ZNF43 Gene
protein-coding GIFtS: 55
GCID: GC19M021987
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Zinc Finger Protein 43(Previous names: zinc finger protein 39-like 1 (KOX 27), zinc finger protein...)
(Previous symbol: ZNF39L1)
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Aliases
for ZNF43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 431 2 | | KOX272 3 | | ZNF39L11 2 3 | | Zinc Finger Protein 43 (HTF6)1 | | Zinc Finger Protein 39-Like 1 (KOX 27)1 2 | | HTF62 | | Zinc Finger Protein HTF62 3 | | ZNF393 | | Zinc Finger Protein KOX272 3 | | Zinc Finger Protein 393 |
Export aliases for ZNF43 gene to outside databasesPrevious GC identifers: GC19M022439 GC19M022321 GC19M021682 GC19M021781 GC19M021526 |
Summaries
for ZNF43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF43 Gene:
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulationand development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc fingerproteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-proteininteractions. (provided by RefSeq, Jul 2008)
GeneCards Summary for ZNF43 Gene: 
ZNF43 (zinc finger protein 43) is a protein-coding gene. Diseases associated with ZNF43 include peripheral primitive neuroectodermal tumor, and primitive neuroectodermal tumor, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF493.
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF43 Gene
|
Genomic Views
for ZNF43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NT_011295.11 NC_018930.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF43 gene promoter:
HOXA9 HOXA9B Nkx3-1 Nkx3-1 v4 p53 Nkx3-1 v1 Meis-1b Nkx3-1 v2 Nkx3-1 v3 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.1-p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p13.1-p12ZNF43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M021987: view genomic region
(about GC identifiers)
Start:
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21,987,752 bp from pter |
End:
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22,034,927 bp from pter |
Size:
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47,176 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr19-,NW_003315964 166,140-170,226 |
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Proteins
for ZNF43 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038 (See
protein sequence)Recommended Name: Zinc finger protein 43 Size: 809 amino acids; 94124 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A8K5N8 P28160 Q53XQ2 Q5H9T3 Q96DG1Alternative splicing: 2 isoforms: P17038-1 P17038-2 Explore the universe of human proteins at neXtProt for ZNF43: NX_P17038
Explore proteomics data for ZNF43 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_P17038
ZNF43 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001243577.1 NP_001243578.1 NP_001243579.1 NP_001243580.1 NP_001243582.1 NP_001243583.1 NP_003414.2
ENSEMBL proteins: ENSP00000469578 ENSP00000469645 ENSP00000347045 ENSP00000470275 ENSP00000469424 ENSP00000470996 ENSP00000471373 ENSP00000471176 Reactome Protein details: P17038
Human Recombinant Protein Products for ZNF43:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF43 for ontologies About GeneDecksing
ZNF43 Antibody Products:
Assay Products for ZNF43: |
Protein
Domains /
Families
for ZNF43 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type
4 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry P17038ProtoNet protein and cluster: P17038 1 Blocks protein domain: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 22 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain
ZNF43 for domains About GeneDecksing
|
Function
for ZNF43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZNF43_HUMAN, P17038Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF43:zinc finger protein 43 (HTF6),KRAB subfamily
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF43 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for ZNF43:
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF43 |
|
Pathways & Interactions
for ZNF43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
SuperPaths for ZNF43 About See pathways by source
| SuperPath | Contained pathways About |
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| 1 | Generic Transcription Pathway | |
Pathways by source See SuperPaths
Show all pathways
2 
Reactome Pathways for ZNF43
ZNF43 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF43
1 Interacting protein for ZNF43 (P170383) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF43 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
IUPHAR,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF43
1 HMDB Compound for ZNF43 About this table
