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Aliases for ZNF433 Gene

Aliases for ZNF433 Gene

  • Zinc Finger Protein 433 2 3 5

External Ids for ZNF433 Gene

Previous GeneCards Identifiers for ZNF433 Gene

  • GC19M011970
  • GC19M011986
  • GC19M011698
  • GC19M012125

Summaries for ZNF433 Gene

GeneCards Summary for ZNF433 Gene

ZNF433 (Zinc Finger Protein 433) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF700.

UniProtKB/Swiss-Prot for ZNF433 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF433 Gene

Genomics for ZNF433 Gene

Regulatory Elements for ZNF433 Gene

Enhancers for ZNF433 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G012983 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -949.1 -949062 3.2 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF625 ZNF136 ZNF844 ZNF442 ZNF788 ENSG00000242615 ZNF709 ZNF799 ZNF564 CCDC130
GH19G011534 1.6 Ensembl ENCODE dbSUPER 11.8 +499.8 499773 2.2 HDGF PKNOX1 ARNT ARID4B YBX1 ZNF2 ZNF766 ZNF207 ZNF143 FOS ZNF136 ZNF700 ZNF627 ZNF44 ZNF799 ZNF442 ZNF763 ZNF625 ZNF844 ZNF440
GH19G011202 1.4 Ensembl ENCODE dbSUPER 10.2 +832.0 832032 3.1 ZNF48 GATA2 ZNF143 FOS ZNF263 REST MEF2D SMARCA4 GLIS1 NR2C1 ZNF627 ZNF844 ZNF136 ZNF625 ANGPTL8 DOCK6 HNRNPA1P10 ZNF763 ZNF439 ZNF433
GH19G012288 1.3 Ensembl ENCODE 10.3 -253.4 -253434 2.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF44 WDR83OS ZNF788 ZNF700 TRMT1 ZNF136 ZNF564 ZNF791 ZNF625-ZNF20 ZNF440
GH19G012872 1.3 Ensembl ENCODE 10.1 -837.6 -837561 1.0 HDGF FOXA2 MLX AGO1 ARID4B SIN3A ZNF2 SLC30A9 ZNF766 CBX5 ZNF136 ZNF442 ZNF625 ZNF844 ZNF799 ZNF564 ENSG00000242615 ZNF788 MRI1 CCDC130
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF433 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF433 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107240 110 1601 PKNOX1 AGO1 ZNF493 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 SP3

Transcription factor binding sites by QIAGEN in the ZNF433 gene promoter:

Genomic Location for ZNF433 Gene

12,014,717 bp from pter
12,035,741 bp from pter
21,025 bases
Minus strand

Genomic View for ZNF433 Gene

Genes around ZNF433 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF433 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF433 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF433 Gene

Proteins for ZNF433 Gene

  • Protein details for ZNF433 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 433
    Protein Accession:
    Secondary Accessions:
    • Q86VX3

    Protein attributes for ZNF433 Gene

    673 amino acids
    Molecular mass:
    77243 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF433 Gene


neXtProt entry for ZNF433 Gene

Post-translational modifications for ZNF433 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF433 Gene

Domains & Families for ZNF433 Gene

Gene Families for ZNF433 Gene

Suggested Antigen Peptide Sequences for ZNF433 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF433: view

Function for ZNF433 Gene

Molecular function for ZNF433 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF433 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF433: view
genes like me logo Genes that share phenotypes with ZNF433: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF433 Gene

Localization for ZNF433 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF433 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF433 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF433 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF433: view

Pathways & Interactions for ZNF433 Gene

SuperPathways for ZNF433 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF433: view

Pathways by source for ZNF433 Gene

2 Reactome pathways for ZNF433 Gene

Gene Ontology (GO) - Biological Process for ZNF433 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF433: view

No data available for SIGNOR curated interactions for ZNF433 Gene

Drugs & Compounds for ZNF433 Gene

No Compound Related Data Available

Transcripts for ZNF433 Gene

mRNA/cDNA for ZNF433 Gene

Unigene Clusters for ZNF433 Gene

Zinc finger protein 433:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF433 Gene

No ASD Table

Relevant External Links for ZNF433 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF433 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF433 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF433 Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for ZNF433 Gene

This gene is overexpressed in Plasma (60.9) and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF433 Gene

Protein tissue co-expression partners for ZNF433 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF433 Gene:


SOURCE GeneReport for Unigene cluster for ZNF433 Gene:

genes like me logo Genes that share expression patterns with ZNF433: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF433 Gene

Orthologs for ZNF433 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF433 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF433 34 35
  • 99.6 (n)
(Mus musculus)
Mammalia LOC102635315 34
  • 68.22 (n)
Zfp433 16
(Bos Taurus)
Mammalia -- 35
  • 51 (a)
Species where no ortholog for ZNF433 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF433 Gene

Gene Tree for ZNF433 (if available)
Gene Tree for ZNF433 (if available)

Paralogs for ZNF433 Gene

(472) SIMAP similar genes for ZNF433 Gene using alignment to 9 proteins: Pseudogenes for ZNF433 Gene

genes like me logo Genes that share paralogs with ZNF433: view

Variants for ZNF433 Gene

Sequence variations from dbSNP and Humsavar for ZNF433 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000036754 -- 12,023,015(+) ATACA(-/C)CCCCC intron-variant
rs1000146377 -- 12,017,194(+) TTTGG(-/T)TTTTT intron-variant
rs1000341634 -- 12,029,911(+) CCTGC(C/T)TCTAC intron-variant
rs1000348481 -- 12,035,664(+) CGCCT(A/G)GAGCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000471168 -- 12,031,364(+) AGATA(C/T)CAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF433 Gene

Variant ID Type Subtype PubMed ID
esv3415797 CNV insertion 20981092
nsv525966 CNV gain 19592680
nsv578619 CNV loss 21841781
nsv978771 CNV duplication 23825009

Variation tolerance for ZNF433 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF433 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF433 Gene

Disorders for ZNF433 Gene

Relevant External Links for ZNF433

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF433 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF433 Gene

Publications for ZNF433 Gene

  1. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. (PMID: 20598377) Nischwitz S. … Weber F. (J. Neuroimmunol. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for ZNF433 Gene

Sources for ZNF433 Gene

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