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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF419 Gene

protein-coding   GIFtS: 48
GCID: GC19P057999

zinc finger protein 419

(Previous name: zinc finger protein 419A )
(Previous symbol: ZNF419A)
  Search for ZNF419
in our new
 Human Malady Compendium 
Biological research products
for ZNF419
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 4191 2
ZNF419A1 2 3
Zinc Finger Protein 419A1 2

External Ids:    HGNC: 206481   Entrez Gene: 797442   Ensembl: ENSG000001051367   UniProtKB: Q96HQ03   

Export aliases for ZNF419 gene to outside databases

Previous GC identifers: GC00U900993 GC19P062691 GC19P054311


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN419_HUMAN, Q96HQ0
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF419 gene promoter:
         COUP-TF1   HTF   COUP   AP-4   HNF-4alpha2   XBP-1   HNF-4alpha1   Nkx6-1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF419 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF419

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF419


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF419 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF419 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P057999:  view genomic region     (about GC identifiers)

Start:
57,999,079 bp from pter      End:
58,006,048 bp from pter
Size:
6,970 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN419_HUMAN, Q96HQ0 (See protein sequence)
Recommended Name: Zinc finger protein 419  
Size: 510 amino acids; 58564 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B4E348 B7ZA41 E9PCP4 Q9H5P0
Alternative splicing: 3 isoforms:  Q96HQ0-1   Q96HQ0-2   Q96HQ0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF419: NX_Q96HQ0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96HQ0

  • ZNF419 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_001091961.1  NP_001091962.1  NP_001091963.1  NP_001091964.1  NP_001091965.1  NP_001091966.1  NP_078967.3  

    ENSEMBL proteins: 
     ENSP00000428075   ENSP00000428181   ENSP00000429471   ENSP00000429880   ENSP00000414709  
     ENSP00000428515   ENSP00000430326   ENSP00000299860   ENSP00000429504   ENSP00000392129  
     ENSP00000428523   ENSP00000221735   ENSP00000427723   ENSP00000429628   ENSP00000388864  
     ENSP00000390916   ENSP00000346136  
    Reactome Protein details: Q96HQ0
    Human Recombinant Protein Products: 
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    Uscn Proteins for ZNF419

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----


    ZNF419 for ontologies           About GeneDecksing



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    Uscn Antibodies for ZNF419
    Search ThermoFisher Antibodies for ZNF419

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    Uscn ELISAs and CLIAs for ZNF419


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF419 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96HQ0

    ProtoNet protein and cluster: Q96HQ0

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN419_HUMAN, Q96HQ0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN419_HUMAN, Q96HQ0
    Function: May be involved in transcriptional regulation

    miRNA
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    hsa-miR-199a-5p hsa-miR-199b-5p
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    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF419

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF419 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF419:
     Decreased viability with pacli 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF419
        Generic Transcription Pathway
    Gene Expression



    ZNF419 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF419

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF419 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF419
    Search CenterWatch for drugs/clinical trials and news about ZNF419 / ZN419 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF419 gene (7 alternative transcripts): 
    NM_001098491.1  NM_001098492.1  NM_001098493.1  NM_001098494.1  NM_001098495.1  NM_001098496.1  NM_024691.3  

    Unigene Cluster for ZNF419:

    Zinc finger protein 419
    Hs.744339  [show with all ESTs]
    Unigene Representative Sequence: AK309427
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000524372 ENST00000523882 ENST00000520540 ENST00000519310 ENST00000442920
    ENST00000523312 ENST00000523439 ENST00000517598 ENST00000347466 ENST00000523138
    ENST00000415379 ENST00000521754 ENST00000221735 ENST00000518999 ENST00000521137
    ENST00000522346 ENST00000424930(uc010ety.1 uc002qov.2 uc002qow.2)
    ENST00000426954(uc010etz.1 uc010eua.1 uc010eub.1 uc010euc.1)


    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF419:
    hsa-miR-199a-5p hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNF419 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF419
    OriGene shRNA RFP: ZNF419
    OriGene siRNA: ZNF419
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF419
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF419 (see all 7)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF419
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    Additional cDNA sequence: 

