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ZNF438 Gene

protein-coding   GIFtS: 46
GCID: GC10M031111

Zinc Finger Protein 438

Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4381 2
bA330O11.12

External Ids:    HGNC: 210291   Entrez Gene: 2209292   Ensembl: ENSG000001836217   UniProtKB: Q7Z4V03   

Export aliases for ZNF438 gene to outside databases

Previous GC identifers: GC10M031174 GC10M030852 GC10M031133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF438 Gene:
ZNF438 (zinc finger protein 438) is a protein-coding gene. Diseases associated with ZNF438 include breast and colorectal cancer, and multiple sclerosis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ZN438_HUMAN, Q7Z4V0
Function: Isoform 1 acts as a transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF438 gene promoter:
         LHX3b/Lhx3b   Egr-1   POU6F1 (c2)   MEF-2A   S8   E2F   E2F-1   FOXO4   LHX3a/Lhx3a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF438 promoter sequence
   Search Chromatin IP Primers for ZNF438

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF438


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.23   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p11.23

ZNF438 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF438 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M031111:  view genomic region     (about GC identifiers)

Start:
31,109,136 bp from pter      End:
31,320,866 bp from pter
Size:
211,731 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN438_HUMAN, Q7Z4V0 (See protein sequence)
Recommended Name: Zinc finger protein 438  
Size: 828 amino acids; 91836 Da
Secondary accessions: A2A3J4 A8K9L5 Q5T426 Q658Q4 Q6ZN65
Alternative splicing: 3 isoforms:  Q7Z4V0-1   Q7Z4V0-2   Q7Z4V0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF438: NX_Q7Z4V0

Explore proteomics data for ZNF438 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF438 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001137238.1  NP_001137239.1  NP_001137240.1  NP_001137241.1  NP_001137242.1  NP_001137243.1  NP_877432.1  

    ENSEMBL proteins: 
     ENSP00000476810   ENSP00000333571   ENSP00000354663   ENSP00000445461   ENSP00000364460  
     ENSP00000406934   ENSP00000412363   ENSP00000387546   ENSP00000413060   ENSP00000410898  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q7Z4V0

    ProtoNet protein and cluster: Q7Z4V0

    UniProtKB/Swiss-Prot: ZN438_HUMAN, Q7Z4V0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    ZNF438 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN438_HUMAN, Q7Z4V0
    Function: Isoform 1 acts as a transcriptional repressor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA17669267
    GO:0046872metal ion binding IEA--
         
    ZNF438 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF438
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN438_HUMAN, Q7Z4V0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17669267

    ZNF438 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF438
    Interactions:

        Search GeneGlobe Interaction Network for ZNF438

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA17669267

    ZNF438 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF438 (ZN438)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF438 gene (7 alternative transcripts): 
    NM_001143766.1  NM_001143767.1  NM_001143768.1  NM_001143769.1  NM_001143770.1  NM_001143771.1  NM_182755.2  

    Unigene Cluster for ZNF438:

    Zinc finger protein 438
    Hs.660642  [show with all ESTs]
    Unigene Representative Sequence: AK097092
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000609683 ENST00000331737 ENST00000361310 ENST00000538351(uc001ivn.3)
    ENST00000375311 ENST00000436087(uc009xlg.3 uc001ivp.4) ENST00000442986(uc010qdz.2 uc010qea.2 uc010qec.1)
    ENST00000413025(uc001ivo.4 uc010qeb.2) ENST00000452305(uc010qdy.2)
    ENST00000444692

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF438
      QuantiFast Probe-based Assays in human, mouse, rat ZNF438

    Additional mRNA sequence: 

    AF428258.1 AF440405.1 AK057323.1 AK097092.1 AK131357.1 AK292730.1 AK294253.1 AL833056.1 
    BC101622.1 BC104669.1 BC104757.1 BC143462.1 BC143464.1 DQ356011.1 DQ356012.1 NR_026560.1 

    14 DOTS entries:

    DT.99931060  DT.406709  DT.121255765  DT.91856762  DT.100745795  DT.102827920  DT.121255762  DT.100672639 
    DT.40242305  DT.99933137  DT.121255721  DT.40204888  DT.95253135  DT.91917746 

    Selected AceView cDNA sequences (see all 53):

