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Aliases for ZNF428 Gene

Aliases for ZNF428 Gene

  • Zinc Finger Protein 428 2 3 5
  • Enzyme-Like Protein PIT13 3 4
  • C19orf37 3 4
  • Chromosome 19 Open Reading Frame 37 2
  • Zfp428 3

External Ids for ZNF428 Gene

Previous HGNC Symbols for ZNF428 Gene

  • C19orf37

Previous GeneCards Identifiers for ZNF428 Gene

  • GC19M048805
  • GC19M044112
  • GC19M040542
  • GC19M044115

Summaries for ZNF428 Gene

GeneCards Summary for ZNF428 Gene

ZNF428 (Zinc Finger Protein 428) is a Protein Coding gene.

Additional gene information for ZNF428 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF428 Gene

Genomics for ZNF428 Gene

Regulatory Elements for ZNF428 Gene

Enhancers for ZNF428 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H043773 2 FANTOM5 Ensembl ENCODE dbSUPER 46.9 -160.0 -160028 12.4 YBX1 ZNF416 ZNF143 SP3 ZC3H11A ZFP41 MEF2D ZNF610 ZNF585B GLIS1 ZNF180 ZNF45 ZNF225 ZNF227 ZNF284 ZNF223 ZNF224 ZNF283 ZNF235 ZNF576
GH19H044140 1.1 ENCODE 25.1 -521.9 -521897 1.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 MXD4 NFYC ZNF45 ZNF225 ZNF576 ZNF221 ZNF180 ZNF227 ZNF234 ZNF283 ZNF235 ZNF226
GH19H044259 1.1 ENCODE 25.1 -640.2 -640159 1.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B ZNF45 ZNF180 ZNF224 ZNF225 ZNF284 ZNF234 CLASRP ZNF227 ZNF235 XRCC1
GH19H043673 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -55.0 -54977 3 PKNOX1 ATF1 ZNF133 SIN3A YBX1 ZNF2 ZBTB7B ZNF121 ZNF143 FOS ZNF45 ZNF225 ZNF283 ZNF180 ZNF234 PLAUR ZNF226 ZNF112 ZNF224 ZNF223
GH19H043751 1.7 FANTOM5 ENCODE dbSUPER 13.8 -136.0 -136003 8.9 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF180 ZNF45 ZNF155 ZNF225 ZNF234 ZNF224 LOC100505715 ZNF284 SMG9 ZNF112
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF428 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF428 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ZNF428 Gene

Genomic Locations for ZNF428 Gene
12,656 bases
Minus strand

Genomic View for ZNF428 Gene

Genes around ZNF428 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF428 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF428 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF428 Gene

Proteins for ZNF428 Gene

  • Protein details for ZNF428 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 428
    Protein Accession:
    Secondary Accessions:
    • O95054
    • Q6X3Y3

    Protein attributes for ZNF428 Gene

    188 amino acids
    Molecular mass:
    20481 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC99795.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP87382.1; Type=Miscellaneous discrepancy; Note=Intron retention at the C-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF428 Gene

Post-translational modifications for ZNF428 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF428 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF428 Gene

Domains & Families for ZNF428 Gene

Gene Families for ZNF428 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF428 Gene


Suggested Antigen Peptide Sequences for ZNF428 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF428: view

No data available for UniProtKB/Swiss-Prot for ZNF428 Gene

Function for ZNF428 Gene

Phenotypes From GWAS Catalog for ZNF428 Gene

Gene Ontology (GO) - Molecular Function for ZNF428 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF428: view

Phenotypes for ZNF428 Gene

GenomeRNAi human phenotypes for ZNF428:
genes like me logo Genes that share phenotypes with ZNF428: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF428 Gene

Localization for ZNF428 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF428 gene
Compartment Confidence
nucleus 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF428 Gene

Pathways & Interactions for ZNF428 Gene

SuperPathways for ZNF428 Gene

No Data Available

Interacting Proteins for ZNF428 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96B54-ZN428_HUMAN ENSP00000300811 for ZNF428 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ZNF428 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF428 Gene

Drugs & Compounds for ZNF428 Gene

No Compound Related Data Available

Transcripts for ZNF428 Gene

mRNA/cDNA for ZNF428 Gene

Unigene Clusters for ZNF428 Gene

Zinc finger protein 428:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF428 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1: - -
SP2: -

Relevant External Links for ZNF428 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF428 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF428 Gene

Protein differential expression in normal tissues from HIPED for ZNF428 Gene

This gene is overexpressed in Adrenal (45.5) and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF428 Gene

Protein tissue co-expression partners for ZNF428 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF428 Gene:


SOURCE GeneReport for Unigene cluster for ZNF428 Gene:

genes like me logo Genes that share expression patterns with ZNF428: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF428 Gene

Orthologs for ZNF428 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF428 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF428 33 34
  • 99.65 (n)
(Canis familiaris)
Mammalia ZNF428 33 34
  • 87.94 (n)
(Bos Taurus)
Mammalia ZNF428 33 34
  • 85.99 (n)
(Mus musculus)
Mammalia Zfp428 33 16 34
  • 83.43 (n)
(Rattus norvegicus)
Mammalia Zfp428 33
  • 82.95 (n)
(Monodelphis domestica)
Mammalia ZNF428 34
  • 69 (a)
Species where no ortholog for ZNF428 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF428 Gene

Gene Tree for ZNF428 (if available)
Gene Tree for ZNF428 (if available)

Paralogs for ZNF428 Gene

(1) SIMAP similar genes for ZNF428 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF428: view

No data available for Paralogs for ZNF428 Gene

Variants for ZNF428 Gene

Sequence variations from dbSNP and Humsavar for ZNF428 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000087418 -- 43,619,999(+) ATATT(C/T)CCCGG intron-variant, upstream-variant-2KB
rs1000164536 -- 43,619,643(+) ACAGC(A/G)CGCAG intron-variant, utr-variant-5-prime
rs1000401373 -- 43,613,417(+) CCCAA(A/C)AAGGC intron-variant, reference, missense
rs1000644119 -- 43,619,548(+) GCCCG(A/G)GACAC intron-variant, nc-transcript-variant
rs1000812446 -- 43,607,002(+) AGTTA(C/G)CTGCG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF428 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV loss 17160897

Variation tolerance for ZNF428 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF428 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF428 Gene

Disorders for ZNF428 Gene

Relevant External Links for ZNF428

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF428 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF428 Gene

Publications for ZNF428 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 60
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 60
  5. Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. (PMID: 19759913) Montes de Oca R … Wilson KL (PloS one 2009) 3 60

Products for ZNF428 Gene

Sources for ZNF428 Gene

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