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Aliases for ZNF418 Gene

Aliases for ZNF418 Gene

  • Zinc Finger Protein 418 2 3 5
  • KIAA1956 4

External Ids for ZNF418 Gene

Previous GeneCards Identifiers for ZNF418 Gene

  • GC00U900991
  • GC19M063129
  • GC19M062988
  • GC19M058296
  • GC19M054744
  • GC19M058433

Summaries for ZNF418 Gene

GeneCards Summary for ZNF418 Gene

ZNF418 (Zinc Finger Protein 418) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF587.

UniProtKB/Swiss-Prot for ZNF418 Gene

  • Transcriptional repressor.

Additional gene information for ZNF418 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF418 Gene

Genomics for ZNF418 Gene

GeneHancer (GH) Regulatory Elements for ZNF418 Gene

Promoters and enhancers for ZNF418 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057934 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.2 196 1.6 MXI1 PKNOX1 SUZ12 NFIB MAX SIN3A ZBTB40 YY1 ETS1 E2F1 ZNF418 LOC100128398 C19orf18 ZNF587 ZNF671 VN1R1 PIR52698
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 65.6 -247.8 -247828 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 54.5 +335.4 335371 1.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 KLF13 ZNF530 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ZNF446 ZNF17 LOC105372482
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50.8 -391.5 -391463 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 41.1 -445.7 -445677 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF418 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF418 gene promoter:

Genomic Locations for ZNF418 Gene

Genomic Locations for ZNF418 Gene
chr19:57,921,884-57,935,408
(GRCh38/hg38)
Size:
13,525 bases
Orientation:
Minus strand
chr19:58,433,252-58,446,761
(GRCh37/hg19)

Genomic View for ZNF418 Gene

Genes around ZNF418 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF418 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF418 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF418 Gene

Proteins for ZNF418 Gene

  • Protein details for ZNF418 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF45-ZN418_HUMAN
    Recommended name:
    Zinc finger protein 418
    Protein Accession:
    Q8TF45
    Secondary Accessions:
    • Q2M1S2
    • Q670L5
    • Q96N18

    Protein attributes for ZNF418 Gene

    Size:
    676 amino acids
    Molecular mass:
    77858 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85542.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF418 Gene

Post-translational modifications for ZNF418 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF418 Gene

Domains & Families for ZNF418 Gene

Gene Families for ZNF418 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF418 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF45

UniProtKB/Swiss-Prot:

ZN418_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF418: view

Function for ZNF418 Gene

Molecular function for ZNF418 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF418: view
genes like me logo Genes that share phenotypes with ZNF418: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF418 Gene

Localization for ZNF418 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF418 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF418 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF418: view

Pathways & Interactions for ZNF418 Gene

SuperPathways for ZNF418 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF418: view

Pathways by source for ZNF418 Gene

2 Reactome pathways for ZNF418 Gene

Gene Ontology (GO) - Biological Process for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF418: view

No data available for SIGNOR curated interactions for ZNF418 Gene

Drugs & Compounds for ZNF418 Gene

No Compound Related Data Available

Transcripts for ZNF418 Gene

Unigene Clusters for ZNF418 Gene

Zinc finger protein 418:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF418 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: - - - - -
SP9: - - - - -
SP10: -

Relevant External Links for ZNF418 Gene

GeneLoc Exon Structure for
ZNF418
ECgene alternative splicing isoforms for
ZNF418

Expression for ZNF418 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF418 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF418 Gene:

ZNF418

SOURCE GeneReport for Unigene cluster for ZNF418 Gene:

Hs.660728

Evidence on tissue expression from TISSUES for ZNF418 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF418: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF418 Gene

Orthologs for ZNF418 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF418 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF418 33 34
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 54 (a)
OneToMany
Species where no ortholog for ZNF418 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF418 Gene

ENSEMBL:
Gene Tree for ZNF418 (if available)
TreeFam:
Gene Tree for ZNF418 (if available)

Paralogs for ZNF418 Gene

(548) SIMAP similar genes for ZNF418 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF418: view

Variants for ZNF418 Gene

Sequence variations from dbSNP and Humsavar for ZNF418 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000217064 -- 57,937,054(-) C/T upstream_transcript_variant
rs1000327425 -- 57,931,763(-) A/G intron_variant
rs1000587079 -- 57,936,541(-) A/G upstream_transcript_variant
rs1000652441 -- 57,936,755(-) C/T upstream_transcript_variant
rs1000831816 -- 57,923,243(-) G/A 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF418 Gene

Variant ID Type Subtype PubMed ID
esv2656655 CNV deletion 23128226
esv2719096 CNV deletion 23290073
esv3644913 CNV gain 21293372
esv3644916 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF418 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF418 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF418

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF418 Gene

Disorders for ZNF418 Gene

Additional Disease Information for ZNF418

No disorders were found for ZNF418 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF418 Gene

Publications for ZNF418 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis. (PMID: 29065170) Pan L … Li J (PloS one 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF418 Gene

Sources for ZNF418 Gene

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