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Aliases for ZNF429 Gene

Aliases for ZNF429 Gene

  • Zinc Finger Protein 429 2 3 5

External Ids for ZNF429 Gene

Previous GeneCards Identifiers for ZNF429 Gene

  • GC19U900125
  • GC19P021480
  • GC19P021688
  • GC19P021178

Summaries for ZNF429 Gene

GeneCards Summary for ZNF429 Gene

ZNF429 (Zinc Finger Protein 429) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF681.

UniProtKB/Swiss-Prot for ZNF429 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF429 Gene

Genomics for ZNF429 Gene

Regulatory Elements for ZNF429 Gene

Enhancers for ZNF429 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F021567 0.5 ENCODE 37.3 +72.3 72266 2.6 PKNOX1 NFYC SP2 CHAMP1 YY1 MBD2 SREBF1 POLR2A NFYB ZBTB33 ENSG00000268555 ZNF429 ZNF708 LINC00664 ENSG00000268081 GC19P021564
GH19F021600 0.8 Ensembl ENCODE 27.8 +106.4 106388 5.7 HDGF PKNOX1 ATF1 ARNT ELK1 GATA2 NCOA1 REST CREB3 MEF2D ENSG00000268555 ZNF429 ZNF708 LOC105372321 ZNF85 GC19P021601 GC19P021614
GH19F021504 0.9 FANTOM5 ENCODE 27.4 +9.4 9354 2.6 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 SP3 ENSG00000268555 ZNF429 ZNF708 ZNF493 ZNF100 ZNF430 PIR57057 PIR58149
GH19F021585 1.3 FANTOM5 Ensembl 20.9 +88.8 88810 0.6 ZNF335 PKNOX1 GTF2E2 SCRT2 ZNF429 ZNF493 ZNF100 ZNF708 ENSG00000268555 GC19M021742
GH19F021610 0.2 ENCODE 19.7 +115.2 115246 2.8 HDAC1 ATF1 TBL1XR1 NFRKB PTRF NFXL1 CHAMP1 SMARCA5 ZBTB11 NCOA1 ENSG00000268555 ZNF429 ZNF708 GC19P021614 GC19P021601
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF429 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF429 Gene

Chromosome:
19
Start:
21,496,682 bp from pter
End:
21,556,270 bp from pter
Size:
59,589 bases
Orientation:
Plus strand

Genomic View for ZNF429 Gene

Genes around ZNF429 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF429 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF429 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF429 Gene

Proteins for ZNF429 Gene

  • Protein details for ZNF429 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V71-ZN429_HUMAN
    Recommended name:
    Zinc finger protein 429
    Protein Accession:
    Q86V71
    Secondary Accessions:
    • A6NLV7
    • Q9BZE6

    Protein attributes for ZNF429 Gene

    Size:
    674 amino acids
    Molecular mass:
    78152 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK01422.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAK01422.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=AAP30884.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAP30884.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

neXtProt entry for ZNF429 Gene

Post-translational modifications for ZNF429 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF429 Gene

Domains & Families for ZNF429 Gene

Gene Families for ZNF429 Gene

Protein Domains for ZNF429 Gene

Suggested Antigen Peptide Sequences for ZNF429 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V71

UniProtKB/Swiss-Prot:

ZN429_HUMAN :
  • Contains 1 KRAB domain.
  • Contains 18 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF429: view

Function for ZNF429 Gene

Molecular function for ZNF429 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with ZNF429: view
genes like me logo Genes that share phenotypes with ZNF429: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF429 Gene

Localization for ZNF429 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF429 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF429 Gene COMPARTMENTS Subcellular localization image for ZNF429 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA --
GO:0000784 nuclear chromosome, telomeric region IDA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZNF429: view

Pathways & Interactions for ZNF429 Gene

SuperPathways for ZNF429 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF429: view

Pathways by source for ZNF429 Gene

2 Reactome pathways for ZNF429 Gene

Interacting Proteins for ZNF429 Gene

Gene Ontology (GO) - Biological Process for ZNF429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001649 osteoblast differentiation IDA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0006369 termination of RNA polymerase II transcription TAS --
genes like me logo Genes that share ontologies with ZNF429: view

No data available for SIGNOR curated interactions for ZNF429 Gene

Transcripts for ZNF429 Gene

Unigene Clusters for ZNF429 Gene

Zinc finger protein 429:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF429 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:

Relevant External Links for ZNF429 Gene

GeneLoc Exon Structure for
ZNF429
ECgene alternative splicing isoforms for
ZNF429

Expression for ZNF429 Gene

mRNA expression in normal human tissues for ZNF429 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF429 Gene:

ZNF429

SOURCE GeneReport for Unigene cluster for ZNF429 Gene:

Hs.572567
genes like me logo Genes that share expression patterns with ZNF429: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF429 Gene

Orthologs for ZNF429 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF429 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF429 35
  • 68 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Rslcan18 35
  • 45 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF429 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF429 Gene

ENSEMBL:
Gene Tree for ZNF429 (if available)
TreeFam:
Gene Tree for ZNF429 (if available)

Paralogs for ZNF429 Gene

(564) SIMAP similar genes for ZNF429 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF429 Gene

genes like me logo Genes that share paralogs with ZNF429: view

Variants for ZNF429 Gene

Sequence variations from dbSNP and Humsavar for ZNF429 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404462 -- 21,529,964(+) aggcc(A/G)aggcg intron-variant
rs10406824 -- 21,538,687(+) TTAAC(C/T)AATGC downstream-variant-500B, utr-variant-3-prime
rs10406870 -- 21,539,485(+) ggcac(A/G)atttc utr-variant-3-prime
rs10411751 -- 21,511,732(+) gctgg(A/G)aggtg intron-variant
rs10411981 -- 21,523,689(+) tgctg(C/T)taatt intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF429 Gene

Variant ID Type Subtype PubMed ID
esv1010333 CNV insertion 20482838
esv2667083 CNV deletion 23128226
esv2718325 CNV deletion 23290073
esv2718335 CNV deletion 23290073
esv2718336 CNV deletion 23290073
esv2751783 CNV loss 17911159
esv2762028 CNV gain 21179565
esv3556176 CNV deletion 23714750
esv4924 OTHER complex 18987735
esv6839 CNV loss 19470904
nsv1061327 CNV gain 25217958
nsv1109177 CNV deletion 24896259
nsv1123235 CNV deletion 24896259
nsv458377 CNV gain 19166990
nsv510759 CNV deletion 20534489
nsv578809 CNV gain 21841781
nsv578952 CNV gain 21841781
nsv833782 CNV loss 17160897
nsv954636 CNV deletion 24416366
nsv963024 CNV duplication 23825009

Variation tolerance for ZNF429 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF429 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF429

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF429 Gene

Disorders for ZNF429 Gene

Relevant External Links for ZNF429

Genetic Association Database (GAD)
ZNF429
Human Genome Epidemiology (HuGE) Navigator
ZNF429
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF429

No disorders were found for ZNF429 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF429 Gene

Publications for ZNF429 Gene

  1. Genome-wide association study of acute post-surgical pain in humans. (PMID: 19207018) Kim H. … Dionne R.A. (Pharmacogenomics 2009) 3 46 64
  2. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 3 4 64
  3. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 46 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for ZNF429 Gene

Sources for ZNF429 Gene

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