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Aliases for ZNF420 Gene

Aliases for ZNF420 Gene

  • Zinc Finger Protein 420 2 3 5
  • ATM And P53-Associated KZNF Protein 3
  • APAK 3

External Ids for ZNF420 Gene

Previous GeneCards Identifiers for ZNF420 Gene

  • GC00U900995
  • GC19P042262
  • GC19P037569
  • GC19P034038
  • GC19P037498

Summaries for ZNF420 Gene

Entrez Gene Summary for ZNF420 Gene

  • The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZNF420 Gene

ZNF420 (Zinc Finger Protein 420) is a Protein Coding gene. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Regulation of TP53 Activity. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF546.

UniProtKB/Swiss-Prot for ZNF420 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF420 Gene

Genomics for ZNF420 Gene

Regulatory Elements for ZNF420 Gene

Enhancers for ZNF420 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF420 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF420 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF420 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF420 Gene

Chromosome:
19
Start:
37,007,813 bp from pter
End:
37,130,324 bp from pter
Size:
122,512 bases
Orientation:
Plus strand

Genomic View for ZNF420 Gene

Genes around ZNF420 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF420 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF420 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF420 Gene

Proteins for ZNF420 Gene

  • Protein details for ZNF420 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAQ5-ZN420_HUMAN
    Recommended name:
    Zinc finger protein 420
    Protein Accession:
    Q8TAQ5
    Secondary Accessions:
    • B2RDY6
    • Q96ML5

    Protein attributes for ZNF420 Gene

    Size:
    688 amino acids
    Molecular mass:
    80247 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF420 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF420 Gene

Post-translational modifications for ZNF420 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF420 Gene

Domains & Families for ZNF420 Gene

Gene Families for ZNF420 Gene

Protein Domains for ZNF420 Gene

Suggested Antigen Peptide Sequences for ZNF420 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TAQ5

UniProtKB/Swiss-Prot:

ZN420_HUMAN :
  • Contains 1 KRAB domain.
  • Contains 19 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF420: view

Function for ZNF420 Gene

Molecular function for ZNF420 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF420 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 20713054
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF420: view
genes like me logo Genes that share phenotypes with ZNF420: view

Animal Model Products

CRISPR Products

miRNA for ZNF420 Gene

miRTarBase miRNAs that target ZNF420

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF420 Gene

Localization for ZNF420 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF420 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF420 Gene COMPARTMENTS Subcellular localization image for ZNF420 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF420 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ZNF420: view

Pathways & Interactions for ZNF420 Gene

genes like me logo Genes that share pathways with ZNF420: view

Gene Ontology (GO) - Biological Process for ZNF420 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0042981 regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with ZNF420: view

No data available for SIGNOR curated interactions for ZNF420 Gene

Drugs & Compounds for ZNF420 Gene

No Compound Related Data Available

Transcripts for ZNF420 Gene

Unigene Clusters for ZNF420 Gene

Zinc finger protein 420:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF420 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for ZNF420 Gene

GeneLoc Exon Structure for
ZNF420
ECgene alternative splicing isoforms for
ZNF420

Expression for ZNF420 Gene

mRNA expression in normal human tissues for ZNF420 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF420 Gene:

ZNF420

SOURCE GeneReport for Unigene cluster for ZNF420 Gene:

Hs.444992
genes like me logo Genes that share expression patterns with ZNF420: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF420 Gene

Orthologs for ZNF420 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF420 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF420 34
  • 92.67 (n)
  • 95.34 (a)
ZNF420 35
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100682968 34
  • 90.61 (n)
  • 91.82 (a)
ZNF420 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp420 34
  • 85.18 (n)
  • 90.83 (a)
Zfp420 16
Zfp420 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC101059449 34
  • 99.76 (n)
  • 99.71 (a)
ZNF420 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp383 34
  • 83.62 (n)
  • 92.04 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
OneToMany
Species where no ortholog for ZNF420 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF420 Gene

ENSEMBL:
Gene Tree for ZNF420 (if available)
TreeFam:
Gene Tree for ZNF420 (if available)

Paralogs for ZNF420 Gene

(563) SIMAP similar genes for ZNF420 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF420 Gene

genes like me logo Genes that share paralogs with ZNF420: view

Variants for ZNF420 Gene

Sequence variations from dbSNP and Humsavar for ZNF420 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3050624 -- 37,091,929(-) ttttt(-/TT/TTT)gagat intron-variant
rs3051686 -- 37,071,804(-) tattt(-/ATTT)ttttg intron-variant
rs3051691 -- 37,039,702(-) TCACA(-/A)AAAAA intron-variant
rs10424841 -- 37,085,648(+) aagag(A/G)acatc intron-variant
rs3213840 -- 37,062,669(+) GTTGA(A/G)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF420 Gene

Variant ID Type Subtype PubMed ID
esv3644277 CNV gain 21293372
esv3893201 CNV gain 25118596
nsv1064851 CNV loss 25217958
nsv2477 CNV deletion 18451855
nsv579461 CNV gain 21841781
nsv833818 CNV gain 17160897
nsv953292 CNV duplication 24416366

Variation tolerance for ZNF420 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF420 Gene

Human Gene Mutation Database (HGMD)
ZNF420
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF420

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF420 Gene

Disorders for ZNF420 Gene

Relevant External Links for ZNF420

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF420

No disorders were found for ZNF420 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF420 Gene

Publications for ZNF420 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK. (PMID: 25961932) Olcina M.M. … Hammond E.M. (Oncogene 2016) 3 65
  4. ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis. (PMID: 25691462) Wang S. … Zhang L. (J Mol Cell Biol 2015) 3 65
  5. Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients. (PMID: 26544568) Gaykalova D.A. … Califano J.A. (PLoS ONE 2015) 3 65

Products for ZNF420 Gene

Sources for ZNF420 Gene

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