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Aliases for ZNF436 Gene

Aliases for ZNF436 Gene

  • Zinc Finger Protein 436 2 3 5
  • DNA-Binding Protein 3
  • KIAA1710 4
  • Zfp46 3
  • ZNF 3

External Ids for ZNF436 Gene

Previous GeneCards Identifiers for ZNF436 Gene

  • GC01M022746
  • GC01M023155
  • GC01M023431
  • GC01M023558
  • GC01M023685
  • GC01M021937

Summaries for ZNF436 Gene

GeneCards Summary for ZNF436 Gene

ZNF436 (Zinc Finger Protein 436) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF189.

UniProtKB/Swiss-Prot for ZNF436 Gene

  • May be a transcriptional repressor.

Gene Wiki entry for ZNF436 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF436 Gene

Genomics for ZNF436 Gene

Regulatory Elements for ZNF436 Gene

Enhancers for ZNF436 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F023366 1.1 ENCODE 38.2 +0.4 394 6.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF436 TCEA3 RPL11 ID3 ZNF436-AS1
GH01F023380 0.7 ENCODE 30.4 -11.7 -11702 1.1 TAL1 BHLHE40 CEBPB ZNF664 ZNF316 IKZF1 ZNF600 MYC EMSY ZNF18 ZNF436 ENSG00000271420 GC01M023400
GH01F023339 0.6 ENCODE 24.5 +26.9 26861 6.3 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF436-AS1 ZNF436 ENSG00000201405 ELOA ZBTB40-IT1 TCEA3 HNRNPR LINC01355
GH01F023512 0.5 FANTOM5 19.6 -143.1 -143119 0.3 ZNF362 ZNF512 NFE2 YY1 ZNF436 ID3 ENSG00000201405 ZNF436-AS1 HNRNPR PIR36355 LOC101928163
GH01F023376 0.8 Ensembl ENCODE 13.9 -7.5 -7484 2.9 HDGF PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF121 FOS JUNB TSHZ1 ZNF436 LINC01355 TCEA3 ENSG00000271420 ENSG00000201405
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF436 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF436 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000280235 1264 3201 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for ZNF436 Gene

Chromosome:
1
Start:
23,359,448 bp from pter
End:
23,369,864 bp from pter
Size:
10,417 bases
Orientation:
Minus strand

Genomic View for ZNF436 Gene

Genes around ZNF436 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF436 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF436 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF436 Gene

Proteins for ZNF436 Gene

  • Protein details for ZNF436 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0F3-ZN436_HUMAN
    Recommended name:
    Zinc finger protein 436
    Protein Accession:
    Q9C0F3
    Secondary Accessions:
    • Q658I9

    Protein attributes for ZNF436 Gene

    Size:
    470 amino acids
    Molecular mass:
    54277 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21801.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF436 Gene

Post-translational modifications for ZNF436 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF436 Gene

No data available for DME Specific Peptides for ZNF436 Gene

Domains & Families for ZNF436 Gene

Gene Families for ZNF436 Gene

Suggested Antigen Peptide Sequences for ZNF436 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0F3

UniProtKB/Swiss-Prot:

ZN436_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF436: view

Function for ZNF436 Gene

Molecular function for ZNF436 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF436 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 23455924
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF436: view
genes like me logo Genes that share phenotypes with ZNF436: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF436 Gene

Localization for ZNF436 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF436 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF436 Gene COMPARTMENTS Subcellular localization image for ZNF436 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF436 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF436: view

Pathways & Interactions for ZNF436 Gene

SuperPathways for ZNF436 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF436: view

Pathways by source for ZNF436 Gene

2 Reactome pathways for ZNF436 Gene

Gene Ontology (GO) - Biological Process for ZNF436 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF436: view

No data available for SIGNOR curated interactions for ZNF436 Gene

Transcripts for ZNF436 Gene

mRNA/cDNA for ZNF436 Gene

Unigene Clusters for ZNF436 Gene

Zinc finger protein 436:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF436 Gene

No ASD Table

Relevant External Links for ZNF436 Gene

GeneLoc Exon Structure for
ZNF436
ECgene alternative splicing isoforms for
ZNF436

Expression for ZNF436 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF436 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF436 Gene

This gene is overexpressed in Heart (46.1) and Stomach (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF436 Gene



Protein tissue co-expression partners for ZNF436 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF436 Gene:

ZNF436

SOURCE GeneReport for Unigene cluster for ZNF436 Gene:

Hs.293798

mRNA Expression by UniProt/SwissProt for ZNF436 Gene:

Q9C0F3-ZN436_HUMAN
Tissue specificity: Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.
genes like me logo Genes that share expression patterns with ZNF436: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZNF436 Gene

Orthologs for ZNF436 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF436 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF436 34 35
  • 99.36 (n)
cow
(Bos Taurus)
Mammalia ZNF436 34 35
  • 92.41 (n)
dog
(Canis familiaris)
Mammalia ZNF436 34 35
  • 92.2 (n)
rat
(Rattus norvegicus)
Mammalia Zfp46 34
  • 84.95 (n)
mouse
(Mus musculus)
Mammalia Zfp46 34 16 35
  • 82.3 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF436 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
ZNF302 35
  • 44 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 37
Species where no ortholog for ZNF436 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF436 Gene

ENSEMBL:
Gene Tree for ZNF436 (if available)
TreeFam:
Gene Tree for ZNF436 (if available)

Paralogs for ZNF436 Gene

(494) SIMAP similar genes for ZNF436 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF436: view

Variants for ZNF436 Gene

Sequence variations from dbSNP and Humsavar for ZNF436 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035579 A breast cancer sample
rs10634507 -- 23,365,917(+) GTCTC(-/A/AA/AAA)AAAAA intron-variant
rs10677282 -- 23,366,374(+) GTGAG(G/T)CAAAA intron-variant
rs10917372 -- 23,364,286(+) aggcc(A/G)gagtg intron-variant
rs10917373 -- 23,365,252(+) ctagc(C/T)gagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF436 Gene

Variant ID Type Subtype PubMed ID
nsv525446 CNV gain 19592680

Variation tolerance for ZNF436 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF436 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF436

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF436 Gene

Disorders for ZNF436 Gene

Relevant External Links for ZNF436

Genetic Association Database (GAD)
ZNF436
Human Genome Epidemiology (HuGE) Navigator
ZNF436
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF436

No disorders were found for ZNF436 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF436 Gene

Publications for ZNF436 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE. (PMID: 17089209) Li Y. … Wu X. (Mol. Biol. Rep. 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64

Products for ZNF436 Gene

Sources for ZNF436 Gene

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