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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF429 Gene

protein-coding   GIFtS: 46
GCID: GC19P021688

Zinc Finger Protein 429

  Search for ZNF429
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 4291 2

External Ids:    HGNC: 208171   Entrez Gene: 3530882   Ensembl: ENSG000001970137   UniProtKB: Q86V713   

Export aliases for ZNF429 gene to outside databases

Previous GC identifers: GC19U900125 GC19P021480 GC19P021178


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF429 Gene: 
ZNF429 (zinc finger protein 429) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot: ZN429_HUMAN, Q86V71
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF429
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF429

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF429


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p13.1

ZNF429 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF429 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P021688:  view genomic region     (about GC identifiers)

Start:
21,679,484 bp from pter      End:
21,739,072 bp from pter
Size:
59,589 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN429_HUMAN, Q86V71 (See protein sequence)
Recommended Name: Zinc finger protein 429  
Size: 674 amino acids; 78152 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAK01422.1; Type=Frameshift; Positions=Several; Sequence=AAK01422.1; Type=Miscellaneous
discrepancy; Sequence=AAP30884.1; Type=Frameshift; Positions=Several; Sequence=AAP30884.1; Type=Miscellaneous
discrepancy;
Secondary accessions: A6NLV7 Q9BZE6

Explore the universe of human proteins at neXtProt for ZNF429: NX_Q86V71

Explore proteomics data for ZNF429 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86V71

  • ZNF429 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF429 Protein Expression
    REFSEQ proteins: NP_001001415.2  
    ENSEMBL proteins: 
     ENSP00000351280   ENSP00000470300   ENSP00000469739  
    Reactome Protein details: Q86V71
    Human Recombinant Protein Products for ZNF429: 
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    Cloud-Clone Corp. Proteins for ZNF429 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF429 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86V71

    ProtoNet protein and cluster: Q86V71

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN429_HUMAN, Q86V71
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF429 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN429_HUMAN, Q86V71
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF429 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF429:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF429 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF429


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF429 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF429
        Generic Transcription Pathway
    Gene Expression



    ZNF429 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF429

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF429 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF429 (ZN429)

    Search CenterWatch for drugs/clinical trials and news about ZNF429 / ZN429

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF429 gene: 
    NM_001001415.2  

    Unigene Clusters for ZNF429:

    Zinc finger protein 429
    Hs.572567 , Hs.709598  [show with all ESTs]
    Unigene Representative Sequences: AK057495, NM_001001415
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594022 ENST00000358491(uc002nqd.1 uc010ecu.2) ENST00000596237
    ENST00000597078 ENST00000596126 ENST00000598747 ENST00000597556 ENST00000594385

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of ZNF429 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF429

    Additional mRNA sequence: 

    AF325191.1 AK308708.1 AY269786.1 

    5 DOTS entries:

    DT.40236894  DT.91678125  DT.95150089  DT.91849541  DT.95081594 

    24/40 AceView cDNA sequences (see all 40):

    BF445865 BE550243 AI360347 BG742323 AI610519 AI433770 BQ188254 AW865337 
    BX102125 AK097381 BG547934 BC040866 AI216833 BU145721 AI681793 BX537835 
    AA608824 CD102453 BM996292 N83176 BI915693 AI191910 AL596889 BU790163 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF429    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -                       -                     
    SP2:                          -     -     -                                 
    SP3:                          -           -           -                     
    SP4:                          -     -     -           -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for ZNF429

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF429 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAATGTGG
    ZNF429 Expression
    About this image


    See ZNF429 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene clusters: Hs.572567 Hs.709598
        SABiosciences Custom PCR Arrays for ZNF429
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF429

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF429 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    1 → many
    GL343733.1(125230-159240)
            Species with no ortholog for ZNF429

    ENSEMBL Gene Tree for ZNF429 (if available)
    TreeFam Gene Tree for ZNF429 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF429 gene
    ZNF4202  ZNF780A2  ZNF6652  ZNF724P2  ZNF72  ZNF232  ZNF4322  ZNF33A2  
    ZNF2342  ZNF302  ZNF5732  ZNF5402  ZNF2512  ZNF6052  ZNF842  ZNF1892  
    ZNF5712  ZNF6302  ZNF932  ZNF162  ZNF2832  ZNF3472  ZNF4842  ZNF1352  
    ZNF1842  ZNF585B2  ZNF412  ZNF6152  ZNF5692  ZNF4702  
    18/566 SIMAP similar genes for ZNF429 using alignment to 3 protein entries:     ZN429_HUMAN (see all proteins) (see all similar genes):
    RHBG    MTO1    ZNF78L1    MGC12518    BIRC5    ZNF724P
    ZNF273    CALCOCO2    SLC24A1    ZNF257    ZNF730    ZNF98
    ZNF43    ZNF100    OK/SW-cl.18    ZNF254    EIF3K    ZNF431

    ZNF429 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/928 SNPs in ZNF429 are shown (see all 928)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837239311,2
    --21686624(+) ATGTTG/TAGTAA 1 -- us2k10--------
    rs81028541,2
    C,F,H--21686650(+) AGACAT/CGTATG 1 -- us2k19Minor allele frequency- C:0.11NS EA NA 658
    rs1896466351,2
    --21686723(+) AGCCTA/GACCAT 1 -- us2k10--------
    rs26508061,2
    C,F,H--21686745(-) TTGCTG/ATTTGG 1 -- us2k16Minor allele frequency- A:0.15NA CSA WA EA 364
    rs608855461,2
    C--21686811(+) TTTTT-/TTTTTTTT
    /TTTTTTTTT
    CCGAG
    2 -- us2k1 cds11NA 2
    rs1812456431,2
    --21686813(+) TTTTCC/TGAGAC 1 -- us2k10--------
    rs730177161,2
    F--21686819(+) GAGACG/AGAGTC 1 -- us2k12Minor allele frequency- A:0.50NA 6
    rs81025261,2
    C,F--21686859(+) ggcgcG/Aatctc 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs81025281,2
    C,F--21686865(+) atctcG/Agctcg 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs582224651,2
    F--21686884(+) TCTGCT/CTCCCG 1 -- us2k11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for ZNF429 (21679484 - 21739072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ZNF429 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718325CNV Deletion23290073
    esv2718336CNV Deletion23290073
    esv2667083CNV Deletion23128226
    esv2718335CNV Deletion23290073
    esv1010333CNV Insertion20482838
    nsv510759CNV Loss20534489
    esv2751783CNV Loss17911159
    nsv833782CNV Loss17160897
    esv6839CNV Loss19470904
    nsv458377CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF429 for disorders           About MalaCards

    ZNF429 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF429
    Human Genome Epidemiology (HuGE) Navigator: ZNF429 (1 document)

    Export disorders for ZNF429 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF429 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF429)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of acute post-surgical pain in humans. (PubMed id 19207018)1, 4 Kim H....Dionne R.A. (2009)
    2. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2 Abrink M.... Hellman L. (1995)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353088 HGNC: 20817 AceView: ZNF429 Ensembl:ENSG00000197013 euGenes: HUgn353088
    ECgene: ZNF429 H-InvDB: ZNF429

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF429 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF429 gene:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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