ZNF436 Gene
protein-coding GIFtS: 52
GCID: GC01M023685
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|
zinc finger protein 436
| |
Aliases
for ZNF436 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4361 2 | | KIAA17101 3 5 | | Zfp461 2 | | ZNF2 | | DNA-Binding Protein2 |
Export aliases for ZNF436 gene to outside databasesPrevious GC identifers: GC01M022746 GC01M023155 GC01M023431 GC01M023558 GC01M021937 |
Summaries
for ZNF436 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN436_HUMAN, Q9C0F3Function: May be a transcriptional repressor
Gene Wiki entry for ZNF436
|
Genomic Views
for ZNF436 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF436 gene promoter:
Egr-3 Ik-2 HNF-1 HNF-1A GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF436
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF436 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36ZNF436 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M023685: view genomic region
(about GC identifiers)
Start:
|
23,685,941 bp from pter |
End:
|
23,696,357 bp from pter |
Size:
|
10,417 bases |
Orientation:
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minus strand |
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Proteins
for ZNF436 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN436_HUMAN, Q9C0F3 (See
protein sequence)Recommended Name: Zinc finger protein 436 Size: 470 amino acids; 54277 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAB21801.1; Type=Erroneous initiation;
Secondary accessions: Q658I9Explore the universe of human proteins at neXtProt for ZNF436: NX_Q9C0F3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C0F3
ZNF436 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001070663.1 NP_085137.1
ENSEMBL proteins: ENSP00000313582 ENSP00000363737 ENSP00000363736 Reactome Protein details: Q9C0F3
Human Recombinant Protein Products for ZNF436:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF436 for ontologies About GeneDecksing
ZNF436 Antibody Products:
Assay Products for ZNF436: |
Protein
Domains /
Families
for ZNF436 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF436 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9C0F3ProtoNet protein and cluster: Q9C0F3 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN436_HUMAN, Q9C0F3Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF436 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN436_HUMAN, Q9C0F3Function: May be a transcriptional repressor Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF436 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for ZNF436:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF436 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF436 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF436 (NM_030634) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF436 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF436 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF436 |
|
Pathways & Interactions
for ZNF436 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF436
ZNF436 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF436
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF436 (Q9C0F33 ENSP000003135824) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF436 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF436 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF436
Search CenterWatch for drugs/clinical trials and news about ZNF436 / ZN436
|
Transcripts
for ZNF436 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF436 gene (2 alternative transcripts): NM_001077195.1 NM_030634.2 Unigene Cluster for ZNF436: Zinc finger protein 436 Hs.293798 [show with all ESTs]Unigene Representative Sequence: NM_0010771953 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314011(uc001bgt.3 uc001bgu.3) ENST00000374609 ENST00000374608
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF436 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF436 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF436 (NM_030634) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF436 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF436 |
Additional cDNA sequence: AB051497.1 AK092364.1 AK308173.1 AL834485.1 BC056400.1 6 DOTS entries: DT.91868075 DT.411324 DT.100693377 DT.40221851 DT.70103000 DT.75104767 24/71 AceView cDNA sequences (see all 71): BP362845 CR611983 AL834485 F09807 AI829509 N73339 NM_030634 CK724968 AL040635 AB051497 BM456820 AI220823 AA383703 BX953990 AI703359 BX112093 BC056400 BG674128 AA564077 AI829223 AA574134 AX747503 BE882281 CD000355
GeneLoc Exon Structure
|
Expression
for ZNF436 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF436 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTGGTAA
About this image
See ZNF436 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF436
SOURCE GeneReport for Unigene cluster: Hs.293798
UniProtKB/Swiss-Prot: ZN436_HUMAN, Q9C0F3Tissue specificity: Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach andpancreas
SABiosciences Custom PCR Arrays for ZNF436
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF436
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF436 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF436 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF436 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF436 |
Orthologs
for ZNF436 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF436 gene from 2/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZNF436 (if available)
TreeFam Gene Tree for ZNF436 (if available) |
Paralogs
for ZNF436 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF436 gene
- ZSCAN22 ZNF7742 ZNF6912 ZNF6292 ZNF5722 ZNF6972 ZNF2052
18/547 SIMAP similar genes for ZNF436 using alignment to 2 protein entries: ZN436_HUMAN (see all proteins)
(see all similar genes):DKFZp547L155 ZNF78L1 ZNF16 ZNF530 ZNF551 kr-znf3
ZNF132 ZNF180 ZNF84 ZFS-4 ZNF271 ZNF300
ZNF782 ZFP2 HZF36 ZNF256 ZNF502 ZNF818P
ZNF436 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF436
PGOHUM00000233109
|
Genomic Variants
for ZNF436 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF436 (23685941 - 23696357 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF436: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF436 |
|
Disorders
/ Diseases
for ZNF436 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF436 for disorders About GeneDecksing
OMIM gene information: 611703
OMIM disorders: --
1  disease for ZNF436: About MalaCardsenamel erosion
Human Genome Epidemiology (HuGE) Navigator: ZNF436 (1 document)
Export disorders for ZNF436 gene to outside databases
|
Publications
for ZNF436 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF436 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZNF436) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE. (PubMed id 17089209)1, 2 Li Y.... Wu X. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF436 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF436 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF436 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF436 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF436 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF436 gene:
Search GeneIP for patents involving ZNF436
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF436 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF436 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF436 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF436 | | | OriGene Protein Over-expression Lysate for ZNF436 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF436 | | OriGene 3'-UTR Clone for ZNF436 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF436 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF436 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF436 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF436 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF436 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF436 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF436 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF436 |
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 | | | ZNF436 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF436 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF436 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF436 |
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