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ZNF429 Gene

protein-coding   GIFtS: 46
GCID: GC19P021688

Zinc Finger Protein 429

  Search for ZNF429
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4291 2

External Ids:    HGNC: 208171   Entrez Gene: 3530882   Ensembl: ENSG000001970137   UniProtKB: Q86V713   

Export aliases for ZNF429 gene to outside databases

Previous GC identifers: GC19U900125 GC19P021480 GC19P021178


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF429 Gene:
ZNF429 (zinc finger protein 429) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN429_HUMAN, Q86V71
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF429
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF429

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF429


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF429 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF429 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P021688:  view genomic region     (about GC identifiers)

Start:
21,679,484 bp from pter      End:
21,739,072 bp from pter
Size:
59,589 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN429_HUMAN, Q86V71 (See protein sequence)
Recommended Name: Zinc finger protein 429  
Size: 674 amino acids; 78152 Da
Sequence caution: Sequence=AAK01422.1; Type=Frameshift; Positions=Several; Sequence=AAK01422.1; Type=Miscellaneous
discrepancy; Sequence=AAP30884.1; Type=Frameshift; Positions=Several; Sequence=AAP30884.1; Type=Miscellaneous
discrepancy;
Secondary accessions: A6NLV7 Q9BZE6

Explore the universe of human proteins at neXtProt for ZNF429: NX_Q86V71

Explore proteomics data for ZNF429 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF429 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001415.2  
    ENSEMBL proteins: 
     ENSP00000351280   ENSP00000470300   ENSP00000469739  
    Reactome Protein details: Q86V71

    ZNF429 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86V71

    ProtoNet protein and cluster: Q86V71

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN429_HUMAN, Q86V71
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF429 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN429_HUMAN, Q86V71
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF429 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF429:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF429
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN429_HUMAN, Q86V71: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF429 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF429 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF429
        Generic Transcription Pathway



    ZNF429 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF429
    Interactions:

        Search GeneGlobe Interaction Network for ZNF429

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF429 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF429 (ZN429)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF429 gene: 
    NM_001001415.2  

    Unigene Cluster for ZNF429:

    Zinc finger protein 429
    Hs.572567
    Unigene Representative Sequence: AK057495
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594022 ENST00000358491(uc002nqd.1 uc010ecu.2) ENST00000596237
    ENST00000597078 ENST00000596126 ENST00000598747 ENST00000597556 ENST00000594385

    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ZNF429 (NM_001001415)
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF429

    Additional mRNA sequence: AK057495.1 

    1 DOTS entry:

    DT.95081594 

    Selected AceView cDNA sequences (see all 40):

    AI360347 BE550243 AI433770 BG742323 BF445865 BQ188254 AI610519 BI915693 
    AI191910 AA608824 N83176 BM996292 BC040866 BU790163 BX102125 AI681793 
    AK097381 BM804663 CD102453 AL596889 AI216833 AI220251 BQ219868 BX537835 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF429    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -                       -                     
    SP2:                          -     -     -                                 
    SP3:                          -           -           -                     
    SP4:                          -     -     -           -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for ZNF429

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF429 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAATGTGG
    ZNF429 Expression
    About this image

    ZNF429 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF429 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.572567
        Custom PCR Arrays for ZNF429
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF429

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF429 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    55(a)
    48(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)
            Species with no ortholog for ZNF429

    ENSEMBL Gene Tree for ZNF429 (if available)
    TreeFam Gene Tree for ZNF429 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF429 gene
    ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
    ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  
    ZNF932  ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2542  ZNF7372  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF5192  
    ZNF4302  ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF429 using alignment to 3 protein entries:     ZN429_HUMAN (see all proteins) (see all similar genes):
    RHBG    MTO1    ZNF78L1    MGC12518    BIRC5    ZNF724P
    ZNF273    CALCOCO2    SLC24A1    ZNF257    ZNF730    ZNF98
    ZNF43    ZNF100    OK/SW-cl.18    ZNF254    EIF3K    ZNF430

    ZNF429 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF429 (see all 928)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837239311,2
    --21686624(+) ATGTTG/TAGTAA 1 -- us2k10--------
    rs81028541,2
    C,F,H--21686650(+) AGACAT/CGTATG 1 -- us2k19Minor allele frequency- C:0.11NS EA NA 658
    rs1896466351,2
    --21686723(+) AGCCTA/GACCAT 1 -- us2k10--------
    rs26508061,2
    C,F,H--21686745(-) TTGCTG/ATTTGG 1 -- us2k16Minor allele frequency- A:0.15NA CSA WA EA 364
    rs608855461,2
    C--21686811(+) TTTTT-/TTTTTTTT
    /TTTTTTTTT
    CCGAG
    2 -- us2k1 cds11NA 2
    rs1812456431,2
    --21686813(+) TTTTCC/TGAGAC 1 -- us2k10--------
    rs730177161,2
    F--21686819(+) GAGACG/AGAGTC 1 -- us2k12Minor allele frequency- A:0.50NA 6
    rs81025261,2
    C,F--21686859(+) ggcgcG/Aatctc 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs81025281,2
    C,F--21686865(+) atctcG/Agctcg 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs582224651,2
    F--21686884(+) TCTGCT/CTCCCG 1 -- us2k11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for ZNF429 (21679484 - 21739072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF429 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718325CNV Deletion23290073
    esv2718336CNV Deletion23290073
    esv2667083CNV Deletion23128226
    esv2718335CNV Deletion23290073
    esv1010333CNV Insertion20482838
    nsv510759CNV Loss20534489
    esv2751783CNV Loss17911159
    nsv833782CNV Loss17160897
    esv6839CNV Loss19470904
    nsv458377CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    ZNF429 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF429
    Human Genome Epidemiology (HuGE) Navigator: ZNF429 (1 document)

    Export disorders for ZNF429 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF429 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF429)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of acute post-surgical pain in humans. (PubMed id 19207018)1, 4 Kim H....Dionne R.A. (Pharmacogenomics 2009)
    2. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2 Abrink M.... Hellman L. (DNA Cell Biol. 1995)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 353088 HGNC: 20817 AceView: ZNF429 Ensembl:ENSG00000197013 euGenes: HUgn353088
    ECgene: ZNF429 H-InvDB: ZNF429

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF429 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF429 gene:
    Search GeneIP for patents involving ZNF429

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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