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Aliases for ZNF431 Gene

Aliases for ZNF431 Gene

  • Zinc Finger Protein 431 2 3
  • KIAA1969 4

External Ids for ZNF431 Gene

Previous GeneCards Identifiers for ZNF431 Gene

  • GC19P021100
  • GC19P021116
  • GC19P021324
  • GC19P020815

Summaries for ZNF431 Gene

GeneCards Summary for ZNF431 Gene

ZNF431 (Zinc Finger Protein 431) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF431 Gene

  • Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5-GCGCCC-3 in the promoter of PTCH1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF431 Gene

Genomics for ZNF431 Gene

Regulatory Elements for ZNF431 Gene

Genomic Location for ZNF431 Gene

Start:
21,142,010 bp from pter
End:
21,196,053 bp from pter
Size:
54,044 bases
Orientation:
Plus strand

Genomic View for ZNF431 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF431 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF431 Gene

Proteins for ZNF431 Gene

  • Protein details for ZNF431 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF32-ZN431_HUMAN
    Recommended name:
    Zinc finger protein 431
    Protein Accession:
    Q8TF32
    Secondary Accessions:
    • A8KAK7
    • Q8IWC4

    Protein attributes for ZNF431 Gene

    Size:
    576 amino acids
    Molecular mass:
    67217 Da
    Quaternary structure:
    • Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1 (By similarity).
    SequenceCaution:
    • Sequence=BAB85555.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF431 Gene

Proteomics data for ZNF431 Gene at MOPED

Post-translational modifications for ZNF431 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF431 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF431 Gene

Domains for ZNF431 Gene

Gene Families for ZNF431 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF431 Gene

Suggested Antigen Peptide Sequences for ZNF431 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF32

UniProtKB/Swiss-Prot:

ZN431_HUMAN :
  • Q8TF32
Domain:
  • The KRAB domain is necessary for its repressive activity.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF431: view

Function for ZNF431 Gene

Molecular function for ZNF431 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5-GCGCCC-3 in the promoter of PTCH1 (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF431 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003676 nucleic acid binding --
GO:0003682 chromatin binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF431: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF431

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF431 Gene

Localization for ZNF431 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF431 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF431 Gene COMPARTMENTS Subcellular localization image for ZNF431 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF431 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with ZNF431: view

Pathways for ZNF431 Gene

SuperPathways for ZNF431 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF431: view

Pathways by source for ZNF431 Gene

2 Reactome pathways for ZNF431 Gene

Interacting Proteins for ZNF431 Gene

Gene Ontology (GO) - Biological Process for ZNF431 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0030154 cell differentiation IEA --
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity ISS --
genes like me logo Genes that share ontologies with ZNF431: view

Transcripts for ZNF431 Gene

Unigene Clusters for ZNF431 Gene

Zinc finger protein 431:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF431

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF431 Gene

No ASD Table

Relevant External Links for ZNF431 Gene

GeneLoc Exon Structure for
ZNF431
ECgene alternative splicing isoforms for
ZNF431

Expression for ZNF431 Gene

mRNA expression in normal human tissues for ZNF431 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF431 Gene

This gene is overexpressed in Esophagus - Mucosa (4.3).

Protein differential expression in normal tissues for ZNF431 Gene

This gene is overexpressed in Cervix (60.1) and Serum (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF431 Gene

SOURCE GeneReport for Unigene cluster for ZNF431 Gene Hs.687547

genes like me logo Genes that share expressions with ZNF431: view

Expression partners for ZNF431 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF431 Gene

Orthologs for ZNF431 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF431 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF431 35
  • 99.19 (n)
  • 99.13 (a)
ZNF431 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 61 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ZNF431:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF431 Gene

ENSEMBL:
Gene Tree for ZNF431 (if available)
TreeFam:
Gene Tree for ZNF431 (if available)

Paralogs for ZNF431 Gene

Selected SIMAP similar genes for ZNF431 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF431: view

Variants for ZNF431 Gene

Sequence variations from dbSNP and Humsavar for ZNF431 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs388229 -- 21,181,374(-) gctat(A/C)aagtg intron-variant, upstream-variant-2KB
rs416001 -- 21,178,614(-) cagca(C/T)acaaa intron-variant
rs1864208 -- 21,149,770(+) TTGTA(A/G)TTGGT intron-variant, upstream-variant-2KB
rs1975056 -- 21,141,129(+) TCTTT(C/G)TTCAC upstream-variant-2KB
rs2115498 -- 21,172,670(+) gtgtt(A/G)tgcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF431 Gene

Variant ID Type Subtype PubMed ID
nsv458377 CNV Gain 19166990
nsv911413 CNV Gain 21882294
esv2665276 CNV Deletion 23128226
esv2718324 CNV Deletion 23290073
dgv72e19 CNV Loss 19470904
esv5243 CNV Deletion 18987735
esv2660807 CNV Deletion 23128226
esv4924 CNV Complex 18987735
dgv551e201 CNV Deletion 23290073
esv2718325 CNV Deletion 23290073
nsv911414 CNV Loss 21882294

Relevant External Links for ZNF431 Gene

HapMap Linkage Disequilibrium report
ZNF431

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF431 Gene

Disorders for ZNF431 Gene

(1) University of Copenhagen DISEASES for ZNF431 Gene

genes like me logo Genes that share disorders with ZNF431: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ZNF431 Gene

Publications for ZNF431 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PMID: 15576338) Rosas-Acosta G. … Wilson V.G. (Mol. Cell Proteomics 2005) 3
  5. A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. (PMID: 21177534) He Z. … Ma L. (J. Biol. Chem. 2011) 3

Products for ZNF431 Gene

Sources for ZNF431 Gene

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