ZNF418 Gene
protein-coding GIFtS: 48
GCID: GC19M058433
|
|
zinc finger protein 418
| |
Aliases
for ZNF418 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4181 2 | | KIAA19561 3 | | FLJ315511 |
Export aliases for ZNF418 gene to outside databasesPrevious GC identifers: GC00U900991 GC19M063129 GC19M062988 GC19M058296 GC19M054744 |
Summaries
for ZNF418 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN418_HUMAN, Q8TF45Function: Transcriptional repressor
|
Genomic Views
for ZNF418 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF418 gene promoter:
GATA-3 AP-1 ATF-2 c-Jun GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF418
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF418 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF418 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M058433: view genomic region
(about GC identifiers)
Start:
|
58,433,252 bp from pter |
End:
|
58,446,755 bp from pter |
Size:
|
13,504 bases |
Orientation:
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minus strand |
|
Proteins
for ZNF418 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN418_HUMAN, Q8TF45 (See
protein sequence)Recommended Name: Zinc finger protein 418 Size: 676 amino acids; 77858 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB85542.1; Type=Erroneous initiation;
Secondary accessions: Q2M1S2 Q670L5 Q96N18Explore the universe of human proteins at neXtProt for ZNF418: NX_Q8TF45
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TF45
ZNF418 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_597717.1
ENSEMBL proteins: ENSP00000379451 ENSP00000407039 Reactome Protein details: Q8TF45
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF418 for ontologies About GeneDecksing
ZNF418 Antibody Products:
Assay Products for ZNF418: |
Protein
Domains /
Families
for ZNF418 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF418 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TF45ProtoNet protein and cluster: Q8TF45 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN418_HUMAN, Q8TF45Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 16 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF418 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN418_HUMAN, Q8TF45Function: Transcriptional repressor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF418
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF418
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF418 (NM_133460) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF418 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF418 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF418 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF418 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF418:
|
Pathways & Interactions
for ZNF418 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF418
ZNF418 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF418
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ZNF418 (Q8TF453 ENSP000003794514) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF418 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF418 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF418
Search CenterWatch for drugs/clinical trials and news about ZNF418 / ZN418
|
Transcripts
for ZNF418 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF418 gene: NM_133460.1 Unigene Cluster for ZNF418: Zinc finger protein 418 Hs.660728 [show with all ESTs]Unigene Representative Sequence: AY6958252 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396147(uc002qqs.1 uc010yhn.1) ENST00000425570(uc010yho.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF418
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF418
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF418 (NM_133460) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF418 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF418 |
Additional cDNA sequence: AB075836.1 AK056113.1 AK293723.1 AK304632.1 AY695825.1 BC112244.1 BC113707.1 8 DOTS entries: DT.97804782 DT.105878 DT.97825158 DT.121503795 DT.121503813 DT.100751895 DT.102845499 DT.95158711 24/120 AceView cDNA sequences (see all 120): BM987016 BI833232 BI760856 CK820063 AK022663 CK820062 AK096401 CN482664 C21240 BQ613755 AY695825 AI150545 BF926933 BM273143 BQ711860 AB075836 NM_133460 BI822651 AI271888 AV704447 AW275034 AV718486 AW771494 AL711598
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF418 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 |
|---|
|
| SP1: | | | | | - | | | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF418
|
Expression
for ZNF418 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF418 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTAATTC
About this image
See ZNF418 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF418
SOURCE GeneReport for Unigene cluster: Hs.660728
SABiosciences Custom PCR Arrays for ZNF418
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF418
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF418 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF418 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF418 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF418 |
Orthologs
for ZNF418 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF418 (if available)
TreeFam Gene Tree for ZNF418 (if available) |
Paralogs
for ZNF418 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF418 gene
- ZNF5492 ZNF2112 ZNF4172 ZNF7922 ZNF7492 ZNF5512 ZNF7762 ZNF5472
- ZNF172 ZNF4162 ZNF5482 ZNF3042 ZNF587B2 ZNF7732 ZNF1322 ZIK12
- ZNF6712 ZNF1342 ZNF2562 ZNF1542 ZNF5522 ZNF7722 ZNF5302 ZNF4192
18/534 SIMAP similar genes for ZNF418 using alignment to 8 protein entries: ZN418_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 FLJ00301 ZFP41 ZNF587B ZNF818P kr-znf3
DKFZp666C237 ZNF56 HZF36 ZNF485 ZNF501 ZNF696
HZF30 ZF6 ZNF323 ZNF417 ZNF502 ZSCAN16
ZNF418 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF418
PGOHUM00000263018
|
Genomic Variants
for ZNF418 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF418 (58433252 - 58446755 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF418: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF418 |
|
Disorders
/ Diseases
for ZNF418 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF418 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF418 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF418) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway. (PubMed id 18084723)1 Li Y....Wu X. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ZNF418 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF418 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF418 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF418 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF418 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF418 gene:
Search GeneIP for patents involving ZNF418
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF418 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF418 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF418 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF418 | | | OriGene Protein Over-expression Lysate for ZNF418 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF418 | | OriGene 3'-UTR Clone for ZNF418 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF418 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF418 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF418 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF418 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF418 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF418 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF418 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF418 |
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 | | | ZNF418 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF418 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF418 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF418 |
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