Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZNF431 Gene

protein-coding   GIFtS: 45
GCID: GC19P021324

Zinc Finger Protein 431

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger Protein 4311 2
KIAA19693

External Ids:    HGNC: 208091   Entrez Gene: 1709592   Ensembl: ENSG000001967057   UniProtKB: Q8TF323   

Export aliases for ZNF431 gene to outside databases

Previous GC identifers: GC19P021100 GC19P021116 GC19P020815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ZNF431 Gene:
ZNF431 (zinc finger protein 431) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN431_HUMAN, Q8TF32
Function: Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by
recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during
embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds
to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF431 gene promoter:
         MyoD   Pax-2   AP-4   Pax-2a   Evi-1   E47   GATA-1   AREB6   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF431 promoter sequence
   Search Chromatin IP Primers for ZNF431

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF431


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF431 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF431 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P021324:  view genomic region     (about GC identifiers)

Start:
21,324,827 bp from pter      End:
21,373,034 bp from pter
Size:
48,208 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZN431_HUMAN, Q8TF32 (See protein sequence)
Recommended Name: Zinc finger protein 431  
Size: 576 amino acids; 67217 Da
Subunit: Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1
(By similarity)
Sequence caution: Sequence=BAB85555.1; Type=Erroneous initiation;
Secondary accessions: A8KAK7 Q8IWC4

Explore the universe of human proteins at neXtProt for ZNF431: NX_Q8TF32

Explore proteomics data for ZNF431 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF431 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_597730.2  
    ENSEMBL proteins: 
     ENSP00000470668   ENSP00000470528   ENSP00000469460   ENSP00000308578   ENSP00000471876  
    Reactome Protein details: Q8TF32

    ZNF431 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZNF431
    GenScript Custom Purified and Recombinant Proteins Services for ZNF431
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF431

     
    Search eBioscience for Proteins for ZNF431 

    ZNF431 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZNF431
    Novus Biologicals ZNF431 Antibodies
    Abcam antibodies for ZNF431
    Cloud-Clone Corp. Antibodies for ZNF431
    Search ThermoFisher Antibodies for ZNF431
    LSBio Antibodies in human, mouse, rat for ZNF431

    ZNF431 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZNF431
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF431
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF431
    Cloud-Clone Corp. CLIAs for ZNF431
    Search eBioscience for ELISAs for ZNF431 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TF32

    ProtoNet protein and cluster: Q8TF32

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN431_HUMAN, Q8TF32
    Domain: The KRAB domain is necessary for its repressive activity (By similarity)
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF431           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN431_HUMAN, Q8TF32
    Function: Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by
    recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during
    embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds
    to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001046core promoter sequence-specific DNA binding ISS--
    GO:0003676nucleic acid binding ----
    GO:0003682chromatin binding ISS--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF431           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF431
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF431

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF431
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF431

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ZNF431 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ZNF431
    SwitchGear 3'UTR luciferase reporter plasmidZNF431 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF431
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF431

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF431

    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF431 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF431 (NM_133473)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF431
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF431

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZNF431
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF431 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF431


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZN431_HUMAN, Q8TF32: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS--

    Find genes that share ontologies with ZNF431           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ZNF431 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF431           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF431
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF431
    Interactions:

        Search GeneGlobe Interaction Network for ZNF431

    5 Interacting proteins for ZNF431 (Q8TF322, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271718 I2D: score=2 
    SMN2Q166372, 3MINT-8271718 I2D: score=2 
    ANXA7P200732, 3MINT-8248992 I2D: score=2 
    CDKN1AP389362, 3MINT-8252505 I2D: score=2 
    TK1P041832, 3MINT-8274423 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0030154cell differentiation IEA--
    GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity ISS--

    Find genes that share ontologies with ZNF431           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF431 (ZN431)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZNF431 gene: 
    NM_133473.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600692 ENST00000599296 ENST00000594425 ENST00000311048(uc002npp.2 uc010ecq.2 uc010ecr.2)
    ENST00000598331 ENST00000593426 ENST00000594821
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF431 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ZNF431
    SwitchGear 3'UTR luciferase reporter plasmidZNF431 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF431
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF431
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF431 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF431 (NM_133473)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF431
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF431
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF431
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF431
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF431
      QuantiFast Probe-based Assays in human, mouse, rat ZNF431

    Selected AceView cDNA sequences (see all 30):

    AB075849 CB267282 CF541205 BG818171 BX456765 BE328274 AW299815 BU732635 
    NM_133473 AA347992 AU118176 BX647597 BC040506 AI888112 AW137191 AW299824 
    AI583033 AU144815 CA428831 BX113520 AK021615 BQ889899 BE897322 AI568752 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZNF431 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATCCGCCC
    ZNF431 Expression
    About this image