    AK026886.1 AK302135.1 AK304569.1 AK307802.1 AK309427.1 AK316156.1 AK316297.1 BC008297.1 
    BC024259.1 

    7 DOTS entries:

    DT.411915  DT.100751895  DT.91676953  DT.100654977  DT.97782148  DT.121495871  DT.91653758 

    24/93 AceView cDNA sequences (see all 93):

    AA335875 AI125173 CR601614 N67859 BE892698 AK026886 BE045934 AA644239 
    AA935668 BU191386 AA683549 BE313724 AA452957 AW594524 BF314022 AK122740 
    BE277061 AI279074 AA447637 NM_024691 BU679602 AI350944 AI652301 BC024259 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF419 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
    SP1:                                      -     -     -                     
    SP2:                    -                 -     -     -                     
    SP3:                    -                                                   
    SP4:                    -     -                                             
    SP5:                    -                                                   


    ECgene alternative splicing isoforms for ZNF419

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF419 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAACATCGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF419 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF419

    SOURCE GeneReport for Unigene cluster: Hs.744339
        SABiosciences Custom PCR Arrays for ZNF419
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF419

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF419 (if available)
    TreeFam Gene Tree for ZNF419 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF419 gene
    ZNF5492  ZNF2112  ZNF4172  ZNF7922  ZNF7492  ZNF5512  ZNF7762  ZNF5472  
    ZNF172  ZNF4162  ZNF5482  ZNF3042  ZNF587B2  ZNF7732  ZNF1322  ZIK12  
    ZNF6712  ZNF1342  ZNF4182  ZNF2562  ZNF1542  ZNF5522  ZNF7722  ZNF5302  
    18/552 SIMAP similar genes for ZNF419 using alignment to 15 protein entries:     ZN419_HUMAN (see all proteins) (see all similar genes):
    FLJ00301    ZNF773    ZNF577    kr-znf3    ZFP41    ZSCAN16
    ZNF78L1    ZNF391    ZNF24    HZF36    ZNF169    DKFZp686H10254
    HZF30    ZNF501    DKFZp666C237    DKFZp686M04222    ZEB1    zf30

    ZNF419 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/202 NCBI SNPs in ZNF419 are shown (see all 202    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs789181651,2
    F,--57997125(+) AATTAG/AATAGT 7 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1914999051,2
    --57997153(+) GTCATC/GTTATT 7 -- us2k10--------
    rs65100781,2
    C,F,A,H,--57997218(+) TAAAAA/TGTCTA 7 -- us2k116Minor allele frequency- T:0.34NS EA WA NA CSA 790
    rs1836327721,2
    --57997228(+) ACATAC/TACTCT 7 -- us2k10--------
    rs113118421,2
    C--57997347(+) CTTTC-/TTTTTT 7 -- us2k1 trp32Minor allele frequency- T:0.00NA CSA 4
    rs744251281,2
    --57997357(+) TTTTTT/AAATTT 7 -- us2k11Minor allele frequency- A:0.50NA 2
    rs771111461,2
    --57997359(+) TTTTAT/ATTTAT 7 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1461973131,2
    --57997401(+) AGGCCA/GGAGTG 7 -- us2k10--------
    rs1485838391,2
    --57997531(+) AGTTCC/GTAGGC 7 -- us2k10--------
    rs1429553451,2
    --57997624(+) ATAATA/CATTCT 7 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF419 (57999079 - 58006048 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ZNF419
         2 CNVs: 3203 67625
    Human Gene Mutation Database (HGMD): ZNF419

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF419
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF419 for disorders           About MalaCards

    ZNF419 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ZNF419 (1 document)

    Export disorders for ZNF419 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF419 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF419)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79744 HGNC: 20648 AceView: FLJ23233 Ensembl:ENSG00000105136 euGenes: HUgn79744
    ECgene: ZNF419 H-InvDB: ZNF419

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF419 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF419 gene:
    Search GeneIP for patents involving ZNF419

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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