ZNF420 Gene
protein-coding GIFtS: 49
GCID: GC19P037498
|
|
zinc finger protein 420
| |
Aliases
for ZNF420 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4201 2 | | FLJ321911 | | APAK2 | | ATM And P53-Associated KZNF Protein2 |
Export aliases for ZNF420 gene to outside databasesPrevious GC identifers: GC00U900995 GC19P042262 GC19P037569 GC19P034038 |
Summaries
for ZNF420 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN420_HUMAN, Q8TAQ5Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF420 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF420 gene promoter:
STAT1 GCNF-1 GCNF Msx-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF420
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF420 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.12ZNF420 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P037498: view genomic region
(about GC identifiers)
Start:
|
37,498,759 bp from pter |
End:
|
37,621,216 bp from pter |
Size:
|
122,458 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF420 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN420_HUMAN, Q8TAQ5 (See
protein sequence)Recommended Name: Zinc finger protein 420 Size: 688 amino acids; 80247 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B2RDY6Explore the universe of human proteins at neXtProt for ZNF420: NX_Q8TAQ5
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAQ5
ZNF420 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653290.2
ENSEMBL proteins: ENSP00000468387 ENSP00000466057 ENSP00000465346 ENSP00000467369 ENSP00000306102 ENSP00000467772 ENSP00000338770 ENSP00000468736 Reactome Protein details: Q8TAQ5
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF420 for ontologies About GeneDecksing
ZNF420 Antibody Products:
Assay Products for ZNF420: |
Protein
Domains /
Families
for ZNF420 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF420 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TAQ5ProtoNet protein and cluster: Q8TAQ5 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN420_HUMAN, Q8TAQ5Similarity: Contains 19 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF420 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN420_HUMAN, Q8TAQ5Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF420 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF420
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF420 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF420 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF420 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF420 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF420:
|
Pathways & Interactions
for ZNF420 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF420
ZNF420 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF420
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for ZNF420 (Q8TAQ52, 3 ENSP000003387704) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF420 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF420 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF420
Search CenterWatch for drugs/clinical trials and news about ZNF420 / ZN420
|
Transcripts
for ZNF420 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF420 gene: NM_144689.3 Unigene Cluster for ZNF420: Zinc finger protein 420 Hs.444992 [show with all ESTs]Unigene Representative Sequence: BC0262109 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000590332 ENST00000587029 ENST00000589461 ENST00000587082 ENST00000304239
ENST00000589245 ENST00000337995(uc002ofl.3) ENST00000585862 ENST00000586540
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF420 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF420
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF420 (NM_144689) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF420 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF420 |
Additional cDNA sequence: AK056695.1 AK056753.1 AK315728.1 BC026210.2 6 DOTS entries: DT.108762 DT.121446766 DT.121446981 DT.121446952 DT.121447000 DT.423548 24/56 AceView cDNA sequences (see all 56): BQ949663 BM052765 AA976476 AK056753 AW316546 AW591586 AI138668 AA934732 NM_144689 BU176809 BM053059 BM693388 BQ188303 AI281179 AI273684 BC026210 AI479265 AI281171 AL710909 AI339586 BM970902 AI638214 BM557617 AK056695
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF420 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF420
|
Expression
for ZNF420 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF420 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCAGAAAT
About this image
See ZNF420 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF420
SOURCE GeneReport for Unigene cluster: Hs.444992
SABiosciences Custom PCR Arrays for ZNF420
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF420
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF420 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF420 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF420 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF420 |
Orthologs
for ZNF420 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF420 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008584771 |
zinc finger protein 184-like |
55.63(n)
52.83(a) |
|
100858477 XM_003643949.1 XP_003643997.1 |
ENSEMBL Gene Tree for ZNF420 (if available)
TreeFam Gene Tree for ZNF420 (if available) |
Paralogs
for ZNF420 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF420 gene
- ZNF5292 ZFP302 ZNF1402 ZNF780A2 ZNF3832 ZNF7902 ZNF5822 ZFP822
- ZNF302 ZNF5732 ZNF5402 ZNF5712 ZNF3312 ZFP142 ZNF4612 ZNF2832
- ZNF4042 ZNF8292 ZNF6072 ZNF5652 ZNF5662 ENSG000002675522
18/555 SIMAP similar genes for ZNF420 using alignment to 8 protein entries: ZN420_HUMAN (see all proteins)
(see all similar genes):smap-7 ZNF850 ZFP57 ZNF738 MGC12518 ZNF705F
ZNF818P ZNF93 MRPS17 ZNF81 KRBOX4 ZSCAN31
ZNF78L1 ZFP90 ZNF506 ZNF90 ZNF846 ZNF585A
ZNF420 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF420
PGOHUM00000234153 PGOHUM00000258068
|
Genomic Variants
for ZNF420 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF420 (37498759 - 37621216 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF420: --
Human Gene Mutation Database (HGMD): ZNF420
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF420 |
|
Disorders
/ Diseases
for ZNF420 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF420 for disorders About MalaCards
ZNF420 for disorders About GeneDecksing
Export disorders for ZNF420 gene to outside databases
|
Publications
for ZNF420 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF420 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF420) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis. (PubMed id 22334068)1 Yuan L....Zhang L. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- ARF-dependent regulation of ATM and p53 associated KZ NF (Apak) protein activity in response to oncogenic stress. (PubMed id 20713054)1 Wang S....Zhang L. (2010)
- Differential regulation of Apak by various DNA damage signals. (PubMed id 19629643)1 Wang S....Chen H. (2010)
- KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. (PubMed id 19377469)1 Tian C....He F. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF420 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF420 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF420 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF420 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF420 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF420 gene:
Search GeneIP for patents involving ZNF420
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF420 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF420 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF420 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF420 | | | OriGene Protein Over-expression Lysate for ZNF420 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF420 | | OriGene 3'-UTR Clone for ZNF420 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF420 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF420 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF420 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF420 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF420 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF420 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF420 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF420 |
| |
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| |  |  |  |  | | | | |
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 | | | ZNF420 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF420 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF420 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF420 |
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