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Aliases for ZNF438 Gene

Aliases for ZNF438 Gene

  • Zinc Finger Protein 438 2 3 5
  • BA330O11.1 3

External Ids for ZNF438 Gene

Previous GeneCards Identifiers for ZNF438 Gene

  • GC10M031174
  • GC10M030852
  • GC10M031133
  • GC10M031111

Summaries for ZNF438 Gene

GeneCards Summary for ZNF438 Gene

ZNF438 (Zinc Finger Protein 438) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF438 Gene

  • Isoform 1 acts as a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF438 Gene

Genomics for ZNF438 Gene

Regulatory Elements for ZNF438 Gene

Promoters for ZNF438 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF438 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF438 Gene

Chromosome:
10
Start:
30,820,207 bp from pter
End:
31,032,407 bp from pter
Size:
212,201 bases
Orientation:
Minus strand

Genomic View for ZNF438 Gene

Genes around ZNF438 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF438 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF438 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF438 Gene

Proteins for ZNF438 Gene

  • Protein details for ZNF438 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4V0-ZN438_HUMAN
    Recommended name:
    Zinc finger protein 438
    Protein Accession:
    Q7Z4V0
    Secondary Accessions:
    • A2A3J4
    • A8K9L5
    • Q5T426
    • Q658Q4
    • Q6ZN65

    Protein attributes for ZNF438 Gene

    Size:
    828 amino acids
    Molecular mass:
    91836 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF438 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF438 Gene

Proteomics data for ZNF438 Gene at MOPED

Post-translational modifications for ZNF438 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF438 Gene

Domains & Families for ZNF438 Gene

Gene Families for ZNF438 Gene

Protein Domains for ZNF438 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4V0

UniProtKB/Swiss-Prot:

ZN438_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF438: view

Function for ZNF438 Gene

Molecular function for ZNF438 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 acts as a transcriptional repressor.

Phenotypes for ZNF438 Gene

GenomeRNAi human phenotypes for ZNF438:
genes like me logo Genes that share phenotypes with ZNF438: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF438 Gene

Localization for ZNF438 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF438 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF438 Gene COMPARTMENTS Subcellular localization image for ZNF438 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF438 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF438: view

Pathways & Interactions for ZNF438 Gene

SuperPathways for ZNF438 Gene

No Data Available

Interacting Proteins for ZNF438 Gene

Gene Ontology (GO) - Biological Process for ZNF438 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 17669267
genes like me logo Genes that share ontologies with ZNF438: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF438 Gene

Drugs & Compounds for ZNF438 Gene

No Compound Related Data Available

Transcripts for ZNF438 Gene

Unigene Clusters for ZNF438 Gene

Zinc finger protein 438:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF438 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: - - - - - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for ZNF438 Gene

GeneLoc Exon Structure for
ZNF438
ECgene alternative splicing isoforms for
ZNF438

Expression for ZNF438 Gene

mRNA expression in normal human tissues for ZNF438 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF438 Gene

This gene is overexpressed in Whole Blood (x7.8).

Protein differential expression in normal tissues from HIPED for ZNF438 Gene

This gene is overexpressed in Plasma (32.3), Peripheral blood mononuclear cells (10.8), Testis (8.4), and CD4 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF438 Gene



SOURCE GeneReport for Unigene cluster for ZNF438 Gene Hs.660642

mRNA Expression by UniProt/SwissProt for ZNF438 Gene

Q7Z4V0-ZN438_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ZNF438: view

Protein tissue co-expression partners for ZNF438 Gene

Primer Products

In Situ Assay Products

Orthologs for ZNF438 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF438 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF438 36
  • 98 (a)
OneToOne
ZNF438 35
  • 99.24 (n)
  • 98.43 (a)
cow
(Bos Taurus)
Mammalia ZNF438 36
  • 58 (a)
OneToOne
ZNF438 35
  • 69.98 (n)
  • 60.3 (a)
dog
(Canis familiaris)
Mammalia ZNF438 35
  • 76.39 (n)
  • 66.95 (a)
ZNF438 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp438 16
Zfp438 36
  • 65 (a)
OneToOne
Zfp438 35
  • 74.61 (n)
  • 65.32 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF438 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF438 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp438 35
  • 74.92 (n)
  • 65.78 (a)
chicken
(Gallus gallus)
Aves ZNF438 35
  • 57.76 (n)
  • 46.58 (a)
ZNF438 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf438 35
  • 51.81 (n)
  • 41.74 (a)
zebrafish
(Danio rerio)
Actinopterygii znf438 36
  • 34 (a)
OneToOne
znf438 35
  • 49.71 (n)
  • 40.41 (a)
Species with no ortholog for ZNF438:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF438 Gene

ENSEMBL:
Gene Tree for ZNF438 (if available)
TreeFam:
Gene Tree for ZNF438 (if available)

Paralogs for ZNF438 Gene

(2) SIMAP similar genes for ZNF438 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF438: view

No data available for Paralogs for ZNF438 Gene

Variants for ZNF438 Gene

Sequence variations from dbSNP and Humsavar for ZNF438 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10160116 - 30,849,888(+) ACTGG(A/G)TTTGT intron-variant, reference, missense
VAR_035580 A breast cancer sample
rs35346752 - 30,845,371(-) AAGAG(G/T)TGGTG nc-transcript-variant, reference, missense
rs994464 -- 30,860,508(-) AGGAA(A/G)ACTTC intron-variant
rs870165 -- 30,860,235(-) TTGCT(A/G)TTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF438 Gene

Variant ID Type Subtype PubMed ID
nsv894995 CNV Gain 21882294
nsv510215 CNV Loss 20534489
esv2325923 CNV Deletion 18987734
esv2556462 CNV Deletion 19546169
esv2669719 CNV Deletion 23128226
nsv508575 CNV Loss 20534489
nsv6243 CNV Loss 18451855
nsv819044 CNV Gain 19587683
dgv23n17 CNV Loss 16327808
nsv821086 CNV Deletion 20802225
nsv825333 CNV Loss 20364138
esv21784 CNV Gain 19812545
nsv498724 CNV Loss 21111241
dgv126e199 CNV Deletion 23128226
nsv514551 CNV Loss 21397061
esv2421350 CNV Deletion 20811451
dgv629n71 CNV Loss 21882294
nsv831823 CNV Gain 17160897
nsv819898 CNV Loss 19587683

Variation tolerance for ZNF438 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF438 Gene

HapMap Linkage Disequilibrium report
ZNF438

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF438 Gene

Disorders for ZNF438 Gene

Relevant External Links for ZNF438

Genetic Association Database (GAD)
ZNF438
Human Genome Epidemiology (HuGE) Navigator
ZNF438
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF438

No disorders were found for ZNF438 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF438 Gene

Publications for ZNF438 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  3. Genome-wide association study of maternal and inherited effects on left-sided cardiac malformations. (PMID: 25138779) Mitchell L.E. … Goldmuntz E. (Hum. Mol. Genet. 2015) 3
  4. Genetics of rheumatoid arthritis contributes to biology and drug discovery. (PMID: 24390342) Okada Y. … Plenge R.M. (Nature 2013) 3
  5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3

Products for ZNF438 Gene

Sources for ZNF438 Gene

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