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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF408 Gene

protein-coding   GIFtS: 45
GCID: GC11P046722

Zinc Finger Protein 408

  Search for ZNF408
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 4081 2
PR Domain Zinc Finger Protein 172 3
PFM143
PRDM173

External Ids:    HGNC: 200411   Entrez Gene: 797972   Ensembl: ENSG000001752137   UniProtKB: Q9H9D43   

Export aliases for ZNF408 gene to outside databases

Previous GC identifers: GC11P047600 GC11P046753 GC11P046686 GC11P046678 GC11P046428


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF408 Gene: 
ZNF408 (zinc finger protein 408) is a protein-coding gene. GO annotations related to this gene include DNA binding and identical protein binding.

UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF408 gene promoter:
         AREB6   CREB   deltaCREB   ATF-2   Lmo2   Nkx2-5   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF408 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF408

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF408


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ZNF408 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF408 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P046722:  view genomic region     (about GC identifiers)

Start:
46,722,317 bp from pter      End:
46,727,466 bp from pter
Size:
5,150 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4 (See protein sequence)
Recommended Name: Zinc finger protein 408  
Size: 720 amino acids; 78439 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF408: NX_Q9H9D4

Explore proteomics data for ZNF408 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H9D4

  • ZNF408 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF408 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171680.1  NP_079017.1  

    ENSEMBL proteins: 
     ENSP00000309606  

    Human Recombinant Protein Products for ZNF408: 
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    Cloud-Clone Corp. Proteins for ZNF408 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF408 for ontologies           About GeneDecksing



    ZNF408 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ZNF408 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H9D4

    ProtoNet protein and cluster: Q9H9D4

    UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4
    Similarity: Contains 10 C2H2-type zinc fingers


    ZNF408 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN408_HUMAN, Q9H9D4
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI14667819
    GO:0008270zinc ion binding ----
    GO:0042802identical protein binding IPI15231747
    GO:0046872metal ion binding IEA--
         
    ZNF408 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF408 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF408 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF408

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for ZNF408 (Q9H9D41, 2, 3 ENSP000003096064) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224979Q9Y3331, 2, 3, ENSP000004140064EBI-347633,EBI-347416 MINT-62595 MINT-62769 MINT-62693 I2D: score=4 STRING: ENSP00000414006
    ENSG00000236826Q9Y3331, 2, 3, ENSP000004146344EBI-347633,EBI-347416 MINT-62595 MINT-62769 MINT-62693 I2D: score=4 STRING: ENSP00000414634
    LSM2Q9Y3331, 2, 3, ENSP000003648134EBI-347633,EBI-347416 MINT-62595 MINT-62769 MINT-62693 I2D: score=4 STRING: ENSP00000364813
    ENSG00000172850Q9Y3331, 2, 3EBI-347633,EBI-347416 MINT-62595 MINT-62769 MINT-62693 I2D: score=4 
    ENSG00000225998Q9Y3331, 2, 3EBI-347633,EBI-347416 MINT-62595 MINT-62769 MINT-62693 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF408 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF408 (ZN408)

    Search CenterWatch for drugs/clinical trials and news about ZNF408 / ZN408

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF408 gene (2 alternative transcripts): 
    NM_001184751.1  NM_024741.2  

    Unigene Cluster for ZNF408:

    Zinc finger protein 408
    Hs.656931  [show with all ESTs]
    Unigene Representative Sequence: NM_024741
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311764(uc001nde.2 uc010rgw.2) ENST00000531866 ENST00000526410
    ENST00000534481 ENST00000527008
    miRNA
    Products:
         
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF408
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF408 (NM_024741)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF408
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF408
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF408

    Additional mRNA sequence: 

    AF346626.1 AK022889.1 AK302180.1 BC013355.2 BC015708.2 

    5 DOTS entries:

    DT.308775  DT.120706588  DT.120706600  DT.102841102  DT.99945789 

    24/121 AceView cDNA sequences (see all 121):

