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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF432 Gene

protein-coding   GIFtS: 46
GCID: GC19M052536

zinc finger protein 432

 Explore 2 diseases affiliated with
ZNF432 via our new
 Human Malady Compendium 
Biological research products
for ZNF432
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 4321 2
KIAA07981 3

External Ids:    HGNC: 208101   Entrez Gene: 96682   Ensembl: ENSG000002560877   UniProtKB: O948923   

Export aliases for ZNF432 gene to outside databases

Previous GC identifers: GC19M057172 GC19M057226 GC19M057190 GC19M057216 GC19M052467


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN432_HUMAN, O94892
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF432 gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF432 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF432

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF432


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF432 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF432 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052536:  view genomic region     (about GC identifiers)

Start:
52,536,361 bp from pter      End:
52,552,106 bp from pter
Size:
15,746 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN432_HUMAN, O94892 (See protein sequence)
Recommended Name: Zinc finger protein 432  
Size: 652 amino acids; 74836 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA34518.2; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for ZNF432: NX_O94892

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O94892

  • ZNF432 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055465.1  
    ENSEMBL proteins: 
     ENSP00000221315  
    Reactome Protein details: O94892
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    Uscn Proteins for ZNF432

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF432 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF432 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O94892

    ProtoNet protein and cluster: O94892

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN432_HUMAN, O94892
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN432_HUMAN, O94892
    Function: May be involved in transcriptional regulation

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF432 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF432:
     Decreased influenza A virus in 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF432
        Generic Transcription Pathway
    Gene Expression



    ZNF432 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF432

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF432 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF432
    Search CenterWatch for drugs/clinical trials and news about ZNF432 / ZN432 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF432 gene: 
    NM_014650.2  

    Unigene Cluster for ZNF432:

    Zinc finger protein 432
    Hs.655934  [show with all ESTs]
    Unigene Representative Sequence: AB018341
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000221315(uc002pyk.3)

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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF432
    Clone
    Products:
         
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF432
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    Additional cDNA sequence: 

    AB018341.1 AK292827.1 BC002858.2 

    2 DOTS entries:

    DT.307847  DT.400726 

    24/73 AceView cDNA sequences (see all 73):

    AK093512 NM_014650 AW002711 F28968 AX748176 AK131334 BQ961564 AK131409 
    AA393349 BC002858 BQ007073 BQ638587 AA827512 BP367484 CB146052 BP377464 
    AW449479 AI224599 AK129938 AB018341 AF086256 AW250845 BQ286436 BX470424 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF432 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF432 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF432

    SOURCE GeneReport for Unigene cluster: Hs.655934
        SABiosciences Custom PCR Arrays for ZNF432
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF432

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF432 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 8)
    --
    44(a)
    36(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    Un(41687425-41690654)
    Un(54164034-54170097)


    ENSEMBL Gene Tree for ZNF432 (if available)
    TreeFam Gene Tree for ZNF432 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF432 gene
    ZNF1752  ZNF6742  LOC1002875152  ZNF6142  ZNF6132  ZNF262  ZNF3502  ZNF812  
    ZNF6492  ZNF6052  ZNF5772  ZNF842  ZNF6302  ZFP372  ZNF4842  ENSG000002296312  
    ZNF1822  ZNF412  ZNF2682  LOC1009964642  ZNF6152  ZNF3002  
    18/425 SIMAP similar genes for ZNF432 using alignment to 5 protein entries:     ZN432_HUMAN (see all proteins) (see all similar genes):
    DKFZp666M039    ZNF436    ZNF615    PRMD9    ZNF350    PRDM9
    HZF36    ZNF146    ZNF589    ZNF613    ZNF614    ZNF323
    DKFZp547L155    ZNF16    ZNF32    ZNF497    ZNF664    ZNF844

    ZNF432 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/331 NCBI SNPs in ZNF432 are shown (see all 331    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388959171,2
    --52536232(+) GTAAGC/TTCATT 1 -- int10--------
    rs1148018151,2
    F,--52536418(+) TGACAT/CAAAAT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1168344391,2
    F,--52536441(+) ATCACC/TGAAGG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs739347331,2
    C,--52536578(+) TTTAAT/ACAGTT 1 -- int12Minor allele frequency- A:0.08WA 120
    rs1493907361,2
    --52536596(+) CTAACA/GTGGTT 1 -- int10--------
    rs1446947971,2
    --52536658(+) AGGACG/TATGTA 1 -- int10--------
    rs588176901,2
    C,F,--52536692(+) GTTGTC/TATAGT 1 -- ut313Minor allele frequency- T:0.17WA NA EA 358
    rs1868143901,2
    --52536776(+) ATTGGC/TACATC 1 -- ut310--------
    rs755496911,2
    C,F,--52536782(+) ACATCA/GAAGAA 1 -- ut311Minor allele frequency- G:0.07WA 118
    rs2006650191,2
    --52536998(+) GAGTTC/TGCTGA 2 Q R mis10--------

    HapMap Linkage Disequilibrium report for ZNF432 (52536361 - 52552106 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ZNF432
         4 CNVs: 8875 3195 34482 53103

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF432

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF432 for disorders           About GeneDecksing

    2 diseases for ZNF432:    About MalaCards
    pituitary adenoma    adenoma


    Export disorders for ZNF432 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF432 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF432)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9668 HGNC: 20810 AceView: ZNF432 Ensembl:ENSG00000256087 euGenes: HUgn9668
    ECgene: ZNF432 H-InvDB: ZNF432

    (According to HUGE)
    About This Section
    HUGE: KIAA0798

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF432 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF432 gene:
    Search GeneIP for patents involving ZNF432

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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