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Aliases for ZNF415 Gene

Aliases for ZNF415 Gene

  • Zinc Finger Protein 415 2 3 5
  • ZfLp 3

External Ids for ZNF415 Gene

Previous GeneCards Identifiers for ZNF415 Gene

  • GC19M058287
  • GC19M058302
  • GC19M053611
  • GC19M049935

Summaries for ZNF415 Gene

GeneCards Summary for ZNF415 Gene

ZNF415 (Zinc Finger Protein 415) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF813.

UniProtKB/Swiss-Prot for ZNF415 Gene

  • Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF415 Gene

Genomics for ZNF415 Gene

Regulatory Elements for ZNF415 Gene

Enhancers for ZNF415 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053129 1.3 FANTOM5 ENCODE dbSUPER 35.5 +1.8 1790 4.4 GATAD2A SOX5 SOX13 MXI1 FOXA2 SAP130 NRF1 FOXA3 CEBPG RBBP5 ZNF415 ZNF160 ZNF665 VN1R103P ZNF347 LOC105372454
GH19G053097 1.3 ENCODE dbSUPER 20.3 +32.2 32159 7.3 HDGF ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 ZNF415 ZNF160 ZNF347 TPM3P6 GC19M053068
GH19G053618 1.2 Ensembl ENCODE 13.1 -487.7 -487735 4.7 FOXA2 MLX ARID4B ZNF48 SP5 MIER2 PPARG KAT8 SREBF1 MIER3 ZNF415 LOC284379 OSTCP3 RN7SL317P
GH19G053093 1 ENCODE dbSUPER 10.9 +37.7 37680 3.1 SOX13 ZMYM3 CEBPG ZNF384 THRB TEAD3 GATA3 ZNF316 MAFK GATAD2A ZNF160 ZNF347 ZNF415 GC19M053068
GH19G053076 0.6 ENCODE 16.4 +56.1 56105 0.8 SOX13 CTCF FOXA3 TEAD4 HLF CEBPB CEBPG RAD21 CEBPA SMC3 ZNF415 ZNF160 GC19M053068
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF415 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF415 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111352 377 1400 MXI1 POLR2A NRF1 RBBP5 ETS1

Transcription factor binding sites by QIAGEN in the ZNF415 gene promoter:

Genomic Location for ZNF415 Gene

Chromosome:
19
Start:
53,107,879 bp from pter
End:
53,133,077 bp from pter
Size:
25,199 bases
Orientation:
Minus strand

Genomic View for ZNF415 Gene

Genes around ZNF415 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF415 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF415 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF415 Gene

Proteins for ZNF415 Gene

  • Protein details for ZNF415 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q09FC8-ZN415_HUMAN
    Recommended name:
    Zinc finger protein 415
    Protein Accession:
    Q09FC8
    Secondary Accessions:
    • F5H287
    • Q09FC7
    • Q09FC9
    • Q09FD0
    • Q6NSZ2
    • Q6P3S0
    • Q9NUR2

    Protein attributes for ZNF415 Gene

    Size:
    603 amino acids
    Molecular mass:
    68798 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF415 Gene

neXtProt entry for ZNF415 Gene

Post-translational modifications for ZNF415 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF415 Gene

Domains & Families for ZNF415 Gene

Gene Families for ZNF415 Gene

Protein Domains for ZNF415 Gene

Suggested Antigen Peptide Sequences for ZNF415 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF415: view

No data available for UniProtKB/Swiss-Prot for ZNF415 Gene

Function for ZNF415 Gene

Molecular function for ZNF415 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.

Gene Ontology (GO) - Molecular Function for ZNF415 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF415: view
genes like me logo Genes that share phenotypes with ZNF415: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF415 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF415
  • Consensus sequence: GRTGMTRGAGCC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF415 Gene

Localization for ZNF415 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF415 Gene

Nucleus. Cytoplasm. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF415 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF415 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF415: view

Pathways & Interactions for ZNF415 Gene

SuperPathways for ZNF415 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF415: view

Pathways by source for ZNF415 Gene

2 Reactome pathways for ZNF415 Gene

Gene Ontology (GO) - Biological Process for ZNF415 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF415: view

No data available for SIGNOR curated interactions for ZNF415 Gene

Transcripts for ZNF415 Gene

Unigene Clusters for ZNF415 Gene

Zinc finger protein 415:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF415 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18: - - - -
SP19: - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - - - - -
SP22: - - - -
SP23: - - - - - - - - - - - - - - - - -

