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Aliases for ZNF418 Gene

Aliases for ZNF418 Gene

  • Zinc Finger Protein 418 2 3
  • KIAA1956 4

External Ids for ZNF418 Gene

Previous GeneCards Identifiers for ZNF418 Gene

  • GC00U900991
  • GC19M063129
  • GC19M062988
  • GC19M058296
  • GC19M054744
  • GC19M058433

Summaries for ZNF418 Gene

GeneCards Summary for ZNF418 Gene

ZNF418 (Zinc Finger Protein 418) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF418 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF418 Gene

Genomics for ZNF418 Gene

Regulatory Elements for ZNF418 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF418 Gene

57,921,884 bp from pter
57,935,429 bp from pter
13,546 bases
Minus strand

Genomic View for ZNF418 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF418 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF418 Gene

Proteins for ZNF418 Gene

  • Protein details for ZNF418 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 418
    Protein Accession:
    Secondary Accessions:
    • Q2M1S2
    • Q670L5
    • Q96N18

    Protein attributes for ZNF418 Gene

    676 amino acids
    Molecular mass:
    77858 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB85542.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF418 Gene

Proteomics data for ZNF418 Gene at MOPED

Post-translational modifications for ZNF418 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF418 Gene

No data available for DME Specific Peptides for ZNF418 Gene

Domains for ZNF418 Gene

Gene Families for ZNF418 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF418 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8TF45
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF418: view

Function for ZNF418 Gene

Molecular function for ZNF418 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF418: view

Phenotypes for ZNF418 Gene

GenomeRNAi human phenotypes for ZNF418:
genes like me logo Genes that share phenotypes with ZNF418: view

Animal Model Products

CRISPR Products

miRNA for ZNF418 Gene

miRTarBase miRNAs that target ZNF418

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF418

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF418 Gene

Localization for ZNF418 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF418 Gene

Subcellular locations from

Jensen Localization Image for ZNF418 Gene COMPARTMENTS Subcellular localization image for ZNF418 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF418: view

Pathways for ZNF418 Gene

SuperPathways for ZNF418 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF418: view

Pathways by source for ZNF418 Gene

2 Reactome pathways for ZNF418 Gene

Gene Ontology (GO) - Biological Process for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF418: view

Transcripts for ZNF418 Gene

Unigene Clusters for ZNF418 Gene

Zinc finger protein 418:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF418

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF418 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: - - - - -
SP9: - - - - -
SP10: -

Relevant External Links for ZNF418 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF418 Gene

mRNA expression in normal human tissues for ZNF418 Gene

SOURCE GeneReport for Unigene cluster for ZNF418 Gene Hs.660728

genes like me logo Genes that share expressions with ZNF418: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ZNF418 Gene

Orthologs for ZNF418 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF418 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF418 35
  • 99.18 (n)
  • 99.38 (a)
ZNF418 36
  • 96 (a)
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
Species with no ortholog for ZNF418:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF418 Gene

Gene Tree for ZNF418 (if available)
Gene Tree for ZNF418 (if available)

Paralogs for ZNF418 Gene

Selected SIMAP similar genes for ZNF418 Gene using alignment to 8 proteins: Pseudogenes for ZNF418 Gene

genes like me logo Genes that share paralogs with ZNF418: view

Variants for ZNF418 Gene

Sequence variations from dbSNP and Humsavar for ZNF418 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1544929 -- 57,924,673(-) TGTGC(C/T)CTGAT intron-variant
rs1544930 -- 57,924,652(-) TCGTA(A/G)TGTGG intron-variant
rs2888999 -- 57,923,606(+) gtctt(A/G)ctctg intron-variant
rs3760622 -- 57,936,536(+) TCATT(C/G)AGCAA upstream-variant-2KB
rs7245442 -- 57,926,315(+) CATTC(A/G)CTGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF418 Gene

Variant ID Type Subtype PubMed ID
esv2656655 CNV Deletion 23128226
esv2719096 CNV Deletion 23290073

Relevant External Links for ZNF418 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF418 Gene

Disorders for ZNF418 Gene

No disorders were found for ZNF418 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF418 Gene

Publications for ZNF418 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway. (PMID: 18084723) Li Y. … Wu X. (Mol. Cell. Biochem. 2008) 3
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3

Products for ZNF418 Gene

Sources for ZNF418 Gene

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