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Aliases for ZNF432 Gene

Aliases for ZNF432 Gene

  • Zinc Finger Protein 432 2 3 5
  • KIAA0798 4

External Ids for ZNF432 Gene

Previous GeneCards Identifiers for ZNF432 Gene

  • GC19M057172
  • GC19M057226
  • GC19M057190
  • GC19M057216
  • GC19M052467
  • GC19M052536

Summaries for ZNF432 Gene

GeneCards Summary for ZNF432 Gene

ZNF432 (Zinc Finger Protein 432) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF615.

UniProtKB/Swiss-Prot for ZNF432 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF432 Gene

Genomics for ZNF432 Gene

Regulatory Elements for ZNF432 Gene

Promoters for ZNF432 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF432 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF432 Gene

Chromosome:
19
Start:
52,031,378 bp from pter
End:
52,095,738 bp from pter
Size:
64,361 bases
Orientation:
Minus strand

Genomic View for ZNF432 Gene

Genes around ZNF432 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF432 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF432 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF432 Gene

Proteins for ZNF432 Gene

  • Protein details for ZNF432 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94892-ZN432_HUMAN
    Recommended name:
    Zinc finger protein 432
    Protein Accession:
    O94892

    Protein attributes for ZNF432 Gene

    Size:
    652 amino acids
    Molecular mass:
    74836 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34518.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF432 Gene

Proteomics data for ZNF432 Gene at MOPED

Post-translational modifications for ZNF432 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF432 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF432 Gene

Domains & Families for ZNF432 Gene

Gene Families for ZNF432 Gene

Protein Domains for ZNF432 Gene

Suggested Antigen Peptide Sequences for ZNF432 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94892

UniProtKB/Swiss-Prot:

ZN432_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF432: view

Function for ZNF432 Gene

Molecular function for ZNF432 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF432: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF432 Gene

Localization for ZNF432 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF432 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF432 Gene COMPARTMENTS Subcellular localization image for ZNF432 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF432 Gene

Pathways & Interactions for ZNF432 Gene

SuperPathways for ZNF432 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF432: view

Pathways by source for ZNF432 Gene

2 Reactome pathways for ZNF432 Gene

Interacting Proteins for ZNF432 Gene

Gene Ontology (GO) - Biological Process for ZNF432 Gene

None

No data available for SIGNOR curated interactions for ZNF432 Gene

Drugs & Compounds for ZNF432 Gene

No Compound Related Data Available

Transcripts for ZNF432 Gene

Unigene Clusters for ZNF432 Gene

Zinc finger protein 432:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF432 Gene

No ASD Table

Relevant External Links for ZNF432 Gene

GeneLoc Exon Structure for
ZNF432
ECgene alternative splicing isoforms for
ZNF432

Expression for ZNF432 Gene

mRNA expression in normal human tissues for ZNF432 Gene

Protein differential expression in normal tissues from HIPED for ZNF432 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF432 Gene



SOURCE GeneReport for Unigene cluster for ZNF432 Gene Hs.655934

genes like me logo Genes that share expression patterns with ZNF432: view

Protein tissue co-expression partners for ZNF432 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF432 Gene

Orthologs for ZNF432 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF432 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF432 35
  • 85.43 (n)
  • 79.45 (a)
dog
(Canis familiaris)
Mammalia ZNF432 35
  • 87.3 (n)
  • 83.87 (a)
chimpanzee
(Pan troglodytes)
Mammalia ZNF432 35
  • 99.54 (n)
  • 99.54 (a)
ZNF432 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF432 36
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-202h22.10 35
  • 53.58 (n)
  • 48.56 (a)
Species with no ortholog for ZNF432:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF432 Gene

ENSEMBL:
Gene Tree for ZNF432 (if available)
TreeFam:
Gene Tree for ZNF432 (if available)

Paralogs for ZNF432 Gene

Paralogs for ZNF432 Gene

(449) SIMAP similar genes for ZNF432 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF432: view

Variants for ZNF432 Gene

Sequence variations from dbSNP and Humsavar for ZNF432 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035577 A breast cancer sample
VAR_035578 A breast cancer sample
rs3450 -- 52,049,746(-) ATTGT(A/G)ATTAA upstream-variant-2KB
rs3834981 -- 52,050,503(+) TTACT(-/G)TTGTT upstream-variant-2KB
rs3752118 -- 52,048,233(+) CTCTA(C/G)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF432 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990
nsv833872 CNV Loss 17160897

Variation tolerance for ZNF432 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF432 Gene

HapMap Linkage Disequilibrium report
ZNF432

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF432 Gene

Disorders for ZNF432 Gene

Relevant External Links for ZNF432

Genetic Association Database (GAD)
ZNF432
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF432

No disorders were found for ZNF432 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF432 Gene

Publications for ZNF432 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 23
  3. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. (PMID: 24280104) Wu A.C. … Tantisira K. (J. Allergy Clin. Immunol. 2014) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for ZNF432 Gene

Sources for ZNF432 Gene

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