ZNF43 Gene
protein-coding GIFtS: 54
GCID: GC19M021987
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zinc finger protein 43(Previous names: zinc finger protein 39-like 1 (KOX 27), zinc finger protein...)
(Previous symbol: ZNF39L1)
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Aliases
for ZNF43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 431 2 | | Zinc Finger Protein HTF62 3 | | KOX271 2 3 | | Zinc Finger Protein KOX272 3 | | ZNF39L11 2 3 | | Zinc Finger Protein 43 (HTF6)1 | | HTF61 2 | | ZNF393 | | Zinc Finger Protein 39-Like 1 (KOX 27)1 2 | | Zinc Finger Protein 393 |
Export aliases for ZNF43 gene to outside databasesPrevious GC identifers: GC19M022439 GC19M022321 GC19M021682 GC19M021781 GC19M021526 |
Summaries
for ZNF43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF43:
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulationand development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc fingerproteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-proteininteractions. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF43
|
Genomic Views
for ZNF43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF43 gene promoter:
HOXA9 HOXA9B Nkx3-1 Nkx3-1 v4 p53 Nkx3-1 v1 Meis-1b Nkx3-1 v2 Nkx3-1 v3 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.1-p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p13.1-p12ZNF43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M021987: view genomic region
(about GC identifiers)
Start:
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21,987,752 bp from pter |
End:
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22,018,977 bp from pter |
Size:
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31,226 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr19-,PATCHES 21,992,491-21,996,577 |
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Proteins
for ZNF43 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038 (See
protein sequence)Recommended Name: Zinc finger protein 43 Size: 809 amino acids; 94124 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A8K5N8 P28160 Q53XQ2 Q5H9T3 Q96DG1Alternative splicing: 2 isoforms: P17038-1 P17038-2 Explore the universe of human proteins at neXtProt for ZNF43: NX_P17038
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17038
ZNF43 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001243577.1 NP_001243578.1 NP_001243579.1 NP_001243580.1 NP_001243582.1 NP_001243583.1 NP_003414.2
ENSEMBL proteins: ENSP00000347045 Reactome Protein details: P17038
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF43 for ontologies About GeneDecksing
ZNF43 Antibody Products:
Assay Products for ZNF43: |
Protein
Domains /
Families
for ZNF43 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF43 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17038ProtoNet protein and cluster: P17038 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 22 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF43:zinc finger protein 43 (HTF6),KRAB subfamily
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF43 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF43 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZNF43:
|
Pathways & Interactions
for ZNF43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF43
ZNF43 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF43
1 Interacting protein for ZNF43 (P170383) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF43 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF43
1 HMDB Compound for ZNF43 About this table
Search CenterWatch for drugs/clinical trials and news about ZNF43
|
Transcripts
for ZNF43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF43 gene (7 alternative transcripts): NM_001256648.1 NM_001256649.1 NM_001256650.1 NM_001256651.1 NM_001256653.1 NM_001256654.1 NM_003423.3 Unigene Cluster for ZNF43: Zinc finger protein 43 Hs.534365 [show with all ESTs]Unigene Representative Sequence: NM_0012566481 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000354959(uc002nqj.3 uc002nqk.3 uc010ecv.3 uc002nql.3 uc002nqm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF43
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF43
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF43 (NM_003423) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF43 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF43 |
Additional cDNA sequence: AF112859.1 AK022905.1 AK097763.1 AK291353.1 BC006528.2 BT009756.1 CR933640.1 M61869.1 X52358.1 X59244.1 11 DOTS entries: DT.100775080 DT.87015253 DT.91822958 DT.95369543 DT.121421704 DT.95261589 DT.121421781 DT.423829 DT.95069576 DT.121421768 DT.97818233 24/63 AceView cDNA sequences (see all 63): AU128362 AA318365 AI479324 BU187775 BU508506 AK097763 BU786847 BT009756 CB306846 BU167813 AI559883 AK022905 BU507408 BC006528 BM272737 CB250507 X59244 BG289688 AL705298 H74324 NM_003423 M61869 BX471947 BG696609
GeneLoc Exon Structure
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Expression
for ZNF43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF43
SOURCE GeneReport for Unigene cluster: Hs.534365
UniProtKB/Swiss-Prot: ZNF43_HUMAN, P17038Tissue specificity: T- and B-cell lines
SABiosciences Custom PCR Arrays for ZNF43
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF43
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF43 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF43 |
Orthologs
for ZNF43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF43 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for ZNF43 (if available)
TreeFam Gene Tree for ZNF43 (if available) |
Paralogs
for ZNF43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF43 gene
- ZNF6162 ZNF1602 ZNF8502 ZNF992 ZNF5462 ZNF6652 ZNF7212 ZNF8362
- ZNF8412 ZNF912 ZNF780B2 ZNF1972 ZNF585A2 ZNF8082 ZNF7292 ZNF3472
- ZNF8452 ZNF1842 ZNF585B2 ZNF6582 ZNF6242 ZNF2082
18/443 SIMAP similar genes for ZNF43 using alignment to 5 protein entries: ZNF43_HUMAN (see all proteins)
(see all similar genes):MGC12518 ZNF273 ZNF738 ZNF78L1 ZNF818P ZFS-1
DKFZp762K012 ZNF232 ZNF254 ZNF345 ZNF429 ZNF675
ZNF85 ZFS-2 DKFZp686B16128 DKFZp686N14223 HZF41 ZNF117
ZNF43 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF43 (21987752 - 22018977 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF43
1 CNV: 4071
1 Inversion: 37202 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF43 |
|
Disorders
/ Diseases
for ZNF43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF43 for disorders About GeneDecksing
OMIM gene information: 603972
OMIM disorders: --
3  diseases for ZNF43: About MalaCardsperipheral primitive neuroectodermal tumor primitive neuroectodermal tumor neuroectodermal tumors
Human Genome Epidemiology (HuGE) Navigator: ZNF43 (1 document)
Export disorders for ZNF43 gene to outside databases
|
Publications
for ZNF43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF43 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ZNF43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines. (PubMed id 1711675)1, 2, 3 Lovering R. and Trowsdale J. (1991)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909)1, 2 Bellefroid E.J....Martial J.A. (1991)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. (PubMed id 17178891)1 Takahashi T....Naganuma A. (2006)
|
External Searches for ZNF43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZNF43 gene:
Search GeneIP for patents involving ZNF43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF43 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF43 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF43 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF43 | | OriGene 3'-UTR Clone for ZNF43 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF43 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF43 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF43 | | OriGene Custom Protein Services for ZNF43 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF43 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF43 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF43 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF43 |
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 | | | ZNF43 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF43 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF43 |
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