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Aliases for ZNF414 Gene

Aliases for ZNF414 Gene

  • Zinc Finger Protein 414 2 3 5
  • ZFP414 3

External Ids for ZNF414 Gene

Previous GeneCards Identifiers for ZNF414 Gene

  • GC19M008483
  • GC19M008230
  • GC19M008575

Summaries for ZNF414 Gene

GeneCards Summary for ZNF414 Gene

ZNF414 (Zinc Finger Protein 414) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF414 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF414 Gene

Genomics for ZNF414 Gene

Regulatory Elements for ZNF414 Gene

Enhancers for ZNF414 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F008353 0.9 Ensembl ENCODE 33.7 +158.5 158530 4.5 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B FEZF1 YY1 ZNF766 ZNF558 ZNF699 ELAVL1 ZNF559 ZNF414 HNRNPM XAB2 ENSG00000269300 RAB11B ENSG00000267510
GH19F007521 1.1 FANTOM5 ENCODE 30.9 +991.3 991307 2.0 HDGF CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ELAVL1 HNRNPM ZNF414 XAB2 TIMM44 ZNF557 SNAPC2 PEX11G MCOLN1 GC19M007510
GH19F008524 0.5 ENCODE 29.4 -12.0 -11976 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF416 FOS SP3 ELAVL1 HNRNPM ZNF558 ZNF699 ZNF414 ZNF559 XAB2 MYO1F ENSG00000269300 ADAMTS10
GH19F009074 0.6 Ensembl ENCODE 28.8 -561.4 -561373 1.7 PKNOX1 ATF1 ARNT SIN3A ZNF2 GLIS2 GATA2 FOS KDM4B JUNB ZNF414 LOC100419831 UBE2L4 MUC16 ENSG00000267510 ZNF559 ZNF558 HNRNPM ZNF177 OR7G1
GH19F008239 0.8 Ensembl ENCODE 27.9 +273.1 273116 3.3 HDGF PKNOX1 ARNT MLX SIN3A ARID4B ZNF2 YY1 CBX5 ZNF416 HNRNPM ELAVL1 ZNF558 XAB2 ZNF414 CERS4 ENSG00000271717 GC19P008268
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF414 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF414 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042847 64 1401 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207

Genomic Location for ZNF414 Gene

Chromosome:
19
Start:
8,509,678 bp from pter
End:
8,514,164 bp from pter
Size:
4,487 bases
Orientation:
Minus strand

Genomic View for ZNF414 Gene

Genes around ZNF414 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF414 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF414 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF414 Gene

Proteins for ZNF414 Gene

  • Protein details for ZNF414 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IQ9-ZN414_HUMAN
    Recommended name:
    Zinc finger protein 414
    Protein Accession:
    Q96IQ9
    Secondary Accessions:
    • A8MY94

    Protein attributes for ZNF414 Gene

    Size:
    312 amino acids
    Molecular mass:
    32782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF414 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF414 Gene

Post-translational modifications for ZNF414 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF414 Gene

No data available for DME Specific Peptides for ZNF414 Gene

Domains & Families for ZNF414 Gene

Gene Families for ZNF414 Gene

Protein Domains for ZNF414 Gene

Suggested Antigen Peptide Sequences for ZNF414 Gene

Graphical View of Domain Structure for InterPro Entry

Q96IQ9

UniProtKB/Swiss-Prot:

ZN414_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF414: view

Function for ZNF414 Gene

Molecular function for ZNF414 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21044950
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF414: view
genes like me logo Genes that share phenotypes with ZNF414: view

Animal Model Products

miRNA for ZNF414 Gene

miRTarBase miRNAs that target ZNF414

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF414 Gene

Localization for ZNF414 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF414 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF414 Gene COMPARTMENTS Subcellular localization image for ZNF414 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF414: view

Pathways & Interactions for ZNF414 Gene

SuperPathways for ZNF414 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF414: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF414 Gene

Transcripts for ZNF414 Gene

Unigene Clusters for ZNF414 Gene

Zinc finger protein 414:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF414 Gene

No ASD Table

Relevant External Links for ZNF414 Gene

GeneLoc Exon Structure for
ZNF414
ECgene alternative splicing isoforms for
ZNF414

Expression for ZNF414 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF414 Gene

Protein differential expression in normal tissues from HIPED for ZNF414 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.4) and Pancreatic juice (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF414 Gene



Protein tissue co-expression partners for ZNF414 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF414 Gene:

ZNF414

SOURCE GeneReport for Unigene cluster for ZNF414 Gene:

Hs.515114
genes like me logo Genes that share expression patterns with ZNF414: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF414 Gene

Orthologs for ZNF414 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF414 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF414 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia ZNF414 34 35
  • 88.46 (n)
cow
(Bos Taurus)
Mammalia ZNF414 34 35
  • 87.4 (n)
rat
(Rattus norvegicus)
Mammalia Zfp414 34
  • 81.19 (n)
mouse
(Mus musculus)
Mammalia Zfp414 34 16 35
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF414 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF414 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF414 35
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZNF414 35
  • 31 (a)
OneToOne
Species where no ortholog for ZNF414 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF414 Gene

ENSEMBL:
Gene Tree for ZNF414 (if available)
TreeFam:
Gene Tree for ZNF414 (if available)

Paralogs for ZNF414 Gene

No data available for Paralogs for ZNF414 Gene

Variants for ZNF414 Gene

Sequence variations from dbSNP and Humsavar for ZNF414 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10408347 -- 8,515,086(+) gacgt(C/G)gaggc upstream-variant-2KB
rs10419077 -- 8,512,468(+) AGCTC(A/G)GGGCT reference, missense
rs1064009 -- 8,513,234(-) GCCCC(C/T)TCCTC reference, synonymous-codon
rs1064010 -- 8,513,116(-) GCCAG(C/T)CTGGC reference, missense
rs112096930 -- 8,512,989(+) TGTTT(C/T)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF414 Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
nsv458350 CNV loss 19166990
nsv578559 CNV loss 21841781
nsv953966 CNV deletion 24416366

Variation tolerance for ZNF414 Gene

Gene Damage Index Score: 10.24; 90.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF414 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF414

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF414 Gene

Disorders for ZNF414 Gene

Relevant External Links for ZNF414

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF414

No disorders were found for ZNF414 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF414 Gene

Publications for ZNF414 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZNF414 Gene

Sources for ZNF414 Gene

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