ZNF425 Gene
protein-coding GIFtS: 44
GCID: GC07M148799
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|
zinc finger protein 425
| |
Aliases
for ZNF425 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4251 2 |
Export aliases for ZNF425 gene to outside databasesPrevious GC identifers: GC00U902913 GC07M148237 GC07M148430 GC07M142877 |
Summaries
for ZNF425 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN425_HUMAN, Q6IV72Function: Acts as a transcriptional repressor
|
Genomic Views
for ZNF425 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF425 gene promoter:
C/EBPbeta HOXA3 HTF Brachyury XBP-1 Tal-1beta POU3F2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF425
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF425 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1ZNF425 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M148799: view genomic region
(about GC identifiers)
Start:
|
148,799,876 bp from pter |
End:
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148,823,438 bp from pter |
Size:
|
23,563 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 148,138,209-148,161,459 |
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Proteins
for ZNF425 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN425_HUMAN, Q6IV72 (See
protein sequence)Recommended Name: Zinc finger protein 425 Size: 752 amino acids; 87721 Da
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly expressed in the nucleus
Developmental stage: Expressed in 30 days old embryos. Almost undetectable in 60 days old embryos and in adults
Secondary accessions: B3KPM1 Q08AG3Explore the universe of human proteins at neXtProt for ZNF425: NX_Q6IV72
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IV72
ZNF425 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001661.1
ENSEMBL proteins: ENSP00000367300 ENSP00000420379 Reactome Protein details: Q6IV72
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF425 for ontologies About GeneDecksing
ZNF425 Antibody Products:
Assay Products for ZNF425: |
Protein
Domains /
Families
for ZNF425 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF425 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6IV72ProtoNet protein and cluster: Q6IV72 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN425_HUMAN, Q6IV72Domain: The C2H2 domain is necessary for the transcriptional repressionSimilarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 19 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF425 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN425_HUMAN, Q6IV72Function: Acts as a transcriptional repressor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF425
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF425
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF425 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF425 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF425 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF425 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF425 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF425
ZNF425 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF425
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IDA | -- |
ZNF425 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF425 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF425
Search CenterWatch for drugs/clinical trials and news about ZNF425 / ZN425
|
Transcripts
for ZNF425 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF425 gene: NM_001001661.2 Unigene Cluster for ZNF425: Zinc finger protein 425 Hs.31743 [show with all ESTs]Unigene Representative Sequence: NM_0010016614 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378061(uc003wfj.3) ENST00000495685 ENST00000483014 ENST00000484196
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF425
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF425
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF425 (NM_001001661) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF425 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF425 |
Additional cDNA sequence: AK056498.1 AK125575.1 AY621067.1 BC125189.1 3 DOTS entries: DT.209011 DT.86836405 DT.75139583 2 AceView cDNA sequences: AA584568 AA613256
GeneLoc Exon Structure
|
Expression
for ZNF425 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF425 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGTGGTCC
About this image
See ZNF425 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF425
SOURCE GeneReport for Unigene cluster: Hs.31743
SABiosciences Custom PCR Arrays for ZNF425
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF425
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF425 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF425 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF425 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF425 |
Orthologs
for ZNF425 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF425 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
BX539313.46 |
-- |
12(a) |
1 → many |
16(27307857-27311657) |
Species with no ortholog for ZNF425
ENSEMBL Gene Tree for ZNF425 (if available)
TreeFam Gene Tree for ZNF425 (if available) |
Paralogs
for ZNF425 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF425 gene
- ZNF7862
18/323 SIMAP similar genes for ZNF425 using alignment to 2 protein entries: ZN425_HUMAN (see all proteins)
(see all similar genes):ZNF ZNF525 MGC12518 ZNF506 ZNF577 ZNF738
ZNF32 ZNF589 ZNF620 ZNF702P ZNF765 ZNF578
ZNF624 ZNF501 ZNF558 ZNF81 ZSCAN21 ZNF248
ZNF425 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF425 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF425 (148799876 - 148823438 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZNF425
1 CNV: 100168
4 Indels: 47261 62740 41038 28488 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF425 |
|
Disorders
/ Diseases
for ZNF425 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF425 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF425 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF425) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen- activated protein kinase signaling pathway. (PubMed id 21266108)1, 2 Wang Y.... Wu X. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF425 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF425 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF425 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF425 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF425 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF425 gene:
Search GeneIP for patents involving ZNF425
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF425 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF425 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF425 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF425 | | | OriGene Protein Over-expression Lysate for ZNF425 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF425 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF425 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF425 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |
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| |  |  |  |  | | | | |
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 | | | ZNF425 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF425 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF425 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF425 |
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