ExUns: 10h · 10i · 10j · 10k · 10l · 10m · 10n
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for ZNF415 Gene

GeneLoc Exon Structure for
ZNF415
ECgene alternative splicing isoforms for
ZNF415

Expression for ZNF415 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF415 Gene

Protein differential expression in normal tissues from HIPED for ZNF415 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF415 Gene



Protein tissue co-expression partners for ZNF415 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF415 Gene:

ZNF415

SOURCE GeneReport for Unigene cluster for ZNF415 Gene:

Hs.147765

mRNA Expression by UniProt/SwissProt for ZNF415 Gene:

Q09FC8-ZN415_HUMAN
Tissue specificity: Expressed in all tissues examined. Isoforms are differentially expressed. Isoform 3 and isoform 5 were highly expressed, isoform 4 moderately expressed, isoform 2 lower expression, the lowest expression level was seem with isoform 1.

Evidence on tissue expression from TISSUES for ZNF415 Gene

  • Nervous system(4.7)
  • Heart(4.3)
genes like me logo Genes that share expression patterns with ZNF415: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF415 Gene

Orthologs for ZNF415 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF415 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF415 34 35
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia LOC788599 34
  • 67.75 (n)
-- 35
  • 39 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 52 (a)
ManyToMany
Species where no ortholog for ZNF415 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF415 Gene

ENSEMBL:
Gene Tree for ZNF415 (if available)
TreeFam:
Gene Tree for ZNF415 (if available)

Paralogs for ZNF415 Gene

Pseudogenes.org Pseudogenes for ZNF415 Gene

genes like me logo Genes that share paralogs with ZNF415: view

Variants for ZNF415 Gene

Sequence variations from dbSNP and Humsavar for ZNF415 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000156017 -- 53,121,936(+) ACCAG(C/G)TATTT intron-variant
rs1000220764 -- 53,118,123(+) TATTA(C/T)ATGCA intron-variant
rs1000494431 -- 53,122,943(+) CAGAA(-/CTCCCTC)CCCTC intron-variant
rs1000568842 -- 53,115,074(+) CTCAA(A/G)CCTGT intron-variant
rs1000599906 -- 53,114,791(+) CCCAC(A/G)AACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF415 Gene

Variant ID Type Subtype PubMed ID
dgv1811n106 CNV deletion 24896259
dgv429n27 CNV gain 19166990
dgv6533n54 CNV gain 21841781
dgv6534n54 CNV loss 21841781
esv1006571 CNV deletion 20482838
esv1316926 CNV deletion 17803354
esv2228870 CNV deletion 18987734
esv23288 CNV gain 19812545
esv2488809 CNV deletion 19546169
esv2718787 CNV deletion 23290073
esv2718810 CNV deletion 23290073
esv2718811 CNV deletion 23290073
esv2758769 CNV loss 17122850
esv3556583 CNV deletion 23714750
esv3574742 CNV gain 25503493
esv3644737 CNV loss 21293372
esv3644738 CNV gain 21293372
esv3893239 CNV gain+loss 25118596
esv5924 CNV loss 19470904
esv8151 CNV loss 19470904
nsv1061016 CNV gain 25217958
nsv1071944 CNV deletion 25765185
nsv1078889 OTHER inversion 25765185
nsv1141887 OTHER inversion 24896259
nsv1149806 CNV deletion 26484159
nsv428370 CNV loss 18775914
nsv435700 CNV deletion 17901297
nsv470153 CNV loss 18288195
nsv515862 CNV gain+loss 19592680
nsv527053 CNV gain 19592680
nsv580068 CNV gain 21841781
nsv580071 CNV gain+loss 21841781
nsv954616 CNV deletion 24416366
nsv960864 CNV duplication 23825009
nsv960865 CNV duplication 23825009

Variation tolerance for ZNF415 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF415 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF415

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF415 Gene

Disorders for ZNF415 Gene

Relevant External Links for ZNF415

Genetic Association Database (GAD)
ZNF415
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF415

No disorders were found for ZNF415 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF415 Gene

Publications for ZNF415 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. A novel human gene ZNF415 with five isoforms inhibits AP-1- and p53- mediated transcriptional activity. (PMID: 17055453) Cheng Y. … Liu M. (Biochem. Biophys. Res. Commun. 2006) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Functional characterization and substrate specificity of a novel gene encoding zinc finger-like protein, ZfLp, in Xenopus laevis oocytes. (PMID: 22863851) Kobayashi Y. … Yamamoto T. (J Toxicol Sci 2012) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for ZNF415 Gene

Sources for ZNF415 Gene

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