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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF431 Gene

protein-coding   GIFtS: 48
GCID: GC19P021324

Zinc Finger Protein 431

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 4311 2
KIAA19693

External Ids:    HGNC: 208091   Entrez Gene: 1709592   Ensembl: ENSG000001967057   UniProtKB: Q8TF323   

Export aliases for ZNF431 gene to outside databases

Previous GC identifers: GC19P021100 GC19P021116 GC19P020815


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF431 Gene: 
ZNF431 (zinc finger protein 431) is a protein-coding gene. Diseases associated with ZNF431 include cleft lip, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN431_HUMAN, Q8TF32
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF431 gene promoter:
         MyoD   Pax-2   AP-4   Pax-2a   Evi-1   E47   GATA-1   AREB6   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF431 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF431

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF431


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF431 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF431 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P021324:  view genomic region     (about GC identifiers)

Start:
21,324,827 bp from pter      End:
21,373,034 bp from pter
Size:
48,208 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN431_HUMAN, Q8TF32 (See protein sequence)
Recommended Name: Zinc finger protein 431  
Size: 576 amino acids; 67217 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAB85555.1; Type=Erroneous initiation;
Secondary accessions: A8KAK7 Q8IWC4

Explore the universe of human proteins at neXtProt for ZNF431: NX_Q8TF32

Explore proteomics data for ZNF431 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TF32

  • ZNF431 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF431 Protein Expression
    REFSEQ proteins: NP_597730.2  
    ENSEMBL proteins: 
     ENSP00000470668   ENSP00000470528   ENSP00000469460   ENSP00000308578   ENSP00000471876  
    Reactome Protein details: Q8TF32
    Human Recombinant Protein Products for ZNF431: 
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    Cloud-Clone Corp. Proteins for ZNF431 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF431 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ZNF431


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TF32

    ProtoNet protein and cluster: Q8TF32

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN431_HUMAN, Q8TF32
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF431 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN431_HUMAN, Q8TF32
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF431 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF431 
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    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF431


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF431 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF431
        Generic Transcription Pathway
    Gene Expression



    ZNF431 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF431

    5 Interacting proteins for ZNF431 (Q8TF322, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271718 I2D: score=2 
    SMN2Q166372, 3MINT-8271718 I2D: score=2 
    ANXA7P200732, 3MINT-8248992 I2D: score=2 
    CDKN1AP389362, 3MINT-8252505 I2D: score=2 
    TK1P041832, 3MINT-8274423 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF431 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF431 (ZN431)

    Search CenterWatch for drugs/clinical trials and news about ZNF431 / ZN431

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF431 gene: 
    NM_133473.2  

    Unigene Cluster for ZNF431:

    Zinc finger protein 431
    Hs.687547  [show with all ESTs]
    Unigene Representative Sequence: NM_133473
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600692 ENST00000599296 ENST00000594425 ENST00000311048(uc002npp.2 uc010ecq.2 uc010ecr.2)
    ENST00000598331 ENST00000593426 ENST00000594821
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF431
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZNF431
    SwitchGear 3'UTR luciferase reporter plasmidZNF431 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF431
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF431
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF431
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF431 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF431 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF431
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF431
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF431

    Additional mRNA sequence: 

    AB075849.1 AK024160.1 AK293072.1 AK308127.1 BC040506.1 BX647597.1 

    12 DOTS entries:

    DT.91654015  DT.100780718  DT.100008579  DT.40290520  DT.422722  DT.121496495  DT.121496651  DT.40267071 
    DT.423277  DT.91752512  DT.95251491  DT.97836776 

    24/30 AceView cDNA sequences (see all 30):

    CB267282 CF541205 AB075849 BG818171 BX456765 AW299824 BX647597 BX113520 
    AA347992 BU732635 AI583033 BC040506 AI568752 AU118176 AW137191 BQ889899 
    AK021615 NM_133473 AI888112 AU144815 BE328274 CA428831 AI376865 AW299815 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF431 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATCCGCCC
    ZNF431 Expression
    About this image


    See ZNF431 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.687547
        SABiosciences Custom PCR Arrays for ZNF431
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF431
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF431

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF431 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    GL343733.1(125230-159240)
            Species with no ortholog for ZNF431

    ENSEMBL Gene Tree for ZNF431 (if available)
    TreeFam Gene Tree for ZNF431 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF431 gene
    ZNF852  ZNF4862  ZNF1952  ZNF7272  ZNF922  ZNF1002  ZNF7322  ZNF6752  
    ZNF1382  ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  
    ZNF2532  ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2672  ZNF2542  ZNF7372  ZNF982  ZNF7162  ZNF7142  ZNF5192  
    ZNF4302  ZNF7302  ZNF7082  ZNF1172  ZNF902  ZNF7262  ZNF7282  
    18/512 SIMAP similar genes for ZNF431 using alignment to 5 protein entries:     ZN431_HUMAN (see all proteins) (see all similar genes):
    ZNF714    ZNF675    ZNF283    ZNF724P    MGC12518    ZNF429
    ZNF701    ZNF677    ZNF257    ZNF98    ZFS-1    ZNF737
    ZNF816    ZNF92    ZNF506    ZNF726    ZFS-4    ZNF676

    ZNF431 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/898 SNPs in ZNF431 are shown (see all 898)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128556461,2
    C--21322849(+) CTGAAG/AGAATC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1431387021,2
    --21322857(+) ATCTGA/GTTTCT 1 -- us2k10--------
    rs1470316501,2
    C--21323113(+) TATCCA/GTGCCC 1 -- us2k10--------
    rs1839703681,2
    --21323159(+) TCCAGA/GATCTG 1 -- us2k10--------
    rs1480998441,2
    --21323504(+) CTGACC/GATCTC 1 -- us2k10--------
    rs1886003101,2
    --21323548(+) ATGCTA/GCAATA 1 -- us2k10--------
    rs1813896211,2
    --21323555(+) AATAGC/GTAACT 1 -- us2k10--------
    rs1863995671,2
    --21323658(+) TTTTTC/TCCCCT 1 -- us2k10--------
    rs1418425961,2
    --21323694(+) AGAATG/TTTGAG 1 -- us2k10--------
    rs1507878881,2
    C--21323715(+) ATACAC/GGTAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF431 (21324827 - 21373034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ZNF431 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718324CNV Deletion23290073
    dgv551e201CNV Deletion23290073
    esv5243CNV Deletion18987735
    esv2718325CNV Deletion23290073
    esv2665276CNV Deletion23128226
    esv2660807CNV Deletion23128226
    dgv72e19CNV Loss19470904
    nsv911414CNV Loss21882294
    nsv911413CNV Gain21882294
    nsv458377CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF431:    About MalaCards
    cleft lip    

    1 disease from the University of Copenhagen DISEASES database for ZNF431:
    Cleft lip

    ZNF431 for disorders           About GeneDecksing


    Export disorders for ZNF431 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF431 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF431)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. A novel KRAB domain-containing zinc finger transcript ion factor ZNF431 directly represses Patched1 transcription. (PubMed id 21177534)1 He Z....Ma L. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. A universal strategy for proteomic studies of SUMO an d other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 170959 HGNC: 20809 AceView: ZNF431 Ensembl:ENSG00000196705 euGenes: HUgn170959
    ECgene: ZNF431 H-InvDB: ZNF431

    (According to HUGE)
    About This Section
    HUGE: KIAA1969

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF431 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF431 gene:
    Search GeneIP for patents involving ZNF431

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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