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Aliases for ZNF415 Gene

Aliases for ZNF415 Gene

  • Zinc Finger Protein 415 2 3 5

External Ids for ZNF415 Gene

Previous GeneCards Identifiers for ZNF415 Gene

  • GC19M058287
  • GC19M058302
  • GC19M053611
  • GC19M049935

Summaries for ZNF415 Gene

GeneCards Summary for ZNF415 Gene

ZNF415 (Zinc Finger Protein 415) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF415 Gene

  • Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF415 Gene

Genomics for ZNF415 Gene

Regulatory Elements for ZNF415 Gene

Promoters for ZNF415 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF415 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF415 gene promoter:

Genomic Location for ZNF415 Gene

Chromosome:
19
Start:
53,107,879 bp from pter
End:
53,133,077 bp from pter
Size:
25,199 bases
Orientation:
Minus strand

Genomic View for ZNF415 Gene

Genes around ZNF415 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF415 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF415 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF415 Gene

Proteins for ZNF415 Gene

  • Protein details for ZNF415 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q09FC8-ZN415_HUMAN
    Recommended name:
    Zinc finger protein 415
    Protein Accession:
    Q09FC8
    Secondary Accessions:
    • F5H287
    • Q09FC7
    • Q09FC9
    • Q09FD0
    • Q6NSZ2
    • Q6P3S0
    • Q9NUR2

    Protein attributes for ZNF415 Gene

    Size:
    603 amino acids
    Molecular mass:
    68798 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF415 Gene

neXtProt entry for ZNF415 Gene

Proteomics data for ZNF415 Gene at MOPED

Post-translational modifications for ZNF415 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF415 Gene

Domains & Families for ZNF415 Gene

Gene Families for ZNF415 Gene

Protein Domains for ZNF415 Gene

Suggested Antigen Peptide Sequences for ZNF415 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q09FC8

UniProtKB/Swiss-Prot:

ZN415_HUMAN :
  • Contains 12 C2H2-type zinc fingers.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF415: view

Function for ZNF415 Gene

Molecular function for ZNF415 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.

Gene Ontology (GO) - Molecular Function for ZNF415 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF415: view
genes like me logo Genes that share phenotypes with ZNF415: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF415 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF415
  • Consensus sequence: GRTGMTRGAGCC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF415 Gene

Localization for ZNF415 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF415 Gene

Nucleus. Cytoplasm. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF415 Gene COMPARTMENTS Subcellular localization image for ZNF415 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF415 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF415: view

Pathways & Interactions for ZNF415 Gene

SuperPathways for ZNF415 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF415: view

Pathways by source for ZNF415 Gene

2 Reactome pathways for ZNF415 Gene

Gene Ontology (GO) - Biological Process for ZNF415 Gene

None

No data available for SIGNOR curated interactions for ZNF415 Gene

Drugs & Compounds for ZNF415 Gene

No Compound Related Data Available

Transcripts for ZNF415 Gene

Unigene Clusters for ZNF415 Gene

Zinc finger protein 415:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF415 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18: - - - -
SP19: - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - - - - -
SP22: - - - -
SP23: - - - - - - - - - - - - - - - - -

ExUns: 10h · 10i · 10j · 10k · 10l · 10m · 10n
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for ZNF415 Gene

GeneLoc Exon Structure for
ZNF415
ECgene alternative splicing isoforms for
ZNF415

Expression for ZNF415 Gene

mRNA expression in normal human tissues for ZNF415 Gene

Protein differential expression in normal tissues from HIPED for ZNF415 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF415 Gene



SOURCE GeneReport for Unigene cluster for ZNF415 Gene Hs.147765

mRNA Expression by UniProt/SwissProt for ZNF415 Gene

Q09FC8-ZN415_HUMAN
Tissue specificity: Expressed in all tissues examined. Isoforms are differentially expressed. Isoform 3 and isoform 5 were highly expressed, isoform 4 moderately expressed, isoform 2 lower expression, the lowest expression level was seem with isoform 1.
genes like me logo Genes that share expression patterns with ZNF415: view

Protein tissue co-expression partners for ZNF415 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF415 Gene

Orthologs for ZNF415 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF415 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF415 35
  • 99.46 (n)
  • 99.1 (a)
ZNF415 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 39 (a)
ManyToMany
LOC788599 35
  • 67.75 (n)
  • 53.93 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 52 (a)
ManyToMany
Species with no ortholog for ZNF415:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF415 Gene

ENSEMBL:
Gene Tree for ZNF415 (if available)
TreeFam:
Gene Tree for ZNF415 (if available)

Paralogs for ZNF415 Gene

Pseudogenes.org Pseudogenes for ZNF415 Gene

genes like me logo Genes that share paralogs with ZNF415: view

Variants for ZNF415 Gene

Sequence variations from dbSNP and Humsavar for ZNF415 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs16984466 - 53,109,602(+) GTTCA(C/G/T)GGGGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1054485 - 53,109,504(-) AAATA(A/C)TTTCT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1133327 - 53,109,492(-) CTACC(A/G)TCAAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1560099 - 53,109,467(-) TAAAT(A/G)TGGGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10410030 - 53,108,802(+) TTCAT(C/T)GCATT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF415 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV Deletion 23290073
dgv1116e1 CNV Complex 17122850
nsv428370 CNV Loss 18775914
nsv912342 CNV Gain 21882294
nsv912343 CNV Loss 21882294
dgv3991n71 CNV Gain+Loss 21882294
nsv435700 CNV Deletion 17901297
esv2488809 CNV Deletion 19546169
nsv527053 CNV Gain 19592680
nsv912345 CNV Loss 21882294
nsv470153 CNV Loss 18288195
dgv429n27 CNV Gain 19166990
esv2718810 CNV Deletion 23290073
esv8151 CNV Loss 19470904
nsv515862 CNV Gain+Loss 19592680
dgv3992n71 CNV Gain 21882294
nsv912349 CNV Gain 21882294
esv2228870 CNV Deletion 18987734
esv5924 CNV Loss 19470904
esv1316926 CNV Deletion 17803354
esv2718811 CNV Deletion 23290073
esv1006571 CNV Deletion 20482838
esv23288 CNV Gain 19812545
nsv912350 CNV Gain 21882294

Variation tolerance for ZNF415 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF415 Gene

HapMap Linkage Disequilibrium report
ZNF415

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF415 Gene

Disorders for ZNF415 Gene

Relevant External Links for ZNF415

Genetic Association Database (GAD)
ZNF415
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF415

No disorders were found for ZNF415 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF415 Gene

Publications for ZNF415 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A novel human gene ZNF415 with five isoforms inhibits AP-1- and p53- mediated transcriptional activity. (PMID: 17055453) Cheng Y. … Liu M. (Biochem. Biophys. Res. Commun. 2006) 3

Products for ZNF415 Gene

Sources for ZNF415 Gene

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