    ZNF431 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF431 Protein Expression
        Custom PCR Arrays for ZNF431
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF431
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF431
    QuantiTect SYBR Green Assays in human, mouse, rat ZNF431
    QuantiFast Probe-based Assays in human, mouse, rat ZNF431
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF431

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF431 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    53(a)
    40(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)
            Species with no ortholog for ZNF431

    ENSEMBL Gene Tree for ZNF431 (if available)
    TreeFam Gene Tree for ZNF431 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZNF431 gene
    ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
    ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  
    ZNF932  ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2542  ZNF7372  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF4292  
    ZNF5192  ZNF4302  ZNF7302  ZNF7082  ZNF1172  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF431 using alignment to 5 protein entries:     ZN431_HUMAN (see all proteins) (see all similar genes):
    ZNF714    ZNF675    ZNF724P    MGC12518    ZNF98    ZNF429
    ZNF283    ZNF737    ZFS-1    ZNF257    ZNF677    ZNF701
    ZNF506    ZNF92    ZNF90    ZNF726    ZFS-4    ZNF676

    Find genes that share paralogs with ZNF431           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZNF431 (see all 898)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128556461,2
    C--21322849(+) CTGAAG/AGAATC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1431387021,2
    --21322857(+) ATCTGA/GTTTCT 1 -- us2k10--------
    rs1470316501,2
    C--21323113(+) TATCCA/GTGCCC 1 -- us2k10--------
    rs1839703681,2
    --21323159(+) TCCAGA/GATCTG 1 -- us2k10--------
    rs1480998441,2
    --21323504(+) CTGACC/GATCTC 1 -- us2k10--------
    rs1886003101,2
    --21323548(+) ATGCTA/GCAATA 1 -- us2k10--------
    rs1813896211,2
    --21323555(+) AATAGC/GTAACT 1 -- us2k10--------
    rs1863995671,2
    --21323658(+) TTTTTC/TCCCCT 1 -- us2k10--------
    rs1418425961,2
    --21323694(+) AGAATG/TTTGAG 1 -- us2k10--------
    rs1507878881,2
    C--21323715(+) ATACAC/GGTAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF431 (21324827 - 21373034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF431 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718324CNV Deletion23290073
    dgv551e201CNV Deletion23290073
    esv5243CNV Deletion18987735
    esv2718325CNV Deletion23290073
    esv2665276CNV Deletion23128226
    esv2660807CNV Deletion23128226
    dgv72e19CNV Loss19470904
    nsv911414CNV Loss21882294
    nsv911413CNV Gain21882294
    nsv458377CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF431
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF431

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease from the University of Copenhagen DISEASES database for ZNF431:
    Cleft lip

    Find genes that share disorders with ZNF431           About GenesLikeMe


    Export disorders for ZNF431 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZNF431 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF431)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. (PubMed id 21177534)1 He Z....Ma L. (J. Biol. Chem. 2011)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (amp 2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 170959 HGNC: 20809 AceView: ZNF431 Ensembl:ENSG00000196705 euGenes: HUgn170959
    ECgene: ZNF431 H-InvDB: ZNF431

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1969

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZNF431 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZNF431 gene:
    Search GeneIP for patents involving ZNF431

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZNF431  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZNF431  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZNF431   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNF431   OriGene Custom Protein Services for ZNF431  

     
     
     Block miRNA regulation of human, mouse, rat ZNF431 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF431
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF431 Predesigned siRNA for gene silencing in human, mouse, rat ZNF431
     QuantiFast Probe-based Assays in human, mouse, rat ZNF431 QuantiTect SYBR Green Assays in human, mouse, rat ZNF431
     Custom PCR Arrays for ZNF431 Search Chromatin IP Primers for ZNF431
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF431  Search GeneGlobe Interaction Network for ZNF431
     Regulatory tfbs in ZNF431 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZNF431 GenScript cDNA clones with any tag delivered in your preferred vector for ZNF431
     GenScript Custom Assay Services for ZNF431 GenScript Custom overexpressing Cell Line Services for ZNF431
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZNF431 (ZN431)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZNF431 antibodies
     Antibodies for ZNF431
     See all of Abcam's Antibodies, Kits and Proteins for ZNF431
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZNF431
     Antibodies for ZNF431
     ELISAs for ZNF431
     CLIAs for ZNF431



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF431
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF431
     SwitchGear 3'UTR luciferase reporter plasmids for ZNF431
     SwitchGear Promoter luciferase reporter plasmids for ZNF431
     Search ThermoFisher Antibodies for ZNF431
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF431
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF431
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF431
     LSBio Antibodies in human, mouse, rat for ZNF431
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ZNF431
      Search eBioscience for proteins for ZNF431
      Search eBioscience for elisas for ZNF431
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZNF431 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4