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Aliases for ZNF418 Gene

Aliases for ZNF418 Gene

  • Zinc Finger Protein 418 2 3 5
  • KIAA1956 4

External Ids for ZNF418 Gene

Previous GeneCards Identifiers for ZNF418 Gene

  • GC00U900991
  • GC19M063129
  • GC19M062988
  • GC19M058296
  • GC19M054744
  • GC19M058433

Summaries for ZNF418 Gene

GeneCards Summary for ZNF418 Gene

ZNF418 (Zinc Finger Protein 418) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF417.

UniProtKB/Swiss-Prot for ZNF418 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF418 Gene

Genomics for ZNF418 Gene

Regulatory Elements for ZNF418 Gene

Enhancers for ZNF418 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G057599 1.1 ENCODE 46.1 +335.4 335371 1.5 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 ZHX2 ZNF606 ZNF549 ZNF417 ZNF418 LOC100128398 ZNF17 ZNF773 LOC105372482 ZNF211 ENSG00000268201
GH19G058181 1.1 ENCODE 45.9 -247.8 -247829 2.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF134 ZNF549 ZNF606 ZNF773 ZNF17 ZNF418 ZNF550 ZNF417 ZNF256 ZNF543
GH19G058517 2.1 FANTOM5 Ensembl ENCODE dbSUPER 19.7 -584.3 -584301 4.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF324B ZNF549 CENPBD1P1 MZF1 ZNF134 ZNF606 LOC100128398 ZNF324 ZBTB45 ZNF418
GH19G057809 1.7 FANTOM5 ENCODE dbSUPER 20.1 +122.2 122191 7.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF264 TRIM28 ZNF17 ZNF417 ZNF256 ZNF543 ZNF805 ZNF606 ZNF773
GH19G058571 1.4 ENCODE dbSUPER 24 -638.7 -638705 4.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZSCAN18 LOC100128398 TRIM28 ZNF418 ENSG00000268201 LOC105372482 ZNF606 LOC105372483 MZF1 ENSG00000268049
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF418 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF418 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111838 407 1200 CTCF MXI1 PKNOX1 NFIB SUZ12 WRNIP1 MAX ZBTB40 YY1 ETS1

Genomic Location for ZNF418 Gene

Chromosome:
19
Start:
57,921,884 bp from pter
End:
57,935,408 bp from pter
Size:
13,525 bases
Orientation:
Minus strand

Genomic View for ZNF418 Gene

Genes around ZNF418 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF418 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF418 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF418 Gene

Proteins for ZNF418 Gene

  • Protein details for ZNF418 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF45-ZN418_HUMAN
    Recommended name:
    Zinc finger protein 418
    Protein Accession:
    Q8TF45
    Secondary Accessions:
    • Q2M1S2
    • Q670L5
    • Q96N18

    Protein attributes for ZNF418 Gene

    Size:
    676 amino acids
    Molecular mass:
    77858 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85542.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF418 Gene

Post-translational modifications for ZNF418 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF418 Gene

Domains & Families for ZNF418 Gene

Gene Families for ZNF418 Gene

Suggested Antigen Peptide Sequences for ZNF418 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF45

UniProtKB/Swiss-Prot:

ZN418_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF418: view

Function for ZNF418 Gene

Molecular function for ZNF418 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF418: view
genes like me logo Genes that share phenotypes with ZNF418: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF418 Gene

Localization for ZNF418 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF418 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF418 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF418: view

Pathways & Interactions for ZNF418 Gene

SuperPathways for ZNF418 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF418: view

Pathways by source for ZNF418 Gene

2 Reactome pathways for ZNF418 Gene

Gene Ontology (GO) - Biological Process for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF418: view

No data available for SIGNOR curated interactions for ZNF418 Gene

Transcripts for ZNF418 Gene

Unigene Clusters for ZNF418 Gene

Zinc finger protein 418:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF418 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: - - - - -
SP9: - - - - -
SP10: -

Relevant External Links for ZNF418 Gene

GeneLoc Exon Structure for
ZNF418
ECgene alternative splicing isoforms for
ZNF418

Expression for ZNF418 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF418 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF418 Gene:

ZNF418

SOURCE GeneReport for Unigene cluster for ZNF418 Gene:

Hs.660728

Evidence on tissue expression from TISSUES for ZNF418 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF418: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF418 Gene

Orthologs for ZNF418 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF418 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF418 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 54 (a)
OneToMany
Species where no ortholog for ZNF418 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF418 Gene

ENSEMBL:
Gene Tree for ZNF418 (if available)
TreeFam:
Gene Tree for ZNF418 (if available)

Paralogs for ZNF418 Gene

(548) SIMAP similar genes for ZNF418 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF418: view

Variants for ZNF418 Gene

Sequence variations from dbSNP and Humsavar for ZNF418 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000217064 -- 57,937,054(+) TGCCT(C/T)AGTCT upstream-variant-2KB
rs1000327425 -- 57,931,763(+) AAGAG(A/G)TGGGG intron-variant
rs1000587079 -- 57,936,541(+) CAGCA(A/G)AACAT upstream-variant-2KB
rs1000652441 -- 57,936,755(+) TGTTT(C/T)TCTTG upstream-variant-2KB
rs1000831816 -- 57,923,243(+) CTGCA(A/G)TGAGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF418 Gene

Variant ID Type Subtype PubMed ID
esv2656655 CNV deletion 23128226
esv2719096 CNV deletion 23290073
esv3644913 CNV gain 21293372
esv3644916 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF418 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF418 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF418

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF418 Gene

Disorders for ZNF418 Gene

Relevant External Links for ZNF418

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF418

No disorders were found for ZNF418 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF418 Gene

Publications for ZNF418 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3 64

Products for ZNF418 Gene

Sources for ZNF418 Gene

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