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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF436 Gene

protein-coding   GIFtS: 54
GCID: GC01M023685

Zinc Finger Protein 436

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 4361 2
KIAA17103 5
ZNF2
Zfp462
DNA-Binding Protein2

External Ids:    HGNC: 208141   Entrez Gene: 808182   Ensembl: ENSG000001259457   OMIM: 6117035   UniProtKB: Q9C0F33   

Export aliases for ZNF436 gene to outside databases

Previous GC identifers: GC01M022746 GC01M023155 GC01M023431 GC01M023558 GC01M021937


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF436 Gene: 
ZNF436 (zinc finger protein 436) is a protein-coding gene. Diseases associated with ZNF436 include enamel erosion, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot: ZN436_HUMAN, Q9C0F3
Function: May be a transcriptional repressor

Gene Wiki entry for ZNF436 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF436 gene promoter:
         Egr-3   Ik-2   HNF-1   HNF-1A   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF436 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF436

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF436


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36

ZNF436 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF436 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023685:  view genomic region     (about GC identifiers)

Start:
23,685,941 bp from pter      End:
23,696,357 bp from pter
Size:
10,417 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN436_HUMAN, Q9C0F3 (See protein sequence)
Recommended Name: Zinc finger protein 436  
Size: 470 amino acids; 54277 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAB21801.1; Type=Erroneous initiation;
Secondary accessions: Q658I9

Explore the universe of human proteins at neXtProt for ZNF436: NX_Q9C0F3

Explore proteomics data for ZNF436 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C0F3

  • ZNF436 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF436 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001070663.1  NP_085137.1  

    ENSEMBL proteins: 
     ENSP00000313582   ENSP00000363737   ENSP00000363736  
    Reactome Protein details: Q9C0F3
    Human Recombinant Protein Products for ZNF436: 
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    Novus Biologicals ZNF436 Lysates
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    Cloud-Clone Corp. Proteins for ZNF436 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ZNF436 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9C0F3

    ProtoNet protein and cluster: Q9C0F3

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN436_HUMAN, Q9C0F3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF436 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN436_HUMAN, Q9C0F3
    Function: May be a transcriptional repressor

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF436 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF436:
     Decreased p24 protein expressi  Increased G1 DNA content 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF436 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF436 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF436
        Generic Transcription Pathway
    Gene Expression



    ZNF436 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF436

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF436 (Q9C0F33 ENSP000003135824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB1P162203, ENSP000003876994I2D: score=1 STRING: ENSP00000387699
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF436 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF436 (ZN436)

    Search CenterWatch for drugs/clinical trials and news about ZNF436 / ZN436

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF436 gene (2 alternative transcripts): 
    NM_001077195.1  NM_030634.2  

    Unigene Cluster for ZNF436:

    Zinc finger protein 436
    Hs.293798  [show with all ESTs]
    Unigene Representative Sequence: NM_001077195
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314011(uc001bgt.3 uc001bgu.3) ENST00000374609 ENST00000374608

    miRNA
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    hsa-miR-4317 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-328 hsa-miR-136 hsa-miR-15a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidZNF436 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF436
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF436

    Additional mRNA sequence: 

    AB051497.1 AK092364.1 AK308173.1 AL834485.1 BC056400.1 

    6 DOTS entries:

    DT.91868075  DT.411324  DT.100693377  DT.40221851  DT.70103000  DT.75104767 

    24/71 AceView cDNA sequences (see all 71):

    AL040635 CR611983 AI829509 NM_030634 AI220823 BM456820 F09807 CK724968 
    AL834485 BP362845 N73339 AB051497 BM468450 AL040636 F12175 AI005217 
    AX747503 CD244735 AI082694 BG291460 AI890860 BE882281 BX434476 AK092364 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF436 expression in normal human tissues (normalized intensities)      ZNF436 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTGGTAA
    ZNF436 Expression
    About this image


    ZNF436 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Breast (Uncategorized)
             breast stroma   
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Skeletal Muscle (Muscoskeletal System)
             tongue squamous cells   
     