    BF061011 BM680571 CA447608 BQ670029 AI816535 BQ671338 BU173878 BM674741 
    AK022889 CR606317 BM817636 BQ059385 CB130839 AF346626 BM717376 BX354336 
    AU279752 BQ707434 H63042 AU130916 BC013355 AW246726 BQ925223 BX353915 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF408    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5
    SP1:                    -     -           -           -                     
    SP2:                          -           -           -                     
    SP3:                    -     -           -                                 
    SP4:                    -     -                                             
    SP5:                                      -                                 


    ECgene alternative splicing isoforms for ZNF408

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF408 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTCGGCG
    ZNF408 Expression
    About this image


    See ZNF408 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF408

    SOURCE GeneReport for Unigene cluster: Hs.656931
        SABiosciences Custom PCR Arrays for ZNF408
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF408

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF408 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp4081 , 5 zinc finger protein 4081, 5 76.83(n)1
    69.18(a)1
      2 (50.63 cM)5
    3814101  NM_001033451.21  NP_001028623.11 
     916436695 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF4086
    Uncharacterized protein
    54(a)
    1 ↔ 1
    1(43109050-43110444)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7934211 zinc finger protein 408-like 51.02(n)
    47.25(a)
      793421  XM_001333131.1  XP_001333167.1 


    ENSEMBL Gene Tree for ZNF408 (if available)
    TreeFam Gene Tree for ZNF408 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF408 gene
    18/46 SIMAP similar genes for ZNF408 using alignment to 1 protein entry:     ZN408_HUMAN(see all similar genes):
    ZNF    ZNF697    ZNF709    ZNF323    ZNF844    ZNF157
    ZNF37A    ZNF419    ZNF558    ZNF565    ZNF589    ZNF92
    ZNF32    ZNF345    ZNF561    ZNF702P    ZNF75A    ZNF416

    ZNF408 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/159 SNPs in ZNF408 are shown (see all 159)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997490921,2
    C--46724242(+) TTGTTG/TGTTTA 2 -- int11Minor allele frequency- T:0.00EU 1323
    rs42974191,2
    C,F--46724289(-) TCACAG/CGCACA 4 /A syn1 ese36Minor allele frequency- C:0.10NA WA EU 6061
    rs799283461,2
    C,F--46724438(+) ACGGCG/ATCCTT 2 -- int11Minor allele frequency- A:0.03EA 120
    rs1402015021,2
    C,F--46724598(+) AGAGGC/TTTCAT 4 L F mis11Minor allele frequency- T:0.00NA 4550
    rs1498468661,2
    C,F--46724643(+) AACTGC/TTGCTG 4 L syn11Minor allele frequency- T:0.00NA 4428
    rs1480555281,2
    C--46724717(+) GTAGC-/AGTGG 
     TGACAGA
    AGTGG
    2 -- cds10--------
    rs1457221871,2
    C,F--46724722(+) AGTGGT/AGACAG 4 /E /V mis11Minor allele frequency- A:0.00NA 4382
    rs773737521,2
    C--46724724(+) TGGTGA/G/TCAGAA 6 T A S mis10--------
    rs3762203071,2
    C--46724728(+) GACAGA/CAGTGG 4 E A mis10--------
    rs1426287771,2
    C--46724801(+) ATGTGA/TCAAAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF408 (46722317 - 46727466 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF408: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF408
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF408

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF408 for disorders           About MalaCards

    ZNF408 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF408

    Export disorders for ZNF408 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF408 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF408)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 3 Lehner B. and Sanderson C.M. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. ZNF408 is mutated in familial exudative vitreoretinopa thy and is crucial for the development of zebrafish retinal vasculature. (PubMed id 23716654)1 Collin R.W....Cremers F.P. (2013)
    6. Genome-wide meta-analysis identifies 56 bone mineral d ensity loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (2012)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    8. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
    9. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    10. A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PubMed id 18255255)1 Gao J....Yu Y. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79797 HGNC: 20041 AceView: ZNF408 Ensembl:ENSG00000175213 euGenes: HUgn79797
    ECgene: ZNF408 H-InvDB: ZNF408

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF408 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF408 gene:
    Search GeneIP for patents involving ZNF408

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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