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Aliases for ZNF419 Gene

Aliases for ZNF419 Gene

  • Zinc Finger Protein 419 2 3
  • Zinc Finger Protein 419A 2 3
  • ZNF419A 3 4
  • ZAPHIR 3

External Ids for ZNF419 Gene

Previous HGNC Symbols for ZNF419 Gene

  • ZNF419A

Previous GeneCards Identifiers for ZNF419 Gene

  • GC00U900993
  • GC19P062691
  • GC19P057999
  • GC19P054311

Summaries for ZNF419 Gene

GeneCards Summary for ZNF419 Gene

ZNF419 (Zinc Finger Protein 419) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF419 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF419 Gene

Genomics for ZNF419 Gene

Regulatory Elements for ZNF419 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF419 Gene

57,487,711 bp from pter
57,496,097 bp from pter
8,387 bases
Plus strand

Genomic View for ZNF419 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF419 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF419 Gene

Proteins for ZNF419 Gene

  • Protein details for ZNF419 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 419
    Protein Accession:
    Secondary Accessions:
    • B4DXU7
    • B4E348
    • B7ZA41
    • E9PCP4
    • E9PED0
    • E9PET3
    • E9PFX9
    • Q9H5P0

    Protein attributes for ZNF419 Gene

    510 amino acids
    Molecular mass:
    58564 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF419 Gene

neXtProt entry for ZNF419 Gene

Proteomics data for ZNF419 Gene at MOPED

Post-translational modifications for ZNF419 Gene

  • Ubiquitination at Lys215 and Lys332
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF419 Gene

Domains for ZNF419 Gene

Gene Families for ZNF419 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF419 Gene

Suggested Antigen Peptide Sequences for ZNF419 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96HQ0
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF419: view

Function for ZNF419 Gene

Molecular function for ZNF419 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF419 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF419: view

Phenotypes for ZNF419 Gene

GenomeRNAi human phenotypes for ZNF419:
genes like me logo Genes that share phenotypes with ZNF419: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF419 Gene

Localization for ZNF419 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF419 Gene

Subcellular locations from

Jensen Localization Image for ZNF419 Gene COMPARTMENTS Subcellular localization image for ZNF419 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF419 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF419: view

Pathways for ZNF419 Gene

SuperPathways for ZNF419 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF419: view

Pathways by source for ZNF419 Gene

2 Reactome pathways for ZNF419 Gene

Interacting Proteins for ZNF419 Gene

Gene Ontology (GO) - Biological Process for ZNF419 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF419: view

Transcripts for ZNF419 Gene

Unigene Clusters for ZNF419 Gene

Zinc finger protein 419:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF419

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF419 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: -
SP6: - -
SP7: - - - - -

Relevant External Links for ZNF419 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF419 Gene

mRNA expression in normal human tissues for ZNF419 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF419 Gene Hs.744339

genes like me logo Genes that share expressions with ZNF419: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ZNF419 Gene

Orthologs for ZNF419 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF419 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF419 35
  • 81.75 (n)
  • 71.65 (a)
-- 36
  • 71 (a)
(Canis familiaris)
Mammalia ZNF419 35
  • 82.51 (n)
  • 73.61 (a)
(Pan troglodytes)
Mammalia ZNF419 35
  • 98.69 (n)
  • 97.45 (a)
-- 36
  • 97 (a)
(Mus musculus)
Mammalia Zfp419 16
Zfp600 36
  • 29 (a)
Species with no ortholog for ZNF419:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF419 Gene

Gene Tree for ZNF419 (if available)
Gene Tree for ZNF419 (if available)

Paralogs for ZNF419 Gene

Selected SIMAP similar genes for ZNF419 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF419: view

Variants for ZNF419 Gene

Sequence variations from dbSNP and Humsavar for ZNF419 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1135692 -- 57,491,596(+) TCTCT(C/G)GGTAA synonymous-codon, reference
rs2019321 -- 57,488,343(+) GGCCC(C/T)TCAAG intron-variant
rs2019474 -- 57,488,444(+) GGCCA(C/T)AGAGG intron-variant
rs2019475 -- 57,488,370(+) TGGGG(G/T)TGAGG intron-variant
rs2074067 -- 57,491,773(+) TCCCC(A/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF419 Gene

Variant ID Type Subtype PubMed ID
nsv912524 CNV Loss 21882294
nsv912525 CNV Loss 21882294
esv24439 CNV Gain 19812545
nsv828655 CNV Gain 20364138
dgv1135e1 CNV Complex 17122850
esv2719071 CNV Deletion 23290073
nsv522762 CNV Loss 19592680

Relevant External Links for ZNF419 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF419 Gene

Disorders for ZNF419 Gene

Relevant External Links for ZNF419

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ZNF419 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF419 Gene

Publications for ZNF419 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A polymorphism in the splice donor site of ZNF419 results in the novel renal cell carcinoma-associated minor histocompatibility antigen ZAPHIR. (PMID: 21738768) Broen K. … Dolstra H. (PLoS ONE 2011) 2 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for ZNF419 Gene

Sources for ZNF419 Gene

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