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Aliases for ZNF410 Gene

Aliases for ZNF410 Gene

  • Zinc Finger Protein 410 2 3 5
  • Another Partner For ARF 1 3 4
  • Zinc Finger Protein APA-1 3 4
  • APA1 3 4
  • Clones 23667 And 23775 Zinc Finger Protein 3
  • APA-1 3

External Ids for ZNF410 Gene

Previous GeneCards Identifiers for ZNF410 Gene

  • GC14P072344
  • GC14P072345
  • GC14P073423
  • GC14P074353
  • GC14P054520

Summaries for ZNF410 Gene

GeneCards Summary for ZNF410 Gene

ZNF410 (Zinc Finger Protein 410) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF143.

UniProtKB/Swiss-Prot for ZNF410 Gene

  • Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF410 Gene

Genomics for ZNF410 Gene

Regulatory Elements for ZNF410 Gene

Enhancers for ZNF410 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F073748 1.6 FANTOM5 ENCODE 20.6 -129.0 -128990 17.4 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ELMSAN1 PNMA1 ZNF410 LOC100420966 LOC100506476 FCF1 RBM25 PTGR2 ENSG00000223300 ENSG00000259005
GH14F073829 1.2 Ensembl ENCODE 10.8 -56.5 -56549 1.9 ATF1 MLX ARID4B DMAP1 BRCA1 ZNF48 FOS PAF1 MXD4 JUNB LOC100506476 ELMSAN1 PTGR2 ENSG00000223300 PNMA1 ZNF410 LOC100506498 GC14P073807
GH14F073849 1.1 ENCODE 11.2 -35.0 -35030 3.5 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF207 ZNF263 SP3 LOC100506476 PTGR2 ZNF410 PNMA1 ENTPD5 FAM161B ENSG00000270576
GH14F073825 1.1 Ensembl ENCODE 10.7 -61.1 -61114 1.0 ARID4B THRB ZNF2 RAD21 ZNF143 THAP11 ZNF654 SP5 CEBPB MIER2 LOC100506476 ELMSAN1 PTGR2 ENSG00000223300 PNMA1 ZNF410 LOC100506498 GC14P073807
GH14F073782 1.1 ENCODE 10.4 -99.5 -99532 9.2 PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LOC100506476 PTGR2 FAM161B PNMA1 ENSG00000223300 ZNF410 LIN52 ACOT1 BBOF1 GC14P073786
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF410 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF410 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000420786 585 3201 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS

Genomic Location for ZNF410 Gene

Chromosome:
14
Start:
73,886,615 bp from pter
End:
73,932,511 bp from pter
Size:
45,897 bases
Orientation:
Plus strand

Genomic View for ZNF410 Gene

Genes around ZNF410 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF410 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF410 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF410 Gene

Proteins for ZNF410 Gene

  • Protein details for ZNF410 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VK4-ZN410_HUMAN
    Recommended name:
    Zinc finger protein 410
    Protein Accession:
    Q86VK4
    Secondary Accessions:
    • B4DDV5
    • B4DR78
    • O00153
    • Q9BQ19

    Protein attributes for ZNF410 Gene

    Size:
    478 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    • Interacts with CDKN2A/p14ARF.

    Alternative splice isoforms for ZNF410 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF410 Gene

Post-translational modifications for ZNF410 Gene

  • Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF410 Gene

Domains & Families for ZNF410 Gene

Gene Families for ZNF410 Gene

Protein Domains for ZNF410 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VK4

UniProtKB/Swiss-Prot:

ZN410_HUMAN :
  • Contains 5 C2H2-type zinc fingers.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF410: view

Function for ZNF410 Gene

Molecular function for ZNF410 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
UniProtKB/Swiss-Prot Induction:
During fibroblast senescence.

