ZNF408 Gene
protein-coding GIFtS: 43
GCID: GC11P046722
|
|
zinc finger protein 408
| |
Aliases
for ZNF408 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4081 2 | | PR Domain Zinc Finger Protein 172 3 | | FLJ128271 | | PFM143 | | PRDM173 |
Export aliases for ZNF408 gene to outside databasesPrevious GC identifers: GC11P047600 GC11P046753 GC11P046686 GC11P046678 GC11P046428 |
Summaries
for ZNF408 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF408 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF408 gene promoter:
AREB6 CREB deltaCREB ATF-2 Lmo2 Nkx2-5 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF408
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF408 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2ZNF408 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P046722: view genomic region
(about GC identifiers)
Start:
|
46,722,317 bp from pter |
End:
|
46,727,466 bp from pter |
Size:
|
5,150 bases |
Orientation:
|
plus strand |
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Proteins
for ZNF408 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4 (See
protein sequence)Recommended Name: Zinc finger protein 408 Size: 720 amino acids; 78439 Da
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZNF408: NX_Q9H9D4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9D4
ZNF408 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171680.1 NP_079017.1
ENSEMBL proteins: ENSP00000309606
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF408 for ontologies About GeneDecksing
ZNF408 Antibody Products:
Assay Products for ZNF408: |
Protein
Domains /
Families
for ZNF408 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF408 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H9D4ProtoNet protein and cluster: Q9H9D4 UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4Similarity: Contains 10 C2H2-type zinc fingers |
Function
for ZNF408 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN408_HUMAN, Q9H9D4Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF408 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF408 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF408 (NM_024741) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF408 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF408 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF408 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF408 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF408 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF408
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/43 Interacting proteins for ZNF408 (Q9H9D41, 2, 3 ENSP000003096064) via UniProtKB, MINT, STRING, and/or I2D (see all 43)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| LSM2 | Q9Y3331, 2, 3, ENSP000003648134 | EBI-347633,EBI-347416 MINT-62595 MINT-62769 MINT-62693 I2D:
score=4 STRING: ENSP00000364813 | | CEP70 | Q8NHQ11, 2, 3, ENSP000002649824 | EBI-347633,EBI-739624 MINT-67519 I2D:
score=5 STRING: ENSP00000264982 | | ZBTB8A | Q96BR92, 3, ENSP000003626094 | MINT-68209 I2D:
score=3 STRING: ENSP00000362609 | | RALYL | Q86SE52, 3 | MINT-67463 I2D:
score=4 | | LDOC1 | O957511, 2, 3, ENSP000003595574 | EBI-347633,EBI-740738 MINT-66592 I2D:
score=5 STRING: ENSP00000359557 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF408 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF408 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF408
Search CenterWatch for drugs/clinical trials and news about ZNF408 / ZN408
|
Transcripts
for ZNF408 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF408 gene (2 alternative transcripts): NM_001184751.1 NM_024741.2 Unigene Cluster for ZNF408: Zinc finger protein 408 Hs.656931 [show with all ESTs]Unigene Representative Sequence: NM_0247415 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311764(uc001nde.2 uc010rgw.2) ENST00000531866 ENST00000526410
ENST00000534481 ENST00000527008
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF408 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF408 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF408 (NM_024741) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF408 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF408 |
Additional cDNA sequence: AF346626.1 AK022889.1 AK302180.1 BC013355.2 BC015708.2 5 DOTS entries: DT.308775 DT.120706588 DT.120706600 DT.102841102 DT.99945789 24/121 AceView cDNA sequences (see all 121): BC015708 CA447608 BC013355 BX354336 BQ670029 BQ671338 CD632274 NM_024741 AA639997 AK022889 BM817636 AW246726 CF243074 BM828902 AI242496 BM680571 BU173878 BX353915 CR606317 AU279752 BF061011 BM674741 BQ709038 AF346626
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF408 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 |
|---|
|
| SP1: | | | | | | | - | | - | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF408
|
Expression
for ZNF408 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF408 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCTCGGCG
About this image
See ZNF408 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF408
SOURCE GeneReport for Unigene cluster: Hs.656931
SABiosciences Custom PCR Arrays for ZNF408
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF408
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF408 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF408 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF408 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF408 |
Orthologs
for ZNF408 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF408 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ZNF4086 |
-- |
56(a) |
1 ↔ 1 |
1(43109050-43110444) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7934211 |
zinc finger protein 408-like |
51.02(n)
47.25(a) |
|
793421 XM_001333131.1 XP_001333167.1 |
ENSEMBL Gene Tree for ZNF408 (if available)
TreeFam Gene Tree for ZNF408 (if available) |
Paralogs
for ZNF408 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF408 gene
- ZNF6682
18/51 SIMAP similar genes for ZNF408 using alignment to 1 protein entry: ZN408_HUMAN(see all similar genes):ZNF ZNF697 ZNF709 ZNF323 ZNF844 ZNF157
ZNF37A ZNF419 ZNF558 ZNF565 ZNF589 ZNF92
ZNF32 ZNF345 ZNF561 ZNF702P ZNF75A ZNF416
ZNF408 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF408 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF408 (46722317 - 46727466 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF408: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF408 |
|
Disorders
/ Diseases
for ZNF408 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF408 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF408 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZNF408) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 3 Lehner B. and Sanderson C.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
- Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1 Rivadeneira F....Uitterlinden A.G. (2009)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PubMed id 18255255)1 Gao J....Yu Y. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for ZNF408 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF408 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF408 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF408 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF408 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF408 gene:
Search GeneIP for patents involving ZNF408
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF408 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF408 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF408 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF408 | | | OriGene Protein Over-expression Lysate for ZNF408 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF408 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF408 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF408 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF408 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF408 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF408 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF408 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF408 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF408 |
| |
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| |  |  |  |  | | | | |
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 |
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 | | | ZNF408 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF408 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF408 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF408 |
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