ZNF428 Gene
protein-coding GIFtS: 39
GCID: GC19M044112
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zinc finger protein 428(Previous name: chromosome 19 open reading frame 37 )
(Previous symbol: C19orf37)
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Aliases
for ZNF428 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4281 2 | | C19orf371 2 3 | | Zfp4281 2 | | Enzyme-Like Protein PIT132 3 | | MGC510821 | | Chromosome 19 Open Reading Frame 371 |
Export aliases for ZNF428 gene to outside databasesPrevious GC identifers: GC19M048805 GC19M040542 |
Summaries
for ZNF428 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZNF428 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF428 gene promoter:
STAT5B STAT1 Pax-5 STAT4 STAT6 STAT1beta STAT5A STAT1alpha STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF428
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF428 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.31 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.31ZNF428 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M044112: view genomic region
(about GC identifiers)
Start:
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44,111,376 bp from pter |
End:
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44,124,014 bp from pter |
Size:
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12,639 bases |
Orientation:
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minus strand |
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Proteins
for ZNF428 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN428_HUMAN, Q96B54 (See
protein sequence)Recommended Name: Zinc finger protein 428 Size: 188 amino acids; 20481 Da
Sequence caution: Sequence=AAC99795.1; Type=Erroneous gene model prediction; Sequence=AAP87382.1; Type=Miscellaneousdiscrepancy; Note=Intron retention at the C-terminus;
Secondary accessions: O95054 Q6X3Y3Explore the universe of human proteins at neXtProt for ZNF428: NX_Q96B54
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96B54
ZNF428 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872304.2
ENSEMBL proteins: ENSP00000300811
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ZNF428 for ontologies About GeneDecksing
ZNF428 Antibody Products:
Assay Products for ZNF428: |
Protein
Domains /
Families
for ZNF428 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF428 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96B54ProtoNet protein and cluster: Q96B54 UniProtKB/Swiss-Prot: ZN428_HUMAN, Q96B54Similarity: Contains 1 C2H2-type zinc finger |
Function
for ZNF428 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF428 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF428
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF428 (NM_182498) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF428 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF428 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZNF428 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF428 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF428
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF428 (Q96B543 ENSP000003008114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZNF428 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF428
Search CenterWatch for drugs/clinical trials and news about ZNF428 / ZN428
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Transcripts
for ZNF428 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF428 gene: NM_182498.3 Unigene Cluster for ZNF428: Zinc finger protein 428 Hs.99093 [show with all ESTs]Unigene Representative Sequence: NM_1824981 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000300811(uc002oxa.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF428 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF428
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF428 (NM_182498) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF428 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF428 |
Additional cDNA sequence: AY257197.1 BC015950.2 BC045799.1 3 DOTS entries: DT.75102345 DT.100714441 DT.95348978 24/74 AceView cDNA sequences (see all 74): AI669242 BQ678031 AY257197 NM_182498 BM699835 AI610583 BU507637 AI077350 BQ435423 BC015950 CF455330 BU528123 BM728229 AI866846 AI659108 BE882529 CA425019 CA432526 CN478475 AA425137 AX747890 BU507159 BI837492 BM850258
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF428 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 |
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| SP1: | | | | | | | - | | - | | | | |
| SP2: | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF428
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Expression
for ZNF428 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF428 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGATGGGG
About this image
See ZNF428 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF428
SOURCE GeneReport for Unigene cluster: Hs.99093
SABiosciences Custom PCR Arrays for ZNF428
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF428
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF428 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF428 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF428 |
Orthologs
for ZNF428 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZNF428 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for ZNF428 (if available)
TreeFam Gene Tree for ZNF428 (if available) |
Paralogs
for ZNF428 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNF428 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF428 (44111376 - 44124014 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF428: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF428 |
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Disorders
/ Diseases
for ZNF428 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF428 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF428 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF428) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Barrier-to-autointegration factor proteome reveals ch romatin-regulatory partners. (PubMed id 19759913)1 Montes de Oca R....Wilson K.L. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF428 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF428 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF428 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF428 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF428 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ZNF428 gene:
Search GeneIP for patents involving ZNF428
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF428 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF428 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF428 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF428 | | | OriGene Protein Over-expression Lysate for ZNF428 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF428 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF428 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF428 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF428 | | OriGene Custom Protein Services for ZNF428 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF428 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF428 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF428 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF428 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF428 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF428 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF428 |
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 | | | ZNF428 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZNF428 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF428 |
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