtKB/Swiss-Prot for ZNF438 Gene

Publications for ZNF438 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  2. Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity. (PMID: 17669267) Zhong Z. … Yu L. (J. Biochem. Mol. Biol. 2007) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for ZNF438 Gene

Sources for ZNF438 Gene

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