Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF425 Gene

Aliases for ZNF425 Gene

  • Zinc Finger Protein 425 2 3 5

External Ids for ZNF425 Gene

Previous GeneCards Identifiers for ZNF425 Gene

  • GC00U902913
  • GC07M148237
  • GC07M148430
  • GC07M148799
  • GC07M142877

Summaries for ZNF425 Gene

GeneCards Summary for ZNF425 Gene

ZNF425 (Zinc Finger Protein 425) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF786.

UniProtKB/Swiss-Prot for ZNF425 Gene

  • Acts as a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF425 Gene

Genomics for ZNF425 Gene

Regulatory Elements for ZNF425 Gene

Promoters for ZNF425 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF425 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF425 Gene

Chromosome:
7
Start:
149,102,784 bp from pter
End:
149,126,346 bp from pter
Size:
23,563 bases
Orientation:
Minus strand

Genomic View for ZNF425 Gene

Genes around ZNF425 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF425 Gene

Proteins for ZNF425 Gene

  • Protein details for ZNF425 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IV72-ZN425_HUMAN
    Recommended name:
    Zinc finger protein 425
    Protein Accession:
    Q6IV72
    Secondary Accessions:
    • B3KPM1
    • Q08AG3

    Protein attributes for ZNF425 Gene

    Size:
    752 amino acids
    Molecular mass:
    87721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF425 Gene

Proteomics data for ZNF425 Gene at MOPED

Post-translational modifications for ZNF425 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF425 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF425 Gene

Domains & Families for ZNF425 Gene

Gene Families for ZNF425 Gene

Protein Domains for ZNF425 Gene

Suggested Antigen Peptide Sequences for ZNF425 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IV72

UniProtKB/Swiss-Prot:

ZN425_HUMAN :
  • The C2H2 domain is necessary for the transcriptional repression.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
Domain:
  • The C2H2 domain is necessary for the transcriptional repression.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF425: view

Function for ZNF425 Gene

Molecular function for ZNF425 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor.

Phenotypes for ZNF425 Gene

genes like me logo Genes that share phenotypes with ZNF425: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF425 Gene

Localization for ZNF425 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF425 Gene

Nucleus. Cytoplasm. Note=Predominantly expressed in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF425 Gene COMPARTMENTS Subcellular localization image for ZNF425 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21266108
genes like me logo Genes that share ontologies with ZNF425: view

Pathways & Interactions for ZNF425 Gene

SuperPathways for ZNF425 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF425: view

Pathways by source for ZNF425 Gene

2 Reactome pathways for ZNF425 Gene

Interacting Proteins for ZNF425 Gene

Gene Ontology (GO) - Biological Process for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 21266108
genes like me logo Genes that share ontologies with ZNF425: view

No data available for SIGNOR curated interactions for ZNF425 Gene

Drugs & Compounds for ZNF425 Gene

No Compound Related Data Available

Transcripts for ZNF425 Gene

mRNA/cDNA for ZNF425 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF425 Gene

Zinc finger protein 425:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF425 Gene

No ASD Table

Relevant External Links for ZNF425 Gene

GeneLoc Exon Structure for
ZNF425
ECgene alternative splicing isoforms for
ZNF425

Expression for ZNF425 Gene

mRNA expression in normal human tissues for ZNF425 Gene

SOURCE GeneReport for Unigene cluster for ZNF425 Gene Hs.31743

genes like me logo Genes that share expression patterns with ZNF425: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF425 Gene

Orthologs for ZNF425 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF425 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF425 35
  • 99.47 (n)
  • 99.6 (a)
ZNF425 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF425 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
Species with no ortholog for ZNF425:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF425 Gene

ENSEMBL:
Gene Tree for ZNF425 (if available)
TreeFam:
Gene Tree for ZNF425 (if available)

Paralogs for ZNF425 Gene

Paralogs for ZNF425 Gene

(307) SIMAP similar genes for ZNF425 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF425: view

Variants for ZNF425 Gene

Sequence variations from dbSNP and Humsavar for ZNF425 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6965052 - 149,105,374(+) TCTTG(A/T)CTGGA reference, missense
rs1137432 -- 149,104,566(-) CTGCA(A/G)CACAT reference, synonymous-codon
rs1969466 -- 149,113,773(-) GAGAT(C/T)GAGAC intron-variant
rs1969467 -- 149,113,212(-) ggatc(A/T)cttga intron-variant
rs1969468 -- 149,113,190(-) cgaga(C/T)tatcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF425 Gene

Variant ID Type Subtype PubMed ID
nsv889402 CNV Loss 21882294
esv2668984 CNV Deletion 23128226
esv2458810 CNV Deletion 19546169
esv2396942 CNV Deletion 18987734
esv2735327 CNV Deletion 23290073
esv1422572 CNV Deletion 17803354
esv7630 CNV Loss 19470904

Variation tolerance for ZNF425 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF425 Gene

HapMap Linkage Disequilibrium report
ZNF425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF425 Gene

Disorders for ZNF425 Gene

Relevant External Links for ZNF425

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF425

No disorders were found for ZNF425 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF425 Gene

Publications for ZNF425 Gene

  1. A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen- activated protein kinase signaling pathway. (PMID: 21266108) Wang Y. … Wu X. (BMB Rep. 2011) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF425 Gene

Sources for ZNF425 Gene

Back to Top

Content