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ZNF414 Gene

protein-coding   GIFtS: 42
GCID: GC19M008575

Zinc Finger Protein 414

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 4141 2
ZFP4142

External Ids:    HGNC: 206301   Entrez Gene: 843302   Ensembl: ENSG000001332507   UniProtKB: Q96IQ93   

Export aliases for ZNF414 gene to outside databases

Previous GC identifers: GC19M008483 GC19M008230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF414 Gene:
ZNF414 (zinc finger protein 414) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZN414_HUMAN, Q96IQ9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF414 gene promoter:
         AML1a   Tal-1   MIF-1   c-Ets-1   E47   Max   AREB6   FOXC1   HSF1short   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF414 promoter sequence
   Search Chromatin IP Primers for ZNF414

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF414


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF414 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF414 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M008575:  view genomic region     (about GC identifiers)

Start:
8,575,462 bp from pter      End:
8,579,048 bp from pter
Size:
3,587 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN414_HUMAN, Q96IQ9 (See protein sequence)
Recommended Name: Zinc finger protein 414  
Size: 312 amino acids; 32782 Da
Secondary accessions: A8MY94
Alternative splicing: 2 isoforms:  Q96IQ9-1   Q96IQ9-2   (No experimental confirmation available. Ref.1 (AK074191) sequence is in conflict in position: 357:A->P)

Explore the universe of human proteins at neXtProt for ZNF414: NX_Q96IQ9

Explore proteomics data for ZNF414 at MOPED


See ZNF414 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001139647.1  NP_115746.2  

ENSEMBL proteins: 
 ENSP00000377504   ENSP00000471378   ENSP00000473079   ENSP00000471863   ENSP00000255616  
 ENSP00000472741  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

2 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96IQ9

ProtoNet protein and cluster: Q96IQ9

UniProtKB/Swiss-Prot: ZN414_HUMAN, Q96IQ9
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 3 C2H2-type zinc fingers


Find genes that share domains with ZNF414           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN414_HUMAN, Q96IQ9
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF414           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN414_HUMAN, Q96IQ9: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with ZNF414           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF414
Interactions:

    Search GeneGlobe Interaction Network for ZNF414

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ZNF414 (Q96IQ92, 3 ENSP000002556164) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TEX11Q8IYF32, 3, ENSP000003409954MINT-66475 I2D: score=5 STRING: ENSP00000340995
TERF2IPENSP000003000864STRING: ENSP00000300086
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with ZNF414           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZNF414 (ZN414)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF414 gene (2 alternative transcripts): 
NM_001146175.1  NM_032370.2  

Unigene Cluster for ZNF414:

Zinc finger protein 414
Hs.515114  [show with all ESTs]
Unigene Representative Sequence: BM544073
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000393927(uc002mke.4) ENST00000596772 ENST00000595348 ENST00000593661
ENST00000594748 ENST00000255616(uc010dwf.3 uc002mkf.3) ENST00000602128
ENST00000599379 ENST00000600906
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hsa-miR-1323 hsa-miR-548o
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Inhib. RNA
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Additional mRNA sequence: 

AK074191.1 AK225034.1 BC007310.1 BC071937.1 

7 DOTS entries:

DT.448638  DT.443753  DT.95075737  DT.75100785  DT.100777168  DT.121419718  DT.75147296 

Selected AceView cDNA sequences (see all 169):

AI521322 BM142086 AI361028 CD671137 CK819885 AI524209 BM712885 BQ186665 
BE549583 BQ186719 AI097099 BQ185933 CD675594 AW005460 BM930236 AW137455 
BM931231 AW188937 BQ773835 AI269258 CF540984 BU633355 CA310546 AW138380 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF414 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGCCAGCCTA
ZNF414 Expression
About this image

ZNF414 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF414 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.515114
    Custom PCR Arrays for ZNF414
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF414 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zfp4141 , 5 zinc finger protein 4141, 5 80(n)1
81.02(a)1
  17 (17.98 cM)5
3288011  NM_026712.31  NP_080988.11 
 336290905 
chicken
(Gallus gallus)
Aves ZNF4146
zinc finger protein 414
34(a)
1 ↔ 1
28(1722253-1725804)
zebrafish
(Danio rerio)
Actinopterygii ZNF4146
zinc finger protein 414
31(a)
1 ↔ 1
2(22451602-22461949) ENSDARG00000079229


ENSEMBL Gene Tree for ZNF414 (if available)
TreeFam Gene Tree for ZNF414 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF414 (see all 186)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs116717681,2
C,H--8575118(+) GCAGTC/GAGAGG 1 -- int12Minor allele frequency- G:0.25WA NA 4
rs2010529761,2
--8575168(+) GACTG-/TCTCAAA 1 -- int10--------
rs1496754391,2
--8575170(+) CTGTCA/TCAAAA 1 -- int10--------
rs1468394141,2
--8575192(+) AAAAA-/GAAAAA 1 -- int10--------
rs2012032791,2
C--8575192(+) AAAAAA/GAAAAA 1 -- int10--------
rs1484346731,2
--8575380(+) AGGTGA/GTCCTC 1 -- int10--------
rs29104421,2
C--8575399(+) TGATCA/GATCCA 1 -- int14Minor allele frequency- G:0.20WA NA EA 360
rs29675741,2
C,F--8575400(+) GATCAA/C/GTCCAT 1 -- int16WA CSA NA EA 364
rs739221241,2
C,F--8575421(+) CTCGAG/ACCCAC 1 -- int12Minor allele frequency- A:0.04WA 120
rs1142331591,2
C,F--8575429(+) CACTAT/CGCTTT 1 -- int11Minor allele frequency- C:0.01WA 118

HapMap Linkage Disequilibrium report for ZNF414 (8575462 - 8579048 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for ZNF414:    About this table    
Variant IDTypeSubtypePubMed ID
dgv3721n71CNV Loss21882294
dgv3720n71CNV Loss21882294
nsv458350CNV Loss19166990
nsv911004CNV Loss21882294
dgv396n27CNV Loss19166990
dgv3722n71CNV Loss21882294
dgv3723n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF414 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF414)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84330 HGNC: 20630 AceView: MGC15716 Ensembl:ENSG00000133250 euGenes: HUgn84330
ECgene: ZNF414 H-InvDB: ZNF414

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF414 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF414 gene:
Search GeneIP for patents involving ZNF414

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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