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ZNF426 Gene

protein-coding   GIFtS: 51
GCID: GC19M009638

Zinc Finger Protein 426

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4261 2

External Ids:    HGNC: 207251   Entrez Gene: 790882   Ensembl: ENSG000001308187   UniProtKB: Q9BUY53   

Export aliases for ZNF426 gene to outside databases

Previous GC identifers: GC19M009861 GC19M009483 GC19M009499 GC19M009219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF426 Gene:
ZNF426 (zinc finger protein 426) is a protein-coding gene. Diseases associated with ZNF426 include kaposi's sarcoma, and sarcoma. An important paralog of this gene is ZNF812.

UniProtKB/Swiss-Prot: ZN426_HUMAN, Q9BUY5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF426 gene promoter:
         Pbx1a   FOXD3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF426 promoter sequence
   Search Chromatin IP Primers for ZNF426

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF426


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF426 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF426 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M009638:  view genomic region     (about GC identifiers)

Start:
9,638,667 bp from pter      End:
9,649,303 bp from pter
Size:
10,637 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN426_HUMAN, Q9BUY5 (See protein sequence)
Recommended Name: Zinc finger protein 426  
Size: 554 amino acids; 63106 Da
Secondary accessions: B3KTL2

Explore the universe of human proteins at neXtProt for ZNF426: NX_Q9BUY5

Explore proteomics data for ZNF426 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys204
  • Modification sites at PhosphoSitePlus

  • See ZNF426 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077011.1  
    ENSEMBL proteins: 
     ENSP00000253115   ENSP00000439017   ENSP00000468100   ENSP00000466469  
    Reactome Protein details: Q9BUY5

    ZNF426 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for ZNF426
    Cloud-Clone Corp. CLIAs for ZNF426


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BUY5

    ProtoNet protein and cluster: Q9BUY5

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN426_HUMAN, Q9BUY5
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF426 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN426_HUMAN, Q9BUY5
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF426 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF426
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF426
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF426

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF426:
    hsa-mir-181a-5p (MIRT025049), hsa-let-7b-5p (MIRT052012)

    Block miRNA regulation of human, mouse, rat ZNF426 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ZNF426
    SwitchGear 3'UTR luciferase reporter plasmidZNF426 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF426

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF426

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF426


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN426_HUMAN, Q9BUY5: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF426 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF426 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF426
        Generic Transcription Pathway



    ZNF426 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF426
    Interactions:

        Search GeneGlobe Interaction Network for ZNF426

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for ZNF426 (Q9BUY52, 3 ENSP000002531154) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66696 I2D: score=5 STRING: ENSP00000311695
    CEP70Q8NHQ12, 3, ENSP000002649824MINT-67582 I2D: score=5 STRING: ENSP00000264982
    NINLQ9Y2I62, 3, ENSP000002788864MINT-67212 I2D: score=5 STRING: ENSP00000278886
    EFEMP2O959672, 3, ENSP000003099534MINT-67862 I2D: score=4 STRING: ENSP00000309953
    LPXNO607112, 3MINT-66472 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF426 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF426 (ZN426)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF426 gene: 
    NM_024106.1  

    Unigene Cluster for ZNF426:

    Zinc finger protein 426
    Hs.594011  [show with all ESTs]
    Unigene Representative Sequence: AB209837
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253115(uc010dws.3 uc002mlq.3) ENST00000535489 ENST00000593003
    ENST00000589289
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF426 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ZNF426
    SwitchGear 3'UTR luciferase reporter plasmidZNF426 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF426
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF426
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF426 (NM_024106)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF426
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF426
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF426
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF426
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF426
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF426
      QuantiFast Probe-based Assays in human, mouse, rat ZNF426

    Additional mRNA sequence: 

    AB209837.1 AK095759.1 BC001791.1 

    8 DOTS entries:

    DT.120633  DT.40304390  DT.95259389  DT.100018341  DT.449124  DT.97838860  DT.102826749  DT.91917588 

    Selected AceView cDNA sequences (see all 46):

    NM_024106 T07511 CB152489 BC001791 BM917690 BE389582 AA101405 AA214087 
    T07512 BM917475 BG289117 BQ651133 BE277095 BE315219 BF686228 BQ651643 
    BQ644246 BQ645288 BQ652846 AK095759 BQ653281 BM469467 BP351887 BM564189 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF426    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                -               
    SP2:                                                


    ECgene alternative splicing isoforms for ZNF426

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF426 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF426 Expression
    About this image

    ZNF426 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF426 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594011
        Custom PCR Arrays for ZNF426
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF426

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF426 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp4261 , 5 zinc finger protein 4261, 5 81.29(n)1
    74.41(a)1
      9 (7.55 cM)5
    2350281  NM_001110309.11  NP_001103779.11 
     204685495 


    ENSEMBL Gene Tree for ZNF426 (if available)
    TreeFam Gene Tree for ZNF426 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF426 gene
    ZNF8122  ZNF7782  ZNF2662  ZNF5602  ZNF8462  ZNF1212  ZNF5612  ZNF5592  
    ZNF5622  
    Selected SIMAP similar genes for ZNF426 using alignment to 3 protein entries:     ZN426_HUMAN (see all proteins) (see all similar genes):
    ZNF625-ZNF20    SALL3    ZNF331    HZF16    ZNF738    ZNF818P
    ZFP41    ZFS-4    ZNF266    ZNF78L1    ZNF596    LOC101928664
    ZNF625    ZNF826P    ZNF614    ZNF169    ZNF720    HZF36

    ZNF426 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF426
    PGOHUM00000238150


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF426 (see all 409)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852690911,2
    --9638169(+) ATATAA/GTGAAC 1 -- int10--------
    rs743970541,2
    F--9638189(+) CTTTTC/TCATGC 1 -- int10--------
    rs48041111,2
    C,F,A,H--9638223(+) TCCTAC/TGTGAT 1 -- int128Minor allele frequency- T:0.32NS EA WA NA CSA 2448
    rs1903519991,2
    --9638224(+) CCTATA/GTGATT 1 -- int10--------
    rs730021641,2
    C,F--9638226(+) TATGTG/AATTTC 1 -- int16Minor allele frequency- A:0.31WA CSA NA 245
    rs1820376401,2
    --9638237(+) TCCTGC/TATGTA 1 -- int10--------
    rs1415671111,2
    --9638249(+) AAAGGA/GCTGAA 1 -- int10--------
    rs1164714811,2
    C,F--9638346(+) ATCTAT/CAAACG 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1461889081,2
    --9638351(+) TAAACA/GTTTTT 1 -- int10--------
    rs1483903321,2
    --9638548(+) ATCTGA/TTGACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF426 (9638667 - 9649303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF426:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911024CNV Loss21882294
    nsv911020CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF426
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF426

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF426:    
    About MalaCards
    kaposi's sarcoma    sarcoma


    ZNF426 for disorders           About GeneDecksing


    Export disorders for ZNF426 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF426 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF426)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expression. (PubMed id 19592062)1 Yang Z....Wood C. (Virology 2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication. (PubMed id 18216089)1 Yang Z....Wood C. (J. Virol. 2008)
    9. The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus. (PubMed id 17409159)1 Yang Z. and Wood C. (J. Virol. 2007)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79088 HGNC: 20725 AceView: ZNF426 Ensembl:ENSG00000130818 euGenes: HUgn79088
    ECgene: ZNF426 H-InvDB: ZNF426

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF426 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF426 gene:
    Search GeneIP for patents involving ZNF426

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