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Aliases for ZNF410 Gene

Aliases for ZNF410 Gene

  • Zinc Finger Protein 410 2 3
  • Another Partner For ARF 1 3 4
  • Zinc Finger Protein APA-1 3 4
  • APA1 3 4
  • Clones 23667 And 23775 Zinc Finger Protein 3
  • APA-1 3

External Ids for ZNF410 Gene

Summaries for ZNF410 Gene

GeneCards Summary for ZNF410 Gene

ZNF410 (Zinc Finger Protein 410) is a Protein Coding gene. An important paralog of this gene is ZIC4.

UniProtKB/Swiss-Prot for ZNF410 Gene

  • Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF410 Gene

Genomics for ZNF410 Gene

Genomic Location for ZNF410 Gene

Start:
73,886,615 bp from pter
End:
73,932,511 bp from pter
Size:
45,897 bases
Orientation:
Plus strand

Genomic View for ZNF410 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF410 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF410 Gene

Regulatory Elements for ZNF410 Gene

Proteins for ZNF410 Gene

  • Protein details for ZNF410 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VK4-ZN410_HUMAN
    Recommended name:
    Zinc finger protein 410
    Protein Accession:
    Q86VK4
    Secondary Accessions:
    • B4DDV5
    • B4DR78
    • O00153
    • Q9BQ19

    Protein attributes for ZNF410 Gene

    Size:
    478 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    • Interacts with CDKN2A/p14ARF.

    Alternative splice isoforms for ZNF410 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF410 Gene

Proteomics data for ZNF410 Gene at MOPED

Post-translational modifications for ZNF410 Gene

  • Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.

No data available for DME Specific Peptides for ZNF410 Gene

Domains for ZNF410 Gene

Gene Families for ZNF410 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF410 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VK4

UniProtKB/Swiss-Prot:

ZN410_HUMAN
Similarity:
  • Contains 5 C2H2-type zinc fingers.:
    • Q86VK4
genes like me logo Genes that share domains with ZNF410: view

Function for ZNF410 Gene

Molecular function for ZNF410 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
UniProtKB/Swiss-Prot Induction: During fibroblast senescence.

Gene Ontology (GO) - Molecular Function for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF410: view

Phenotypes for ZNF410 Gene

GenomeRNAi human phenotypes for ZNF410:
genes like me logo Genes that share phenotypes with ZNF410: view

miRNA for ZNF410 Gene

miRTarBase miRNAs that target ZNF410

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF410 Gene

Localization for ZNF410 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF410 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF410 Gene COMPARTMENTS Subcellular localization image for ZNF410 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF410: view

Pathways for ZNF410 Gene

SuperPathways for ZNF410 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF410: view

No data available for Pathways by source for ZNF410 Gene

Transcripts for ZNF410 Gene

Unigene Clusters for ZNF410 Gene

Zinc finger protein 410:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF410 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d ·
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6:
SP7:
SP8: - - - - - -
SP9: - - -
SP10: - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - -
SP15: - -
SP16: - - - -
SP17: - - - - - - - - - - - - - - - - -
SP18: -
SP19:
SP20: - - - - - - - - - - - -
SP21: - - - - - - - -
SP22:
SP23: - - - - - - - -
SP24:
SP25:

ExUns: 10e · 10f ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4:
SP5:
SP6: - -
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:
SP22: - -
SP23:
SP24: - - - - - -
SP25: - - -

Relevant External Links for ZNF410 Gene

GeneLoc Exon Structure for
ZNF410
ECgene alternative splicing isoforms for
ZNF410

Expression for ZNF410 Gene

mRNA expression in normal human tissues for ZNF410 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF410 Gene

SOURCE GeneReport for Unigene cluster for ZNF410 Gene Hs.270869

mRNA Expression by UniProt/SwissProt for ZNF410 Gene

Q86VK4-ZN410_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with ZNF410: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF410 Gene

Orthologs for ZNF410 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF410 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF410 35
  • 99.86 (n)
  • 99.79 (a)
ZNF410 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF410 35
  • 93.93 (n)
  • 96.15 (a)
ZNF410 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF410 35
  • 94.35 (n)
  • 96.65 (a)
ZNF410 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp410 35
  • 91.28 (n)
  • 94.14 (a)
Zfp410 16
Zfp410 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF410 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp410 35
  • 91.14 (n)
  • 94.35 (a)
chicken
(Gallus gallus)
Aves ZNF410 35
  • 80.68 (n)
  • 89.2 (a)
ZNF410 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF410 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16594 35
tropical clawed frog
(Silurana tropicalis)
Amphibia znf410 35
  • 67.99 (n)
  • 69.69 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14332 35
znf410 35
  • 63.43 (n)
  • 64.24 (a)
znf410 36
  • 57 (a)
OneToOne
Species with no ortholog for ZNF410:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF410 Gene

ENSEMBL:
Gene Tree for ZNF410 (if available)
TreeFam:
Gene Tree for ZNF410 (if available)

Paralogs for ZNF410 Gene

Paralogs for ZNF410 Gene

genes like me logo Genes that share paralogs with ZNF410: view

Variants for ZNF410 Gene

Sequence variations from dbSNP and Humsavar for ZNF410 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs727523 -- 73,911,432(-) GATTG(A/T)TTATA intron-variant
rs758244 -- 73,921,464(-) CCATG(C/T)GGAAA intron-variant
rs917419 -- 73,908,587(-) CAATA(C/T)GGGAG intron-variant
rs1013644 -- 73,900,861(-) CAGCT(A/G)GTGAG intron-variant
rs1043709 -- 73,932,156(+) GCTTT(C/T)TTCGT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF410 Gene

Variant ID Type Subtype PubMed ID
nsv826992 CNV Loss 20364138
nsv826993 CNV Loss 20364138

Relevant External Links for ZNF410 Gene

HapMap Linkage Disequilibrium report
ZNF410

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF410 Gene

Disorders for ZNF410 Gene

Relevant External Links for ZNF410

Genetic Association Database (GAD)
ZNF410
Human Genome Epidemiology (HuGE) Navigator
ZNF410
genes like me logo Genes that share disorders with ZNF410: view

No data available for UniProtKB/Swiss-Prot for ZNF410 Gene

Publications for ZNF410 Gene

  1. Induction of extracellular matrix-remodeling genes by the senescence- associated protein APA-1. (PMID: 12370286) Benanti J.A. … Galloway D.A. (Mol. Cell. Biol. 2002) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF410 Gene

Sources for ZNF410 Gene

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