Search CenterWatch for drugs/clinical trials and news about ZNF43
|
Transcripts
for ZNF43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF43 gene (7 alternative transcripts): NM_001256648.1 NM_001256649.1 NM_001256650.1 NM_001256651.1 NM_001256653.1 NM_001256654.1 NM_003423.3 Unigene Cluster for ZNF43: Zinc finger protein 43 Hs.534365 [show with all ESTs]Unigene Representative Sequence: NM_00125664811 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000594012 ENST00000595461 ENST00000354959(uc002nqj.3 uc002nqk.3 uc010ecv.3 uc002nql.3 uc002nqm.3)
ENST00000598381 ENST00000599906 ENST00000596899 ENST00000598288 ENST00000593551
ENST00000593886 ENST00000599414 ENST00000594312
Primer
Products: |  | OriGene qPCR primer pairs and template standards for ZNF43
OriGene qSTAR qPCR primer pairs in human, mouse for ZNF43
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF43 |
Additional mRNA sequence: AF112859.1 AK022905.1 AK097763.1 AK291353.1 BC006528.2 BT009756.1 CR933640.1 M61869.1 X52358.1 X59244.1 11 DOTS entries: DT.100775080 DT.87015253 DT.91822958 DT.95369543 DT.121421704 DT.95261589 DT.121421781 DT.423829 DT.95069576 DT.121421768 DT.97818233 24/63 AceView cDNA sequences (see all 63): AI479324 BU508506 BU507408 AK097763 AK022905 AU128362 BU187775 BC006528 BM272737 BU786847 CB306846 BT009756 BU167813 AI559883 AA318365 AA339257 NM_003423 CB250507 AL705298 BQ707571 BX471947 BG289688 BG696609 H74324
GeneLoc Exon Structure
|
Expression
for ZNF43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF43 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image
See ZNF43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF43
SOURCE GeneReport for Unigene cluster: Hs.534365
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038Tissue specificity: T- and B-cell lines
SABiosciences Custom PCR Arrays for ZNF43
Primer
Products: | | OriGene qPCR primer pairs and template standards for ZNF43
OriGene qSTAR qPCR primer pairs in human, mouse for ZNF43
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF43 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF43 |
Orthologs
for ZNF43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF43 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
1420007402 |
-- |
79.49(n) |
|
142000740 |
Species with no ortholog for ZNF43
ENSEMBL Gene Tree for ZNF43 (if available)
TreeFam Gene Tree for ZNF43 (if available) |
Paralogs
for ZNF43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF43 gene
- ZNF4932
18/467 SIMAP similar genes for ZNF43 using alignment to 5 protein entries: ZNF43_HUMAN (see all proteins)
(see all similar genes):ZNF730 MGC12518 ZNF675 ZNF273 ZNF98 ZNF429
ZNF90 ZNF506 ZNF724P ZNF100 ZNF430 ZNF738
ZNF257 ZNF493 ZNF66 ZNF726 ZNF78L1 ZNF818P
ZNF43 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF43 (21987752 - 22034927 bp)
Structural Variations
Database of Genomic Variants (DGV) 10/11 variations for ZNF43 (see all 11): About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF43 |
|
Disorders
/ Diseases
for ZNF43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF43 for disorders About GeneDecksing
OMIM gene information: 603972
OMIM disorders: --
2  diseases for ZNF43: About MalaCardsperipheral primitive neuroectodermal tumor primitive neuroectodermal tumor
Genetic Association Database (GAD): ZNF43
Human Genome Epidemiology (HuGE) Navigator: ZNF43 (1 document)
Export disorders for ZNF43 gene to outside databases
|
Publications
for ZNF43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF43 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ZNF43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines. (PubMed id 1711675)1, 2, 3 Lovering R. and Trowsdale J. (1991)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909)1, 2 Bellefroid E.J....Martial J.A. (1991)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. (PubMed id 17178891)1 Takahashi T....Naganuma A. (2006)
|
External Searches for ZNF43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZNF43 gene:
Search GeneIP for patents involving ZNF43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF43 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF43 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF43 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF43 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF43 |
| |  |  |  |  | | | | |
 |
 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF43 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF43 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF43 |
| |  |  | | | | LSBio Antibodies in human, mouse, rat for ZNF43 |
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