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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF417 Gene

protein-coding   GIFtS: 48
GCID: GC19M058417

Zinc Finger Protein 417

  Search for ZNF417
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 4171 2

External Ids:    HGNC: 206461   Entrez Gene: 1476872   Ensembl: ENSG000001734807   UniProtKB: Q8TAU33   

Export aliases for ZNF417 gene to outside databases

Previous GC identifers: GC00U900990 GC19M063111 GC19M054728


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF417 Gene: 
ZNF417 (zinc finger protein 417) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN417_HUMAN, Q8TAU3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF417
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF417 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF417

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF417


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF417 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF417 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M058417:  view genomic region     (about GC identifiers)

Start:
58,411,664 bp from pter      End:
58,427,978 bp from pter
Size:
16,315 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN417_HUMAN, Q8TAU3 (See protein sequence)
Recommended Name: Zinc finger protein 417  
Size: 575 amino acids; 65733 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF417: NX_Q8TAU3

Explore proteomics data for ZNF417 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TAU3

  • ZNF417 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF417 Protein Expression
    REFSEQ proteins: NP_689688.2  
    ENSEMBL proteins: 
     ENSP00000472352   ENSP00000311319   ENSP00000472272   ENSP00000471689   ENSP00000471325  
     ENSP00000471471   ENSP00000469176   ENSP00000442760  
    Reactome Protein details: Q8TAU3
    Human Recombinant Protein Products for ZNF417: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF417 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF417 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TAU3

    ProtoNet protein and cluster: Q8TAU3

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN417_HUMAN, Q8TAU3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF417 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN417_HUMAN, Q8TAU3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF417 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF417 
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    miRNA
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    hsa-miR-3142 hsa-miR-629*
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF417


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF417 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF417
        Generic Transcription Pathway
    Gene Expression



    ZNF417 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF417

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/19 Interacting proteins for ZNF417 (Q8TAU32, 3 ENSP000003113194) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66598 I2D: score=4 STRING: ENSP00000311695
    CEP72Q9P2092, 3, ENSP000002649354MINT-67447 I2D: score=4 STRING: ENSP00000264935
    TRIM37O949722, 3, ENSP000002622944MINT-67756 I2D: score=4 STRING: ENSP00000262294
    ENSG00000215641P143733I2D: score=1 
    ENSG00000229006P143733I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF417 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF417 (ZN417)

    Search CenterWatch for drugs/clinical trials and news about ZNF417 / ZN417

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF417 gene: 
    NM_152475.2  

    Unigene Cluster for ZNF417:

    Zinc finger protein 417
    Hs.567710  [show with all ESTs]
    Unigene Representative Sequence: NM_152475
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594396 ENST00000312026(uc002qqq.3 uc010yhm.2 uc002qqr.3)
    ENST00000595559 ENST00000597515 ENST00000598526 ENST00000598629 ENST00000599251
    ENST00000536263
    miRNA
    Products:
         
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF417:
    hsa-miR-3142 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidZNF417 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Primer
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    OriGene qPCR primer pairs and template standards for ZNF417
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF417
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF417

    Additional mRNA sequence: 

    AK293789.1 BC025783.1 BC103757.1 

    13 DOTS entries:

    DT.86849824  DT.97862743  DT.100773928  DT.306335  DT.91653802  DT.100040721  DT.100773927  DT.100773929 
    DT.100773930  DT.101978126  DT.121503780  DT.121503889  DT.91749895 

    24/120 AceView cDNA sequences (see all 120):

    BQ613755 BI760856 AV704447 AI271888 AK096401 C21240 BM273143 BI833232 
    CK820063 BM987016 BQ711860 AB075836 BI822651 CK820062 AK022663 AI150545 
    AY695825 CN482664 NM_133460 BF926933 CA430364 AI400621 AK056113 AI370595 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF417 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF417 Expression
    About this image


    See ZNF417 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF417

    SOURCE GeneReport for Unigene cluster: Hs.567710
        SABiosciences Custom PCR Arrays for ZNF417
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF417

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF417 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    cow
    (Bos taurus)
    Mammalia LOC7899601 zinc finger protein 416-like 67.67(n)
    57.6(a)
      789960  XM_002695508.2  XP_002695554.2 


    ENSEMBL Gene Tree for ZNF417 (if available)
    TreeFam Gene Tree for ZNF417 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF417 gene
    ZNF5871 2  ZNF5492  ENSG000002695332  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  
    ZNF587B2  ZNF7732  ZIK12  ZNF1342  ZNF6712  ZNF7722  ZNF5302  ZNF4192  
    ZNF2112  ZNF7922  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  ZNF5472  ZNF5842  
    ENSG000002690262  ZNF3042  ZNF1322  ZNF5862  ZNF4182  ZNF2562  ZNF5522  ZNF1542  
    ZNF8142  
    18/533 SIMAP similar genes for ZNF417 using alignment to 8 protein entries:     ZN417_HUMAN (see all proteins) (see all similar genes):
    ZNF587    ZNF78L1    ZNF418    ZNF814    HZF36    kr-znf3
    ZNF776    DKFZp313M0722    ZNF323    ZNF818P    FLJ00301    ZKSCAN8
    ZNF146    ZNF774    ZNF696    ZNF530    ZNF773    ZNF22

    ZNF417 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/334 SNPs in ZNF417 are shown (see all 334)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72529681,2
    C--58416650(+) gtgccC/Tgtaat 1 -- ds50010--------
    rs1884189131,2
    --58416770(+) ACTGCA/GTCTCA 1 -- ds50010--------
    rs788285831,2
    F--58416829(+) CGCCCG/AGCTGG 1 -- ds50011Minor allele frequency- A:0.10NA 120
    rs350695511,2
    C,F--58417269(+) AAGAGA/C/GCTGCA 2 -- ut313NA 124
    rs584951741,2
    C--58417343(+) TTTTGT/-TTTTT 1 -- ut311Minor allele frequency- -:0.50NA 2
    rs784624261,2
    C--58417415(+) TGCAAC/GCTCCA 1 -- ut313Minor allele frequency- G:0.07NA EA 242
    rs65101121,2
    C,F,A,H--58417426(+) TTTCCG/AAGGAA 1 -- ut3125Minor allele frequency- A:0.43NA NS EA WA CSA 2492
    rs671543711,2
    --58417490(+) TAAAA-/TAAAAA 1 -- ut310--------
    rs104198021,2
    C--58417555(+) TTGAAC/TGAGCC 1 -- ut310--------
    rs1809280161,2
    --58417689(+) TATGTA/GCTTAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF417 (58411664 - 58427978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF417:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719094CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF417 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF417)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147687 HGNC: 20646 AceView: MGC34079andZNF418 Ensembl:ENSG00000173480 euGenes: HUgn147687
    ECgene: ZNF417 H-InvDB: ZNF417

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF417 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF417 gene:
    Search GeneIP for patents involving ZNF417

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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