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Aliases for ZNF408 Gene

Aliases for ZNF408 Gene

  • Zinc Finger Protein 408 2 3
  • PR Domain Zinc Finger Protein 17 4
  • PRDM17 4
  • PFM14 4

External Ids for ZNF408 Gene

Previous GeneCards Identifiers for ZNF408 Gene

  • GC11P047600
  • GC11P046753
  • GC11P046686
  • GC11P046678
  • GC11P046428

Summaries for ZNF408 Gene

GeneCards Summary for ZNF408 Gene

ZNF408 (Zinc Finger Protein 408) is a Protein Coding gene. Diseases associated with ZNF408 include exudative vitreoretinopathy. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for ZNF408 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF408 Gene

Genomics for ZNF408 Gene

Regulatory Elements for ZNF408 Gene

Genomic Location for ZNF408 Gene

Start:
46,700,767 bp from pter
End:
46,705,916 bp from pter
Size:
5,150 bases
Orientation:
Plus strand

Genomic View for ZNF408 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF408 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF408 Gene

Proteins for ZNF408 Gene

  • Protein details for ZNF408 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9D4-ZN408_HUMAN
    Recommended name:
    Zinc finger protein 408
    Protein Accession:
    Q9H9D4
    Secondary Accessions:

    Protein attributes for ZNF408 Gene

    Size:
    720 amino acids
    Molecular mass:
    78439 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF408 Gene

Proteomics data for ZNF408 Gene at MOPED

Post-translational modifications for ZNF408 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF408 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF408 Gene

Domains for ZNF408 Gene

Gene Families for ZNF408 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF408 Gene

Suggested Antigen Peptide Sequences for ZNF408 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9D4

UniProtKB/Swiss-Prot:

ZN408_HUMAN :
  • Q9H9D4
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF408: view

Function for ZNF408 Gene

Molecular function for ZNF408 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF408 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 14667819
GO:0042802 identical protein binding IPI 15231747
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF408: view

miRNA for ZNF408 Gene

miRTarBase miRNAs that target ZNF408

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF408 Gene

Localization for ZNF408 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF408 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF408 Gene COMPARTMENTS Subcellular localization image for ZNF408 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF408 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF408: view

Pathways for ZNF408 Gene

SuperPathways for ZNF408 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF408 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF408: view

No data available for Pathways by source for ZNF408 Gene

Transcripts for ZNF408 Gene

Unigene Clusters for ZNF408 Gene

Zinc finger protein 408:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF408 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for ZNF408 Gene

GeneLoc Exon Structure for
ZNF408
ECgene alternative splicing isoforms for
ZNF408

Expression for ZNF408 Gene

mRNA expression in normal human tissues for ZNF408 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF408 Gene

SOURCE GeneReport for Unigene cluster for ZNF408 Gene Hs.656931

genes like me logo Genes that share expressions with ZNF408: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF408 Gene

Orthologs for ZNF408 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF408 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF408 35
  • 99.26 (n)
  • 99.17 (a)
ZNF408 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF408 35
  • 82.16 (n)
  • 78.65 (a)
ZNF408 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF408 35
  • 85.21 (n)
  • 82.75 (a)
ZNF408 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp408 35
  • 76.99 (n)
  • 69.18 (a)
Zfp408 16
Zfp408 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF408 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362202 35
  • 76.16 (n)
  • 68.44 (a)
lizard
(Anolis carolinensis)
Reptilia ZNF408 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf408 35
  • 56.28 (n)
  • 52.95 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7747 35
zebrafish
(Danio rerio)
Actinopterygii LOC793421 35
  • 50.65 (n)
  • 47.26 (a)
ZNF408 36
  • 35 (a)
OneToOne
Species with no ortholog for ZNF408:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF408 Gene

ENSEMBL:
Gene Tree for ZNF408 (if available)
TreeFam:
Gene Tree for ZNF408 (if available)

Paralogs for ZNF408 Gene

genes like me logo Genes that share paralogs with ZNF408: view

No data available for Paralogs for ZNF408 Gene

Variants for ZNF408 Gene

Sequence variations from dbSNP and Humsavar for ZNF408 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4297419 -- 46,702,739(-) TCACA(C/G)GCACA reference, synonymous-codon
rs11038972 -- 46,703,770(+) TTGTT(G/T)TTTTT intron-variant
rs11820768 -- 46,706,179(+) GCAGC(A/G)CTACT downstream-variant-500B
rs12278651 -- 46,703,983(+) tgtct(C/T)tgcct intron-variant
rs35287195 -- 46,705,758(-) ACCAC(A/C)AAGCA missense, reference

Relevant External Links for ZNF408 Gene

HapMap Linkage Disequilibrium report
ZNF408
Human Gene Mutation Database (HGMD)
ZNF408

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF408 Gene

Disorders for ZNF408 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNF408 Gene including...

Search for ZNF408 Gene in MalaCards »

Relevant External Links for ZNF408

Genetic Association Database (GAD)
ZNF408
genes like me logo Genes that share disorders with ZNF408: view

No data available for UniProtKB/Swiss-Prot for ZNF408 Gene

Publications for ZNF408 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 48
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for ZNF408 Gene

Sources for ZNF408 Gene

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