Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF428 Gene

Aliases for ZNF428 Gene

  • Zinc Finger Protein 428 2 3 5
  • Enzyme-Like Protein PIT13 3 4
  • C19orf37 3 4
  • Chromosome 19 Open Reading Frame 37 2
  • Zfp428 3

External Ids for ZNF428 Gene

Previous HGNC Symbols for ZNF428 Gene

  • C19orf37

Previous GeneCards Identifiers for ZNF428 Gene

  • GC19M048805
  • GC19M044112
  • GC19M040542
  • GC19M044115

Summaries for ZNF428 Gene

GeneCards Summary for ZNF428 Gene

ZNF428 (Zinc Finger Protein 428) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF428 Gene

Genomics for ZNF428 Gene

Regulatory Elements for ZNF428 Gene

Enhancers for ZNF428 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F043773 1.2 FANTOM5 Ensembl ENCODE 23.3 -159.8 -159812 12.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 ZNF302 ZNF45 ZNF180 ZNF225 ZNF284 ZNF224 ZNF234 KCNN4 XRCC1 ZNF223 LOC100505715
GH19F043751 1.1 FANTOM5 ENCODE 13.3 -136.0 -136003 8.9 CREB3L1 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF416 ZNF548 ZNF263 SP3 ZNF180 ZNF45 ZNF234 ZNF224 ZNF284 ZNF225 ZNF230 XRCC1 SMG9 LOC100505715
GH19F043200 0.5 Ensembl ENCODE 13.2 +416.7 416675 6.2 ZNF493 ZFP64 ARID4B DMAP1 FEZF1 GLI4 ZNF48 ZNF121 ZNF302 ZNF416 ZNF45 ZNF224 ZNF225 ZNF526 ZNF234 ZNF284 PSG4 XRCC1 ZNF230 IRGQ
GH19F044259 0.9 ENCODE 13.2 -640.2 -640159 1.4 HDGF PKNOX1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF180 ZNF45 ZNF234 ZNF224 ZNF284 ZNF225 ZNF230 EXOC3L2 XRCC1 ZNF233
GH19F044140 0.2 ENCODE 13.2 -521.9 -521897 1.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 SP3 NFYC ZNF225 ZNF45 ZNF234 LOC100505715 PINLYP ZNF180 LOC105372418 ZNF223 LOC105372414 ENSG00000267614
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF428 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF428 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001014963 574 1801 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143
ENSR00001817888 -626 201 ZNF362 MTA2 NRF1 ZEB2 DPF2 SMARCB1 SMARCA4 POLR2A IRF1 MLLT1

Genomic Location for ZNF428 Gene

Chromosome:
19
Start:
43,607,219 bp from pter
End:
43,619,874 bp from pter
Size:
12,656 bases
Orientation:
Minus strand

Genomic View for ZNF428 Gene

Genes around ZNF428 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF428 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF428 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF428 Gene

Proteins for ZNF428 Gene

  • Protein details for ZNF428 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B54-ZN428_HUMAN
    Recommended name:
    Zinc finger protein 428
    Protein Accession:
    Q96B54
    Secondary Accessions:
    • O95054
    • Q6X3Y3

    Protein attributes for ZNF428 Gene

    Size:
    188 amino acids
    Molecular mass:
    20481 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC99795.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP87382.1; Type=Miscellaneous discrepancy; Note=Intron retention at the C-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF428 Gene

Post-translational modifications for ZNF428 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF428 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF428 Gene

Domains & Families for ZNF428 Gene

Gene Families for ZNF428 Gene

Protein Domains for ZNF428 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF428 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B54

UniProtKB/Swiss-Prot:

ZN428_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF428: view

Function for ZNF428 Gene

Gene Ontology (GO) - Molecular Function for ZNF428 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF428: view

Phenotypes for ZNF428 Gene

GenomeRNAi human phenotypes for ZNF428:
genes like me logo Genes that share phenotypes with ZNF428: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF428 Gene

Localization for ZNF428 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF428 Gene COMPARTMENTS Subcellular localization image for ZNF428 gene
Compartment Confidence
nucleus 4
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF428 Gene

Pathways & Interactions for ZNF428 Gene

SuperPathways for ZNF428 Gene

No Data Available

Interacting Proteins for ZNF428 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300811%0d%0a9606.ENSP00000310275%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000300811 Q96B54-ZN428_HUMAN for ZNF428 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZNF428 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF428 Gene

Transcripts for ZNF428 Gene

mRNA/cDNA for ZNF428 Gene

Unigene Clusters for ZNF428 Gene

Zinc finger protein 428:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF428 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1: - -
SP2: -
SP3:

Relevant External Links for ZNF428 Gene

GeneLoc Exon Structure for
ZNF428
ECgene alternative splicing isoforms for
ZNF428

Expression for ZNF428 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF428 Gene

Protein differential expression in normal tissues from HIPED for ZNF428 Gene

This gene is overexpressed in Adrenal (45.5) and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF428 Gene



Protein tissue co-expression partners for ZNF428 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF428 Gene:

ZNF428

SOURCE GeneReport for Unigene cluster for ZNF428 Gene:

Hs.99093
genes like me logo Genes that share expression patterns with ZNF428: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF428 Gene

Orthologs for ZNF428 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF428 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF428 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia ZNF428 34 35
  • 87.94 (n)
cow
(Bos Taurus)
Mammalia ZNF428 34 35
  • 85.99 (n)
mouse
(Mus musculus)
Mammalia Zfp428 34 16 35
  • 83.43 (n)
rat
(Rattus norvegicus)
Mammalia Zfp428 34
  • 82.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF428 35
  • 69 (a)
OneToOne
Species where no ortholog for ZNF428 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF428 Gene

ENSEMBL:
Gene Tree for ZNF428 (if available)
TreeFam:
Gene Tree for ZNF428 (if available)

Paralogs for ZNF428 Gene

(1) SIMAP similar genes for ZNF428 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF428: view

No data available for Paralogs for ZNF428 Gene

Variants for ZNF428 Gene

Sequence variations from dbSNP and Humsavar for ZNF428 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1008148 -- 43,611,806(+) accca(C/T)tgact intron-variant, upstream-variant-2KB
rs10408803 -- 43,613,506(+) TCATA(C/G)CCGAT intron-variant, reference, missense
rs10410000 -- 43,613,430(+) GAGAT(C/T)GCAGC intron-variant, reference, missense
rs10424087 -- 43,608,523(+) ttctc(A/G)ggagg intron-variant
rs10424446 -- 43,615,337(+) agcaa(C/T)ctgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF428 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV loss 17160897

Variation tolerance for ZNF428 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF428 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF428

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF428 Gene

Disorders for ZNF428 Gene

Relevant External Links for ZNF428

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF428

No disorders were found for ZNF428 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF428 Gene

Publications for ZNF428 Gene

  1. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64
  4. Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. (PMID: 19759913) Montes de Oca R. … Wilson K.L. (PLoS ONE 2009) 3 64
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64

Products for ZNF428 Gene

Sources for ZNF428 Gene

Content
Loading form....