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Aliases for ZNF419 Gene

Aliases for ZNF419 Gene

  • Zinc Finger Protein 419 2 3 5
  • Zinc Finger Protein 419A 2 3
  • ZNF419A 3 4
  • ZAPHIR 3

External Ids for ZNF419 Gene

Previous HGNC Symbols for ZNF419 Gene

  • ZNF419A

Previous GeneCards Identifiers for ZNF419 Gene

  • GC00U900993
  • GC19P062691
  • GC19P057999
  • GC19P054311

Summaries for ZNF419 Gene

GeneCards Summary for ZNF419 Gene

ZNF419 (Zinc Finger Protein 419) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF419 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF419 Gene

Genomics for ZNF419 Gene

Regulatory Elements for ZNF419 Gene

Enhancers for ZNF419 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF419 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF419 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF419 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF419 Gene

Chromosome:
19
Start:
57,487,711 bp from pter
End:
57,496,097 bp from pter
Size:
8,387 bases
Orientation:
Plus strand

Genomic View for ZNF419 Gene

Genes around ZNF419 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF419 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF419 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF419 Gene

Proteins for ZNF419 Gene

  • Protein details for ZNF419 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HQ0-ZN419_HUMAN
    Recommended name:
    Zinc finger protein 419
    Protein Accession:
    Q96HQ0
    Secondary Accessions:
    • B4DXU7
    • B4E348
    • B7ZA41
    • E9PCP4
    • E9PED0
    • E9PET3
    • E9PFX9
    • Q9H5P0

    Protein attributes for ZNF419 Gene

    Size:
    510 amino acids
    Molecular mass:
    58564 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF419 Gene

neXtProt entry for ZNF419 Gene

Proteomics data for ZNF419 Gene at MOPED

Post-translational modifications for ZNF419 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF419

No data available for DME Specific Peptides for ZNF419 Gene

Domains & Families for ZNF419 Gene

Protein Domains for ZNF419 Gene

Suggested Antigen Peptide Sequences for ZNF419 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HQ0

UniProtKB/Swiss-Prot:

ZN419_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF419: view

Function for ZNF419 Gene

Molecular function for ZNF419 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF419 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF419: view

Phenotypes for ZNF419 Gene

genes like me logo Genes that share phenotypes with ZNF419: view

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF419 Gene

Localization for ZNF419 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF419 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF419 Gene COMPARTMENTS Subcellular localization image for ZNF419 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF419 Gene

Pathways & Interactions for ZNF419 Gene

SuperPathways for ZNF419 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF419: view

Pathways by source for ZNF419 Gene

2 Reactome pathways for ZNF419 Gene

Interacting Proteins for ZNF419 Gene

Gene Ontology (GO) - Biological Process for ZNF419 Gene

None

No data available for SIGNOR curated interactions for ZNF419 Gene

Drugs & Compounds for ZNF419 Gene

No Compound Related Data Available

Transcripts for ZNF419 Gene

Unigene Clusters for ZNF419 Gene

Zinc finger protein 419:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF419 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: -
SP6: - -
SP7: - - - - -

Relevant External Links for ZNF419 Gene

GeneLoc Exon Structure for
ZNF419
ECgene alternative splicing isoforms for
ZNF419

Expression for ZNF419 Gene

mRNA expression in normal human tissues for ZNF419 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF419 Gene Hs.744339

genes like me logo Genes that share expression patterns with ZNF419: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF419 Gene

Orthologs for ZNF419 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF419 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF419 35
  • 81.75 (n)
  • 71.65 (a)
-- 36
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF419 35
  • 82.51 (n)
  • 73.61 (a)
chimpanzee
(Pan troglodytes)
Mammalia ZNF419 35
  • 98.69 (n)
  • 97.45 (a)
-- 36
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp600 36
  • 29 (a)
ManyToMany
Species with no ortholog for ZNF419:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF419 Gene

ENSEMBL:
Gene Tree for ZNF419 (if available)
TreeFam:
Gene Tree for ZNF419 (if available)

Paralogs for ZNF419 Gene

(529) SIMAP similar genes for ZNF419 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF419: view

Variants for ZNF419 Gene

Sequence variations from dbSNP and Humsavar for ZNF419 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2074076 - 57,492,978(+) GACAA(C/G)AGGGC intron-variant, downstream-variant-500B, reference, missense
rs2074077 - 57,493,563(+) AGAGA(A/G)TTCAC intron-variant, reference, missense
rs7259303 -- 57,493,195(+) CTTTG(A/G)TCAGA intron-variant, downstream-variant-500B, reference, missense
rs12978073 -- 57,488,571(+) TTTTT(C/G)TTTGT intron-variant
rs8103487 -- 57,489,250(+) TATTA(A/C)CTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF419 Gene

Variant ID Type Subtype PubMed ID
nsv912524 CNV Loss 21882294
nsv912525 CNV Loss 21882294
esv24439 CNV Gain 19812545
nsv828655 CNV Gain 20364138
dgv1135e1 CNV Complex 17122850
esv2719071 CNV Deletion 23290073
nsv522762 CNV Loss 19592680

Variation tolerance for ZNF419 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF419 Gene

HapMap Linkage Disequilibrium report
ZNF419
Human Gene Mutation Database (HGMD)
ZNF419

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF419 Gene

Disorders for ZNF419 Gene

Relevant External Links for ZNF419

Genetic Association Database (GAD)
ZNF419
Human Genome Epidemiology (HuGE) Navigator
ZNF419
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF419

No disorders were found for ZNF419 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF419 Gene

Publications for ZNF419 Gene

  1. A polymorphism in the splice donor site of ZNF419 results in the novel renal cell carcinoma-associated minor histocompatibility antigen ZAPHIR. (PMID: 21738768) Broen K. … Dolstra H. (PLoS ONE 2011) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for ZNF419 Gene

Sources for ZNF419 Gene

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