ZNF426 Gene
protein-coding GIFtS: 47
GCID: GC19M009638
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|
zinc finger protein 426
| |
Aliases
for ZNF426 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4261 2 | | MGC26631 |
Export aliases for ZNF426 gene to outside databasesPrevious GC identifers: GC19M009861 GC19M009483 GC19M009499 GC19M009219 |
Summaries
for ZNF426 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN426_HUMAN, Q9BUY5Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF426 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF426 gene promoter:
Pbx1a FOXD3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF426
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF426 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2ZNF426 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M009638: view genomic region
(about GC identifiers)
Start:
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9,638,667 bp from pter |
End:
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9,649,303 bp from pter |
Size:
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10,637 bases |
Orientation:
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minus strand |
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Proteins
for ZNF426 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN426_HUMAN, Q9BUY5 (See
protein sequence)Recommended Name: Zinc finger protein 426 Size: 554 amino acids; 63106 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B3KTL2Explore the universe of human proteins at neXtProt for ZNF426: NX_Q9BUY5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BUY5
ZNF426 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077011.1
ENSEMBL proteins: ENSP00000253115 ENSP00000439017 ENSP00000468100 ENSP00000466469 Reactome Protein details: Q9BUY5
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF426 for ontologies About GeneDecksing
ZNF426 Antibody Products:
Assay Products for ZNF426: |
Protein
Domains /
Families
for ZNF426 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF426 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BUY5ProtoNet protein and cluster: Q9BUY5 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN426_HUMAN, Q9BUY5Similarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF426 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN426_HUMAN, Q9BUY5Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF426 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF426
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF426 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF426 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF426 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF426 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF426 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF426
ZNF426 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF426
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/12 Interacting proteins for ZNF426 (Q9BUY52, 3 ENSP000002531154) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF426 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF426 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF426
Search CenterWatch for drugs/clinical trials and news about ZNF426 / ZN426
|
Transcripts
for ZNF426 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF426 gene: NM_024106.1 Unigene Cluster for ZNF426: Zinc finger protein 426 Hs.594011 [show with all ESTs]Unigene Representative Sequence: AB2098374 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000253115(uc010dws.3 uc002mlq.3) ENST00000535489 ENST00000593003
ENST00000589289
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF426 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF426
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF426 (NM_024106) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF426 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF426 |
Additional cDNA sequence: AB209837.1 AK095759.1 BC001791.1 8 DOTS entries: DT.120633 DT.40304390 DT.95259389 DT.100018341 DT.449124 DT.97838860 DT.102826749 DT.91917588 24/46 AceView cDNA sequences (see all 46): CB152489 BM917690 BM917475 BC001791 AA214087 AA101405 T07512 BE389582 NM_024106 T07511 BQ645288 BQ643881 BF686228 BE743628 BQ644246 BF981905 BE315219 BQ651643 BP351187 BE277095 BQ651133 BM564189 BG289117 BQ940754
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF426 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF426
|
Expression
for ZNF426 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF426 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF426 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF426
SOURCE GeneReport for Unigene cluster: Hs.594011
SABiosciences Custom PCR Arrays for ZNF426
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF426
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF426 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF426 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF426 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF426 |
Orthologs
for ZNF426 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF426 (if available)
TreeFam Gene Tree for ZNF426 (if available) |
Paralogs
for ZNF426 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF426 gene
- ZNF8122 ZNF7782 ZNF2662 ZNF5602 ZNF8462 ZNF1212 ZNF5612 ZNF5592
- ZNF5622
18/531 SIMAP similar genes for ZNF426 using alignment to 3 protein entries: ZN426_HUMAN (see all proteins)
(see all similar genes):SALL3 ZNF331 HZF16 ZNF738 ZNF818P ZNF596
ZFP41 ZFS-4 ZNF266 ZNF78L1 ZNF124 ZNF625
ZNF826P ZNF75A ZNF720 HZF36 ZNF317 ZNF778
ZNF426 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF426
PGOHUM00000238150
|
Genomic Variants
for ZNF426 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF426 (9638667 - 9649303 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF426: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF426 |
|
Disorders
/ Diseases
for ZNF426 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF426 for disorders About GeneDecksing
2  diseases for ZNF426: About MalaCardskaposi's sarcoma sarcoma
Export disorders for ZNF426 gene to outside databases
|
Publications
for ZNF426 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF426 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZNF426) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediat ed gene expression. (PubMed id 19592062)1 Yang Z....Wood C. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication. (PubMed id 18216089)1 Yang Z....Wood C. (2008)
- The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus. (PubMed id 17409159)1 Yang Z. and Wood C. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF426 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF426 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF426 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF426 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF426 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF426 gene:
Search GeneIP for patents involving ZNF426
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF426 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF426 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF426 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF426 | | | OriGene Protein Over-expression Lysate for ZNF426 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF426 | | OriGene 3'-UTR Clone for ZNF426 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF426 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF426 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF426 | | OriGene Custom Protein Services for ZNF426 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF426 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF426 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF426 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF426 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF426 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF426 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF426 |
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 | | | ZNF426 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF426 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF426 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF426 |
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