    CA309854 NM_182755 AK131357 AW007325 BQ004646 AI056759 BM674747 AI563915 
    BM717381 AI369618 BX093705 AW293842 AI198234 BI861876 AF428258 CA309823 
    BG614813 AA330854 AI537321 CD358112 CA309853 BM826307 BU159443 BU662129 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF438    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c
    SP1:                          -                                                               
    SP2:        -     -           -                 -           -     -                           
    SP3:                                            -                                             
    SP4:                    -     -                 -                                             
    SP5:                          -                 -                                             


    ECgene alternative splicing isoforms for ZNF438

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF438 expression in normal human tissues (normalized intensities)      ZNF438 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTATTTT
    ZNF438 Expression
    About this image


    ZNF438 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    ZNF438 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF438 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660642

    UniProtKB/Swiss-Prot: ZN438_HUMAN, Q7Z4V0
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF438 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp4381 , 5 zinc finger protein 4381, 5 74.61(n)1
    65.32(a)1
      18 (3.02 cM)5
    2401861  NM_178722.51  NP_848837.31 
     52100315 
    chicken
    (Gallus gallus)
    Aves ZNF4381 zinc finger protein 438 57.76(n)
    46.58(a)
      420474  XM_418576.3  XP_418576.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf4381 zinc finger protein 438 51.81(n)
    41.74(a)
      100493562  XM_002940336.2  XP_002940382.2 
    zebrafish
    (Danio rerio)
    Actinopterygii znf4381 zinc finger protein 438 49.71(n)
    40.41(a)
      798757  NM_001077161.1  NP_001070629.1 


    ENSEMBL Gene Tree for ZNF438 (if available)
    TreeFam Gene Tree for ZNF438 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF438 gene
    2 SIMAP similar genes for ZNF438 using alignment to 4 protein entries:     ZN438_HUMAN (see all proteins):
    ZNF844    ZNF72

    ZNF438 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF438 (see all 3924)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355804
    A breast cancer sample4--see VAR_0355802 K N mis40--------
    rs1915127291,2
    --31133212(+) ATTAGA/CTGAAG 8 -- int10--------
    rs2006519701,2
    C--31133244(+) TTTTG-/ATATATG 8 -- int10--------
    rs618456931,2
    F--31133339(+) AATCTG/AAGTCC 8 -- int11Minor allele frequency- A:0.50NA 2
    rs776724481,2
    F--31133340(+) ATCTGA/CGTCCT 8 -- int12Minor allele frequency- C:0.06CSA WA 120
    rs732543281,2
    C,F--31133364(+) TTAAAC/TTATTG 8 -- int11Minor allele frequency- T:0.50WA 2
    rs359184301,2
    C,F--31133423(+) CCAGAG/TAATTT 8 -- int13Minor allele frequency- T:0.07NA EA 242
    rs763069971,2
    C,F--31133533(+) GAAAAC/TATCTG 8 -- int11Minor allele frequency- T:0.09WA 118
    rs355854681,2
    C,F--31133581(+) CTGTAT/CTTGAA 8 -- ut31 nc-transcript-variant7Minor allele frequency- C:0.08NA EA 428
    rs169154991,2
    C,F--31133590(+) AAGAAC/GAGCCT 8 -- ut31 nc-transcript-variant3Minor allele frequency- G:0.01NA 142

    HapMap Linkage Disequilibrium report for ZNF438 (31109136 - 31320866 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF438 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2556462CNV Deletion19546169
    nsv821086CNV Deletion20802225
    esv2325923CNV Deletion18987734
    esv2421350CNV Deletion20811451
    esv2669719CNV Deletion23128226
    dgv126e199CNV Deletion23128226
    nsv510215CNV Loss20534489
    dgv629n71CNV Loss21882294
    dgv23n17CNV Loss16327808
    nsv819898CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF438
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF438

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for ZNF438:    About MalaCards
    breast and colorectal cancer    multiple sclerosis    alzheimer's disease    colorectal cancer


    ZNF438 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ZNF438
    Human Genome Epidemiology (HuGE) Navigator: ZNF438 (2 documents)

    Export disorders for ZNF438 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF438 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF438)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity. (PubMed id 17669267)1, 2 Zhong Z.... Yu L. (J. Biochem. Mol. Biol. 2007)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (Nature 2011)
    9. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PubMed id 20195266)4 Adkins D.E....van den Oord E.J. (Mol. Psychiatry 2011)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 220929 HGNC: 21029 AceView: LOC220929 Ensembl:ENSG00000183621 euGenes: HUgn220929
    ECgene: ZNF438 H-InvDB: ZNF438

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF438 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF438 gene:
    Search GeneIP for patents involving ZNF438

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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