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Aliases for ZNF426 Gene

Aliases for ZNF426 Gene

  • Zinc Finger Protein 426 2 3 5
  • KSHV RTA Binding Protein 3
  • K-RBP 3

External Ids for ZNF426 Gene

Previous GeneCards Identifiers for ZNF426 Gene

  • GC19M009861
  • GC19M009483
  • GC19M009499
  • GC19M009638
  • GC19M009219

Summaries for ZNF426 Gene

Entrez Gene Summary for ZNF426 Gene

  • Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for ZNF426 Gene

ZNF426 (Zinc Finger Protein 426) is a Protein Coding gene. Diseases associated with ZNF426 include kaposi sarcoma. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF562.

UniProtKB/Swiss-Prot for ZNF426 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF426 Gene

Genomics for ZNF426 Gene

Regulatory Elements for ZNF426 Gene

Promoters for ZNF426 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF426 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF426 gene promoter:

Genomic Location for ZNF426 Gene

Chromosome:
19
Start:
9,523,224 bp from pter
End:
9,538,645 bp from pter
Size:
15,422 bases
Orientation:
Minus strand

Genomic View for ZNF426 Gene

Genes around ZNF426 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF426 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF426 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF426 Gene

Proteins for ZNF426 Gene

  • Protein details for ZNF426 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUY5-ZN426_HUMAN
    Recommended name:
    Zinc finger protein 426
    Protein Accession:
    Q9BUY5
    Secondary Accessions:
    • B3KTL2

    Protein attributes for ZNF426 Gene

    Size:
    554 amino acids
    Molecular mass:
    63106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF426 Gene

Proteomics data for ZNF426 Gene at MOPED

Post-translational modifications for ZNF426 Gene

  • Ubiquitination at Lys 204
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF426 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF426 Gene

Domains & Families for ZNF426 Gene

Gene Families for ZNF426 Gene

Protein Domains for ZNF426 Gene

Suggested Antigen Peptide Sequences for ZNF426 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUY5

UniProtKB/Swiss-Prot:

ZN426_HUMAN :
  • Contains 1 KRAB domain.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF426: view

Function for ZNF426 Gene

Molecular function for ZNF426 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF426: view

Animal Model Products

CRISPR Products

miRNA for ZNF426 Gene

miRTarBase miRNAs that target ZNF426

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF426 Gene

Localization for ZNF426 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF426 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF426 Gene COMPARTMENTS Subcellular localization image for ZNF426 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF426 Gene

Pathways & Interactions for ZNF426 Gene

SuperPathways for ZNF426 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF426: view

Pathways by source for ZNF426 Gene

2 Reactome pathways for ZNF426 Gene

Gene Ontology (GO) - Biological Process for ZNF426 Gene

None

No data available for SIGNOR curated interactions for ZNF426 Gene

Drugs & Compounds for ZNF426 Gene

No Compound Related Data Available

Transcripts for ZNF426 Gene

Unigene Clusters for ZNF426 Gene

Zinc finger protein 426:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF426 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for ZNF426 Gene

GeneLoc Exon Structure for
ZNF426
ECgene alternative splicing isoforms for
ZNF426

Expression for ZNF426 Gene

mRNA expression in normal human tissues for ZNF426 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF426 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF426 Gene



SOURCE GeneReport for Unigene cluster for ZNF426 Gene Hs.594011

genes like me logo Genes that share expression patterns with ZNF426: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF426 Gene

Orthologs for ZNF426 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF426 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF426 35
  • 99.52 (n)
  • 99.1 (a)
ZNF426 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 34 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 52 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp426 36
  • 73 (a)
OneToOne
Zfp426 16
Zfp426 35
  • 81.29 (n)
  • 74.41 (a)
rat
(Rattus norvegicus)
Mammalia Zfp426 35
  • 80.87 (n)
  • 75.23 (a)
Species with no ortholog for ZNF426:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF426 Gene

ENSEMBL:
Gene Tree for ZNF426 (if available)
TreeFam:
Gene Tree for ZNF426 (if available)

Paralogs for ZNF426 Gene

Paralogs for ZNF426 Gene

(531) SIMAP similar genes for ZNF426 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF426 Gene

genes like me logo Genes that share paralogs with ZNF426: view

Variants for ZNF426 Gene

Sequence variations from dbSNP and Humsavar for ZNF426 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2042200 - 9,536,222(+) AATCA(A/G)CAGCT reference, missense, utr-variant-5-prime
rs10420644 - 9,529,390(+) TTGTG(C/T)GCTAG reference, missense, utr-variant-5-prime
rs733102 -- 9,535,910(-) ATCAC(A/G)TTTAG intron-variant
rs733103 -- 9,535,864(-) TTTGC(A/G)TTTTC intron-variant
rs888870 -- 9,535,461(+) ggtgg(A/G)aggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF426 Gene

Variant ID Type Subtype PubMed ID
nsv911020 CNV Gain 21882294
nsv911024 CNV Loss 21882294

Variation tolerance for ZNF426 Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 10.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF426 Gene

HapMap Linkage Disequilibrium report
ZNF426
Human Gene Mutation Database (HGMD)
ZNF426

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF426 Gene

Disorders for ZNF426 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF426 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kaposi sarcoma
  • human herpesvirus 8
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF426

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF426
genes like me logo Genes that share disorders with ZNF426: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF426 Gene

Publications for ZNF426 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZNF426 Gene

Sources for ZNF426 Gene

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