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Aliases for ZNF416 Gene

Aliases for ZNF416 Gene

  • Zinc Finger Protein 416 2 3 5

External Ids for ZNF416 Gene

Previous GeneCards Identifiers for ZNF416 Gene

  • GC00U900989
  • GC19M062775
  • GC19M058082
  • GC19M054395

Summaries for ZNF416 Gene

GeneCards Summary for ZNF416 Gene

ZNF416 (Zinc Finger Protein 416) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZIK1.

UniProtKB/Swiss-Prot for ZNF416 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF416 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF416 Gene

Genomics for ZNF416 Gene

Regulatory Elements for ZNF416 Gene

Enhancers for ZNF416 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H057599 1.1 ENCODE 19.4 -20.9 -20858 1.5 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 ZHX2 MXD4 ZNF606 ZNF549 ZNF135 ZNF132 ZNF418 ZNF417 ZNF446 ZNF17 LOC105372482 LOC100128398
GH19H057809 1.6 FANTOM5 ENCODE dbSUPER 12.1 -234.0 -234038 7.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 TRIM28 ZNF264 ZNF805 ZNF543 ENSG00000269867 ZNF134 ZNF587 ZNF324B ZNF586 ZNF416
GH19H058511 1.6 Ensembl ENCODE dbSUPER 10.6 -934.1 -934068 3.9 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP5 ZNF584 ZNF446 ZNF606 ZNF549 CENPBD1P1 ZNF417 ZNF134 ZNF776 MZF1 ZNF324B
GH19H057278 1.4 ENCODE dbSUPER 12.1 +297.7 297705 6.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF207 ZNF264 ZNF805 ZNF543 ZNF134 ZNF416 ZNF256 TRAPPC2B ZNF547 ZNF460 LOC100128398
GH19H058498 1.4 ENCODE dbSUPER 12 -920.0 -919985 2.2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZNF584 ZNF324B TRIM28 LOC105372483 ENSG00000268543 ZBTB45 ZNF132 ENSG00000268912 ZNF134 ZNF416
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF416 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF416 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111809 380 1200 PKNOX1 ATF1 ZNF133 ARID4B SIN3A BRCA1 YY1 ETS1 ELK1 ZNF207

Genomic Locations for ZNF416 Gene

Genomic Locations for ZNF416 Gene
8,171 bases
Minus strand

Genomic View for ZNF416 Gene

Genes around ZNF416 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF416 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF416 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF416 Gene

Proteins for ZNF416 Gene

  • Protein details for ZNF416 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 416
    Protein Accession:
    Secondary Accessions:
    • Q9NWW8

    Protein attributes for ZNF416 Gene

    594 amino acids
    Molecular mass:
    67188 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91257.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF416 Gene

Post-translational modifications for ZNF416 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF416 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF416 Gene

Domains & Families for ZNF416 Gene

Gene Families for ZNF416 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF416 Gene

Suggested Antigen Peptide Sequences for ZNF416 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF416: view

Function for ZNF416 Gene

Molecular function for ZNF416 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF416 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF416: view
genes like me logo Genes that share phenotypes with ZNF416: view

miRNA for ZNF416 Gene

Targeted motifs for ZNF416 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF416
  • Consensus sequence: WDNCTGGGCA Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF416 Gene

Localization for ZNF416 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF416 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF416 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF416 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF416: view

Pathways & Interactions for ZNF416 Gene

SuperPathways for ZNF416 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF416: view

Pathways by source for ZNF416 Gene

2 Reactome pathways for ZNF416 Gene

Interacting Proteins for ZNF416 Gene

Gene Ontology (GO) - Biological Process for ZNF416 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF416: view

No data available for SIGNOR curated interactions for ZNF416 Gene

Drugs & Compounds for ZNF416 Gene

No Compound Related Data Available

Transcripts for ZNF416 Gene

mRNA/cDNA for ZNF416 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF416 Gene

Zinc finger protein 416:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF416 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for ZNF416 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF416 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF416 Gene

Protein differential expression in normal tissues from HIPED for ZNF416 Gene

This gene is overexpressed in Platelet (51.8) and Peripheral blood mononuclear cells (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF416 Gene

Protein tissue co-expression partners for ZNF416 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF416 Gene:


SOURCE GeneReport for Unigene cluster for ZNF416 Gene:

genes like me logo Genes that share expression patterns with ZNF416: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF416 Gene

Orthologs for ZNF416 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF416 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF416 33 34
  • 99.66 (n)
(Bos Taurus)
Mammalia ZNF416 33
  • 76.33 (n)
-- 34
  • 59 (a)
(Rattus norvegicus)
Mammalia Zfp418 33
  • 68.4 (n)
(Mus musculus)
Mammalia Zfp418 33 16 34
  • 68.3 (n)
Species where no ortholog for ZNF416 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF416 Gene

Gene Tree for ZNF416 (if available)
Gene Tree for ZNF416 (if available)

Paralogs for ZNF416 Gene

(484) SIMAP similar genes for ZNF416 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF416: view

Variants for ZNF416 Gene

Sequence variations from dbSNP and Humsavar for ZNF416 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000028527 -- 57,570,723(+) GGACA(A/C)TGCCT downstream-variant-500B
rs1000669958 -- 57,579,024(+) CCCAG(A/G)GTTCC upstream-variant-2KB
rs1000993940 -- 57,573,504(+) GACCG(C/T)ACATG reference, missense
rs1001201647 -- 57,576,982(+) TGTGA(G/T)TCCCA intron-variant
rs1001881866 -- 57,576,648(+) TCTTA(A/G)GTCAC intron-variant

Variation tolerance for ZNF416 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF416 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF416 Gene

Disorders for ZNF416 Gene

Relevant External Links for ZNF416

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF416 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF416 Gene

Publications for ZNF416 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ZNF416 Gene

Sources for ZNF416 Gene

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