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ZNF43 Gene

protein-coding   GIFtS: 54
GCID: GC19M021987

Zinc Finger Protein 43

(Previous names: zinc finger protein 39-like 1 (KOX 27), zinc finger protein...)
(Previous symbol: ZNF39L1)
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Aliases
for ZNF43 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 431 2     KOX272 3
ZNF39L11 2 3     Zinc Finger Protein 43 (HTF6)1
Zinc Finger Protein 39-Like 1 (KOX 27)1 2     HTF62
Zinc Finger Protein HTF62 3     ZNF393
Zinc Finger Protein KOX272 3     Zinc Finger Protein 393

External Ids:    HGNC: 131091   Entrez Gene: 75942   Ensembl: ENSG000001985217   OMIM: 6039725   UniProtKB: P170383   

Export aliases for ZNF43 gene to outside databases

Previous GC identifers: GC19M022439 GC19M022321 GC19M021682 GC19M021781 GC19M021526


Summaries
for ZNF43 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF43 Gene:
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene
regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the
zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in
protein-protein interactions. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF43 Gene:
ZNF43 (zinc finger protein 43) is a protein-coding gene. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF43 Gene


Genomic Views
for ZNF43 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF43 gene promoter:
         HOXA9   HOXA9B   Nkx3-1   Nkx3-1 v4   p53   Nkx3-1 v1   Meis-1b   Nkx3-1 v2   Nkx3-1 v3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF43 promoter sequence
   Search Chromatin IP Primers for ZNF43

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1-p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p13.1-p12

ZNF43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF43 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M021987:  view genomic region     (about GC identifiers)

Start:
 21,987,752 bp from pter      End:
 22,034,927 bp from pter
Size:
 47,176 bases      Orientation:
 minus strand

1 alternative location:
Chr19-,NW_003315964 166,140-170,226     

Proteins
for ZNF43 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038 (See protein sequence)
Recommended Name: Zinc finger protein 43  
Size: 809 amino acids; 94124 Da
Secondary accessions: A8K5N8 P28160 Q53XQ2 Q5H9T3 Q96DG1
Alternative splicing: 2 isoforms:  P17038-1   P17038-2   

Explore the universe of human proteins at neXtProt for ZNF43: NX_P17038

Explore proteomics data for ZNF43 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys679
  • Modification sites at PhosphoSitePlus

    • See ZNF43 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001243577.1  NP_001243578.1  NP_001243579.1  NP_001243580.1  NP_001243582.1  NP_001243583.1  NP_003414.2  

    ENSEMBL proteins: 
     ENSP00000469578   ENSP00000469645   ENSP00000347045   ENSP00000470275   ENSP00000469424  
     ENSP00000470996   ENSP00000471373   ENSP00000471176  
    Reactome Protein details: P17038

    ZNF43 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF43

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    antibodies-online kits for ZNF43 (3 products) 

    Domains /
    Families
    for ZNF43 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17038

    ProtoNet protein and cluster: P17038

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 22 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF43           About GenesLikeMe


    Function
    for ZNF43 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF43_HUMAN, P17038
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF43:
    zinc finger protein 43 (HTF6),KRAB subfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF43           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZNF43:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF43

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    Localization
    for ZNF43 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF43_HUMAN, P17038: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF43           About GenesLikeMe


    Pathways & Interactions
    for ZNF43 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF43 About    
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1Gene Expression
    		Generic Transcription Pathway0.40
    		Gene Expression0.40


    Find genes that share SuperPaths with ZNF43           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF43
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF43
    Interactions:

        Search GeneGlobe Interaction Network for ZNF43

    1 Interacting protein for ZNF43 (P170383) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF43           About GenesLikeMe



    Drugs & Compounds
    for ZNF43 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF43

    1 HMDB Compound for ZNF43    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--



    Transcripts
    for ZNF43 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF43 gene (7 alternative transcripts): 
    NM_001256648.1  NM_001256649.1  NM_001256650.1  NM_001256651.1  NM_001256653.1  NM_001256654.1  NM_003423.3  

    Unigene Cluster for ZNF43:

    Zinc finger protein 43
    Hs.534365  [show with all ESTs]
    Unigene Representative Sequence: NM_001256648
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594012 ENST00000595461 ENST00000354959(uc002nqj.3 uc002nqk.3 uc010ecv.3 uc002nql.3 uc002nqm.3)
    ENST00000598381 ENST00000599906 ENST00000596899 ENST00000598288 ENST00000593551
    ENST00000593886 ENST00000599414 ENST00000594312
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    Additional mRNA sequence: 

    AF112859.1 AK022905.1 AK097763.1 AK291353.1 BC006528.2 BT009756.1 CR933640.1 M61869.1 
    X52358.1 X59244.1 

    11 DOTS entries:

    DT.100775080  DT.87015253  DT.91822958  DT.95369543  DT.121421704  DT.95261589  DT.121421781  DT.423829 
    DT.95069576  DT.121421768  DT.97818233 