Gene Ontology (GO) - Molecular Function for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF410: view

Phenotypes for ZNF410 Gene

genes like me logo Genes that share phenotypes with ZNF410: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF410 Gene

Localization for ZNF410 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF410 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF410 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF410: view

Pathways & Interactions for ZNF410 Gene

SuperPathways for ZNF410 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF410: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF410 Gene

Transcripts for ZNF410 Gene

Unigene Clusters for ZNF410 Gene

Zinc finger protein 410:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF410 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d ·
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6:
SP7:
SP8: - - - - - -
SP9: - - -
SP10: - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - -
SP15: - -
SP16: - - - -
SP17: - - - - - - - - - - - - - - - - -
SP18: -
SP19:
SP20: - - - - - - - - - - - -
SP21: - - - - - - - -
SP22:
SP23: - - - - - - - -
SP24:
SP25:

ExUns: 10e · 10f ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4:
SP5:
SP6: - -
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:
SP22: - -
SP23:
SP24: - - - - - -
SP25: - - -

Relevant External Links for ZNF410 Gene

GeneLoc Exon Structure for
ZNF410
ECgene alternative splicing isoforms for
ZNF410

Expression for ZNF410 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF410 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF410 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF410 Gene:

ZNF410

SOURCE GeneReport for Unigene cluster for ZNF410 Gene:

Hs.270869

mRNA Expression by UniProt/SwissProt for ZNF410 Gene:

Q86VK4-ZN410_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZNF410: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF410 Gene

Orthologs for ZNF410 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF410 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF410 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia ZNF410 34 35
  • 94.35 (n)
cow
(Bos Taurus)
Mammalia ZNF410 34 35
  • 93.93 (n)
mouse
(Mus musculus)
Mammalia Zfp410 34 16 35
  • 91.28 (n)
rat
(Rattus norvegicus)
Mammalia Zfp410 34
  • 91.14 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF410 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF410 34 35
  • 80.68 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF410 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf410 34
  • 67.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16594 34
zebrafish
(Danio rerio)
Actinopterygii znf410 34 35
  • 63.43 (n)
Dr.14332 34
Species where no ortholog for ZNF410 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF410 Gene

ENSEMBL:
Gene Tree for ZNF410 (if available)
TreeFam:
Gene Tree for ZNF410 (if available)

Paralogs for ZNF410 Gene

Pseudogenes.org Pseudogenes for ZNF410 Gene

genes like me logo Genes that share paralogs with ZNF410: view

Variants for ZNF410 Gene

Sequence variations from dbSNP and Humsavar for ZNF410 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1013644 -- 73,900,861(-) CAGCT(A/G)GTGAG intron-variant
rs10142980 -- 73,905,944(+) ATATA(C/T)ACACA intron-variant
rs10143057 -- 73,905,982(+) aTATA(C/T)ATATA intron-variant
rs10151095 -- 73,899,602(+) TGCCA(A/G)TGAGA intron-variant
rs10151507 -- 73,899,776(+) gttat(A/G)gagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF410 Gene

Variant ID Type Subtype PubMed ID
dgv663e212 CNV loss 25503493
esv3634923 CNV loss 21293372
esv3634924 CNV loss 21293372
nsv1035460 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv1116033 CNV deletion 24896259
nsv826992 CNV loss 20364138
nsv826993 CNV loss 20364138

Variation tolerance for ZNF410 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF410 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF410

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF410 Gene

Disorders for ZNF410 Gene

Relevant External Links for ZNF410

Genetic Association Database (GAD)
ZNF410
Human Genome Epidemiology (HuGE) Navigator
ZNF410
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF410

No disorders were found for ZNF410 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF410 Gene

Publications for ZNF410 Gene

  1. Induction of extracellular matrix-remodeling genes by the senescence- associated protein APA-1. (PMID: 12370286) Benanti J.A. … Galloway D.A. (Mol. Cell. Biol. 2002) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4 64
  5. [Apa1 VDR polymorphism and osteoporosis risk in postmenopausal Mexican women]. (PMID: 26290023) CastelA!n-MartA-nez O.D. … Clark P. (Gac Med Mex 2015) 3 64

Products for ZNF410 Gene

Sources for ZNF410 Gene

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