Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF425 Gene

Aliases for ZNF425 Gene

  • Zinc Finger Protein 425 2 3 5

External Ids for ZNF425 Gene

Previous GeneCards Identifiers for ZNF425 Gene

  • GC00U902913
  • GC07M148237
  • GC07M148430
  • GC07M148799
  • GC07M142877

Summaries for ZNF425 Gene

GeneCards Summary for ZNF425 Gene

ZNF425 (Zinc Finger Protein 425) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF786.

UniProtKB/Swiss-Prot for ZNF425 Gene

  • Acts as a transcriptional repressor.

Additional gene information for ZNF425 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF425 Gene

Genomics for ZNF425 Gene

Regulatory Elements for ZNF425 Gene

Enhancers for ZNF425 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H149143 1.6 Ensembl ENCODE dbSUPER 38.8 -20.2 -20178 6 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 CBX5 ZNF143 ZNF783 LOC155060 ZNF398 ZNF212 ZNF425 ZNF282 ZNF786 ENSG00000271664 ZNF777 ZNF767P
GH07H149124 1.2 ENCODE 36.9 -0.5 -481 3 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 SSRP1 ZNF610 GLIS1 ZNF212 ZNF783 ENSG00000271664 ZNF398 ZNF425 ZNF282 LOC155060 ZNF777 ZNF767P LOC643438
GH07H149064 1.4 Ensembl ENCODE 31.4 +60.8 60804 2 HDGF MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF398 ZNF212 ZNF425 ZNF786 ZNF783 ZNF746 ZNF282 ENSG00000271664 RNU6-650P PDIA4
GH07H149089 1.4 FANTOM5 ENCODE 20.9 +35.4 35361 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF425 ZNF783 LOC155060 ZNF212 ENSG00000271664 ZNF767P ZNF862 ZNF777 ENSG00000273314 ZNF398
GH07H149171 0.7 ENCODE 22.2 -46.0 -45971 1 FOXA2 ZNF792 CEBPB CEBPG ZSCAN9 ZSCAN21 ATF4 JUND CEBPA FOSL2 ZNF282 ZNF425 LOC100420549 PIR52308
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF425 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF425 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219584 -254 2801 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 SSRP1 ZNF610 GLIS1

Genomic Location for ZNF425 Gene

Chromosome:
7
Start:
149,102,784 bp from pter
End:
149,126,346 bp from pter
Size:
23,563 bases
Orientation:
Minus strand

Genomic View for ZNF425 Gene

Genes around ZNF425 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF425 Gene

Proteins for ZNF425 Gene

  • Protein details for ZNF425 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IV72-ZN425_HUMAN
    Recommended name:
    Zinc finger protein 425
    Protein Accession:
    Q6IV72
    Secondary Accessions:
    • B3KPM1
    • Q08AG3

    Protein attributes for ZNF425 Gene

    Size:
    752 amino acids
    Molecular mass:
    87721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF425 Gene

Post-translational modifications for ZNF425 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF425 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF425 Gene

Domains & Families for ZNF425 Gene

Gene Families for ZNF425 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF425 Gene

Suggested Antigen Peptide Sequences for ZNF425 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IV72

UniProtKB/Swiss-Prot:

ZN425_HUMAN :
  • The C2H2 domain is necessary for the transcriptional repression.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C2H2 domain is necessary for the transcriptional repression.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF425: view

Function for ZNF425 Gene

Molecular function for ZNF425 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF425 Gene

Gene Ontology (GO) - Molecular Function for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF425: view

Phenotypes for ZNF425 Gene

genes like me logo Genes that share phenotypes with ZNF425: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF425
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF425 Gene

Localization for ZNF425 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF425 Gene

Nucleus. Cytoplasm. Note=Predominantly expressed in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF425 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 21266108
GO:0005737 cytoplasm IDA,IEA 21266108
genes like me logo Genes that share ontologies with ZNF425: view

Pathways & Interactions for ZNF425 Gene

SuperPathways for ZNF425 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF425: view

Pathways by source for ZNF425 Gene

2 Reactome pathways for ZNF425 Gene

Gene Ontology (GO) - Biological Process for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 21266108
genes like me logo Genes that share ontologies with ZNF425: view

No data available for SIGNOR curated interactions for ZNF425 Gene

Drugs & Compounds for ZNF425 Gene

No Compound Related Data Available

Transcripts for ZNF425 Gene

mRNA/cDNA for ZNF425 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF425 Gene

Zinc finger protein 425:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF425
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF425 Gene

No ASD Table

Relevant External Links for ZNF425 Gene

GeneLoc Exon Structure for
ZNF425
ECgene alternative splicing isoforms for
ZNF425

Expression for ZNF425 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF425 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF425 Gene:

ZNF425

SOURCE GeneReport for Unigene cluster for ZNF425 Gene:

Hs.31743

Evidence on tissue expression from TISSUES for ZNF425 Gene

  • Heart(4)
genes like me logo Genes that share expression patterns with ZNF425: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF425 Gene

Orthologs for ZNF425 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF425 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF425 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia ZNF425 34
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
OneToMany
-- 34
  • 33 (a)
OneToMany
Species where no ortholog for ZNF425 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF425 Gene

ENSEMBL:
Gene Tree for ZNF425 (if available)
TreeFam:
Gene Tree for ZNF425 (if available)

Paralogs for ZNF425 Gene

Paralogs for ZNF425 Gene

(307) SIMAP similar genes for ZNF425 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF425: view

Variants for ZNF425 Gene

Sequence variations from dbSNP and Humsavar for ZNF425 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000049038 -- 149,125,009(+) TACAA(A/C)GAAGA intron-variant, upstream-variant-2KB
rs1000103298 -- 149,122,653(+) CTACA(A/G)GTTTT intron-variant
rs1000177579 -- 149,109,983(+) CCAAT(A/T)CCCCT intron-variant
rs1000398837 -- 149,125,310(+) ATTAA(A/G)CCTCA intron-variant, upstream-variant-2KB
rs1001074488 -- 149,106,740(+) AAGCA(A/G)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF425 Gene

Variant ID Type Subtype PubMed ID
dgv3692n106 CNV deletion 24896259
esv1422572 CNV deletion 17803354
esv2396942 CNV deletion 18987734
esv2458810 CNV deletion 19546169
esv2668984 CNV deletion 23128226
esv2735327 CNV deletion 23290073
esv3542626 CNV deletion 23714750
esv3615426 CNV loss 21293372
esv7630 CNV loss 19470904
nsv1018754 CNV gain 25217958
nsv1076964 CNV deletion 25765185
nsv1147688 CNV deletion 26484159
nsv955965 CNV deletion 24416366

Variation tolerance for ZNF425 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF425 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF425 Gene

Disorders for ZNF425 Gene

Relevant External Links for ZNF425

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF425

No disorders were found for ZNF425 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF425 Gene

Publications for ZNF425 Gene

  1. A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen-activated protein kinase signaling pathway. (PMID: 21266108) Wang Y … Wu X (BMB reports 2011) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 60

Products for ZNF425 Gene

Sources for ZNF425 Gene

Content
Loading form....