    Selected AceView cDNA sequences (see all 63):

    CB306846 BU786847 AU128362 AI559883 AI479324 BU507408 BU508506 AK097763 
    BC006528 AK022905 BU187775 AA318365 BM272737 BU167813 BT009756 BE613562 
    R99693 H74324 AL705298 CB250507 BG289688 M61869 X59244 BM008050 

    GeneLoc Exon Structure


    Expression
    for ZNF43 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF43 Expression
    About this image

    ZNF43 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZNF43 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534365

    UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038
    Tissue specificity: T- and B-cell lines

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    Orthologs
    for ZNF43 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF43 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp4581 zinc finger protein 458 67.34(n)
    56.76(a)    		   238690  NM_001001152.2  NP_001001152.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1420007402   -- 79.49(n)    142000740 


    ENSEMBL Gene Tree for ZNF43 (if available)
    TreeFam Gene Tree for ZNF43 (if available)

    Paralogs
    for ZNF43 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF43 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF4932  ZNF5462  ZNF992  ZNF8362  ZNF7212  
    ZNF5942  ZFP622  ZNF8412  ZNF780B2  ZNF1972  ZNF1072  ZNF585A2  ZNF8082  
    ZNF3472  ZNF8452  ZNF585B2  ZNF6582  ZNF6292  ZNF6242  ZNF2682  ZNF8142  
    Selected SIMAP similar genes for ZNF43 using alignment to 5 protein entries:     ZNF43_HUMAN (see all proteins) (see all similar genes):
    ZNF730    MGC12518    ZNF675    ZNF273    ZNF98    ZNF429
    ZNF90    ZNF724P    ZNF506    ZNF100    ZNF738    ZNF430
    ZNF257    ZNF726    ZNF493    ZNF66    ZNF78L1    ZNF818P

    Find genes that share paralogs with ZNF43           About GenesLikeMe



    Genomic Variants
    for ZNF43 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF43 (see all 1103)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0355694
    		A colorectal cancer sample4--see VAR_0355692 R C mis40--------
    rs741740411,2
    		C--21922200(+) GCATC-/T/TTT 
                TTTTT     		14 -- ut311NA 2
    rs347851981,2
    		C--21961016(+) GTCTC-/AAAAAA 5 -- int11Minor allele frequency- A:0.00NA 2
    rs1485510461,2
    		C--21987368(+) TTATGG/TGTCTA 7 -- ds50010--------
    rs1890837541,2
    		--21987404(+) AAAGTC/TTGCAT 7 -- ds50010--------
    rs1419024961,2
    		C--21987459(+) TTCAAC/TAGAAA 7 -- ds50010--------
    rs1810024521,2
    		--21987658(+) TATGTA/GTATAT 7 -- ds50010--------
    rs1506287161,2
    		C--21987764(+) CTCAGA/GAATGT 7 -- ut310--------
    rs1173292961,2
    		C,F--21988033(+) GAGGCC/TGAGGC 7 -- ut312Minor allele frequency- T:0.07NA EA 240
    rs2019363401,2
    		C--21988040(+) AGGCA-/GGCAGA 7 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF43 (21987752 - 22034927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF43 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718343CNV Deletion23290073
    dgv552e201CNV Deletion23290073
    esv2718335CNV Deletion23290073
    nsv833783CNV Loss17160897
    nsv833784CNV Loss17160897
    dgv3810n71CNV Loss21882294
    dgv3808n71CNV Gain21882294
    esv731CNV CNV17122850
    esv4924CNV Complex18987735
    dgv1066e1CNV Complex17122850

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    Disorders / Diseases
    for ZNF43 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 603972    OMIM disorders: --


    Find genes that share disorders with ZNF43           About GenesLikeMe

    Genetic Association Database (GAD): ZNF43
    Human Genome Epidemiology (HuGE) Navigator: ZNF43 (1 document)

    Export disorders for ZNF43 gene to outside databases

    Publications
    for ZNF43 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF43 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF43)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines. (PubMed id 1711675)1, 2, 3 Lovering R. and Trowsdale J. (Nucleic Acids Res. 1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909)1, 2 Bellefroid E.J....Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. (PubMed id 17178891)1 Takahashi T....Naganuma A. (Cancer Res. 2006)

    External Searches for ZNF43 gene

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    Genome Databases showing ZNF43 gene

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    Entrez Gene: 7594 HGNC: 13109 AceView: ZNF43 Ensembl:ENSG00000198521 euGenes: HUgn7594
    ECgene: ZNF43 H-InvDB: ZNF43

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    Specialized Databases showing ZNF43 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    PharmGKB entry for ZNF43 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF43 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
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