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Aliases for ZNF414 Gene

Aliases for ZNF414 Gene

  • Zinc Finger Protein 414 2 3 5
  • ZFP414 3

External Ids for ZNF414 Gene

Previous GeneCards Identifiers for ZNF414 Gene

  • GC19M008483
  • GC19M008230
  • GC19M008575

Summaries for ZNF414 Gene

GeneCards Summary for ZNF414 Gene

ZNF414 (Zinc Finger Protein 414) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF414 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF414 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF414 Gene

Genomics for ZNF414 Gene

Regulatory Elements for ZNF414 Gene

Enhancers for ZNF414 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H008239 1.6 Ensembl ENCODE dbSUPER 27.9 +273.7 273740 2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B ZNF2 YY1 CBX5 ZNF416 ZNF558 HNRNPM ELAVL1 ZNF317 XAB2 ENSG00000269300 ZNF414 CERS4 ARHGEF18 MAP2K7
GH19H008524 1.3 ENCODE dbSUPER 29.4 -12.0 -11976 2.4 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF416 ZNF143 HNRNPM ELAVL1 ZNF558 ZNF699 ZNF317 ZNF266 ZNF559 XAB2 ZNF414 ENSG00000269300
GH19H008511 1.7 FANTOM5 ENCODE dbSUPER 22 -1.9 -1902 8.4 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 CBX5 ZNF143 XAB2 ZNF414 ZNF317 MYO1F ZNF177 ZNF266 PRAM1 HNRNPM MAP2K7 ENSG00000267273
GH19H008608 1.4 FANTOM5 ENCODE 19 -96.6 -96633 4.7 HDGF ATF1 FOXA2 SIN3A DMAP1 ZNF2 ZNF121 GLIS2 KLF7 KAT8 ZNF266 ZNF699 ZNF317 XAB2 ZNF558 ZNF559 HNRNPM ZNF177 ELAVL1 ZNF414
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF414 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF414 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106845 64 1001 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207

Genomic Locations for ZNF414 Gene

Genomic Locations for ZNF414 Gene
4,487 bases
Minus strand

Genomic View for ZNF414 Gene

Genes around ZNF414 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF414 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF414 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF414 Gene

Proteins for ZNF414 Gene

  • Protein details for ZNF414 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 414
    Protein Accession:
    Secondary Accessions:
    • A8MY94

    Protein attributes for ZNF414 Gene

    312 amino acids
    Molecular mass:
    32782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF414 Gene


neXtProt entry for ZNF414 Gene

Post-translational modifications for ZNF414 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF414 Gene

No data available for DME Specific Peptides for ZNF414 Gene

Domains & Families for ZNF414 Gene

Gene Families for ZNF414 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF414 Gene

Suggested Antigen Peptide Sequences for ZNF414 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF414: view

Function for ZNF414 Gene

Molecular function for ZNF414 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF414 Gene

Gene Ontology (GO) - Molecular Function for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21044950
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF414: view
genes like me logo Genes that share phenotypes with ZNF414: view

Animal Model Products

miRNA for ZNF414 Gene

miRTarBase miRNAs that target ZNF414

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF414 Gene

Localization for ZNF414 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF414 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF414 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF414: view

Pathways & Interactions for ZNF414 Gene

SuperPathways for ZNF414 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF414: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF414 Gene

Drugs & Compounds for ZNF414 Gene

No Compound Related Data Available

Transcripts for ZNF414 Gene

Unigene Clusters for ZNF414 Gene

Zinc finger protein 414:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF414 Gene

No ASD Table

Relevant External Links for ZNF414 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF414 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF414 Gene

Protein differential expression in normal tissues from HIPED for ZNF414 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.4) and Pancreatic juice (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF414 Gene

Protein tissue co-expression partners for ZNF414 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF414 Gene:


SOURCE GeneReport for Unigene cluster for ZNF414 Gene:


Evidence on tissue expression from TISSUES for ZNF414 Gene

  • Eye(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with ZNF414: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF414 Gene

Orthologs for ZNF414 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF414 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF414 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia ZNF414 33 34
  • 88.46 (n)
(Bos Taurus)
Mammalia ZNF414 33 34
  • 87.4 (n)
(Rattus norvegicus)
Mammalia Zfp414 33
  • 81.19 (n)
(Mus musculus)
Mammalia Zfp414 33 16 34
  • 80 (n)
(Monodelphis domestica)
Mammalia ZNF414 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF414 34
  • 55 (a)
(Gallus gallus)
Aves ZNF414 34
  • 34 (a)
(Danio rerio)
Actinopterygii ZNF414 34
  • 31 (a)
Species where no ortholog for ZNF414 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF414 Gene

Gene Tree for ZNF414 (if available)
Gene Tree for ZNF414 (if available)

Paralogs for ZNF414 Gene

No data available for Paralogs for ZNF414 Gene

Variants for ZNF414 Gene

Sequence variations from dbSNP and Humsavar for ZNF414 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000887123 -- 8,511,029(+) CCTGC(G/T)GGCAG intron-variant
rs1001164823 -- 8,511,997(+) GGCCT(C/T)CAGGG intron-variant
rs1001887416 -- 8,512,260(+) CGGGG(A/C)TTCCC intron-variant
rs1001918505 -- 8,511,983(+) GCTGG(C/G)CTGGG intron-variant
rs1002900278 -- 8,513,268(+) ACACC(A/T)CCTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF414 Gene

Variant ID Type Subtype PubMed ID
nsv953966 CNV deletion 24416366
nsv578559 CNV loss 21841781
nsv458350 CNV loss 19166990
dgv6258n54 CNV loss 21841781
dgv396n27 CNV loss 19166990
dgv137n111 CNV deletion 26073780

Variation tolerance for ZNF414 Gene

Gene Damage Index Score: 10.24; 90.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF414 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF414 Gene

Disorders for ZNF414 Gene

Relevant External Links for ZNF414

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF414 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF414 Gene

Publications for ZNF414 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee OH … Songyang Z (Molecular & cellular proteomics : MCP 2011) 3 60

Products for ZNF414 Gene

Sources for ZNF414 Gene

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