     Epithelium (Uncategorized)
             head and neck epithelial cells   
     
     Oral Cavity (Muscoskeletal System)
             tongue squamous cells   

    See ZNF436 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF436

    SOURCE GeneReport for Unigene cluster: Hs.293798

    UniProtKB/Swiss-Prot: ZN436_HUMAN, Q9C0F3
    Tissue specificity: Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach
    and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF436 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp461 , 5 zinc finger protein 461, 5 82.3(n)1
    94.69(a)1
      4 (68.34 cM)5
    227041  NM_009557.31  NP_033583.21 
     1362846835 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF4366
    --
    Uncharacterized protein
    39(a)
    33(a)
    1 ↔ 1
    possible ortholog
    2(189436253-189451580)
    GL344516.1(3581-57538)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-53d3.36
    si:dkeyp-53d3.3
    43(a)
    possible ortholog
    22(2605686-2617104)
    fruit fly
    (Drosophila melanogaster)
    Insecta Meics6
    Meiotic central spindle
    21(a)
    1 → many
    3L(13955758-13957802)


    ENSEMBL Gene Tree for ZNF436 (if available)
    TreeFam Gene Tree for ZNF436 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF436 gene
    ZNF1802  ZNF3222  ZNF712  ZNF5722  ZFP22  ZNF6972  ZKSCAN72  ZNF6782  
    ZNF7742  ZNF102  ZFP372  ZSCAN22  ZNF3292  ZNF8522  ZNF5442  ZFP32  
    ZNF6062  ZNF8352  ZNF5022  
    18/548 SIMAP similar genes for ZNF436 using alignment to 2 protein entries:     ZN436_HUMAN (see all proteins) (see all similar genes):
    DKFZp547L155    ZNF78L1    ZNF16    ZNF530    kr-znf3    ZNF132
    ZNF180    ZNF84    ZFS-4    ZNF271    ZNF782    ZNF300
    ZFP2    HZF36    ZNF256    ZNF502    ZNF818P    ZNF304

    ZNF436 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF436
    PGOHUM00000233109


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/177 SNPs in ZNF436 are shown (see all 177)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355794
    A breast cancer sample4--see VAR_0355792 C G mis40--------
    rs1481408821,2
    --23685478(+) TTGGCC/TACACT 2 -- ds50010--------
    rs792537361,2
    C,F--23685489(+) GGTCTC/TGAAAT 2 -- ds50015Minor allele frequency- T:0.13CSA WA NA EA 362
    rs1419222301,2
    --23685722(+) TTCGTA/TGAAAA 2 -- ds50010--------
    rs6047421,2
    C,F,O,A,H--23685785(+) GATACT/CGTACT 2 -- ds500133Minor allele frequency- C:0.08MN NA NS EA WA 3516
    rs774125461,2
    F--23685838(+) TGTACG/TGAATG 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs413020191,2
    C--23685880(+) AATGAA/CTCTGA 2 -- ds50010--------
    rs1407852701,2
    --23685902(+) TAAATG/TAATCA 2 -- ds50010--------
    rs1893788661,2
    --23685959(+) TATATC/TTTTAA 2 -- ut310--------
    rs413001201,2
    C,F--23685968(+) AATTAT/CAGAAT 2 -- ut312Minor allele frequency- C:0.16NA EA 240

    HapMap Linkage Disequilibrium report for ZNF436 (23685941 - 23696357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF436:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525446CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611703    OMIM disorders: --

    2 diseases for ZNF436:    About MalaCards
    enamel erosion    


    ZNF436 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF436
    Human Genome Epidemiology (HuGE) Navigator: ZNF436 (1 document)

    Export disorders for ZNF436 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF436 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF436)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE. (PubMed id 17089209)1, 2 Li Y.... Wu X. (2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    6. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80818 HGNC: 20814 AceView: ZNF436 Ensembl:ENSG00000125945 euGenes: HUgn80818
    ECgene: ZNF436 H-InvDB: ZNF436

    (According to HUGE)
    About This Section
    HUGE: KIAA1710

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF436 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF436 gene:
    Search GeneIP for patents involving ZNF436

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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