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Aliases for ZNF431 Gene

Aliases for ZNF431 Gene

  • Zinc Finger Protein 431 2 3 5
  • KIAA1969 4

External Ids for ZNF431 Gene

Previous GeneCards Identifiers for ZNF431 Gene

  • GC19P021100
  • GC19P021116
  • GC19P021324
  • GC19P020815

Summaries for ZNF431 Gene

GeneCards Summary for ZNF431 Gene

ZNF431 (Zinc Finger Protein 431) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and core promoter sequence-specific DNA binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF431 Gene

  • Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5-GCGCCC-3 in the promoter of PTCH1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF431 Gene

Genomics for ZNF431 Gene

Regulatory Elements for ZNF431 Gene

Enhancers for ZNF431 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF431 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF431 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF431 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF431 Gene

Chromosome:
19
Start:
21,142,004 bp from pter
End:
21,196,053 bp from pter
Size:
54,050 bases
Orientation:
Plus strand

Genomic View for ZNF431 Gene

Genes around ZNF431 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF431 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF431 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF431 Gene

Proteins for ZNF431 Gene

  • Protein details for ZNF431 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF32-ZN431_HUMAN
    Recommended name:
    Zinc finger protein 431
    Protein Accession:
    Q8TF32
    Secondary Accessions:
    • A8KAK7
    • Q8IWC4

    Protein attributes for ZNF431 Gene

    Size:
    576 amino acids
    Molecular mass:
    67217 Da
    Quaternary structure:
    • Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1 (By similarity).
    SequenceCaution:
    • Sequence=BAB85555.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF431 Gene

Proteomics data for ZNF431 Gene at MOPED

Post-translational modifications for ZNF431 Gene

  • Ubiquitination at Lys 5
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF431 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF431

No data available for DME Specific Peptides for ZNF431 Gene

Domains & Families for ZNF431 Gene

Gene Families for ZNF431 Gene

Protein Domains for ZNF431 Gene

Suggested Antigen Peptide Sequences for ZNF431 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF32

UniProtKB/Swiss-Prot:

ZN431_HUMAN :
  • The KRAB domain is necessary for its repressive activity.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • The KRAB domain is necessary for its repressive activity.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF431: view

Function for ZNF431 Gene

Molecular function for ZNF431 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5-GCGCCC-3 in the promoter of PTCH1 (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF431 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
genes like me logo Genes that share ontologies with ZNF431: view

Phenotypes for ZNF431 Gene

genes like me logo Genes that share phenotypes with ZNF431: view

Animal Model Products

CRISPR Products

miRNA for ZNF431 Gene

miRTarBase miRNAs that target ZNF431

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF431 Gene

Localization for ZNF431 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF431 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF431 Gene COMPARTMENTS Subcellular localization image for ZNF431 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF431 Gene

Pathways & Interactions for ZNF431 Gene

SuperPathways for ZNF431 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF431: view

Pathways by source for ZNF431 Gene

2 Reactome pathways for ZNF431 Gene

Interacting Proteins for ZNF431 Gene

Gene Ontology (GO) - Biological Process for ZNF431 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZNF431: view

No data available for SIGNOR curated interactions for ZNF431 Gene

Drugs & Compounds for ZNF431 Gene

No Compound Related Data Available

Transcripts for ZNF431 Gene

Unigene Clusters for ZNF431 Gene

Zinc finger protein 431:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF431 Gene

No ASD Table

Relevant External Links for ZNF431 Gene

GeneLoc Exon Structure for
ZNF431
ECgene alternative splicing isoforms for
ZNF431

Expression for ZNF431 Gene

mRNA expression in normal human tissues for ZNF431 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF431 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF431 Gene

This gene is overexpressed in Cervix (60.1) and Serum (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF431 Gene



SOURCE GeneReport for Unigene cluster for ZNF431 Gene Hs.687547

genes like me logo Genes that share expression patterns with ZNF431: view

Protein tissue co-expression partners for ZNF431 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF431 Gene

Orthologs for ZNF431 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF431 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF431 35
  • 99.19 (n)
  • 99.13 (a)
ZNF431 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 61 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ZNF431:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF431 Gene

ENSEMBL:
Gene Tree for ZNF431 (if available)
TreeFam:
Gene Tree for ZNF431 (if available)

Paralogs for ZNF431 Gene

(514) SIMAP similar genes for ZNF431 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF431: view

Variants for ZNF431 Gene

Sequence variations from dbSNP and Humsavar for ZNF431 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17445374 - 21,143,555(+) GGACG(A/G)CTTGA reference, missense, utr-variant-5-prime
rs7256576 -- 21,166,508(+) TGTTT(C/T)ATGTC intron-variant
rs7256860 -- 21,181,691(+) TGTTA(C/T)TCTCA intron-variant, upstream-variant-2KB
rs7258575 -- 21,161,387(+) GAATT(G/T)TATTA intron-variant, upstream-variant-2KB
rs7259520 -- 21,148,895(+) ttagc(A/G/T)gtaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF431 Gene

Variant ID Type Subtype PubMed ID
nsv458377 CNV Gain 19166990
nsv911413 CNV Gain 21882294
esv2665276 CNV Deletion 23128226
esv2718324 CNV Deletion 23290073
dgv72e19 CNV Loss 19470904
esv5243 CNV Deletion 18987735
esv2660807 CNV Deletion 23128226
esv4924 CNV Complex 18987735
dgv551e201 CNV Deletion 23290073
esv2718325 CNV Deletion 23290073
nsv911414 CNV Loss 21882294

Variation tolerance for ZNF431 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF431 Gene

Disorders for ZNF431 Gene

Relevant External Links for ZNF431

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF431

No disorders were found for ZNF431 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF431 Gene

Publications for ZNF431 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. (PMID: 21177534) He Z. … Ma L. (J. Biol. Chem. 2011) 3
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF431 Gene

Sources for ZNF431 Gene

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